EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • PhD 1998, Freie Universität Berlin, Germany
    Predoctoral and postdoctoral research at the National Institutes of Health (NIH), Bethesda, USA
    Group leader at EMBL since 1999.
    Head of Gene Expression Unit 2006-2010.
    Head of Cell Biology and Biophysics Unit since 2010.
    ERC Advanced Investigator since 2016.


Total: 169 publication(s)


Schuh M, Ellenberg J. (2007)

Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes

Cell 130(3):484-498. doi: 10.1016/j.cell.2007.06.025
Europe PMC | doi

Mora-Bermúdez F, Gerlich D, Ellenberg J. (2007)

Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase

Nat. Cell Biol. 9(7):822-831. doi: 10.1038/ncb1606
Europe PMC | doi

Simpson JC, Cetin C, Erfle H, Joggerst B, Liebel U, Ellenberg J, Pepperkok R. (2007)

An RNAi screening platform to identify secretion machinery in mammalian cells

Paper presented at the International Workshop on Molecular Systems Biology, Bielefeld, GERMANY, JUN, 2006.J. Biotechnol. 129(2):352-365. doi: 10.1016/j.jbiotec.2006.12.027
Europe PMC | doi

Dultz E, Ellenberg J. (2007)

Nuclear envelope

CURR BIOL 17(5):R154-R156. doi: 10.1016/j.cub.2006.12.035
Europe PMC | doi

Tarendeau F, Boudet J, Guilligay D, Mas PJ, Bougault CM, Boulo S, Baudin F, Ruigrok RW, Daigle N, Ellenberg J, Cusack S, Simorre JP, Hart DJ. (2007)

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

Nat. Struct. Mol. Biol. 14(3):229-233. doi: 10.1038/nsmb1212
Europe PMC | doi

Mora-Bermúdez F, Ellenberg J. (2007)

Measuring structural dynamics of chromosomes in living cells by fluorescence microscopy

Methods 41(2):158-167. doi: 10.1016/j.ymeth.2006.07.035
Europe PMC | doi

Erfle H, Neumann B, Liebel U, Rogers P, Held M, Walter T, Ellenberg J, Pepperkok R. (2007)

Reverse transfection on cell arrays for high content screening microscopy.

Nat Protoc 2(2):392-399. doi: 10.1038/nprot.2006.483
Europe PMC | doi


Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prévôt B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R. (2006)

Minimizing the risk of reporting false positives in large-scale RNAi screens

Nat. Methods 3(10):777-779. doi: 10.1038/nmeth1006-777
Europe PMC | doi

Pepperkok R, Ellenberg J. (2006)

High-throughput fluorescence microscopy for systems biology

Nat. Rev. Mol. Cell Biol. 7(9):690-696. doi: 10.1038/nrm1979
Europe PMC | doi

Gerlich D, Koch B, Dupeux F, Peters JM, Ellenberg J. (2006)

Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication

Curr. Biol. 16(15):1571-1578. doi: 10.1016/j.cub.2006.06.068
Europe PMC | doi

Keppler A, Arrivoli C, Sironi L, Ellenberg J. (2006)

Fluorophores for live cell imaging of AGT fusion proteins across the visible spectrum

BioTechniques 41(2):167-70, 172, 174-5. doi: 10.2144/000112216
Europe PMC | doi

Kudo NR, Wassmann K, Anger M, Schuh M, Wirth KG, Xu H, Helmhart W, Kudo H, McKay M, Maro B, Ellenberg J, de Boer P, Nasmyth K. (2006)

Resolution of chiasmata in oocytes requires separase-mediated proteolysis

Cell 126(1):135-146. doi: 10.1016/j.cell.2006.05.033
Europe PMC | doi

Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW. (2006)

NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules

Mol. Biol. Cell 17(6):2646-2660. doi: 10.1091/mbc.e05-12-1178
Europe PMC | doi

Neumann B, Held M, Liebel U, Erfle H, Rogers P, Pepperkok R, Ellenberg J. (2006)

High-throughput RNAi screening by time-lapse imaging of live human cells.

