Future Seminars
Seminar Colour Guide:
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| Career Event | Friday, 30 October 2020, 11:00EMBL Careers Webinar | Careers in science communicationLucas Sanchez, Scienseed, Spain | Sophie Lutter, OXGENE, United KingdomHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Hamburg |
| Career Event | Friday, 30 October 2020, 11:00EMBL Careers Webinar | Careers in science communicationLucas Sanchez, Scienseed, Spain | Sophie Lutter, OXGENE, United KingdomHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Rome |
| Faculty Seminar | Friday, 30 October 2020, 11:00Hybrid molecular reporters for biological imagingClaire Deo, Cell Biology and Biophysics Unit, EMBL Heidelberg, Germany, , GermanyHost: Jamie HackettVirtual seminar, EMBL Rome Abstract: Advances in biology rely on the development of novel advanced molecular probes, able to report on the dynamics of biomolecules in complex systems. In this talk, I will present our groupâs current efforts on building innovative hybrid probes utilizing small-molecule fluorophores in combination with genetically encoded tags. Our approach, at the interface of synthetic chemistry and protein engineering, has the promise to overcome many limitations of currently available reporters. |
| Career Event | Friday, 30 October 2020, 11:00EMBL Careers Webinar | Careers in science communicationLucas Sanchez, Scienseed, Spain | Sophie Lutter, OXGENE, United KingdomHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Heidelberg |
| Career Event | Friday, 30 October 2020, 11:00EMBL Careers Webinar | Careers in science communicationLucas Sanchez, Scienseed, Spain | Sophie Lutter, OXGENE, United KingdomHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Grenoble |
| Career Event | Friday, 30 October 2020, 11:00EMBL Careers Webinar | Careers in science communicationLucas Sanchez, Scienseed, Spain | Sophie Lutter, OXGENE, United KingdomHost: EMBL Fellows' Career ServiceVirtual Seminar, EMBL Barcelona |
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| EMBL Distinguished Visitor Lecture | |
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| EMBL Barcelona Postdoc Seminar Series | Tuesday, 3 November 2020, 15:00Illuminating cerebral organoid development using single-cell genomics.Zhisong He, ETH, Zurich, SwitzerlandHost: Miki Ebisuya and Miquel Marin RieraVirtual Seminar, EMBL Barcelona Abstract: Elucidating mechanisms of human brain development is crucial for understanding human-specific cognitive abilities and neurodevelopmental disorders. Here, we used single-cell genomic technologies to characterize the cell type heterogeneity and developmental dynamics of cerebral organoids to understand early human brain development. We compared the differentiation trajectories of cerebral organoids over the entire course from iPSCs in humans with chimpanzees and macaques, and found that human neuronal development occurred more slowly. Human-specific gene expression changes could be linked with changes in chromatin accessibility. In addition, we developed a barcoded CRISPR-inducible lineage recording system coupled with single-cell transcriptomics, and applied it to cerebral organoids. We observed increased fate restriction over time, and found that iPSC clones accumulate in distinct brain regions. Our understanding of human brain development is far from complete, but the combination of cerebral organoid and single-cell genomic technologies has shown its potential to shed new light on these complex processes. |
| EMBL Barcelona Postdoc Seminar Series | Tuesday, 3 November 2020, 15:45Engineering T cell circuits that can sense antigen density with an ultrasensitive threshold
Rogelio Hernandez-Lopez, UCSF, USAHost: James Sharpe and Nicola GrittiVirtual Seminar, EMBL Barcelona Abstract: T cells can be redirected to kill tumor cells via synthetic T cell receptors (known as chimeric antigen receptors or CARs). However, CAR T cells, while efficient at tumor killing, still lack the ability to discriminate cancer cells from normal tissue that share common surface proteins, known as antigens. This prevents widespread use of CAR T cells against several cancer types due to toxicity and potentially lethal side effects. I have approached this problem of antigen density discrimination by engineering T cell circuits that can sense antigen density with an ultrasensitive response. I will discuss the design of a two-step recognition-activation circuit that allows T cells to selectively kill cancer cells where the tumor associated antigen is overexpressed ~100 fold relative to normal cells, both in vitro and in vivo. Such a scenario is found in breast, ovarian and lung cancers, for example. |
