Seminar Colour Guide:              
Company Representative
Tuesday, 23 January 2018, 10:00Add to calendarBiology at Enamine: Things you can do having 2.5 million compounds next door.Iaroslava Kos, Bienta/Enamine Biology Services, GermanyHost: Joe LewisSmall Operon, EMBL Heidelberg
Tags: Chemistry and Chemical Biology
EMBL Distinguished Visitor Lecture
Friday, 26 January 2018, 11:00Add to calendarNeural motionGilles Laurent, Max Planck Institute for Brain Research, GermanyHost: Robert PrevedelLarge Operon, EMBL Heidelberg
Abstract: This talk will mainly examine neural population dynamics, drawing from our past and present work on three different systems and animal species: the olfactory system of an insect (sensory), the camouflage system of a cephalopod (sensory and motor) and the cerebral cortex of a reptile (cortical). The identification of common features in the dynamics of such distant and different neural systems reveals the existence of a hidden order in neural activity, and suggests the existence of common principles of neural population behavior. Our work on reptilian cortex reveals some potential mechanisms for these deterministic dynamics.
External Faculty Speaker
Friday, 26 January 2018, 13:00Add to calendarESX type VII secretion key to mycobacterial host-pathogen interaction Roland Brosch, Institut Pasteur, Integrated Mycobacterial Pathogenomics Unit, 25 Rue du Dr Roux, 75015 Paris, FranceHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Friday, 2 February 2018, 13:00Add to calendarEvolution of neural cell types and nervous systems - from sponges to humanDetlev Arendt, EMBL, Heidelberg, GermanyHost: Rob MeijersSeminar Room 48e
External Faculty Speaker
Monday, 5 February 2018, 11:00Add to calendarTo be announcedDr. Elena Seiradake , University of Oxford, United KingdomHost: Valentina SperanziniEMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Monday, 5 February 2018, 17:15Add to calendarAntibodies and bicyclic peptides - paradigm shifts in the world of pharmaceutical drugsSir Dr. Gregory Winter, MRC Laboratory of Molecular Biology, Trinity College Cambridge, Bicycle Therapeutics, United KingdomHost: Carsten Schultz/Magic BulletLarge Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 7 February 2018, 12:30Add to calendarFostering Equality & Diversity at EMBLCornelius Gross, EMBL, Rome, ItalyHost: Christian Loew,Melissa Graewert and Liliana ChodakSeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Thursday, 8 February 2018, 14:00Add to calendarDevelopment and Evolution of commissural circuitsAlain Chetodal, Institut de la Vision, Paris, FranceHost: Rob MeijersZMNH Falkenried 94, 20251 Hamburg - Etage EG
Seminar given by an external postdoc
Friday, 9 February 2018, 11:00Add to calendarNeuronal correlates of social interactions in amygdala circuitsMaria Sol Fustiñana, FMI, Basel, Switzerland, SwitzerlandHost: Cornelius GrossCNR Seminar Room, EMBL Rome
Abstract: Social behaviors encompass a complex set of conducts, which are impaired in several psychiatric disorders including autism spectrum disorder (ASD) and social anxiety disorder. In humans, the amygdala has been implicated in the regulation of social interactions and ASD patients exhibit abnormal amygdala activity upon exposure to social stimuli. In rodents, the amygdala has mainly been studied in the context of fear and anxiety-like behaviors. However, the role of the amygdala during social behavior in freely-interacting rodents has not been addressed. We established a naturalistic paradigm in which two mice freely interact while recording neuronal activity. To make this complex behavior tractable, we developed a set of algorithms to automatically score active and passive behaviors, including initiated interactions, approach, avoidance and aggression. To record neuronal activity, we combined cell-type specific targeting and deep brain calcium imaging in the basal nucleus of the amygdala (BA) using a head-mounted miniature microscope. At the single cell level, our data revealed neuronal responses time-locked to social interactions. At the population level, amygdala neurons can be robustly divided into anti-correlated clusters which exhibit slow dynamics and predict the animal s active engagement in social interactions. Taken together, our results indicate that the BA is part of the brain s circuitry engaged during social interactions.
