EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • PhD 1998, Université Paris-Sud II.

  • Postdoctoral Research at EMBL.

  • Group Leader, 2005-2017.

  • Visiting Research Scientist at EMBL since 2018.


Total: 62 publication(s)


Letort G, Bennabi I, Dmitrieff S, Nedelec F, Verlhac MH, Terret ME. (2019)

A computational model of the early stages of acentriolar meiotic spindle assembly.

Mol. Biol. Cell doi: 10.1091/mbc.E18-10-0644
Europe PMC | doi


Wollrab V, Belmonte JM, Baldauf L, Leptin M, Nédeléc F, Koenderink GH. (2018)

Polarity sorting drives remodeling of actin-myosin networks.

J. Cell. Sci. doi: 10.1242/jcs.219717
Europe PMC | doi

Roostalu J, Rickman J, Thomas C, Nédélec F, Surrey T. (2018)

Determinants of Polar versus Nematic Organization in Networks of Dynamic Microtubules and Mitotic Motors.

Cell 175(3):796-808.e14. doi: 10.1016/j.cell.2018.09.029
Europe PMC | doi

Mund M, van der Beek JA, Deschamps J, Dmitrieff S, Hoess P, Monster JL, Picco A, Nédélec F, Kaksonen M, Ries J. (2018)

Systematic Nanoscale Analysis of Endocytosis Links Efficient Vesicle Formation to Patterned Actin Nucleation.

Cell 174(4) doi: 10.1016/j.cell.2018.06.032
Europe PMC | doi

Burdyniuk M, Callegari A, Mori M, Nédélec F, Lénárt P. (2018)

F-Actin nucleated on chromosomes coordinates their capture by microtubules in oocyte meiosis.

J. Cell Biol. 217(8) doi: 10.1083/jcb.201802080
Europe PMC | doi

Lacroix B, Letort G, Pitayu L, Sallé J, Stefanutti M, Maton G, Ladouceur AM, Canman JC, Maddox PS, Maddox AS, Minc N, Nédélec F, Dumont J. (2018)

Microtubule Dynamics Scale with Cell Size to Set Spindle Length and Assembly Timing.

Dev Cell 45(4):496-511.e6. doi: 10.1016/j.devcel.2018.04.022
Europe PMC | doi

Descovich CP, Cortes DB, Ryan S, Nash J, Zhang L, Maddox PS, Nedelec F, Maddox AS. (2018)

Crosslinkers both drive and brake cytoskeletal remodeling and furrowing in cytokinesis.

Mol. Biol. Cell 29(5) doi: 10.1091/mbc.E17-06-0392
Europe PMC | doi

Bun P, Dmitrieff S, Belmonte JM, Nédélec FJ, Lénárt P. (2018)

A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes

Elife 7 doi: 10.7554/eLife.31469
Europe PMC | doi


Gimpel P, Lee YL, Sobota RM, Calvi A, Koullourou V, Patel R, Mamchaoui K, Nédélec F, Shackleton S, Schmoranzer J, Burke B, Cadot B, Gomes ER. (2017)

Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.

Curr Biol 27(19):2999-3009.e9. doi: 10.1016/j.cub.2017.08.031
Europe PMC | doi

Dmitrieff S, Nédélec F. (2017)

ConfocalGN: A minimalistic confocal image generator

SoftwareX 6:243-247. doi: 10.1016/j.softx.2017.09.002

Belmonte JM, Leptin M, Nédélec F. (2017)

A Theory that Predicts Behaviors of Disordered Cytoskeletal Networks

Mol. Syst. Biol. 13(9):941. doi: 10.15252/msb.20177796
Europe PMC | doi

Lee YL, Gimpel P, Sobota R, Calvi A, Koullourou V, Patel R, Mamchaoui K, Nedelec F, Shackleton S, Schmoranzer J, Burke B, Cadot B, Gomes E. (2017)

Nesprin-1 recruits Akap450-mediated microtubule nucleation activity to the nuclear envelope to facilitate proper nuclear migration in skeletal muscle

MECH DEVELOP 145:S63. doi: 10.1016/j.mod.2017.04.137

Ding WY, Ong HT, Hara Y, Wongsantichon J, Toyama Y, Robinson RC, Nédélec F, Zaidel-Bar R. (2017)

Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis.

