Prevedel Group: Advanced optical techniques for deep tissue microscopy

Advanced optical techniques for deep tissue microscopy

The Prevedel group develops new optical approaches and techniques to non-invasively image dynamic cellular processes in living tissue. To advance the frontiers of deep tissue microscopy we integrate concepts from diverse physical fields, such as wavefront engineering, photo-acoustics and computational imaging. At the same time, we engineer innovative optical and mechanical hardware solutions for our microscopes to adapt them to particular samples and imaging conditions. In order to interpret our recordings, we also develop custom software to automate the extraction of relevant parameters from our data.

Prevedel Group

Selected publications

Rupprecht P, Prevedel R, Groessl F, Haubensak WE, Vaziri A. (2015)
Optimizing and extending light-sculpting microscopy for fast functional imaging in neuroscience
Biomed Opt Express 6:353-368. doi: 10.1364/BOE.6.000353
Europe PMC | doi

Prevedel R, Yoon YG, Hoffmann M, Pak N, Wetzstein G, Kato S, Schrodel T, Raskar R, Zimmer M, Boyden ES, Vaziri A. (2014)
Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy
Nat Methods 11:727-U161. doi: 10.1038/NMETH.2964
Europe PMC | doi

Schrodel T, Prevedel R, Aumayr K, Zimmer M, Vaziri A. (2013)
Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light
Nat Methods 10:1013-1020. doi: 10.1038/NMETH.2637
Europe PMC | doi