The Diz-Muñoz group uses atomic force microscopy and live cell imaging to characterise and modify mechanical properties of cells and tissues. We also aim to develop non-contact techniques to measure and control such properties.
This will allow us to pursue a comprehensive understanding of the specific contribution of different force inputs (e.g. adhesion, membrane tension, contractility, stiffness) for cell polarization. Moreover, this will provide an avenue to assess how these inputs affect signaling and set a framework to theoretically describe the complex reality of cell migration.
Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. Alba Diz-Muñoz, Kevin Thurley, Sana Chintamen, Steven J. Altschuler, Lani F. Wu, Daniel A. Fletcher, and Orion D. Weiner. PLoS Biology (2016) vol. 14(6).
Use the force: membrane tension as an organizer of diverse cellular functions. Alba Diz-Muñoz, Daniel A. Fletcher and Orion D. Weiner. Trends Cell Biol (2013) vol. 23 (2).
Control of directed cell migration in vivo by membrane to cortex attachment. Alba Diz-Muñoz , Michael Krieg , Martin Bergert, Itziar Ibarlucea-Benitez, Daniel Muller, Ewa Paluch and Carl-Philipp Heisenberg. PLoS Biology (2010) vol. 8 (11).