J Cell Biol 216(5):1371-1386. doi: 10.1083/jcb.201603070
Europe PMC | doi

Dmitrieff S, Alsina A, Mathur A, Nédélec FJ. (2017)

Balance of microtubule stiffness and cortical tension determines the size of blood cells with marginal band across species.

Proc. Natl. Acad. Sci. U.S.A. 114(17):4418-4423. doi: 10.1073/pnas.1618041114
Europe PMC | doi

Nédélec F. (2017)

preconfig: A Versatile Configuration File Generator for Varying Parameters.

J Open Res Softw 5(1):9. doi: 10.5334/jors.156

Gibeaux R, Politi AZ, Philippsen P, Nédélec F. (2017)

Mechanism of Nuclear Movements in a Multinucleated Cell.

Mol. Biol. Cell 28(3):1-33. doi: 10.1091/mbc.e16-11-0806
Europe PMC | doi


Letort G, Nedelec F, Blanchoin L, Théry M. (2016)

Centrosome centering and decentering by microtubule network rearrangement.

Mol. Biol. Cell 27(18):2833-28343. doi: 10.1091/mbc.E16-06-0395
Europe PMC | doi

Maître JL, Turlier H, Illukkumbura R, Eismann B, Niwayama R, Nédélec F, Hiiragi T. (2016)

Asymmetric division of contractile domains couples cell positioning and fate specification

Nature 536(7616):344-348. doi: 10.1038/nature18958
Europe PMC | doi

Dmitrieff S, Nédélec F. (2016)

Amplification of actin polymerization forces.

J. Cell Biol. 212(7):763-766. doi: 10.1083/jcb.201512019
Europe PMC | doi

De Simone A, Nédélec F, Gönczy P. (2016)

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation.

Cell Rep 14(9):2250-2262. doi: 10.1016/j.celrep.2016.01.077
Europe PMC | doi

Ennomani H, Letort G, Guérin C, Martiel JL, Cao W, Nédélec F, De La Cruz EM, Théry M, Blanchoin L. (2016)

Architecture and Connectivity Govern Actin Network Contractility.

Curr. Biol. 26(5):616-626. doi: 10.1016/j.cub.2015.12.069
Europe PMC | doi

Belmonte JM, Nédélec F. (2016)

Large-scale microtubule networks contract quite well.

Elife 5 doi: 10.7554/elife.14076
Europe PMC | doi


Dmitrieff S, Nédélec F. (2015)

Membrane Mechanics of Endocytosis in Cells with Turgor.

PLoS Comput. Biol. 11(10) doi: 10.1371/journal.pcbi.1004538
Europe PMC | doi

Maître JL, Niwayama R, Turlier H, Nédélec F, Hiiragi T. (2015)

Pulsatile cell-autonomous contractility drives compaction in the mouse embryo.

Nat. Cell Biol. 17(7):849-855. doi: 10.1038/ncb3185
Europe PMC | doi

Letort G, Politi AZ, Ennomani H, Théry M, Nedelec F, Blanchoin L. (2015)

Geometrical and mechanical properties control actin filament organization.

PLoS Comput. Biol. 11(5) doi: 10.1371/journal.pcbi.1004245
Europe PMC | doi

Picco A, Mund M, Ries J, Nédélec F, Kaksonen M. (2015)

Visualizing the functional architecture of the endocytic machinery.

Elife 4 doi: 10.7554/eLife.04535
Europe PMC | doi


Ward JJ, Roque H, Antony C, Nedelec FJ. (2014)

Mechanical design principles of a mitotic spindle.

Elife 3 doi: 10.7554/eLife.03398
Europe PMC | doi

Mori M, Somogyi K, Kondo H, Monnier N, Falk HJ, Machado P, Bathe M, Nédélec F, Lénárt P. (2014)

An arp2/3 nucleated f-actin shell fragments nuclear membranes at nuclear envelope breakdown in starfish oocytes.

