Computational Postdoctoral Fellow
Location: EMBL-EBI, Hinxton near Cambridge, UK
Staff Category: Postdoctoral Fellow
Contract Duration: 3 years
Grading: Year 1 Stipend (£2,829 per month after tax)
Closing Date: 21 August 2020
Reference Number: EBI01680
We are looking for a postdoctoral fellow to join the Open Targets program under the leadership of Dr Ana Cvejic (Wellcome Sanger Institute), Moritz Gerstung (EBI) and Omer Bayraktar (WSI).

Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This pioneering public-private partnership between Sanofi, Celgene, EMBL-EBI, GlaxoSmithKline, and the Wellcome Sanger Institute, aims to provide a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community.   

Your role

In this project you will analyse newly single cell (scRNA-Seq and scATAC-Seq) as well as novel and spatial transcriptomics data sets (In Situ Sequencing and 10x visium) generated in the Cvejic and Bayraktar labs to understand the molecular properties of immune cells infiltrating tumour sites. The underlying data sets comprise thousands of unique molecular signals measured for tens of thousands of cells or physical locations in each tumour.

You will employ methods from high dimensional and spatial statistics developed in the Gerstung group to chart and understand the nature of different tumour-associated immune cells, how they interact and change biological functions and how the underlying molecular changes could be exploited as therapeutic targets.

You will be part of a multidisciplinary team and will be tasked with proactively seeking and maintaining appropriate collaborations.

You will also be expected to drive forward the project, working closely with biologists, clinicians and bioinformaticians within and outside the group to accomplish scientific objectives.  

You have

The post-holder will be passionate about science, hardworking, and excited to learn and improve skills in an outstanding research environment. In addition, the successful post-holder will have:
  • A PhD in Bioinformatics, Computational Biology, Biostatistics or in a related quantitative field (e.g. Mathematics, Physics, Statistics), and a passion for problem solving 
  • Extensive experience in a research environment with a well-established publication track record 
  • Formal and extensive training in mathematical and statistical analysis of complex data sets 
  • An understanding, experience and published outcomes from analysing and interpreting large datasets using statistical programming languages (e.g. R or Python) 
  • The ability to effectively communicate with collaborators and occasionally present oral communication to large groups 
  • Proven independent working style, technical problem solving, data analysis and generation of novel ideas 

You might also have

  • Experience with single cell data analysis
  • Training in statistical methods appropriate for biological research 
  • Experience in genomics approaches and in method development 

Why join us

EMBL-EBI is a worldwide leader in bioinformatics. As part of the European Molecular Biology Laboratory (EMBL), we are a non-profit, intergovernmental organisation funded by over 27 member states and two associate member states. We encourage personal and professional development and are committed to ensuring our employees feel valued, supported and empowered to reach their potential at work. 

Surrounded by picturesque South Cambridgeshire countryside, our Campus provides employees with a relaxed atmosphere where the pursuit of scientific discovery and meaningful work, underpin every role. In addition, our employees have access to a wide range of benefits including:
  • 30 days annual leave per year plus 8 bank holidays
  • Flexible work arrangements
  • Unique pension scheme including 17% employer contribution
  • Private medical insurance for you and your immediate family (including all prescriptions and generous dental & optical cover)
  • Death benefit, long-term care, accident at work and unemployment insurances
  • Relocation package including installation grant (if required)
  • On-site library and subsidised on-site gym and cafeteria
  • Casual dress code
  • Free shuttle bus to and from Campus
  • Extensive sports and social club activities (run on campus and remotely)

What else you need to know

To apply please submit a covering letter and CV through our online system. EMBL is an inclusive, equal opportunity employer. Applications are encouraged from all nationalities and this has continued after Brexit. For more information please see our website. Visa information will be discussed in more depth with applicants selected for interview.

Fixed-term Fellows contract for a duration of 3 years. 

Applications will close at 23:00 BST on the date listed above.