Future Seminars
Seminar Colour Guide:
| Company Representative | |
| External Faculty Speaker | |
| External Faculty Speaker | |
| Career Event | Monday, 3 February 2020, 16:00Career Talks Series 2020
Scientific publishing: How to become a journal editorStacey-Lynn Paiva, PhD, Associate Editor at Nature Reviews Drug Discovery , Andrea Leibfried, PhD, Executive Director at Life Science Alliance, GermanyHost: EMBL Fellows Career ServiceLarge Operon, EMBL Heidelberg |
| External Faculty Speaker | Wednesday, 5 February 2020, 11:00Quantitative Modeling of Protein-DNA Binding Specificity Remo Rohs, University of Southern California, USAHost: Judith ZauggSmall Operon, EMBL Heidelberg Abstract: Many structures of protein-DNA complexes have been solved and high-throughput binding assays were developed because structural biology and genomics researchers were equally puzzled by the question of how proteins bind DNA with high specificity. However, there was little communication between these two fields of research. High-throughput DNA shape prediction established a cross talk between both fields. The primary goal of DNA shape analysis remains the quest for mechanistic insights into protein-DNA readout modes based on sequencing data without the need of structure determination. A plethora of high-throughput sequencing data is available from a variety of experimental approaches. In contrast, structural biology, albeit being an atomic-resolution approach, often reports the binding of a single protein to only a single DNA target. A number of studies incorporated DNA shape features in the quantitative modeling of binding specificities. These studies emphasized the importance of interactions between nucleotide positions within a binding site and its flanks, although the definitions of DNA sequence versus shape still differ in the structural biology and genomics fields. Next steps discussed in the talk focus on understanding biological phenomena such as purifying selection, additional layers of binding specificity determinants such as DNA methylation and histone modifications, and new computational approaches including deep learning and quantum computing. |
| Science and Society | Friday, 21 February 2020, 15:00The pursuit of a dream: science for me and for allJoana Moscoso, Smart Separations | Co-founder & Director, Native Scientist, PortugalLarge Operon, EMBL Heidelberg Abstract: Joana will talk about her career path and the work Native Scientist is doing to promote cultural diversity in science, education and society. She will explain the methodology behind Native Scientist work and the impact it is having on people's lives. She will share her motivations for science outreach and her experience of creating a non-profit during her PhD and managing it for the past 6 years, alongside a career as a researcher and now a business development manager. |