Curr. Biol. 24(12):1421-1428. doi: 10.1016/j.cub.2014.05.019
Europe PMC | doi

Athale CA, Dinarina A, Nedelec F, Karsenti E. (2014)

Collective behavior of minus-ended motors in mitotic microtubule asters gliding toward DNA

Phys Biol 11(1):016008. doi: 10.1088/1478-3975/11/1/016008
Europe PMC | doi

Tarnawska K, Pugieux C, Nédélec F. (2014)

Mitotic spindle assembly on chromatin patterns made with deep UV photochemistry

Methods Cell Biol. 120:3-17. doi: 10.1016/b978-0-12-417136-7.00001-x
Europe PMC | doi

Pugieux C, Dmitrieff S, Tarnawska K, Nédélec F. (2014)

Spindle assembly on immobilized chromatin micropatterns

Meth. Enzymol. 540:435-448. doi: 10.1016/b978-0-12-397924-7.00024-8
Europe PMC | doi


Wennekamp S, Mesecke S, Nédélec F, Hiiragi T. (2013)

A self-organization framework for symmetry breaking in the mammalian embryo

Nat. Rev. Mol. Cell Biol. 14(7):452-459. doi: 10.1038/nrm3602
Europe PMC | doi

Gibeaux R, Politi AZ, Nédélec F, Antony C, Knop M. (2013)

Spindle pole body-anchored Kar3 drives the nucleus along microtubules from another nucleus in preparation for nuclear fusion during yeast karyogamy

Genes Dev. 27(3):335-349. doi: 10.1101/gad.206318.112
Europe PMC | doi


Rupp B, Nédélec F. (2012)

Patterns of molecular motors that guide and sort filaments

Lab Chip 12(22):4903-4910. doi: 10.1039/c2lc40250e
Europe PMC | doi


Loughlin R, Wilbur JD, McNally FJ, Nédélec FJ, Heald R. (2011)

Katanin contributes to interspecies spindle length scaling in Xenopus

Cell 147(6):1397-1407. doi: 10.1016/j.cell.2011.11.014
Europe PMC | doi

Petry S, Pugieux C, Nédélec FJ, Vale RD. (2011)

Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts

Proc. Natl. Acad. Sci. U.S.A. 108(35):14473-14478. doi: 10.1073/pnas.1110412108
Europe PMC | doi


Loughlin R, Heald R, Nédélec F. (2010)

A computational model predicts Xenopus meiotic spindle organization

J. Cell Biol. 191(7):1239-1249. doi: 10.1083/jcb.201006076
Europe PMC | doi

Renshaw MJ, Ward JJ, Kanemaki M, Natsume K, Nédélec FJ, Tanaka TU. (2010)

Condensins promote chromosome recoiling during early anaphase to complete sister chromatid separation

Dev. Cell 19(2):232-244. doi: 10.1016/j.devcel.2010.07.013
Europe PMC | doi

Ward JJ, Nédélec FJ. (2010)

Computational cell biology at the home of the helix

EMBO Rep. 11(6):413-415. doi: 10.1038/embor.2010.77
Europe PMC | doi

Pugieux C, Nédélec F. (2010)

La chromatine façonne le fuseau mitotique [Mitotic spindle assembly depends on chromatin geometry]

Med Sci (Paris) 26(2):139-142. doi: 10.1051/medsci/2010262139
Europe PMC | doi


Brun L, Rupp B, Ward JJ, Nédélec F. (2009)

A theory of microtubule catastrophes and their regulation

Proc. Natl. Acad. Sci. U.S.A. 106(50):21173-21178. doi: 10.1073/pnas.0910774106
Europe PMC | doi

Dinarina A, Pugieux C, Corral MM, Loose M, Spatz J, Karsenti E, Nédélec F. (2009)

Chromatin shapes the mitotic spindle

Cell 138(3):502-513. doi: 10.1016/j.cell.2009.05.027
Europe PMC | doi

Fu C, Ward JJ, Loiodice I, Velve-Casquillas G, Nedelec FJ, Tran PT. (2009)

Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation

Dev. Cell 17(2):257-267. doi: 10.1016/j.devcel.2009.06.012
Europe PMC | doi

Pinot M, Chesnel F, Kubiak JZ, Arnal I, Nedelec FJ, Gueroui Z. (2009)

Effects of confinement on the self-organization of microtubules and motors

Curr. Biol. 19(11):954-960. doi: 10.1016/j.cub.2009.04.027
Europe PMC | doi

Foethke D, Makushok T, Brunner D, Nédélec F. (2009)

Force- and length-dependent catastrophe activities explain interphase microtubule organization in fission yeast

