Chemogenomics Analyst
Location:EMBL-EBI Hinxton near Cambridge, UK
Staff Category:Staff Member
Contract Duration:2 Years
Grading:5 (monthly salary starting at £2,507 after tax). For more information about pay and benefits click here
Closing Date:9th April 2017
Reference Number:EBI_00897

Job Description

We are looking to recruit a scientist to support our work for the Horizon 2020 project “Coordinated Research Infrastructures Building Enduring Life-science services” (Corbel). The role is to facilitate scientists in their use of chemogenomics resources by enabling database searching and evaluation of data.

  • To be responsible for liaising with scientists engaged in Corbel and advising on the use of chemogenomics resources to progress their projects;
  • To help in the identification and analysis of bioactivity data from multiple database resources;
  • To construct and utilize appropriate workflows to facilitate the pharmacological profiling of molecules and chemotypes, the identification of potential off-target effects and the development of target prediction models;
  • To identify interoperability gaps between resources and help with developing solutions;
  • To organize and run appropriate training courses for scientists engaged in the Corbel project;

The appointee will report to the ChEMBL Group Leader.

At EMBL-EBI, we help scientists realise the potential of ‘big data’ in biology by enabling them to exploit complex information to make discoveries that benefit mankind. Working for EMBL-EBI gives you an opportunity to apply your skills and energy for the greater good. As part of the European Molecular Biology Laboratory (EMBL), we are a non-profit, intergovernmental organisation funded by 22 member states and two associate member states and proud to be an equal-opportunity employer. We are located on the Wellcome Genome Campus near Cambridge in the UK, and our 600 staff are engineers, technicians, scientists and other professionals from all over the world.

Qualifications and Experience

You will have a PhD (or equivalent) in a chemical, biological or biomedical science. You will also have sound knowledge of chemoinformatics, pharmacology and mechanisms of drug action.

At least 5 years postgraduate experience of working in a research environment on multi-disciplinary projects is ideal. Prior experience of data analysis and working with chemical structures and bioactivity data is essential. Experience of handling and manipulating large data sets is also essential. You will also have a good understanding of the components of the drug discovery process.

Proficiency in a programming/scripting language such as python, Perl etc. is needed, as well as having experience of working with chemoinformatics toolkits such as RDkit. Experience working with workflow tools such as knime or pipeline pilot is also highly desirable. Experience with statistical analysis software and the ability to query relational databases using SQL would also be advantageous.

You will work closely with members of the ChEMBL Group as well as scientists working on the Corbel project. You will therefore need to be a team player, engaging with multiple collaborators and be able to independently identify innovative solutions to diverse drug discovery questions. You will have excellent communication skills (both verbal and presentational) and will need to be able to deliver bespoke training sessions.

Benefits

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. The remuneration package comprises a competitive salary, a comprehensive pension scheme and health insurance, educational and other family related benefits where applicable, as well as financial support for relocation and installation.

We have an informal culture, international working environment and excellent professional development opportunities but one of the really amazing things about us is the concentration of technical and scientific expertise – something you probably won’t find anywhere else.

If you’ve ever visited the campus you’ll have experienced first-hand our friendly, collegial and supportive atmosphere, set in the beautiful Cambridgeshire countryside. Our staff also enjoy excellent sports facilities including a gym, a free shuttle bus, an on-site nursery, cafés and restaurant and a library.

Application Instructions

To apply please submit a covering letter and CV, with two referees, through our online system

Additional Information

Applications are welcome from all nationalities - visa information will be discussed in more depth with applicants selected for interview.

EMBL-EBI is committed to achieving gender balance and strongly encourages applications from women, who are currently under-represented at all levels. Appointment will be based on merit alone.

This position is limited to the project duration specified.

Applications will close at 23:00 GMT on the date listed above.