EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • PhD 2001, Max Planck Institute for Dynamics and Self-Organisation, Göttingen.
    Postdoctoral research at the Kavli Institute for Theoretical Physics, Santa Barbara, California.
    Group leader at EMBL Heidelberg since 2007.


Total: 35 publication(s)


de Medeiros G, Kromm D, Balazs B, Norlin N, Günther S, Izquierdo E, Ronchi P, Komoto S, Krzic U, Schwab Y, Peri F, de Renzis S, Leptin M, Rauzi M, Hufnagel L. (2020)

Cell and tissue manipulation with ultrashort infrared laser pulses in light-sheet microscopy.

Sci Rep 10(1) doi: 10.1038/s41598-019-54349-x
Europe PMC | doi


Wagner N, Norlin N, Gierten J, de Medeiros G, Balázs B, Wittbrodt J, Hufnagel L, Prevedel R. (2019)

Instantaneous isotropic volumetric imaging of fast biological processes.

Nat. Methods 16(6) doi: 10.1038/s41592-019-0393-z
Europe PMC | doi


Caroti F, González Avalos E, Noeske V, González Avalos P, Kromm D, Wosch M, Schuetz L, Hufnagel L, Lemke S. (2018)

Decoupling from yolk sac is required for extraembryonic tissue spreading in the scuttle fly Megaselia abdita.

Elife 7 doi: 10.7554/eLife.34616
Europe PMC | doi

Durrieu L, Kirrmaier D, Schneidt T, Kats I, Raghavan S, Hufnagel L, Saunders TE, Knop M. (2018)

Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis.

Mol. Syst. Biol. 14(9) doi: 10.15252/msb.20188355
Europe PMC | doi

Reichmann J, Nijmeijer B, Hossain MJ, Eguren M, Schneider I, Politi AZ, Roberti MJ, Hufnagel L, Hiiragi T, Ellenberg J. (2018)

Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos.

Science 361(6398):189-193. doi: 10.1126/science.aar7462
Europe PMC | doi


Kimura K, Mamane A, Sasaki T, Sato K, Takagi J, Niwayama R, Hufnagel L, Shimamoto Y, Joanny JF, Uchida S, Kimura A. (2017)

Endoplasmic-reticulum-mediated microtubule alignment governs cytoplasmic streaming.

Nat Cell Biol 19(4) doi: 10.1038/ncb3490
Europe PMC | doi


Hufnagel L, Pepperkok R. (2016)

Let there be light-at the right place.

Nat. Biotechnol. 34(12):1246-1247. doi: 10.1038/nbt.3738
Europe PMC | doi

Niwayama R, Nagao H, Kitajima ST, Hufnagel L, Shinohara K, Higuchi T, Ishikawa T, Kimura A. (2016)

Bayesian Inference of Forces Causing Cytoplasmic Streaming in Caenorhabditis elegans Embryos and Mouse Oocytes.

PLoS ONE 11(7) doi: 10.1371/journal.pone.0159917
Europe PMC | doi

de Medeiros G, Balázs B, Hufnagel L. (2016)

Light-sheet imaging of mammalian development.

Semin. Cell Dev. Biol. 55:148-155. doi: 10.1016/j.semcdb.2015.11.001
Europe PMC | doi

Hoyer P, de Medeiros G, Balázs B, Norlin N, Besir C, Hanne J, Kräusslich HG, Engelhardt J, Sahl SJ, Hell SW, Hufnagel L. (2016)

Breaking the diffraction limit of light-sheet fluorescence microscopy by RESOLFT.

Proc. Natl. Acad. Sci. U.S.A. 113(13):3442-3446. doi: 10.1073/pnas.1522292113
Europe PMC | doi

Strnad P, Gunther S, Reichmann J, Krzic U, Balazs B, de Medeiros G, Norlin N, Hiiragi T, Hufnagel L, Ellenberg J. (2016)

Inverted light-sheet microscope for imaging mouse pre-implantation development.

Nat. Methods 13(2):139-142. doi: 10.1038/nmeth.3690
Europe PMC | doi

Kappe CN, Schuetz L, Gunther S, Hufnagel L, Lemke S, Leitte H. (2016)

Reconstruction and Visualization of Coordinated 3D Cell Migration Based on Optical Flow.

IEEE Trans Vis Comput Graph 22(1):995-1004. doi: 10.1109/tvcg.2015.2467291
Europe PMC | doi


Medeiros Gd, Norlin N, Günther S, Albert M, Panavaite L, Fiuza UM, Peri F, Hiiragi T, Krzic U, Hufnagel L. (2015)

Confocal multiview light-sheet microscopy.

Nat Commun 6 doi: 10.1038/ncomms9881
Europe PMC | doi

Rauzi M, Krzic U, Saunders TE, Krajnc M, Ziherl P, Hufnagel L, Leptin M. (2015)

Embryo-scale tissue mechanics during Drosophila gastrulation movements.

Nat Commun 6:8677. doi: 10.1038/ncomms9677
Europe PMC | doi

Dietrich JE, Panavaite L, Gunther S, Wennekamp S, Groner AC, Pigge A, Salvenmoser S, Trono D, Hufnagel L, Hiiragi T. (2015)

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.

EMBO Rep. 16(8):1005-1021. doi: 10.15252/embr.201540162
Europe PMC | doi

Schiegg M, Hanslovsky P, Haubold C, Koethe U, Hufnagel L, Hamprecht FA. (2015)

Graphical Model for Joint Segmentation and Tracking of Multiple Dividing Cells.