Nat. Methods 3(5):385-390. doi: 10.1038/nmeth876
Europe PMC | doi

Schuh M, Ellenberg J. (2006)

Nuclear actin: a lack of export allows formation of filaments

Curr. Biol. 16(9):R321-3. doi: 10.1016/j.cub.2006.03.081
Europe PMC | doi

Beaudouin J, Mora-Bermúdez F, Klee T, Daigle N, Ellenberg J. (2006)

Dissecting the contribution of diffusion and interactions to the mobility of nuclear proteins

Biophys. J. 90(6):1878-1894. doi: 10.1529/biophysj.105.071241
Europe PMC | doi

Gerlich D, Hirota T, Koch B, Peters JM, Ellenberg J. (2006)

Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells

Curr. Biol. 16(4):333-344. doi: 10.1016/j.cub.2005.12.040
Europe PMC | doi

Lénárt P, Ellenberg J. (2006)

Monitoring the permeability of the nuclear envelope during the cell cycle

Methods 38(1):17-24. doi: 10.1016/j.ymeth.2005.07.010
Europe PMC | doi

Neumann B, Held M, Liebel U, Erfle H, Rogers P, Pepperkok R, Ellenberg J. (2006)

Time-lapse microscopy-based genome wide RNAI screening in live human cells.

Paper presented at the 2006 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Arlington, VA (USA), 6-9 April 2006.I S Biomed Imaging 1:245-246. doi: 10.1109/ISBI.2006.1624898


Chusainow J, Ajuh PM, Trinkle-Mulcahy L, Sleeman JE, Ellenberg J, Lamond AI. (2005)

FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35

RNA 11(8):1201-1214. doi: 10.1261/rna.7277705
Europe PMC | doi

Lénárt P, Bacher CP, Daigle N, Hand AR, Eils R, Terasaki M, Ellenberg J. (2005)

A contractile nuclear actin network drives chromosome congression in oocytes

Nature 436(7052):812-818. doi: 10.1038/nature03810
Europe PMC | doi

Rabut G, Ellenberg, J. (2005)

Photobleaching techniques to study mobility and molecular dynamics of proteins in live cells: FRAP, iFRAP and FLIP

Cold Spring Harbor Press.Live Cell Imaging: A Laboratory Manual 101-127.


Dechat T, Gajewski A, Korbei B, Gerlich D, Daigle N, Haraguchi T, Furukawa K, Ellenberg J, Foisner R. (2004)

LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly

J. Cell. Sci. 117(Pt 25):6117-6128. doi: 10.1242/jcs.01529
Europe PMC | doi

Hirota T, Gerlich D, Koch B, Ellenberg J, Peters JM. (2004)

Distinct functions of condensin I and II in mitotic chromosome assembly

J. Cell. Sci. 117(Pt 26):6435-6445. doi: 10.1242/jcs.01604
Europe PMC | doi

Rabut G, Doye V, Ellenberg J. (2004)

Mapping the dynamic organization of the nuclear pore complex inside single living cells

Nat. Cell Biol. 6(11):1114-1121. doi: 10.1038/ncb1184
Europe PMC | doi

Rabut G, Ellenberg J. (2004)

Automatic real-time three-dimensional cell tracking by fluorescence microscopy

J Microsc 216(Pt 2):131-137. doi: 10.1111/j.0022-2720.2004.01404.x
Europe PMC | doi

Bubulya PA, Prasanth KV, Deerinck TJ, Gerlich D, Beaudouin J, Ellisman MH, Ellenberg J, Spector DL. (2004)

Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei

J. Cell Biol. 167(1):51-63. doi: 10.1083/jcb.200404120
Europe PMC | doi

Sumara I, Giménez-Abián JF, Gerlich D, Hirota T, Kraft C, de la Torre C, Ellenberg J, Peters JM. (2004)

