Seminar Colour Guide:              
External Faculty Speaker
Wednesday, 25 September 2019, 14:00Add to calendarHow do regulatory networks decode X-chromosomal dosage information to control X inactivation and stem cell differentiation?
Edda Schulz, Max Planck Institute for Molecular Genetics, Berlin, GermanyHost: Justin Crocker and Rafael GalupaSmall Operon, EMBL Heidelberg
Abstract: Edda Schulz uses an interdisciplinary approach, combining mathematical modeling, quantitative experiments and functional genomics, to understand how gene-regulatory networks decode quantitative information and make molecular decisions. A focus of the group is how increased X-chromosomal dosage in female embryonic stem cells triggers X-chromosome inactivation and modulates pluripotency and differentiation. To this end, the group combines theoretical systems biology approaches with CRISPR screens and single-cell experiments.
External Faculty Speaker
Thursday, 26 September 2019, 09:30Add to calendarPrecision and Plasticity in Animal TranscriptionAngela DePace, Harvard Medical School, Systems Biology Department, , USAHost: Justin CrockerSmall Operon, EMBL Heidelberg
Tags: Systems Biology
EMBL Distinguished Visitor Lecture
Thursday, 26 September 2019, 15:00Add to calendarTHE MOLECULAR MACHINERY OF INTRACELLULAR PROTEIN DEGRADATION: STRUCTURAL STUDIES EX SITU AND IN SITUWolfgang Baumeister, Max Planck Institute of Biochemistry, GermanyHost: Julia Mahamid, Martin BeckLarge Operon, EMBL Heidelberg
Abstract: The 26S proteasome operates at the executive end of the ubiquitin-proteasome pathway for the controlled degradation of intracellular proteins. The 2.5 MDa complex comprises two subcomplexes: the 20S core where proteolysis takes place and one or two regulatory particles which prepare substrates for degradation. Whereas the structure of its 20S core particle has been determined by X-ray crystallography more than two decades ago, the structure of the regulatory particle, which recruits substrates, unfolds them, and assists in their translocation into the core particle remained elusive for a long time. Only in recent years has its structure been determined to high resolution using cryo-electron microscopy single particle analysis.

Cryo-electron tomography allows to perform structural studies of macromolecular and supramolecular structures in situ, i.e. in their functional cellular environments. We used this method to study the 26S proteasome in a number of cellular settings revealing their precise location, assembly and activity status as well as their interactions with other molecular players of the cellular degradation machinery.
Seminar given by an external postdoc
Tuesday, 8 October 2019, 10:00Add to calendarA role for liquid-liquid phase separation in ESCRT-mediated nuclear envelope reformationAlexander Von Appen, University of California, Biochemistry and Biophysics, San Francisco, USAHost: Martin BeckSmall Operon, EMBL Heidelberg
Tags: Biocomputing, Structural Biology, Chemistry and Chemical Biology, Biophysics
External Faculty Speaker
Tuesday, 15 October 2019, 14:30Add to calendarAtomic Structures of Vaccinia DNA-Dependent RNA Polymerase Complexes: The Mechanism of Poxvirus Transcription
Clemens Grimm, Institut für Biochemie, Biozentrum der Universitaet Wuerzburg Am Hubland, , GermanyHost: Christoph MuellerSmall Operon, EMBL Heidelberg
Tags: Biocomputing, Structural Biology
External Faculty Speaker
Wednesday, 23 October 2019, 15:00Add to calendarMechano-chemical feedback designs for directed epithelial morphogenesisShiladitya Banerjee, UCL Department of Physics & Astronomy , Faculty of Maths & Physical Sciences, United KingdomHost: Alba Diz-MuñozThe Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Thursday, 24 October 2019, 15:00Add to calendarTo be announcedItai Yanai, New York University, School of Medicine, USAHost: Theodore AlexandrovLarge Operon, EMBL Heidelberg
Company Representative
Monday, 18 November 2019, 11:30Add to calendarCareers talk and applying to Industry seminar from BASFMariana Ruiz Velasco Leyva and Julia Jähnigen, BASF, Ludwigshafen, GermanyHost: EMBL Fellows Career ServiceLarge Operon, EMBL Heidelberg
Abstract: This 1h15min seminar will include 2 talks. The first will be from Mariana Ruiz Velasco Leyva, a former EMBL predoc, on her transition to BASF. Mariana is now working as a computational scientist in BASF's data science and visualization team. Mariana will also be joined by Julia Jähnigen, from BASF s talent acquisition team, who will talk about the recruitment process at BASF, and her tips for applicants to industry.
Science and Society
Tuesday, 19 November 2019, 15:00Add to calendarImaging human embryos: A history
Nick Hopwood, University of Cambridge, United KingdomHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Abstract: Images of human embryos and foetuses are everywhere. We see them in newspapers, clinics, classrooms, laboratories, family albums and on the Internet. Though debates about reproduction and evolution have at times made these images controversial, we tend to take them for granted. Yet 250 years ago human development was still nowhere to be seen. The talk will explore how, since the end of the eighteenth century, developing embryos and foetuses have been collected and dissected, drawn, modelled and photographed, selected and arranged in series, published, displayed and viewed. It will trace how the resulting images became the dominant representations of pregnancy and sometimes also of the history of life on earth, and follow their more recent incarnations as biomedical symbols of hope and fear. And it will consider how images in various media constructed relations to other entities, to other species and to people involved in producing, using and viewing the pictures.
EMBL Distinguished Visitor Lecture
Thursday, 21 November 2019, 11:00Add to calendarTo be announcedPascale Cossart, Pasteur Institute, FranceLarge Operon, EMBL Heidelberg