Scientific Officer
Location: Heidelberg, Germany
Staff Category: Staff Member
Contract Duration: 3 years (renewable)
Grading: 6, 7 or 8; depending on experience and qualifications
Closing Date: 30 June 2021
Reference Number: HD01977
The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world aimed to explore the secrets of life. EMBL integrates 27 members states and currently employs 1800 people across its six sites in Heidelberg, Barcelona, Grenoble, Hamburg, Hinxton, and Rome. EMBL Heidelberg is the headquarters site located in Heidelberg, Germany, integrating both research groups and core facilities.

Metabolomics Core Facility (https://www.embl.de/mcf) led by Theodore Alexandrov provides services for the analysis of metabolites and lipids to the internal EMBL users as well as to external users. The services include untargeted and targeted measurements of various classes of molecules ranging from small metabolites to lipids in a variety of biological matrices.

The facility is equipped with a high-resolution mass spectrometry system (HRMS), triple quadrupole with an ion trap (QTRAP) mass spectrometer coupled with ultra-high performance liquid chromatography (UHPLC), and direct infusion system (NanoMate) for separation and detection of various classes of small molecules, metabolites, lipids, and drugs.

For more information on the facility, please visit the facility website (https://www.embl.de/mcf) that presents more information about the services, instrumentation, protocols, spectral library as well as video tutorials prepared together with EMBL videolab and publications of the facility members and users.  

Your role

EMBL is looking for a Scientific Officer to join the Metabolomics Core Facility. The key responsibilities will include:
  • Operating, maintaining, troubleshooting and record keeping for liquid chromatography, high resolution mass spectrometry instruments such as Orbitrap and QTRAP-QQQ mass spectrometers
  • Perform metabolomics and/or lipidomics experiments, follow analytical workflows and quality control systems from sample preparation to LC-MS analysis followed by in-depth data analysis for reporting results to the users
  • Advising users on the experimental design, sample collection and processing in order to ensure validity and reliability of the results
  • Managing requests, incoming samples, metabolite and lipid standards, spectral libraries and effectively using them for data analysis
  • Contributing to administrative responsibilities of the facility such as ordering and maintaining lab inventory, invoicing users, day-to-day lab activities
We are seeking for excellent candidates with experience. Depending on the experience and qualifications, the seniority of the position can be adjusted.

You have

Applicants should have a Masters / Ph.D. degree or equivalent in Analytical Sciences, Chemistry or related disciplines. One or more years of relevant hands-on experience in the mass spectrometry field particularly working with LC-MS/MS are essential. Practical experience in either metabolomics-, lipidomics- or small molecule-applications using mass spectrometry and with data analysis tools is required. Hands-on experience in bioanalytical methods for small molecule analysis, characterization of complex biological samples, and structural identification using LC-MS/MS is required. Communication skills in English, demonstrated ability or willingness to work in an interdisciplinary environment are required.

You might also have

  • Knowledge of metabolite or lipid identification, as well as performing large scale data processing and statistical analysis using software such as CompoundDiscoverer, Progenesis QI, Sciex OS as well as academic software for metabolomics
  • Experience working in the facility environment
  • Experience working with diverse samples ranging from cells and tissues to microbial extracts and biofluids

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. We offer a highly collaborative, cutting-edge and vibrant international atmosphere with a very collegial and family-friendly working environment with excellent professional development opportunities. The remuneration package includes a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family. Our staff also enjoy excellent conferences and training facilities, shuttle bus, an on-site kindergarten, a gourmet canteen and cafeteria, as well as off-site retreats. The knowledge of the German language is not required.

What else you need to know

The facility staff is integrated into the research team led by Theodore Alexandrov with the focus on spatial and single-cell metabolomics with several joint projects and developments, as well as joint meetings, activities, and retreats.

Please note that appointments on fixed term contracts can be renewed up to 9 years, depending on circumstances at the time of the review.