Location: EMBL-EBI, Hinxton near Cambridge, UK
Staff Category: Staff Member
Contract Duration: 2 years and 6 months
Grading: 5 or 6 (monthly salary starting at £2,631.99 after tax)
Closing Date: 1 April 2019
Reference Number: EBI01371
Are you a Bioinformatician or data scientist who wants to integrate and mine genomic and phenotypic cancer data? Do you have the skills to research, design, and develop analyses for data genetic contributors for cancer? If so, this position is for you!   EMBL-EBI Mouse Informatics is building off recent successes in developing a cancer model platform (see Conte et al Nucleic Acids Research, Jan 2019) and has secured funding with the EurOPDX consortium to expand our team to harmonise, analyse and help disseminate the rich ‘Omics' and pphenotypical data from this world-leading cancer research consortium. This unique opportunity will provide the candidate unfettered access to unique datasets with direct relevance to human health while taking part in global collaborations and publishing in top-tier journals.

Your role

We are searching for a highly skilled bioinformatician to support the EurOPDX consortium in their analysis of genomic and drug response data from Patient Derived Xenograft  (PDX) models.  PDX models are generated by the implantation of human tumor tissues or cells into severely immunodeficient mouse host strains are  a versatile oncology research platform for studying tumor biology and for testing chemotherapeutic approaches. The EurOPDX has recently been funded by the EC to create a network of Europe’s leading cancer research institutes to coordinate production and research activities with PDX models. The EMBL-EBI partner is responsible for developing standards, harmonising PDX-related data and developing analysis pipelines to feedback results the consortium partners and the wider cancer research community.   The candidate will have the exciting opportunity to re-use, design and develop analyses pipeline to explore one of the fundamental problems of biology- how do our genes contribute to cancer ? The ideal candidate will have practical knowledge of NGS algorithms, demonstrable experience with commonly used cancer bioinformatics and strong programming skills (Python, R, Java, or equivalent). The candidate will be part of growing team that is contributing to the state-of-the-art for phenomics and will form global collaborations with peers in dedicated data analysis groups. The candidate will also frequently liaison with the biologists and clinicians that are part of the PDX communities and have the opportunity to present their work at international meetings and publish in peer-reviewed journals.

You have

The ideal candidate will have 3-years experience in bioinformatics and hold a postgraduate degree in Bioinformatics and related fields, although candidates with equivalent experience will also be considered.
  • Solid skillset and experience in working in Bioinformatics
  • Practical knowledge of NGS algorithms and available resources for cancer bioinformatics
  • Performed comparisons between NGS data sets
  • Proficiency with handling large data sets and developing robust analysis pipelines
  Willingness to undertake international travel and availability for US based teleconferences is essential for this post. Excellent interpersonal, communication and English skills are also essential as the role will involve liaising with other scientists at the EBI and from around the world.

You might also have

  • Familiarity with using ontologies

Why join us

At EMBL-EBI, we help scientists realise the potential of ‘big data’ in biology by enabling them to exploit complex information to make discoveries that benefit mankind. Working for EMBL-EBI gives you an opportunity to apply your skills and energy for the greater good. As part of the European Molecular Biology Laboratory (EMBL), we are a non-profit, intergovernmental organisation funded by 22 member states and two associate member states. We are located on the Wellcome Genome Campus near Cambridge in the UK, and our 600 staff are engineers, technicians, scientists and other professionals from all over the world.   EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. The remuneration package comprises a competitive salary, a comprehensive pension scheme and health insurance, educational and other family related benefits where applicable, as well as financial support for relocation and installation. For more information about pay and benefits click here.   We have an informal culture, international working environment and excellent professional development opportunities but one of the really amazing things about us is the concentration of technical and scientific expertise – something you probably won’t find anywhere else.   If you’ve ever visited the campus you’ll have experienced first-hand our friendly, collegial and supportive atmosphere, set in the beautiful Cambridgeshire countryside. Our staff also enjoy excellent sports facilities including a gym, a free shuttle bus, an on-site nursery, cafés and restaurant and a library.

What else do I need to know

To view a copy of the full job description please click here.

To apply please submit a covering letter and CV through our online system.

Applications are welcome from all nationalities and this will continue after Brexit. For more information please see our website. Visa information will be discussed in more depth with applicants selected for interview.

EMBL-EBI is committed to achieving gender balance and strongly encourages applications from women, who are currently under-represented at all levels. Appointment will be based on merit alone. This position is limited to the project duration specified.

Applications will close at 23:00 GMT on the date listed above.