Roles of polo-like kinase 1 in the assembly of functional mitotic spindles

Curr. Biol. 14(19):1712-1722. doi: 10.1016/j.cub.2004.09.049
Europe PMC | doi

Leung AK, Gerlich D, Miller G, Lyon C, Lam YW, Lleres D, Daigle N, Zomerdijk J, Ellenberg J, Lamond AI. (2004)

Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells

J. Cell Biol. 166(6):787-800. doi: 10.1083/jcb.200405013
Europe PMC | doi

Giannone G, Rondé P, Gaire M, Beaudouin J, Haiech J, Ellenberg J, Takeda K. (2004)

Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions

J. Biol. Chem. 279(27):28715-28723. doi: 10.1074/jbc.m404054200
Europe PMC | doi

Giménez-Abián JF, Sumara I, Hirota T, Hauf S, Gerlich D, de la Torre C, Ellenberg J, Peters JM. (2004)

Regulation of sister chromatid cohesion between chromosome arms

Curr. Biol. 14(13):1187-1193. doi: 10.1016/j.cub.2004.06.052
Europe PMC | doi

Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V. (2004)

The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis

Mol. Biol. Cell 15(7):3333-3344. doi: 10.1091/mbc.e03-12-0878
Europe PMC | doi

Conrad C, Erfle H, Warnat P, Daigle N, Lörch T, Ellenberg J, Pepperkok R, Eils R. (2004)

Automatic identification of subcellular phenotypes on human cell arrays

Genome Res. 14(6):1130-1136. doi: 10.1101/gr.2383804
Europe PMC | doi

Rabut G, Lénárt P, Ellenberg J. (2004)

Dynamics of nuclear pore complex organization through the cell cycle

Curr. Opin. Cell Biol. 16(3):314-321. doi: 10.1016/j.ceb.2004.04.001
Europe PMC | doi

Forler D, Rabut G, Ciccarelli FD, Herold A, Köcher T, Niggeweg R, Bork P, Ellenberg J, Izaurralde E. (2004)

RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export

Mol. Cell. Biol. 24(3):1155-1167. doi: 10.1128/mcb.24.3.1155-1167.2004
Europe PMC | doi

Strickland L, von Dassow G, Ellenberg J, Foe V, Lenart P, Burgess D. (2004)

Light microscopy of echinoderm embryos

Methods Cell Biol. 74:371-409. doi: 10.1016/S0091-679X(04)74016-9
Europe PMC | doi


Gerlich D, Ellenberg J. (2003)

Dynamics of chromosome positioning during the cell cycle

Curr. Opin. Cell Biol. 15(6):664-671. doi: 10.1016/j.ceb.2003.10.014
Europe PMC | doi

Gerlich D, Ellenberg J. (2003)

4D imaging to assay complex dynamics in live specimens

Nat. Cell Biol. Suppl:S14-9.
Europe PMC

Raemaekers T, Ribbeck K, Beaudouin J, Annaert W, Van Camp M, Stockmans I, Smets N, Bouillon R, Ellenberg J, Carmeliet G. (2003)

NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization

J. Cell Biol. 162(6):1017-1029. doi: 10.1083/jcb.200302129
Europe PMC | doi

Gerlich D, Beaudouin J, Kalbfuss B, Daigle N, Eils R, Ellenberg J. (2003)

Global chromosome positions are transmitted through mitosis in mammalian cells

Cell 112(6):751-764. doi: 10.1016/s0092-8674(03)00189-2
Europe PMC | doi

Lénárt P, Rabut G, Daigle N, Hand AR, Terasaki M, Ellenberg J. (2003)

Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading fenestration of nuclear membranes

J. Cell Biol. 160(7):1055-1068. doi: 10.1083/jcb.200211076
Europe PMC | doi

Reid G, Hübner MR, Métivier R, Brand H, Denger S, Manu D, Beaudouin J, Ellenberg J, Gannon F. (2003)

Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling

Mol. Cell 11(3):695-707. doi: 10.1016/s1097-2765(03)00090-x
Europe PMC | doi

Lénárt P, Ellenberg J. (2003)