Mol. Syst. Biol. 5:241. doi: 10.1038/msb.2008.76
Europe PMC | doi


Athale CA, Dinarina A, Mora-Coral M, Pugieux C, Nedelec F, Karsenti E. (2008)

Regulation of microtubule dynamics by reaction cascades around chromosomes

Science 322(5905):1243-1247. doi: 10.1126/science.1161820
Europe PMC | doi

Jékely G, Colombelli J, Hausen H, Guy K, Stelzer E, Nédélec F, Arendt D. (2008)

Mechanism of phototaxis in marine zooplankton

Nature 456(7220):395-399. doi: 10.1038/nature07590
Europe PMC | doi

Channels WE, Nédélec FJ, Zheng Y, Iglesias PA. (2008)

Spatial regulation improves antiparallel microtubule overlap during mitotic spindle assembly

Biophys. J. 94(7):2598-2609. doi: 10.1529/biophysj.107.117671
Europe PMC | doi


Kozlowski C, Srayko M, Nedelec F. (2007)

Cortical microtubule contacts position the spindle in C. elegans embryos

Cell 129(3):499-510. doi: 10.1016/j.cell.2007.03.027
Europe PMC | doi

Janson ME, Loughlin R, Loïodice I, Fu C, Brunner D, Nédélec FJ, Tran PT. (2007)

Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast

Cell 128(2):357-368. doi: 10.1016/j.cell.2006.12.030
Europe PMC | doi


Karsenti E, Nédélec F, Surrey T. (2006)

Modelling microtubule patterns

Nat. Cell Biol. 8(11):1204-1211. doi: 10.1038/ncb1498
Europe PMC | doi


Goshima G, Nédélec F, Vale RD. (2005)

Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins

J. Cell Biol. 171(2):229-240. doi: 10.1083/jcb.200505107
Europe PMC | doi


Karsenti E, Nédélec F. (2004)

The mitotic spindle and actin tails

Biol. Cell 96(3):237-240. doi: 10.1016/j.biolcel.2003.12.008
Europe PMC | doi


Nédélec F, Surrey T, Karsenti E. (2003)

Self-organisation and forces in the microtubule cytoskeleton

Curr. Opin. Cell Biol. 15(1):118-124. doi: 10.1016/s0955-0674(02)00014-5
Europe PMC | doi


Nédélec F. (2002)

Computer simulations reveal motor properties generating stable antiparallel microtubule interactions

J. Cell Biol. 158(6):1005-1015. doi: 10.1083/jcb.200202051
Europe PMC | doi


Surrey T, Nedelec F, Leibler S, Karsenti E. (2001)

Physical properties determining self-organization of motors and microtubules

Science 292(5519):1167-1171. doi: 10.1126/science.1059758
Europe PMC | doi

Nédélec F, Surrey T, Maggs AC. (2001)

Dynamic concentration of motors in microtubule arrays

Phys. Rev. Lett. 86(14):3192-3195. doi: 10.1103/physrevlett.86.3192
Europe PMC | doi

Nédélec F, Surrey T. (2001)

Assaying spatial organization of microtubules by kinesin motors

Methods Mol. Biol. 164:213-222. doi: 10.1385/1-59259-069-1:213
Europe PMC | doi

Nédélec F, Surrey T. (2001)

Dynamics of microtubule aster formation by motor complexes

C. R. Acad. Sci. IV-Phys. 2(6):841-847. doi: 10.1016/s1296-2147(01)01227-6
Europe PMC | doi


Nédélec F, Surrey T. (2000)

De l'action collective des moteurs à l'ordre cellulaire

médecine/sciences 16(6-7):739-744. doi: 10.4267/10608/1725


Surrey T, Elowitz MB, Wolf PE, Yang F, Nédélec F, Shokat K, Leibler S. (1998)

Chromophore-assisted light inactivation and self-organization of microtubules and motors

Proc. Natl. Acad. Sci. U.S.A. 95(8):4293-4298. doi: 10.1073/pnas.95.8.4293
Europe PMC | doi


Nédélec FJ, Surrey T, Maggs AC, Leibler S. (1997)

Self-organization of microtubules and motors

Nature 389(6648):305-308. doi: 10.1038/38532
Europe PMC | doi