Postdoctoral Fellow
Location:EMBL-EBI Hinxton near Cambridge, UK
Staff Category:Postdoctoral Fellow
Contract Duration:2 years
Grading:Year 1 Stipend
Closing Date:28th May 2017
Reference Number:EBI_00935

Job Description

We are looking for a highly motivated Postdoctoral fellow to investigate context dependent changes in cell signalling using single cell microscopy, image analysis and modelling. Our group is interested in studying the molecular sources of phenotypic novelty. Within this broad scope the group has been focused on the study of function, specificity and genetic determinants of post-translational regulatory networks. As part of this research agenda, we are interested in understanding how changes in cellular states driven by differentiation, tissue of origin, genetic background or cell-to-cell communication alter signaling networks of the cells. More details can be found at http://www.ebi.ac.uk/beltrao.

The successful applicant would be combining our ongoing work on condition dependent phosphoproteomics (Ochoa et al. Mol Sys Bio 2016, http://phosphate.com) and variant effect predictions (http://mutfunc.com) with single cell microscopy readouts and modeling of cell signaling with the aim of understanding changes in kinase signaling due to genetic or differentiation differences. These studies will be part of a broader collaborative effort with microscopy labs working on cell imaging of human cells in different contexts (e.g. cancer, differentiation and cell cycle). The proposed projects will involve quantitative analysis of single-cells and cell populations by live-cell imaging and reverse engineering approaches for network reconstruction.

EMBL-EBI is part of the European Molecular Biology Laboratory (EMBL) and it is a world-leading bioinformatics centre providing biological data to the scientific community with expertise in data storage, analysis and representation. EMBL-EBI provides freely available data from life science experiments, performs basic research in computational biology and offers an extensive user training programme, supporting researchers in academic and industry. We have close ties with both the University of Cambridge and the Wellcome Trust Sanger Institute.

Qualifications and Experience

Considered applicants must hold a PhD in Life Sciences and have previous experience in quantitative approaches and computational biology. The ideal candidate will have expertise in modelling of dynamical systems and image analysis. Experience in mammalian cell signaling will be considered an asset. The postholder should enjoy working in a highly collaborative and interdisciplinary environment. Good written and oral communication skills are essential.

Informal enquiries about the post can be directed to pbeltrao@ebi.ac.uk

Benefits

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. The remuneration package comprises a competitive salary, a comprehensive pension scheme and health insurance, educational and other family related benefits where applicable, as well as financial support for relocation and installation.



We have an informal culture, international working environment and excellent professional development opportunities but one of the really amazing things about us is the concentration of technical and scientific expertise – something you probably won’t find anywhere else.



If you’ve ever visited the campus you’ll have experienced first-hand our friendly, collegial and supportive atmosphere, set in the beautiful Cambridgeshire countryside. Our staff also enjoy excellent sports facilities including a gym, a free shuttle bus, an on-site nursery, cafés and restaurant and a library.


Application Instructions

To apply please submit a covering letter and CV, with two referees, through our online system.

Additional Information

Applications are welcome from all nationalities - visa information will be discussed in more depth with applicants selected for interview.

EMBL-EBI is committed to achieving gender balance and strongly encourages applications from women, who are currently under-represented at all levels. Appointment will be based on merit alone.

Applications will close at 23:00 GMT on the date listed above.