EMBL Distinguished Visitor Lecture
Thursday, 15 February 2018, 11:00Add to calendarTo be announcedMichael N. Hall, Biozentrum, University of Basel, SwitzerlandHost: Matthias HentzeLarge Operon, EMBL Heidelberg
External Faculty Speaker
Friday, 16 February 2018, 11:00Add to calendarStudying Human Brain Development and Evolution in Cerebral OrganoidsMadeline Lancaster, MRC Laboratory of Molecular Biology, United KingdomHost: Cornelius GrossCNR Seminar Room, EMBL Rome
Abstract: Human brain development exhibits a number of unique characteristics, such as dramatic size expansion and variation in relative abundance of specific neuron populations. Until very recently, model organisms were the only experimental tools available to functionally examine brain developmental mechanisms on the whole organ scale. This has obvious limitations when it comes to human-specific features.

In an effort to better understand human brain development, we developed a human model system, called cerebral organoids. Cerebral organoids, or mini-brains , are 3D tissues generated from human pluripotent stem cells that allow modelling of brain development in vitro. Through a process of directed differentiation and a supportive 3D microenvironment, neural precursor tissue can spontaneously self-organize to form the stereotypic organization of the early human embryonic brain. We were able to show that cerebral organoids can also model a neurodevelopmental disorder, microcephaly, characterised by a significantly reduced brain size. This makes brain organoids particularly powerful for not only examining human specific mechanisms, but also pathogenesis of neurological disease.

We have now performed extensive characterization of brain organoids and their potential uses, as well as improvements to better control their differentiation. Current findings reveal the timed generation of excitatory neurons and inhibitory interneurons as well as their proper migration and positioning. We are now using this system to perform the first functional tests of putative brain evolution genes in a human model system. These studies are revealing some interesting roles for these factors in regulation of human neurogenesis.
External Faculty Speaker
Friday, 16 February 2018, 11:00Add to calendarTo be announcedStephan Preibisch, Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), GermanyHost: Yannick SchwabSmall Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 22 February 2018, 11:00Add to calendarTo be announcedProf. Anna Pyle , Yale University, USAHost: Isabel Chillon and Almudena Ponce Salvatierra EMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Friday, 23 February 2018, 11:00Add to calendarZebrafish colour vision: Rainbows in the eyesTom Baden, School of Life Sciences, University of Sussex, Brighton, UK, United KingdomHost: Hiroki AsariCNR Seminar Room, EMBL Rome
Abstract: All sensory systems are specialised to efficiently provide information critical within an animal's sensory-ecological niche. In vertebrate vision, the retina of all visual species follows a common set anatomical and functional motifs, yet each species has tweaked details in this network to tune its vision for its natural visual environment. Accordingly, comparing functional processing strategies employed in different species that live in different visual envioronments provides a window into how neuronal networks evolve to better suit novel computational demands. In reference to our existing functional database on the retina of mice, we now study the retina of zebrafish in the context of their natural habitat to address these questions with a particular emphasis on colour vision.
EMBL Distinguished Visitor Lecture
Friday, 9 March 2018, 10:00Add to calendarExcitability and Voltage sensorsFrancisco Bezanilla, Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA, USAHost: Paul HeppenstallCNR Seminar Room, EMBL Rome
Abstract: The nerve impulse generation depends on voltage-dependent sodium channels that turn on before voltage dependent potassium channels. In both channels, the voltage dependence depends on charge displacement in the electric field within the channel protein. This charge movement constitutes a voltage and time dependent capacitance that generates gating currents. A combination of voltage clamp techniques with simultaneous site-directed fluorescence techniques has given us insights of the molecular details of the voltage sensor operation, including the paths followed by the arginine residues within the protein core. The nature of the core where these residues move determine why sodium channels are faster than potassium channels, which is the basis of excitability. But the lipid bilayer, the seat of membrane capacitance, also can play a role in excitability. Membrane capacitance increases with temperature, therefore by changing the temperature quickly a depolarizing current is produced (i=VdC/dt). We have used light to heat transducers such as gold nanoparticles or carbon particles to elicit these capacitive currents by short laser pulses of visible or near infrared light. When excitable cells are under zero current clamp conditions, the light-induced depolarizing current changes the membrane potential and turns on sodium channel voltage sensors, thus eliciting action potentials in excitable tissues. This technique, we call optocapacitance, makes excitable cells light sensitive by just adding gold nanoparticles or other light absorbing materials. (Supported by NIH GM030376)
