Bioinformatics Developer
Location: EMBL-EBI, Hinxton near Cambridge, UK
Staff Category: Staff Member
Contract Duration: End of July 2024
Grading: Grade 5 or 6 (starting at £2,738 or £3,063 per month after tax) + other paid benefits
Closing Date: 29 May 2021
Reference Number: EBI01840
Genome sequencing to discover and analyse an individual’s genotype can help understand potential disease mechanisms and improve diagnosis, however the reference sequences currently used in this process were derived from a limited number of people which limits the variants that can be discovered. As part of the Human Pangenome Reference Consortium (HPRC), we will work to enable the adoption a new graph genome reference, constructed from the sequences of over 300 individuals of diverse ancestries.

Your role

You will help adapt our variation tools, pipelines and resources to utilise this new reference and make pangenome data available to the community. Your primary responsibilities will include:
  • Investigating and integrating new data formats and tools
  • Developing and maintaining efficient methods for large-scale variant data management
  • Developing and maintaining tools for the functional annotation of variants
  • Collaborating with members of the broader Ensembl team both on specific development projects and to contribute to regular data/software releases
  • Engaging with the HPRC to understand tool availability and data quality
  • Sharing our work at internal meetings and scientific conferences and engaging with our user community to provide support and understand their needs

You have

  • High proficiency in at least one programming language, preferably with knowledge of Python or Perl
  • Experience of working with large-scale genomics data, preferably sequence variation data
  • Experience of working collaboratively in a production development environment
  • The ability to work to deadlines while delivering a high-quality product
  • Clear and accurate technical communication skills
  • High proficiency working in a UNIX/Linux environment

You might also have

  • Experience of the design and development of efficient large-scale data analysis pipelines
  • Familiarity with bioinformatics software and formats such as CRAM, VCF, bcftools and GATK
  • Experience of the design and development of user-friendly tools/APIs
  • Experience of the use of relational database systems
  • Familiarity with Ensembl APIs and services

Why join us

Do something meaningful
At EMBL-EBI you can apply your talent and passion to accelerate science and tackle some of humankind's greatest challenges. EMBL-EBI is a worldwide leader in the storage, analysis and dissemination of large biological datasets. We provide the global research community with access to publicly available databases and tools which are crucial for the advancement of healthcare, food security, and biodiversity.

Join a culture of innovation
We are located on the Wellcome Genome Campus, alongside other prominent research and biotech organisations, and surrounded by beautiful Cambridgeshire countryside. This is a highly collaborative and inclusive community where our employees enjoy a relaxed atmosphere. We are committed to ensuring our employees feel valued, supported and empowered to reach their professional potential.

Enjoy lots of benefits:
  • Financial incentives: Monthly family, child and non-resident allowances, annual salary review, pension scheme including 17% employer contribution, death benefit, long-term care, accident-at-work and unemployment insurances
  • Flexible working arrangements
  • Private medical insurance for you and your immediate family (including all prescriptions and generous dental & optical cover)
  • Generous time off: 30 days annual leave per year, in addition to eight bank holidays
  • Relocation package including installation grant (if applicable)
  • Campus life: Free shuttle bus to and from work, on-site library, subsidised on-site gym and cafeteria, casual dress code, extensive sports and social club activities (on campus and remotely)
  • Family benefits: On-site nursery, child sick leave, generous parental leave, holiday clubs on campus and monthly family and child allowances
  • Benefits for non-UK residents: Visa exemption, education grant for private schooling, financial support to travel back to your home country every second year and a monthly non-resident allowance.
For more details please see our employee benefits page

What else you need to know

  • Contract duration: This position is a project based role until July 2024
  • International applicants: We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants
  • Diversity and inclusion: At EMBL-EBI, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ+ and individuals from all nationalities. 
  • Job location: This role is based in Hinxton, UK and you will be required to relocate once it is safe to do so, if you are currently based abroad. Read more about how we are recruiting during the pandemic
Your application: To apply please submit a cover letter and a CV through our online system. We aim to provide a response within two weeks after the closing date