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| External Faculty Speaker | Thursday, 12 November 2020, 16:00How cell fate decisions are established and maintained by facultative heterochromatinOliver Bell, Keck School of Medicine of the
University of Southern California, USAHost: Arnaud KrebsVirtual seminar, EMBL Heidelberg Abstract: Inactivation of tissue non-specific genes is required for establishment of cell fate identity. Selective targeting of heterochromatin modifications by pathways involving Polycomb goup proteins or Heterochromatin Protein 1 (HP1) enforces transcriptional silencing. In addition, readers and writers of heterochromatin modifications promote epigenetic feedback loops that propagate the silent state through replication and cell division and ensure integrity of tissues and organs. The precise mechanisms underlying initiation and maintenance of repressive heterochromatin domains are poorly understood. To gain insight, we have developed a synthetic approach to recapitulate facultative heterochromatin in mouse embryonic stem cells providing an entry point to discriminate between initiation and maintenance of gene transcriptional gene silencing. |
| Faculty Seminar | |
| Career Event | Friday, 13 November 2020, 11:00EMBL Careers Webinar | Applying to postdoc fellowshipsIna Huppertz, EMBL Heidelberg, Germany | Barbara Pauly, Human Frontier Science Program (HFSP), France | Luca Scorrano, Veneto Institute of Molecular Medicine, ItalyHost: EMBL Fellows' Career Service + EMBL Grants ServicesVirtual seminar, EMBL Heidelberg |
| Career Event | Friday, 13 November 2020, 11:00EMBL Careers Webinar | Applying to postdoc fellowshipsIna Huppertz, EMBL Heidelberg, Germany | Barbara Pauly, Human Frontier Science Program (HFSP), France | Luca Scorrano, Veneto Institute of Molecular Medicine, ItalyHost: EMBL Fellows' Career Service + EMBL Grants ServicesVirtual seminar, EMBL Rome |
| Career Event | Friday, 13 November 2020, 11:00EMBL Careers Webinar | Applying to postdoc fellowshipsIna Huppertz, EMBL Heidelberg, Germany | Barbara Pauly, Human Frontier Science Program (HFSP), France | Luca Scorrano, Veneto Institute of Molecular Medicine, ItalyHost: EMBL Fellows' Career Service + EMBL Grants ServicesVirtual seminar, EMBL Hamburg |
| Career Event | Friday, 13 November 2020, 11:00EMBL Careers Webinar | Applying to postdoc fellowshipsIna Huppertz, EMBL Heidelberg, Germany | Barbara Pauly, Human Frontier Science Program (HFSP), France | Luca Scorrano, Veneto Institute of Molecular Medicine, ItalyHost: EMBL Fellows' Career Service + EMBL Grants ServicesVirtual seminar, EMBL Grenoble |
| Career Event | Friday, 13 November 2020, 11:00EMBL Careers Webinar | Applying to postdoc fellowshipsIna Huppertz, EMBL Heidelberg, Germany | Barbara Pauly, Human Frontier Science Program (HFSP), France | Luca Scorrano, Veneto Institute of Molecular Medicine, ItalyHost: EMBL Fellows' Career Service + EMBL Grants ServicesVirtual Seminar, EMBL Barcelona |
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| Career Event | Friday, 27 November 2020, 11:00EMBL Careers Webinar | Careers in European science policy and administrationNadia El-Mjiyad, European Research Council, Belgium | James Morris, Science Europe, BelgiumHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Hamburg |
| Career Event | Friday, 27 November 2020, 11:00EMBL Careers Webinar | Careers in European science policy and administrationNadia El-Mjiyad, European Research Council, Belgium | James Morris, Science Europe, BelgiumHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Rome |
| Career Event | Friday, 27 November 2020, 11:00EMBL Careers Webinar | Careers in European science policy and administrationNadia El-Mjiyad, European Research Council, Belgium | James Morris, Science Europe, BelgiumHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Heidelberg |
| Career Event | Friday, 27 November 2020, 11:00EMBL Careers Webinar | Careers in European science policy and administrationNadia El-Mjiyad, European Research Council, Belgium | James Morris, Science Europe, BelgiumHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Grenoble |
| Career Event | Friday, 27 November 2020, 11:00EMBL Careers Webinar | Careers in European science policy and administrationNadia El-Mjiyad, European Research Council, Belgium | James Morris, Science Europe, BelgiumHost: EMBL Fellows' Career ServiceVirtual Seminar, EMBL Barcelona |
| Faculty Seminar | Friday, 27 November 2020, 11:00Towards data-driven strategies to study context-specific cell signallingEvangelia Petsalaki , EMBL-EBI, Hinxton, UK, United KingdomHost: Jamie HackettVirtual seminar, EMBL Rome Abstract: Our group aims to understand and describe the organisation principles of cell signalling that allow the diverse and context-specific cell responses and phenotypes.