Hamburg Speaker
Friday, 9 March 2018, 13:00Add to calendarProtein-ligand interaction energy for crystallographic model building and validationDaria Beshnova, EMBL, Hamburg Unit, GermanyHost: Victor LamzinSeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Tuesday, 13 March 2018, 14:00Add to calendarMultiple ways of altering the gene regulatory program in cancers: focus on transcription factors, DNA methylation, and microRNAsAnthony Mathelier, Centre for Molecular Medicine Norway (NCMM), NorwayHost: Judith ZauggSmall Operon, EMBL Heidelberg
Abstract: While most cancer studies focused on patient variations lying in protein-coding regions, the noncoding ~98% of the genome, containing cis-regulatory regions that control when and where genes are expressed, is largely unexplored.Transcription factors are key proteins binding to cis-regulatory regions to modulate the rate of gene transcription. Delineating the specific positions at which a TF binds DNA is of high importance in deciphering gene regulation. As cancer is a disease of disrupted cellular regulation, it is critical to analyze these regions to highlight patient somatic mutations and epigenetic modifications altering the gene regulatory program of the cells.
In this talk, I will present our recent works on improving our capacity to predict direct TF-DNA interactions and highlighting somatic mutations and DNA methylation alteration that shift the regulation of protein coding and microRNA genes expression in cancer patients.
Hamburg Speaker
Friday, 16 March 2018, 13:00Add to calendarTo be announcedMartin Schroer, EMBL, Hamburg Unit, GermanyHost: Dmitri SvergunSeminar Room 48e, EMBL Hamburg
Science and Society
Friday, 16 March 2018, 14:00Add to calendarThe global burden of infectious diseases: past, present, and a glimpse into the futureClaire Standley, Georgetown University, USAHost: Halldór Stefánsson Chadwick Amphitheatre, Institute Laue Langevin, Grenoble
Science and Society
Friday, 16 March 2018, 14:00Add to calendarTo be announcedProf. Bruno Strasser, Geneva University, SwitzerlandHost: Erika Pellegrini & Halldor StefanssonChadwick Amphitheatre, Institute Laue Langevin, Grenoble, EMBL Grenoble
EMBL Distinguished Visitor Lecture
Tuesday, 20 March 2018, 11:00Add to calendarTo be announcedAndrea Musacchio, Max Planck Institute of Molecular Physiology, GermanyHost: Christian HäringLarge Operon, EMBL Heidelberg
Hamburg Speaker
Friday, 23 March 2018, 13:00Add to calendarCollagen fibril under stress: insight from molecular dynamics simulationsAgnieszka Obarska, EMBL, Hamburg Unit, GermanyHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Friday, 6 April 2018, 10:00Add to calendarEpigenomic Signatures of Neuronal Diversity in the Mammalian BrainJoseph Ecker, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA, USAHost: Cornelius GrossCNR Seminar Room, EMBL Rome
Abstract: DNA methylation is a chemical modification that occurs predominantly on CG dinucleotides in mammalian genomes. However, recent studies from our laboratory have revealed that non-CG methylation (mCH) is more abundant than CG methylation and non-randomly distributed in the genomes of brain cells. mCH accumulates during the establishment of neural circuits and is associated with Rett syndrome. A comprehensive understanding of how neural circuits spanning the entire brain generate the full repertoire of perception and behaviors requires a list of brain cell types, as well the means to target each cell type in order to interrogate the functional interactions that give rise to the emergent properties of the whole system. Neuronal diversity is essential for mammalian brain function but poses a challenge to molecular profiling. To facilitate cell-type-specific epigenomic studies, we have developed approaches to isolate nuclei from subtypes of neocortical neurons, revealing highly distinctive epigenomic landscapes. Hundreds of thousands of regions differ in chromatin accessibility and DNA methylation signatures characteristic of gene regulatory regions which are predicted to bind distinct cohorts of neuron subtype-specific transcription factors. Surprisingly, neuronal epigenomes reflect both past and present gene expression, with DNA hyper-methylation at developmentally critical genes appearing as a novel epigenomic signature in mature neurons. More recently, we have developed single cell methylome profiling methods that now allow an unbiased census of the diversity of neuronal cell types in the mammalian brain. Taken together, these approaches are beginning to link the functional and transcriptional complexity of neurons to their underlying epigenomic diversity.

Hamburg Speaker
Friday, 13 April 2018, 13:00Add to calendarZipping and unzipping transcriptional regulation Vivian Pogenberg, EMBL Hamburg Unit, GermanyHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Thursday, 19 April 2018, 14:00Add to calendarTo be announcedSean Carroll, University of Wisconsin-Madison, USAHost: Anne EphrussiLarge Operon, EMBL Heidelberg
Science and Society
Friday, 20 April 2018, 10:00Add to calendarThe Serengeti Rules; The Quest to Discover How Life Works and Why It MattersSean Carroll, Howard Hughes Medical Institute, USAHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
EMBL - Sapienza Lecture
Friday, 27 April 2018, 11:00Add to calendarTo be announcedNathaniel Heintz, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USAHost: Cornelius GrossSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Rome
Tags: Neurobiology
Hamburg Speaker
Friday, 4 May 2018, 13:00Add to calendarStructure of the Mycobacterial Type VII Secretion SystemKatherine Beckham, EMBL Hamburg Unit, GermanyHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 7 May 2018, 11:00Add to calendarTo be announcedIvan Dikic, Goethe University Frankfurt, GermanyHost: Christoph MüllerLarge Operon, EMBL Heidelberg
Science and Society
Monday, 7 May 2018, 18:00Add to calendarThe Human Genome; a promise or a constraint for the future?Denis Duboule, Federal Institute of Technology, SwitzerlandHost: Halldór StefánssonPrint Media Academy
Abstract: Ever since the first release of the human genome sequence in 2001, our knowledge of both the structure and function of our chromosomes has increased exponentially. Today, we are close to being in a position to use this knowledge and the accompanying technology to modify our own genetic material, these ...good old chromosomes, which haven t changed much since Cro-magnon , as stated by Jean Rostand in the late 1950 s. There are two distinct, though somewhat related frameworks where such potential modifications are currently being discussed and where various justifications are being formalized and put forward into the public domain. The first has to do with precision medicine , i.e. the possibility to use our genetic material as one of the major parameters, either to cure or to predict diseases. The second and perhaps more controversial context is that of trans-humanism, i.e. to try to move towards a novel human being (homo novus), as a result of genetic modifications along with technological assistance. In both cases, these future developments raise important questions and understandable concerns within our society, in particular regarding ethical and legal issues. In the meantime, and partly as a consequence of these valid societal questions, the critical scientific items underlying these potential advances are difficult to address in a rational context. Yet the discussions as to whether such future developments are consistent with our values, whether they are desirable or even necessary would likely be enriched by asking in parallel the questions related to the actual possibilities and feasibility of such approaches, i.e. to what extent our genome can either be interrogated to anticipate pathological states, or be modified to potentially improve human performances. From this utilitarian viewpoint, an important question is whether the increasing knowledge of our genetic material, its origin and its functioning make these new steps more or less likely to occur in a foreseeable future.
Science and Society
Monday, 14 May 2018, 14:00Add to calendarWhy is left-handedness ubiquitous and constant in space and time?Rik Smits, Science writer, NetherlandsHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Abstract: The issue of handedness is riddled with mystery. For one thing, it is not as clear as most people think what it really means for someone to be right- or left-handed. And why should there be both left- and right-handers at all? Furthermore, what could be the evolutionary advantage of having a left-handed fraction in a predominantly right-handed population, and why is there only one left-hander for every nine right-handers?
Another puzzling phenomenon is the association of left-handedness with a wide range of mental as well as physical and even cultural afflictions. It has long been noted that almost any group suffering from some negative trait, ranging from mild forms of brain damage to bizarre things like encarceration and even smoking, is likely to have a slightly above-average number of lefthanders in its ranks. On the other hand, virtually no group of randomly selected lefthanders can be correlated with any of these traits.
