Postdoctoral Fellow - Structural biology of Plasmodium falciparum membrane complexes
Location: Hamburg, Germany
Staff Category: Postdoctoral Fellow
Contract Duration: 2 years
Grading: Stipend
Closing Date: 4 July 2021
Reference Number: HH00199
We are seeking for a highly motivated structural biologist with cryo-EM expertise to study membrane complexes of the malaria parasite Plasmodium falciparum. The research portfolio of the Hamburg Unit is mainly focused on structures of membrane proteins and large protein complexes by diverse structural biology approaches including X-ray crystallography and cryo-electron microscopy. You will be affiliated with the research group of Christian Löw at EMBL Hamburg located at the recently established Centre for Structural Systems Biology (CSSB) on DESY campus in Hamburg, and work in a close collaborative project with the groups of Jan Kosinski (EMBL Hamburg), Michael Filarsky (University of Hamburg), the cryo-EM Multi-user facility and the protein production team at CSSB.The Löw laboratory is specialized in structural biology of integral membrane proteins and uses innovative approaches to study their structure, function and dynamics.  

Your role

You will work in a team of structural and computational biologists at CSSB and investigate membrane protein complexes in the transmissible gametocyte stages of the malaria parasite Plasmodium falciparum. You will design, perform and troubleshoot experiments in an independent manner, and lead your own research project. The work aims at biological discoveries comprising both methodological and applied aspects.  

You have

  • A Ph.D. degree in biochemistry, biophysics or structural biology (or a related field)
  • Experience in structure determination of proteins and protein complexes by cryo-EM
  • Working experience in molecular biology and protein biochemistry with a demonstrated record of accomplishments
  • Ability to plan and pursue a research project independently and in a team
  • Willingness to learn new skills as projects require
  • Excellent communication, interpersonal and English language skills

You might also have

  • Experience in other structural biology methods (X-ray crystallography, SAXS, NMR, …)
  • Experimental expertise in the field of membrane proteins • Familiarity with eukaryotic expression systems

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family. Scientists and engineers at the EMBL Hamburg Unit benefit from cutting-edge technology to enable leading research in Structural Biology using on-site synchrotron radiation beamlines operated by EMBL Hamburg and opportunities for collaboration with colleagues from all six EMBL sites.  

What else you need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1600 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome. Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research. Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.