Future Seminars
Seminar Colour Guide:
| External Faculty Speaker | Tuesday, 27 June 2017, 14:00Quantitative FRET studies and integrative modeling unravel the structure and dynamics of biomolecular systems in vitro and in live cellsClaus Seidl, Molekulare Physikalische Chemie , Heinrich-Heine-Universität Düsseldorf, GermanyHost: Edward LemkeRoom 202, EMBL Heidelberg |
| Seminar given by an external postdoc | |
| External Faculty Speaker | |
| External Faculty Speaker | |
| Seminar given by an external postdoc | Friday, 30 June 2017, 11:00Active polymer models for the 3D organization of chromosomesJohannes Nuebler, Institute for Medical Engineering and Science,, Massachusetts Institute of Technology, USAHost: Christian HaeringSmall Operon, EMBL Heidelberg Abstract: Eukaryotic chromatin, DNA together with associated proteins, is far from being simply a randomly arranged polymer in the cell nucleus. Rather, it has a high degree of spatial organization on length scales ranging from individual nucleosomes up to entire chromosomes of hundreds of millions of base pairs. Furthermore, chromatin is dynamic: for example, enhancers find promoters to activate genes and chromosomes segregate and compactify for cell division. We build polymer models in order to identify mechanisms behind the 3D organization of chromatin. The interplay of its polymeric nature with active formation of growing chromatin loops by molecular motors emerges as a general organizational principle throughout the cell cycle. Additionally, loop extrusion competes with spatial segregation of active and inactive chromatin. This interplay highlights that chromatin is complex, active matter. We address the physics of this interplay and its relation to nuclear organization. |
| Seminar given by an external postdoc | |
| EMBL Distinguished Visitor Lecture | Thursday, 6 July 2017, 11:00Segmental patterning of the vertebrate embryoOlivier Pourquié, Harvard Medical School, Department of Genetics/The Brigham and Women s Hospital, USAHost: Alexander AulehlaThe Operon, EMBL Heidelberg |
| Seminar given by an external postdoc | |
| External Faculty Speaker | Thursday, 27 July 2017, 10:00Transcriptomic deconvolution of heterogeneous tumor samples Wenyi Wang, The University of Texas M. D. Anderson Cancer Center, USAHost: Jan KorbelSmall Operon, EMBL Heidelberg Abstract: Tumor tissue samples are comprised of a mixture of cancerous and surrounding stromal cells. Understanding tumor heterogeneity is crucial to analyzing gene signatures associated with cancer prognosis and treatment decisions. Compared with the experimental approach of laser capture micro-dissection to isolate different tissue components, in silico dissection of mixed cell samples is faster and cheaper. Numerous computational approaches previously developed all have their limitations to deconvolute heterogeneous tumor samples. In this talk, I will present a new three-component deconvolution model, DeMixT, that can account for the immune cell compartment explicitly and is able to address the challenging problem when the observed signals are assumed to come from a mixture of three cell compartments, infiltrated immune cells, tumor microenvironment and cancerous tissues. |
| External Faculty Speaker | |
| External Faculty Speaker | |
| Seminar given by an external postdoc | |
| EMBL Distinguished Visitor Lecture | Thursday, 14 September 2017, 11:00To be announcedGene Myers, MPI-CBG, Dresden, GermanyHost: Stefano De RenzisThe Operon, EMBL Heidelberg |
| Science and Society | Monday, 18 September 2017, 15:00The Ethics of Biomedical Big Data: Between individual and public health interestsBrent Mittelstadt, University of Oxford, United KingdomHost: Halldór StefánssonLarge Operon, EMBL Heidelberg |
| Seminar given by an external postdoc | |
| External Faculty Speaker | |
| EMBL Distinguished Visitor Lecture | Thursday, 9 November 2017, 11:00To be announcedBing Ren, University of California, USAHost: Jan KorbelThe Operon, EMBL Heidelberg |
| EMBL Distinguished Visitor Lecture | Wednesday, 15 November 2017, 11:00To be announcedDavid Baker, University of Washington, USAHost: Janosch HennigThe Operon, EMBL Heidelberg |
| Science and Society | Thursday, 23 November 2017, 15:00Molecular gastronomy: questions of scientific strategy and applicationsHervé This, International Centre for Molecular Gastronomy AgroParisTech-INRA, FranceHost: Halldór StefánssonLarge Operon, EMBL Heidelberg Abstract: Molecular gastronomy is the scientific discipline that looks for the mechanisms of phenomena occurring during food preparation. It was created (formally in 1988) because it was realized that a wealth of original phenomena were neglected by physical chemistry, so that possibilities of discoveries were many. It develops in many countries of the world (and should not be confused with cooking, and in particular with "molecular cooking" or "molecular cuisine", which are applications).How to make discoveries? This question is of course not restricted to molecular gastronomy, but some examples of results can show various ways of getting scientific results, the most important being probably the set up of new observation tools, or the idea that "Any result should be considered as a "projection" of general cases that we have to invent". Concerning applications, the latest is called "note by note cooking", and it is the exact equivalent of synthetic music, a reason why it could also be called synthetic cooking. The definition is simply: make food from pure compounds, instead of tradition food ingredients (vegetables, meats, fruits, fishs, eggs...). This culinary trend is spreading today. |
| Science and Society | Monday, 4 December 2017, 15:00Improbable Research and the Ig Nobel PrizesMarc Abrahams, Ig Nobel Prize, USAHost: Halldór StefánssonThe Operon, EMBL Heidelberg |