It is well established that signalling responses happen through complex networks. However, most signalling research still uses linear pathways as the ground truth. Moreover, signalling responses are highly dependent on context, such as tissue type, genetic background etc and therefore these static pathways are not always suitable. There is also a high bias in the literature towards kinases and pathways for which reagents and prior knowledge is readily available. This leaves a huge dark space in our understanding of cell signalling and significantly hinders studies of its general principles. Data-driven methods to study cell signalling using phosphoproteomics have typically been developed on transcriptomics data. Due to fundamental differences of these data types, including the sparsity of phosphoproteomics, these methods perform poorly on signalling network inference. Finally, large-scale essentiality datasets that can shed light on the context in which different signalling-related genes and pathways are crucial have thus far been severely underused in largescale omics data integrative efforts, likely due to their inaccessibility to non-expert users.
In this talk I will present two projects where we try to mitigate some of the above issues. For the first one I will present a method for data-driven machine-learning-based approach that takes advantage of global phosphoproteomics datasets to predict kinase regulatory networks, including their direction and sign of regulation. Our predicted kinase regulatory network is able to recapitulate known signalling pathways and agrees with orthogonal validation datasets. We were able to provide predictions for a large fraction of the understudied kinase space and found that kinase regulatory networks are denser than previously suspected.
For the second one I will present CEN-tools, an integrative webserver and python package, that allows users to navigate the contexts of different gene essentialities. I will demonstrate examples of its use in discovering new gene-gene relationships and important putative signalling targets for different cancers
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| Career Event | Friday, 4 December 2020, 11:00EMBL Careers Webinar | Applying to group leader positionsMonica Bettencourt-Dias, Instituto Gulbenkian de Ciencia, Portugal | Jason Chin, MRC Laboratory for Molecular Biology, UK | Patrick Meraldi, Universite de Geneve, SwitzerlandHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Hamburg |
| Career Event | Friday, 4 December 2020, 11:00EMBL Careers Webinar | Applying to group leader positionsMonica Bettencourt-Dias, Instituto Gulbenkian de Ciencia, Portugal | Jason Chin, MRC Laboratory for Molecular Biology, UK | Patrick Meraldi, Universite de Geneve, SwitzerlandHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Grenoble |
| External Faculty Speaker | |
| Career Event | Friday, 4 December 2020, 11:00EMBL Careers Webinar | Applying to group leader positions Monica Bettencourt-Dias, Instituto Gulbenkian de Ciencia, Portugal | Jason Chin, MRC Laboratory for Molecular Biology, UK | Patrick Meraldi, Universite de Geneve, SwitzerlandHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Rome |
| Career Event | Friday, 4 December 2020, 11:00EMBL Careers Webinar | Applying to group leader positions Monica Bettencourt-Dias, Instituto Gulbenkian de Ciencia, Portugal | Jason Chin, MRC Laboratory for Molecular Biology, UK | Patrick Meraldi, Universite de Geneve, SwitzerlandHost: EMBL Fellows' Career ServiceVirtual Seminar, EMBL Barcelona |
| Career Event | Friday, 4 December 2020, 11:00EMBL Careers Webinar | Applying to group leader positions Monica Bettencourt-Dias, Instituto Gulbenkian de Ciencia, Portugal | Jason Chin, MRC Laboratory for Molecular Biology, UK | Patrick Meraldi, Universite de Geneve, SwitzerlandHost: EMBL Fellows' Career ServiceVirtual seminar, EMBL Heidelberg |
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| Science and Society | Friday, 11 December 2020, 11:00Livestock, the Global Environment, and COVID-19: a reflection on Livestock Systems before and after the PandemicAlessandra Falcucci, Lead Geographic Information Systems analyst, Global Livestock Environmental Assessment Model (GLEAM), Food & Agricultural Organisation of the UN, NOT SPECIFIEDHost: Lucia von BredowVirtual seminar, EMBL Heidelberg Abstract: This talk will explore livestock, the global environment, and COVID-19, and will reflect on livestock systems before and after the pandemic.
