EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


Total: 15 publication(s)


Singh HR, Nardozza AP, Möller IR, Knobloch G, Kistemaker HAV, Hassler M, Harrer N, Blessing C, Eustermann S, Kotthoff C, Huet S, Mueller-Planitz F, Filippov DV, Timinszky G, Rand KD, Ladurner AG. (2017)

A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene.

Mol Cell 68(5):860-871.e7. doi: 10.1016/j.molcel.2017.11.019
Europe PMC | doi

Kschonsak M, Merkel F, Bisht S, Metz J, Rybin V, Hassler M, Haering CH. (2017)

Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.

Cell 171(3):588-600. doi: 10.1016/j.cell.2017.09.008
Europe PMC | doi


Eeftens JM, Katan AJ, Kschonsak M, Hassler M, de Wilde L, Dief EM, Haering CH, Dekker C. (2016)

Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic.

Cell Rep 14(8):1813-1818. doi: 10.1016/j.celrep.2016.01.063
Europe PMC | doi


Hondele M, Stuwe T, Hassler M, Halbach F, Bowman A, Zhang ET, Nijmeijer B, Kotthoff C, Rybin V, Amlacher S, Hurt E, Ladurner AG. (2013)

Structural basis of histone H2A-H2B recognition by the essential chaperone FACT

Nature 499(7456):111-114. doi: 10.1038/nature12242
Europe PMC | doi

Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, Ladurner AG. (2013)

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation

Nat. Struct. Mol. Biol. 20(4):508-514. doi: 10.1038/nsmb.2523
Europe PMC | doi

Oppikofer M, Kueng S, Keusch JJ, Hassler M, Ladurner AG, Gut H, Gasser SM. (2013)

Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation

EMBO J. 32(3):437-449. doi: 10.1038/emboj.2012.343
Europe PMC | doi


Hassler M, Ladurner AG. (2012)

Towards a structural understanding of PARP1 activation and related signalling ADP-ribosyl-transferases

Curr. Opin. Struct. Biol. 22(6):721-729. doi: 10.1016/j.sbi.2012.08.005
Europe PMC | doi

Ali AA, Timinszky G, Arribas-Bosacoma R, Kozlowski M, Hassa PO, Hassler M, Ladurner AG, Pearl LH, Oliver AW. (2012)

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

Nat. Struct. Mol. Biol. 19(7):685-692. doi: 10.1038/nsmb.2335
Europe PMC | doi


Hassler M, Jankevicius G, Ladurner AG. (2011)

PARG: a macrodomain in disguise

Structure 19(10):1351-1353. doi: 10.1016/j.str.2011.09.007
Europe PMC | doi

Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE. (2011)

Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79

Genes Dev. 25(17):1835-1846. doi: 10.1101/gad.17175111
Europe PMC | doi

Murawska M, Hassler M, Renkawitz-Pohl R, Ladurner A, Brehm A. (2011)

Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression

PLoS Genet. 7(7):e1002206. doi: 10.1371/journal.pgen.1002206
Europe PMC | doi


Hassler M, Singh S, Yue WW, Luczynski M, Lakbir R, Sanchez-Sanchez F, Bader T, Pearl LH, Mittnacht S. (2007)

Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture

Mol. Cell 28(3):371-385. doi: 10.1016/j.molcel.2007.08.023
Europe PMC | doi

Yue WW, Hassler M, Roe SM, Thompson-Vale V, Pearl LH. (2007)

Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase

EMBO J. 26(20):4402-4412. doi: 10.1038/sj.emboj.7601856
Europe PMC | doi


Berger I, Bieniossek C, Schaffitzel C, Hassler M, Santelli E, Richmond TJ. (2003)

Direct interaction of Ca2+/calmodulin inhibits histone deacetylase 5 repressor core binding to myocyte enhancer factor 2

J. Biol. Chem. 278(20):17625-17635. doi: 10.1074/jbc.m301646200
Europe PMC | doi


Hassler M, Richmond TJ. (2001)

The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex

EMBO J. 20(12):3018-3028. doi: 10.1093/emboj/20.12.3018
Europe PMC | doi