But the greatest conundrum of all is the ubiquity and stability of left-handedness. All communities, however isolated, seem to have around 10% lefthanders, and this seems to have been so ever since hominids began making tools. We know there is a hereditary factor involved, but for classical Darwinism, left-handedness is a tough nut to crack, all the more so in view of its the doubtful evolutionary value. As it turns out, however, there are other, positively detrimental traits which show similar characteristics, and there might be a more or less common explanation for their extraordinary resilience.
Hamburg Speaker
Friday, 18 May 2018, 13:00Add to calendarModel-building challenges for crystallographic maps at low-resolution
Grzegorz Chojnowski, EMBL Hamburg Unit, GermanyHost: Victor LamzinSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 25 May 2018, 13:00Add to calendarStructural characterisation of the von Willebrand factorEmma Ruoqi Xu, EMBL, Hamburg Unit, GermanyHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 4 June 2018, 11:00Add to calendarTo be announcedRudolf Jaenisch, MIT, The Whitehead Institute for Biomedical Research, USAHost: Nadezhda AbazovaLarge Operon, EMBL Heidelberg
Science and Society
Friday, 22 June 2018, 14:00Add to calendarSlow, closed, expensive and ineffective: How science publishing is killing science and how to fix itMichael Eisen, University of California, Berkeley, USAHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Abstract: The Internet was invented so that scientists could communicate their research results with each other. Yet twenty years after the birth of the modern Internet most of the the scientific literature one of greatest public works projects of all time remains locked behind expensive pay walls.

Every year universities, governments and other organizations spend in excess of $10 billion dollars to buy back access to papers their researchers gave to journals for free, while most teachers, students, health care providers and members of the public are left out in the cold. Even worse, the stranglehold existing journals have on academic publishing has stifled efforts to improve the ways scholars communicate with each other and the public, slowing scientific progress and increasing the divide between researchers and the public.

In my talk I will describe how we got to this ridiculous place. How twenty years of avarice from publishers, conservatism from researchers, fecklessness from universities and funders, and a basic lack of common sense from everyone has made the research community and public miss the manifest opportunities created by the Internet to transform how scholars communicate their ideas and discoveries. I will also talk about various ongoing efforts to liberate the scholarly literature where we have succeeded and where there is more work to be done. And finally, with these efforts gaining traction, I will describe where I think scholarly communication is headed in the next decade.
Science and Society
Thursday, 12 July 2018, 18:00Add to calendarWie Gliazellen zu Nervenzellen werden: neue Ansätze zur Therapie nach GehirnverletzungenMagdalena Götz, Ludwig-Maximilians-Universität München, GermanyHost: Halldór StefánssonPrint Media Academy
Abstract: Das menschliche Gehirn kann abgestorbene Nervenzellen größtenteils nicht mehr ersetzen. Um dies zu ändern, untersuchen wir die Mechanismen, wie Nervenzellen während der Entwicklung gebildet werden, um dies dann auch im erwachsenen Gehirn nach Verletzung auslösen zu können. Tatsächlich werden Nervenzellen während der Entwicklung von radialen Gliazellen gebildet, einem Zelltyp der bislang nur als Stützzelle angesehen wurde. Diese Gliazellen gehen bei der Reifung des Säugergehirns verloren und differenzieren in andere Gliazellen aus. Dementsprechend geht auch die Fähigkeit zur Bildung neuer Nervenzellen in den meisten Gehirnregionen verloren, mit Ausnahme weniger Regionen, in welchen radiale Gliazellen erhalten bleiben, und tatsächlich zeitlebens noch neue Nervenzellen gebildet werden. In vielen anderen Wirbeltieren bleiben diese Gliazellen weitverbreitet erhalten (Barbosa et al., Science 2015), und Gehirnverletzungen können ohne Narbenbildung völlig geheilt werden (Baumgart et al., Glia 2010). Wir arbeiten daran zu verstehen, wie diese radialen Gliazellen Nervenzellen bilden, und wie wir die Bildung von Nervenzellen auch in den differenzierten Gliazellen des Säugergehirns wieder auslösen können (als Übersichtsartikel: Masserdotti et al., Development 2016). Diesbezüglich haben wir gerade in den letzten Jahren große Fortschritte gemacht und es gelingt uns nun, viele narbenbildende Gliazellen in reife Nervenzellen nach Gehirnverletzung im Mausmodell umzuwandeln (Gascon et al., Cell Stem Cell 2016). Zudem konnten wir zeigen, dass auch Gehirnregionen, in denen normalerweise keine neue Nervenzellen im Erwachsenenstadium gebildet werden, die Fähigkeit besitzen, neue Nervenzellen wieder passend in das Nervenzellnetzwerk zu integrieren und die Funktion der abgestorbenen Nervenzellen wieder zu ersetzen. Die große Frage ist nun, ob dies auch für lokal aus Gliazellen umgewandelte Nervenzellen möglich ist.
