Postdoctoral Fellow
Location: Grenoble, France
Staff Category: Postdoctoral Fellow
Contract Duration: 2 years
Grading: NA
Closing Date: 15 March 2021
Reference Number: GR00161
A 2-year postdoc position is available immediately in the group of Dr. Marco Marcia at the European Molecular Biology Laboratory (EMBL) in Grenoble, France (https://www.embl.fr/research/unit/marcia), one of the highest ranked scientific research organisations worldwide. We are seeking to recruit an outstanding candidate with a strong interest in deciphering the molecular mechanism of long non-coding RNAs involved in cancer and development. Examples of recent work of the lab in the field are: Uroda et al, Mol Cell 2019 (doi: 10.1016/j.molcel.2019.07.025) and Uroda et al, Nat Prot 2020 (doi: 10.1038/s41596-020-0323-7). The candidate will have direct access to and will make use of research infrastructure located at EMBL Grenoble and at all other EMBL sites (Heidelberg, Hinxton near Cambridge, Rome, Barcelona and Hamburg; http://intranet.embl.de/scientific_services/index.html). Moreover, the candidate will have collaborative or service access to facilities located at the European Photon Neutron Campus (EPN) within the context of the Partnership for Structural Biology (PSB; https://www.psb-grenoble.eu/), and at other outstanding research institutes in Grenoble (particularly the Institute of Advanced Biosciences, IAB; https://iab.univ-grenoble-alpes.fr/).

Your role

In this position, the candidate will identify cellular interaction partners of target lncRNAs studied by the lab, with particular priority to human MEG3, by means of hybridization capture and proteomic, transcriptomic, and genomic analysis. The candidate will then validate these interactions by in vivo and in vitro biochemical and imaging techniques, and formulate and test mechanistic hypotheses to describe the specific and selective cellular functions of the target lncRNA.

The candidate will also participate in routinary lab activities, i.e. weekly group meetings, progress reports, sharing of responsibilities related to instruments and tasks that ensure the efficient progression of the lab research activities.

You have

Applicants should hold a Ph.D. in biochemistry, molecular, cellular biology or related fields, and have a solid background in biochemical analysis of proteins and/or RNA complexes. Experience in RNA hybridization capture and affinity purification of endogenous RNA-protein complexes (CHART, ChIRP, I-DRIP, RAP) would be an advantage. The laboratory pursues an interdisciplinary structural and cellular approach in the characterization of specific lncRNAs, and has direct access to on-site and intra-institutional state-of-the-art Proteomics, Genomics, Imaging, Genetic engineering, Flow Cytometry, and Structural Biology facilities. Motivation to work in a multidisciplinary and international environment and commitment to secure independent postdoctoral funding are essential.  

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises from a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family. Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

What else you need to know

The position is open immediately. Applications will be considered on a rolling basis, as soon as submitted, and until the position is filled. Informal inquires can be addressed to Dr. Marco Marcia directly (mmarcia@embl.fr).