Nuclear envelope dynamics in oocytes: from germinal vesicle breakdown to mitosis

Curr. Opin. Cell Biol. 15(1):88-95. doi: 10.1016/s0955-0674(02)00011-x
Europe PMC | doi


Hinkle B, Slepchenko B, Rolls MM, Walther TC, Stein PA, Mehlmann LM, Ellenberg J, Terasaki M. (2002)

Chromosomal association of Ran during meiotic and mitotic divisions

J. Cell. Sci. 115(Pt 23):4685-4693. doi: 10.1242/jcs.00136
Europe PMC | doi

Kruse C, Jaedicke A, Beaudouin J, Bohl F, Ferring D, Guttler T, Ellenberg J, Jansen RP. (2002)

Ribonucleoprotein-dependent localization of the yeast class V myosin Myo4p

J. Cell Biol. 159(6):971-982. doi: 10.1083/jcb.200207101
Europe PMC | doi

Burke B, Ellenberg J. (2002)

Remodelling the walls of the nucleus

Nat. Rev. Mol. Cell Biol. 3(7):487-497. doi: 10.1038/nrm860
Europe PMC | doi

Ellenberg J. (2002)

Dynamics of nuclear envelope proteins during the cell cycle in mammalian cells

Dynamics of Nuclear Envelope Assembly in Embryos and Somatic Cells 18-25.

Schmitt A, Gutierrez GJ, Lénárt P, Ellenberg J, Nebreda AR. (2002)

Histone H3 phosphorylation during Xenopus oocyte maturation: regulation by the MAP kinase/p90Rsk pathway and uncoupling from DNA condensation

FEBS Lett. 518(1-3):23-28. doi: 10.1016/s0014-5793(02)02630-3
Europe PMC | doi

Beaudouin J, Gerlich D, Daigle N, Eils R, Ellenberg J. (2002)

Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina

Cell 108(1):83-96. doi: 10.1016/s0092-8674(01)00627-4
Europe PMC | doi


Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V. (2001)

An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells

J. Cell Biol. 154(6):1147-1160. doi: 10.1083/jcb.200101081
Europe PMC | doi

Gerlich D, Beaudouin J, Gebhard M, Ellenberg J, Eils R. (2001)

Four-dimensional imaging and quantitative reconstruction to analyse complex spatiotemporal processes in live cells

Nat. Cell Biol. 3(9):852-855. doi: 10.1038/ncb0901-852
Europe PMC | doi

Daigle N, Beaudouin J, Hartnell L, Imreh G, Hallberg E, Lippincott-Schwartz J, Ellenberg J. (2001)

Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells

J. Cell Biol. 154(1):71-84. doi: 10.1083/jcb.200101089
Europe PMC | doi

Rabut G, Ellenberg J. (2001)

Nucleocytoplasmic transport: diffusion channel or phase transition?

Curr. Biol. 11(14):R551-4. doi: 10.1016/s0960-9822(01)00340-2
Europe PMC | doi

Terasaki M, Campagnola P, Rolls MM, Stein PA, Ellenberg J, Hinkle B, Slepchenko B. (2001)

A new model for nuclear envelope breakdown

Mol. Biol. Cell 12(2):503-510. doi: 10.1091/mbc.12.2.503
Europe PMC | doi


Dey A, Ellenberg J, Farina A, Coleman AE, Maruyama T, Sciortino S, Lippincott-Schwartz J, Ozato K. (2000)

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

Mol. Cell. Biol. 20(17):6537-6549. doi: 10.1128/mcb.20.17.6537-6549.2000
Europe PMC | doi

Nehls S, Snapp EL, Cole NB, Zaal KJ, Kenworthy AK, Roberts TH, Ellenberg J, Presley JF, Siggia E, Lippincott-Schwartz J. (2000)