The sustainability of the livestock systems is the focus of growing public debate, extensively discussed in the media and increasingly on the agenda of high-level political meetings. Over the last 30 years, consumption of meat, milk and eggs in lower middle-income countries has more than tripled. Population growth, urbanisation, income gains and globalisation continue to fuel the âlivestock revolutionâ. According to FAO projections, under a business-as-usual scenario, demand for meat will increase by a further 60% by 2030, compared to 2006, and by over 200% by 2050. This represents a big source of challenges and opportunities on how to reduce environmental impacts, while continuing to meet societyâs needs. |
| Science and Society | Friday, 11 December 2020, 11:00Livestock, the Global Environment, and COVID-19: a reflection on Livestock Systems before and after the PandemicAlessandra Falcucci, Lead Geographic Information Systems analyst, Global Livestock Environmental Assessment Model (GLEAM), Food & Agricultural Organisation of the UN, ItalyHost: Lucia von BredowVirtual seminar, EMBL Rome Abstract: This talk will explore livestock, the global environment, and COVID-19, and will reflect on livestock systems before and after the pandemic.
The sustainability of the livestock systems is the focus of growing public debate, extensively discussed in the media and increasingly on the agenda of high-level political meetings. Over the last 30 years, consumption of meat, milk and eggs in lower middle-income countries has more than tripled. Population growth, urbanisation, income gains and globalisation continue to fuel the âlivestock revolutionâ. According to FAO projections, under a business-as-usual scenario, demand for meat will increase by a further 60% by 2030, compared to 2006, and by over 200% by 2050. This represents a big source of challenges and opportunities on how to reduce environmental impacts, while continuing to meet societyâs needs. |
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| Science and Society | Friday, 26 February 2021, 14:00Challenging the Misrepresentation of Science and Evidence in Public LifeTracey Brown, OBE, Sense About Science, United KingdomHost: Lucia von BredowIBS Seminar Room, EMBL Grenoble Abstract: There is much concern about the public regard for standards and norms of evidence and anxiety that carefully assembled facts and data are becoming seemingly dispensable. In 2016, âpost-truthâ officially entered the dictionary; in the years since, commentators have worried that societies are no longer interested in the carefully assembled data and conclusions of scientific inquiry. Across Europe, conferences have sprung up among research and regulatory bodies asking how to operate in a world of Facebook filter bubbles and alternative facts.
Amid this anxiety, we are in danger of seeing only memes that reinforce it, of believing that people just hear what they are already disposed to hear, that there is no scope for persuasion and factual credibility is pointless. Sense about Scienceâs experience of working with the public tells a different story - in fact, many different stories, of the public interest in sound science and evidence. That interest in science and evidence is borne out in surveys: scientists are still trusted to tell the truth and are the only group to enjoy consistently strong public trust since the 1970s. In the UK, an Ipsos MORI 2016 poll found that 86% of people want the government to consult experts on complex subjects. Working with the public reminds us that monitoring and analysing are key to public empowerment and democratic accountability; and it expands our imagination about how researchers can collaborate with the public more effectively. Sense about Science's public-led, expert-fed approach has served up some interesting lessons for discussion. The question before the research world therefore is how to equip people to make sense of their natural and social systems: how can we truly embark on those journeys together, with the public and in the public interest? |
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| Science and Society | Friday, 16 April 2021, 13:00TBCZehra Sayers, Sabanci Universitesi, TurkeyHost: Lucia von BredowSeminar Room 48e, EMBL Hamburg |
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