Postdoctoral Fellowships in Single Molecule and Super Resolution Microscopy of Disordered Protein dynamics and Viral Interaction mechanisms (2 Positions)
Location:EMBL Heidelberg and JGU, IMB Mainz, Germany
Staff Category:Postdoctoral Fellow
Contract Duration:1 year (renewable, 3 years foreseen)
Closing Date:10 June 2018
Reference Number:HD_01298

Job Description

The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations worldwide. The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Barcelona (Spain), Grenoble (France), Hamburg (Germany), Hinxton near Cambridge (UK), Rome (Italy).

In higher eukaryotes, proteins that lack apparent folded structure are enriched in many vital processes. The group of Dr. Lemke at the JGU and IMB Mainz as well as the EMBL, studies interactions between intrinsically disordered proteins and structured proteins in vital cellular processes, such as nuclear transport and host pathogen interactions. Since such highly dynamic systems are inaccessible by most conventional approaches, the group applies a multidisciplinary approach combining single molecule, microfluidics and super-resolution techniques with chemical biology tools.

As part of an ERC funded project “Next generation Single Molecule Protein Fluorescence” as well as large consortia on pathogen mechanisms (SDB1129) we are now looking for two postdoctoral fellows with a strong interest in further expanding quantitative single molecule and super resolution based technologies to understand the molecular mechanisms of intrinsically disordered proteins as well as viral interactions with nuclear pore complexes.

The projects are ideally suited for candidates with a strong background in the physical sciences, such as advanced fluorescence techniques, soft matter sciences, optical engineering, data analysis, physical chemistry and/or computer heavy disciplines. Previous experience in programming will be seen as a major advantage.

The interest to work interdisciplinary including aspects in biochemistry, chemical/synthetic biology, mammalian cell culture and genetic engineering is important for the success of the projects. Extensive on the project training can be provided in these areas so that candidates with little hands on experience in the experimental biosciences but the strong wish to engage into those are particularly encouraged to apply. High interest and motivation are the main selection criteria and candidates from other disciplines that want to venture into these areas are explicitly welcome to apply.

The group of Dr. Lemke is embedded into the interdisciplinary environment of the IMB Mainz and the newly built Biocentre of the JGU Mainz, as well as the Structural and Computational Biology, and Cell Biology and Biophysics Units at the EMBL Heidelberg. This setting offers interactions with a large range of groups spanning various techniques from the molecular to the systems level. Applicants should feel comfortable to work in such interdisciplinary and international environments and show interest in long-term stays between the different sites (commutable distance).

Application Instructions

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Additional Information

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises from a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.