EMBL Distinguished Visitor Lecture
Friday, 14 September 2018, 10:00Add to calendarGene regulatory principles in human development, disease and evolutionJoanna Wysocka , Institute for Stem Cell Biology & Regenerative Medicine, Stanford, California, USAHost: Jamie HackettCNR Seminar Room, EMBL Rome
EMBL Distinguished Visitor Lecture
Monday, 24 September 2018, 14:00Add to calendarTo be announcedMasayo Takahashi, Riken Center for Developmental Biology, JapanHost: Anne EphrussiLarge Operon, EMBL Heidelberg
External Faculty Speaker
Friday, 5 October 2018, 11:00Add to calendarThe neural basis of mental modelsAlla Karpova, Janelia HHMI, Ashburn Virginia, USA, USAHost: Cornelius GrossCNR Seminar Room, EMBL Rome
Abstract: The overall interest of my lab is to understand how model-based inference is accomplished by neural circuits. Over the past few years we have focused on the role that the rodent medial prefrontal cortex (mPFC), an area homologous to primate anterior cingulate cortex (ACC), plays in encoding the internal abstraction of the environmental rules. We have designed behavioral tasks in which these rules change evolve in a complex manner although with latent regularities and which are designed to either elicit exploration of a rich strategy space, or to isolate the point of commitment to individual strategies. Recordings of the ensemble activity in mPFC revealed that moments of abrupt change in behavioral strategy are associated with marked transitions in the pattern of neural activity across the mPFC, one interpretation of which is that such changes signify a change of prior expectations associated with different behavioral strategies. In turn, targeted inactivation of mPFC at the moment of commitment to a particular strategy leads to reduced exploration of the strategy space in favor of persistence with the default strategy. In contrast, such persistence is abolished by inactivation of mPFC at trial s end. The apparent presence at least two distinct computations related to strategy adjustment in mPFC, separated in time, is further confirmed by circuit-specific perturbation experiments that argue that there two computations are segregated within the mPFC micro-circuitry. Together with previous findings in the field, our findings lend credence to the view that the mammalian cingulate cortex uses higher order statistics about the environment to determine when to explore alternative strategies and to pick which strategy should be explored.
EMBL Distinguished Visitor Lecture
Tuesday, 9 October 2018, 11:00Add to calendarTo be announcedCraig Thompson, Memorial Sloan Kettering Cancer Center, USAHost: Joel Perez-PerriLarge Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 12 October 2018, 10:00Add to calendarEpigenetic regulation by histone acetylationAsifa Akhtar, Max Planck Institute of Immunobiology, and Epigenetics,Freiburg, Germany , , GermanyHost: Philip AvnerCNR Seminar Room, EMBL Rome
Abstract: Our lab is studying the chromatin and epigenetic mechanisms regulated by histone acetylation using evolutionary conserved complexes associated with MOF, a MYST family of histone acetyl transferase. In files and mammals MOF is associated with the MSL and NSL complexes, which are important regulators of gene expression. In flies the MSL complex is well known for regulation of the X chromosome by the process of dosage compensation, while the NSL complex regulates expression of house keeping genes. In mammals, both complexes appear to be involved in regulating diverse cellular processes. The recent progress of our work will be presented.
EMBL Distinguished Visitor Lecture
Friday, 9 November 2018, 11:00Add to calendarTo be announcedMartha Bulyk, Harvard University, USAHost: Aleksander JankowskiLarge Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 7 December 2018, 11:00Add to calendarTo be announcedPetra Schwille, Max Planck Institute of Biochemistry, GermanyHost: Rainer PepperkokLarge Operon, EMBL Heidelberg