Proteins are the main effectors of the genomic message. Following up on intense genome sequencing efforts, Proteomics and Structural Biology have emerged as key disciplines, aiming at defining and characterising (functionally, structurally, etc.) the full set of proteins expressed from genomes. This required the development of new techniques as well as expansion of classic methods to a format, where high-throughput technology can be employed.
In this course, you will learn about the theory and practice of various methods that are used to explore protein identity, structure and function. You will be exposed to classic concepts and recent development in mass spectrometry and to the study of protein-protein interactions in cells. In addition, you will be guided through the principles, technical challenges, and applications of Structural Biology methods including Electron Microscopy, X-ray Crystallography, Nuclear Magnetic Resonance Specrtoscopy, and Biophysics. Finally, we will expand the view to the 'omics scale to include how structural methods can be used in a high- or at least medium-throughput format.
In addition to lectures and hands-on practicals, the module offers an interactive Journal Club in a small group format, in which course course participants will give presentations about selected papers in the fields of Proteomics and Structural Biology.