Seminar Colour Guide:              
External Faculty Speaker
Tuesday, 27 June 2017, 14:00Add to calendarQuantitative FRET studies and integrative modeling unravel the structure and dynamics of biomolecular systems in vitro and in live cellsClaus Seidl, Molekulare Physikalische Chemie , Heinrich-Heine-Universität Düsseldorf, GermanyHost: Edward LemkeRoom 202, EMBL Heidelberg
Tags: Biophysics, Cell Biology, Chemistry and Chemical Biology, Imaging and Image Analysis, Structural Biology
Seminar given by an external postdoc
Wednesday, 28 June 2017, 10:00Add to calendarMultiparameter Imaging with biosensors Vsevolod Belousov, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russian FederationHost: Stefan TerjungATC - Courtyard A+B, EMBL Heidelberg
External Faculty Speaker
Thursday, 29 June 2017, 09:00Add to calendarImaging malaria parasites Freddy Frischknecht, University Clinic Heidelberg, GermanyHost: Stefan TerjungATC - Courtyard A+B, EMBL Heidelberg
External Faculty Speaker
Thursday, 29 June 2017, 10:00Add to calendarFoerster Resonance Energy TransferMark Hink, University of Amsterdam, NetherlandsHost: Stefan TerjungATC - Courtyard A+B, EMBL Heidelberg
Seminar given by an external postdoc
Friday, 30 June 2017, 11:00Add to calendarActive polymer models for the 3D organization of chromosomesJohannes Nuebler, Institute for Medical Engineering and Science,, Massachusetts Institute of Technology, USAHost: Christian HaeringSmall Operon, EMBL Heidelberg
Abstract: Eukaryotic chromatin, DNA together with associated proteins, is far from being simply a randomly arranged polymer in the cell nucleus. Rather, it has a high degree of spatial organization on length scales ranging from individual nucleosomes up to entire chromosomes of hundreds of millions of base pairs. Furthermore, chromatin is dynamic: for example, enhancers find promoters to activate genes and chromosomes segregate and compactify for cell division. We build polymer models in order to identify mechanisms behind the 3D organization of chromatin. The interplay of its polymeric nature with active formation of growing chromatin loops by molecular motors emerges as a general organizational principle throughout the cell cycle. Additionally, loop extrusion competes with spatial segregation of active and inactive chromatin. This interplay highlights that chromatin is complex, active matter. We address the physics of this interplay and its relation to nuclear organization.Tags: Cell Biology
Seminar given by an external postdoc
Monday, 3 July 2017, 11:00Add to calendarCRISPR/Cpf1: a simpler, sharper blade for genome editingPablo Alcon, Novo Nordisk Foundation Center for Protein Research, DenmarkHost: Christoph MuellerSmall Operon, EMBL Heidelberg
Tags: Biocomputing, Structural Biology
EMBL Distinguished Visitor Lecture
Thursday, 6 July 2017, 11:00Add to calendarSegmental patterning of the vertebrate embryoOlivier Pourquié, Harvard Medical School, Department of Genetics/The Brigham and Women s Hospital, USAHost: Alexander AulehlaThe Operon, EMBL Heidelberg
Seminar given by an external postdoc
Thursday, 13 July 2017, 15:00Add to calendarRegulation of Autophagy by the Atg1 KinaseAnne Schreiber, ETH Zurich, SwitzerlandHost: Christian HäringSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Thursday, 27 July 2017, 10:00Add to calendarTranscriptomic deconvolution of heterogeneous tumor samples Wenyi Wang, The University of Texas M. D. Anderson Cancer Center, USAHost: Jan KorbelSmall Operon, EMBL Heidelberg
Abstract: Tumor tissue samples are comprised of a mixture of cancerous and surrounding stromal cells. Understanding tumor heterogeneity is crucial to analyzing gene signatures associated with cancer prognosis and treatment decisions. Compared with the experimental approach of laser capture micro-dissection to isolate different tissue components, in silico dissection of mixed cell samples is faster and cheaper. Numerous computational approaches previously developed all have their limitations to deconvolute heterogeneous tumor samples. In this talk, I will present a new three-component deconvolution model, DeMixT, that can account for the immune cell compartment explicitly and is able to address the challenging problem when the observed signals are assumed to come from a mixture of three cell compartments, infiltrated immune cells, tumor microenvironment and cancerous tissues.
External Faculty Speaker
Friday, 28 July 2017, 10:00Add to calendarNews in SMLM methods: Less phototoxic sptPALM imaging of
living cells and dense fluorophore labeling without compromising the
biological target
Ulrike Endersfelder, Max Planck Institute for Terrestrial Microbiology, GermanyHost: Jonas RiesSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Wednesday, 2 August 2017, 11:00Add to calendarEndogenous chromosomal lesions: How cells deal with unavoidable DNA damageJiri Lukas, University of Copenhagen, DenmarkHost: Yannick Schwab/Beate NeumannSmall Operon, EMBL Heidelberg
Seminar given by an external postdoc
Wednesday, 6 September 2017, 10:00Add to calendarTo be announcedLorena Benedetti, Yale University School of Medicine, USAHost: Jan EllenbergSmall Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Thursday, 14 September 2017, 11:00Add to calendarTo be announcedGene Myers, MPI-CBG, Dresden, GermanyHost: Stefano De RenzisThe Operon, EMBL Heidelberg
Science and Society
Monday, 18 September 2017, 15:00Add to calendarThe Ethics of Biomedical Big Data: Between individual and public health interestsBrent Mittelstadt, University of Oxford, United KingdomHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Seminar given by an external postdoc
Monday, 2 October 2017, 10:30Add to calendarTo be announcedMeghan Driscoll, UT Southwestern Medical Center, USAHost: Jan EllenbergSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Monday, 9 October 2017, 15:00Add to calendartbdRikard Holmdahl, Karolinska Institute, SwedenHost: Janosch HennigSmall Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 9 November 2017, 11:00Add to calendarTo be announcedBing Ren, University of California, USAHost: Jan KorbelThe Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 15 November 2017, 11:00Add to calendarTo be announcedDavid Baker, University of Washington, USAHost: Janosch HennigThe Operon, EMBL Heidelberg
Science and Society
Thursday, 23 November 2017, 15:00Add to calendarMolecular gastronomy: questions of scientific strategy and applicationsHervé This, International Centre for Molecular Gastronomy AgroParisTech-INRA, FranceHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Abstract: Molecular gastronomy is the scientific discipline that looks for the mechanisms of phenomena occurring during food preparation. It was created (formally in 1988) because it was realized that a wealth of original phenomena were neglected by physical chemistry, so that possibilities of discoveries were many. It develops in many countries of the world (and should not be confused with cooking, and in particular with "molecular cooking" or "molecular cuisine", which are applications).
How to make discoveries? This question is of course not restricted to molecular gastronomy, but some examples of results can show various ways of getting scientific results, the most important being probably the set up of new observation tools, or the idea that "Any result should be considered as a "projection" of general cases that we have to invent".
Concerning applications, the latest is called "note by note cooking", and it is the exact equivalent of synthetic music, a reason why it could also be called synthetic cooking. The definition is simply: make food from pure compounds, instead of tradition food ingredients (vegetables, meats, fruits, fishs, eggs...). This culinary trend is spreading today.
Science and Society
Monday, 4 December 2017, 15:00Add to calendarImprobable Research and the Ig Nobel PrizesMarc Abrahams, Ig Nobel Prize, USAHost: Halldór StefánssonThe Operon, EMBL Heidelberg