Dynamics and retention of misfolded proteins in native ER membranes

Nat. Cell Biol. 2(5):288-295. doi: 10.1038/35010558
Europe PMC | doi


Zaal KJ, Smith CL, Polishchuk RS, Altan N, Cole NB, Ellenberg J, Hirschberg K, Presley JF, Roberts TH, Siggia E, Phair RD, Lippincott-Schwartz J. (1999)

Golgi membranes are absorbed into and reemerge from the ER during mitosis

Cell 99(6):589-601. doi: 10.1016/s0092-8674(00)81548-2
Europe PMC | doi

Ellenberg J, Lippincott-Schwartz J. (1999)

Dynamics and mobility of nuclear envelope proteins in interphase and mitotic cells revealed by green fluorescent protein chimeras

Methods 19(3):362-372. doi: 10.1006/meth.1999.0872
Europe PMC | doi

Ostlund C, Ellenberg J, Hallberg E, Lippincott-Schwartz J, Worman HJ. (1999)

Intracellular trafficking of emerin, the Emery-Dreifuss muscular dystrophy protein

J. Cell. Sci. 112 ( Pt 11)(11):1709-1719.
Europe PMC

Ellenberg J, Lippincott-Schwartz J, Presley JF. (1999)

Dual-colour imaging with GFP variants

Trends Cell Biol. 9(2):52-56. doi: 10.1016/s0962-8924(98)01420-2
Europe PMC | doi

Lippincott-Schwartz J, Presley JF, Zaal KJ, Hirschberg K, Miller CD, Ellenberg J. (1999)

Monitoring the dynamics and mobility of membrane proteins tagged with green fluorescent protein

Methods Cell Biol. 58:261-281.
Europe PMC


Hirschberg K, Miller CM, Ellenberg J, Presley JF, Siggia ED, Phair RD, Lippincott-Schwartz J. (1998)

Kinetic analysis of secretory protein traffic and characterization of golgi to plasma membrane transport intermediates in living cells

J. Cell Biol. 143(6):1485-1503. doi: 10.1083/jcb.143.6.1485
Europe PMC | doi

Ellenberg J, Lippincott-Schwartz J, Presley JF. (1998)

Two-color green fluorescent protein time-lapse imaging

BioTechniques 25(5):838-42, 844-6. doi: 10.2144/98255bt01
Europe PMC | doi

Sloan-Lancaster J, Presley J, Ellenberg J, Yamazaki T, Lippincott-Schwartz J, Samelson LE. (1998)

ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation

J. Cell Biol. 143(3):613-624. doi: 10.1083/jcb.143.3.613
Europe PMC | doi

Cole NB, Ellenberg J, Song J, DiEuliis D, Lippincott-Schwartz J. (1998)

Retrograde transport of Golgi-localized proteins to the ER

J. Cell Biol. 140(1):1-15. doi: 10.1083/jcb.140.1.1
Europe PMC | doi


Ellenberg J, Siggia ED, Moreira JE, Smith CL, Presley JF, Worman HJ, Lippincott-Schwartz J. (1997)

Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis

J. Cell Biol. 138(6):1193-1206. doi: 10.1083/jcb.138.6.1193
Europe PMC | doi

Ellenberg J, Lippincott-Schwartz J. (1997)

Fluorescence photobleaching techniques

Cold Spring Harbor Laboratory Press, Cold Spring Harbor.Cells: A Laboratory Manual 2(79):1-23.

Yang M, Ellenberg J, Bonifacino JS, Weissman AM. (1997)

The transmembrane domain of a carboxyl-terminal anchored protein determines localization to the endoplasmic reticulum

J. Biol. Chem. 272(3):1970-1975. doi: 10.1074/jbc.272.37.23000
Europe PMC | doi


Müller-Röber B, Ellenberg J, Provart N, Willmitzer L, Busch H, Becker D, Dietrich P, Hoth S, Hedrich R. (1995)

Cloning and electrophysiological analysis of KST1, an inward rectifying K+ channel expressed in potato guard cells.

EMBO J. 14(11):2409-2416. doi: 10.1002/j.1460-2075.1995.tb07238.x
Europe PMC | doi