Bioinformatics 31(6) doi: 10.1093/bioinformatics/btu764
Europe PMC | doi


Beira JV, Springhorn A, Gunther S, Hufnagel L, Pyrowolakis G, Vincent JP. (2014)

The Dpp/TGFβ-Dependent Corepressor Schnurri Protects Epithelial Cells from JNK-Induced Apoptosis in Drosophila Embryos.

Dev. Cell 31(2):240-247. doi: 10.1016/j.devcel.2014.08.015
Europe PMC | doi

Streichan SJ, Hoerner CR, Schneidt T, Holzer D, Hufnagel L. (2014)

Spatial constraints control cell proliferation in tissues.

Proc. Natl. Acad. Sci. U.S.A. 111(15):5586-5591. doi: 10.1073/pnas.1323016111
Europe PMC | doi

Revenu C, Streichan S, Donà E, Lecaudey V, Hufnagel L, Gilmour D. (2014)

Quantitative cell polarity imaging defines leader-to-follower transitions during collective migration and the key role of microtubule-dependent adherens junction formation

Development 141(6):1282-1291. doi: 10.1242/dev.101675
Europe PMC | doi

Erceg J, Saunders TE, Girardot C, Devos DP, Hufnagel L, Furlong EE. (2014)

Subtle changes in motif positioning cause tissue-specific effects on robustness of an enhancer's activity

PLoS Genet. 10(1):e1004060. doi: 10.1371/journal.pgen.1004060
Europe PMC | doi


Krzic U, Gunther S, Saunders TE, Streichan SJ, Hufnagel L. (2012)

Multiview light-sheet microscope for rapid in toto imaging

Nat. Methods 9(7):730-733. doi: 10.1038/nmeth.2064
Europe PMC | doi

Puliafito A, Hufnagel L, Neveu P, Streichan S, Sigal A, Fygenson DK, Shraiman BI. (2012)

Collective and single cell behavior in epithelial contact inhibition

Proc. Natl. Acad. Sci. U.S.A. 109(3):739-744. doi: 10.1073/pnas.1007809109
Europe PMC | doi

Chiou KK, Hufnagel L, Shraiman BI. (2012)

Mechanical stress inference for two dimensional cell arrays

PLoS Comput. Biol. 8(5):e1002512. doi: 10.1371/journal.pcbi.1002512
Europe PMC | doi


Capoulade J, Wachsmuth M, Hufnagel L, Knop M. (2011)

Quantitative fluorescence imaging of protein diffusion and interaction in living cells

Nat. Biotechnol. 29(9):835-839. doi: 10.1038/nbt.1928
Europe PMC | doi

Streichan SJ, Valentin G, Gilmour D, Hufnagel L. (2011)

Collective cell migration guided by dynamically maintained gradients

Phys Biol 8(4):045004. doi: 10.1088/1478-3975/8/4/045004
Europe PMC | doi

Krzic U, Günther S, Hufnagel L, von Gegerfelt D, Karlsson H, Illy E, Hellström J. (2011)

Lichtscheiben‐Fluoreszenzmikroskopie (SPIM) und Laser‐Anregung in orange zur Abbildung lebender Organismen

BioPhotonik 2011(1):42-44.

Krzic U, Günther S, Hufnagel L, von Gegerfelt D, Karlsson H, Illy E, Hellström J. (2011)

Light Sheet Fluorescence Microscopy (SPIM) and laser excitation in orange for imaging of live organisms

Photonik Int 2011(1):41-43.


Brockmann D, Hufnagel L. (2007)

Front propagation in reaction-superdiffusion dynamics: Taming Levy flights with fluctuations

PHYS REV LETT 98(17) doi: 10.1103/PhysRevLett.98.178301

Hufnagel L, Teleman AA, Rouault H, Cohen SM, Shraiman BI. (2007)

On the mechanism of wing size determination in fly development

Proc. Natl. Acad. Sci. U.S.A. 104(10):3835-3840. doi: 10.1073/pnas.0607134104
Europe PMC | doi


Hufnagel L, Kreuger J, Cohen SM, Shraiman BI. (2006)

On the role of glypicans in the process of morphogen gradient formation

Dev. Biol. 300(2):512-522. doi: 10.1016/j.ydbio.2006.08.076
Europe PMC | doi

Brockmann D, Hufnagel L, Geisel T. (2006)

The scaling laws of human travel

Nature 439(7075):462-465. doi: 10.1038/nature04292
Europe PMC | doi


Brockmann D, Hufnagel L, Geisel T. (2005)

Dynamics of Modern Epidemics

SARS: A Case Study in Emerging Infections. Oxford University Press.


Hufnagel L, Brockmann D, Geisel T. (2004)

Forecast and control of epidemics in a globalized world

Proc. Natl. Acad. Sci. U.S.A. 101(42):15124-15129. doi: 10.1073/pnas.0308344101
Europe PMC | doi


Weiss M, Hufnagel L, Ketzmerick R. (2003)

Can simple renormalization theories describe the trapping of chaotic trajectories in mixed systems?

Phys Rev E Stat Nonlin Soft Matter Phys 67(4 Pt 2):046209. doi: 10.1103/physreve.67.046209
Europe PMC | doi


Weiss M, Hufnagel L, Ketzmerick R. (2002)

Universal power-law decay in Hamiltonian systems?

Phys. Rev. Lett. 89(23):239401; author reply 239402. doi: 10.1103/physrevlett.89.239401
Europe PMC | doi