Seminar Colour Guide:              
Hamburg Speaker
Wednesday, 26 June 2019, 13:00Add to calendarTransmembrane helix-helix recognition of bitopic proteins studied by high-resolution NMR: Implications for cell signaling and human pathologies Eduard Bocharov , Laboratory of Biomolecular NMR spectroscopy, Department of Structural Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Russian FederationHost: Dmitri SvergunSeminar Room 48e
Abstract: 1 Laboratory of Biomolecular NMR Spectroscopy, Department of Structural Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russian Federation
2 Laboratory of Aging and Age-related Neurodegenerative Diseases, Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology (State University), Moscow, Russian Federation,
e-mail address: bon@nmr.ru
Bitopic proteins having only one helical transmembrane (TM) domain are a class of biologically significant membrane proteins, including the type I receptors, which are involved in the regulation of different cellular processes in human organism. Either destroying or enhancing of their biological activity can result in many human diseases. Recent studies have been making it increasingly clear that specific helix-helix interactions of single-span TM domains are critical for lateral dimerization and modulation of biological function of bitopic proteins. Establishing structure-function relationship requires precise structural information about this class of objects. A combination of high-resolution NMR spectroscopy with optical spectroscopy, protein engineering and molecular modeling made it possible studies of the nature and the mechanisms of important TM helix-helix recognition and interactions inside the supramolecular complexes (detergent micelles and lipid bicelles) mimicking membrane environment. Using a robust strategy, we investigated recombinant TM fragments of a number bitopic proteins from different families of receptor tyrosine kinases, apoptotic proteins, as well as amyloid precursor protein APP, which play important roles in normal and in pathological conditions (e.g. oncogenesis and Alzheimer disease) of human organism by providing cell signaling, maintaining cellular homeostasis and controlling cell fate. We established spatial structure and internal dynamics of the monomeric and dimeric TM domains, characterized diverse TM helix-helix packing interfaces and obtained detailed atomistic picture of intra- and intermolecular interactions. Obtained information about structural-dynamic properties of the TM domains of studied bitopic proteins along with the available biophysical and biochemical data provides useful insights into the bitopic protein functioning at the atomic level.
The work is supported by iNEXT and by the Russian Foundation for Basic Research (projects 17-04-02045, 17-00-00489, 18-04-01289 and 18-54-74001).
Science and Society
Friday, 28 June 2019, 13:00Add to calendarInfectious disease interventions for population health and human development
Till Bärnighausen, Heidelberg University, GermanyHost: Melissa GraewertSeminar Room 48e, EMBL Hamburg
Abstract: Infectious disease epidemics are cutting into life expectancies and inhibt human development in many countries worldwide. Interventions to prevent and treat infectious diseases can thus lead to major improvements in population health, social and economic outcomes. I will present modern infectious disease interventions research including all stages of the research process, with examples from large-scale population and health systems intervention studies in African and Asia, including novel programs to fight HIV, reduce sexually transmitted infections and to expand vaccination coverage. I will show empirical evidence for substantial improvements in popualtion health, educational attainment, labor market productivity and social functioning.
Hamburg Speaker
Friday, 5 July 2019, 13:00Add to calendarTo be announcedAzadeh Shahsavar, EMBL Hamburg Unit, GermanyHost: Thomas R. SchneiderSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 12 July 2019, 11:00Add to calendarLife under Pressure: How do the Proteins Work?Toshiko Ichiye, Georgetown University, Washington, USAHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 12 July 2019, 13:00Add to calendarTo be announcedKenneth Verstraete, VIB-UGent Center for Inflammation Research, Ghent, BelgiumHost: Dmitri SvergunSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 27 September 2019, 13:00Add to calendarTo be announcedStefan Fiedler, EMBL Hamburg Unit, GermanyHost: Stefan FiedlerSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 22 November 2019, 13:00Add to calendarTo be announcedSebastian Glatt, Max Planck Research Group Leader, , Malopolska Centre of Biotechnology (MCB), Jagiellonian University Krakow, PolandHost: Jan KosinskiSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 29 November 2019, 13:00Add to calendarTo be announcedSamuel Pazicky, EMBL Hamburg Unit, GermanyHost: Christian LoewSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 6 December 2019, 13:00Add to calendarTo be announcedKim Bartels, EMBL Hamburg Unit, GermanyHost: Christian LoewSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 13 December 2019, 13:00Add to calendarTo be announcedThomas Crosskey, EMBL Hamburg Unit, GermanyHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg