Future Seminars
Seminar Colour Guide:
| External Faculty Speaker | Wednesday, 25 September 2019, 14:00How do regulatory networks decode X-chromosomal dosage information to control X inactivation and stem cell differentiation? Abstract: Edda Schulz uses an interdisciplinary approach, combining mathematical modeling, quantitative experiments and functional genomics, to understand how gene-regulatory networks decode quantitative information and make molecular decisions. A focus of the group is how increased X-chromosomal dosage in female embryonic stem cells triggers X-chromosome inactivation and modulates pluripotency and differentiation. To this end, the group combines theoretical systems biology approaches with CRISPR screens and single-cell experiments. Edda Schulz, Max Planck Institute for Molecular Genetics, Berlin, GermanyHost: Justin Crocker and Rafael GalupaSmall Operon, EMBL Heidelberg |
| External Faculty Speaker | |
| EMBL Distinguished Visitor Lecture | Thursday, 26 September 2019, 15:00THE MOLECULAR MACHINERY OF INTRACELLULAR PROTEIN DEGRADATION: STRUCTURAL STUDIES EX SITU AND IN SITUWolfgang Baumeister, Max Planck Institute of Biochemistry, GermanyHost: Julia Mahamid, Martin BeckLarge Operon, EMBL Heidelberg Abstract: The 26S proteasome operates at the executive end of the ubiquitin-proteasome pathway for the controlled degradation of intracellular proteins. The 2.5 MDa complex comprises two subcomplexes: the 20S core where proteolysis takes place and one or two regulatory particles which prepare substrates for degradation. Whereas the structure of its 20S core particle has been determined by X-ray crystallography more than two decades ago, the structure of the regulatory particle, which recruits substrates, unfolds them, and assists in their translocation into the core particle remained elusive for a long time. Only in recent years has its structure been determined to high resolution using cryo-electron microscopy single particle analysis. Cryo-electron tomography allows to perform structural studies of macromolecular and supramolecular structures in situ, i.e. in their functional cellular environments. We used this method to study the 26S proteasome in a number of cellular settings revealing their precise location, assembly and activity status as well as their interactions with other molecular players of the cellular degradation machinery. |
| Seminar given by an external postdoc | |
| External Faculty Speaker | |
| External Faculty Speaker | |
| EMBL Distinguished Visitor Lecture | |
| Company Representative | Monday, 18 November 2019, 11:30Careers talk and applying to Industry seminar from BASFMariana Ruiz Velasco Leyva and Julia Jähnigen, BASF, Ludwigshafen, GermanyHost: EMBL Fellows Career ServiceLarge Operon, EMBL Heidelberg Abstract: This 1h15min seminar will include 2 talks. The first will be from Mariana Ruiz Velasco Leyva, a former EMBL predoc, on her transition to BASF. Mariana is now working as a computational scientist in BASF's data science and visualization team. Mariana will also be joined by Julia Jähnigen, from BASF s talent acquisition team, who will talk about the recruitment process at BASF, and her tips for applicants to industry. |
| Science and Society | Tuesday, 19 November 2019, 15:00Imaging human embryos: A history Abstract: Images of human embryos and foetuses are everywhere. We see them in newspapers, clinics, classrooms, laboratories, family albums and on the Internet. Though debates about reproduction and evolution have at times made these images controversial, we tend to take them for granted. Yet 250 years ago human development was still nowhere to be seen. The talk will explore how, since the end of the eighteenth century, developing embryos and foetuses have been collected and dissected, drawn, modelled and photographed, selected and arranged in series, published, displayed and viewed. It will trace how the resulting images became the dominant representations of pregnancy and sometimes also of the history of life on earth, and follow their more recent incarnations as biomedical symbols of hope and fear. And it will consider how images in various media constructed relations to other entities, to other species and to people involved in producing, using and viewing the pictures.Nick Hopwood, University of Cambridge, United KingdomHost: Halldór StefánssonLarge Operon, EMBL Heidelberg |
| EMBL Distinguished Visitor Lecture | Thursday, 21 November 2019, 11:00To be announcedPascale Cossart, Pasteur Institute, FranceLarge Operon, EMBL Heidelberg |