Seminar Colour Guide:              
Company Representative
Tuesday, 21 January 2020, 15:00Add to calendar"Powering the Synthetic Biology and Genomics Revolution"Emily Leproust, TWIST, USAHost: Vladimir BenesSmall Operon, EMBL Heidelberg
Tags: Systems Biology, Cell Biology, Gene Regulation
External Faculty Speaker
Tuesday, 21 January 2020, 16:00Add to calendar"From Cancer Mutation to Vaccine - NGS library preparation for development of individualized neoantigen specific cancer therapies"Irina Giese, TRON Mainz, GermanyHost: Vladimir BenesSmall Operon, EMBL Heidelberg
Tags: Cell Biology, Cell Regulation and Signaling, Gene Regulation
External Faculty Speaker
Friday, 24 January 2020, 11:00Add to calendarPoly-omic Analysis of human iPS cells in Health and DiseaseAngus Lamond, Centre for Gene Regulation and Expression, University of Dundee, United KingdomHost: Edith HeardSmall Operon, EMBL Heidelberg
Tags: Cell Biology
Career Event
Monday, 3 February 2020, 16:00Add to calendarCareer Talks Series 2020 Scientific publishing: How to become a journal editorStacey-Lynn Paiva, PhD, Associate Editor at Nature Reviews Drug Discovery , Andrea Leibfried, PhD, Executive Director at Life Science Alliance, GermanyHost: EMBL Fellows Career ServiceLarge Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 5 February 2020, 11:00Add to calendarQuantitative Modeling of Protein-DNA Binding Specificity Remo Rohs, University of Southern California, USAHost: Judith ZauggSmall Operon, EMBL Heidelberg
Abstract: Many structures of protein-DNA complexes have been solved and high-throughput binding assays were developed because structural biology and genomics researchers were equally puzzled by the question of how proteins bind DNA with high specificity. However, there was little communication between these two fields of research. High-throughput DNA shape prediction established a cross talk between both fields. The primary goal of DNA shape analysis remains the quest for mechanistic insights into protein-DNA readout modes based on sequencing data without the need of structure determination. A plethora of high-throughput sequencing data is available from a variety of experimental approaches. In contrast, structural biology, albeit being an atomic-resolution approach, often reports the binding of a single protein to only a single DNA target. A number of studies incorporated DNA shape features in the quantitative modeling of binding specificities. These studies emphasized the importance of interactions between nucleotide positions within a binding site and its flanks, although the definitions of DNA sequence versus shape still differ in the structural biology and genomics fields. Next steps discussed in the talk focus on understanding biological phenomena such as purifying selection, additional layers of binding specificity determinants such as DNA methylation and histone modifications, and new computational approaches including deep learning and quantum computing. Tags: Biocomputing
Science and Society
Friday, 21 February 2020, 15:00Add to calendarThe pursuit of a dream: science for me and for allJoana Moscoso, Smart Separations | Co-founder & Director, Native Scientist, PortugalLarge Operon, EMBL Heidelberg
Abstract: Joana will talk about her career path and the work Native Scientist is doing to promote cultural diversity in science, education and society. She will explain the methodology behind Native Scientist work and the impact it is having on people's lives. She will share her motivations for science outreach and her experience of creating a non-profit during her PhD and managing it for the past 6 years, alongside a career as a researcher and now a business development manager.