EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

ORCID iD: iD icon0000-0002-9073-9612

Publications

Total: 28 publication(s)

2020

Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Köhrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y, Bartenschlager R. (2020)

Integrative imaging reveals SARS-CoV-2-induced reshaping of subcellular morphologies.

Cell Host Microbe 28(6):853-866.e5. doi: 10.1016/j.chom.2020.11.003
Europe PMC | doi


2019

Exner T, Beretta CA, Gao Q, Afting C, Romero-Brey I, Bartenschlager R, Fehring L, Poppelreuther M, Füllekrug J. (2019)

Lipid droplet quantification based on iterative image processing.

J Lipid Res 60(7):1333-1344. doi: 10.1194/jlr.D092841
Europe PMC | doi

Lee JY, Cortese M, Haselmann U, Tabata K, Romero-Brey I, Funaya C, Schieber NL, Qiang Y, Bartenschlager M, Kallis S, Ritter C, Rohr K, Schwab Y, Ruggieri A, Bartenschlager R. (2019)

Spatiotemporal coupling of the hepatitis C virus replication cycle by creating a lipid droplet-proximal membranous replication compartment.

Cell Rep 27(12):3602-3617.e5. doi: 10.1016/j.celrep.2019.05.063
Europe PMC | doi

Exner T, Romero-Brey I, Yifrach E, Rivera-Monroy J, Schrul B, Zouboulis CC, Stremmel W, Honsho M, Bartenschlager R, Zalckvar E, Poppelreuther M, Füllekrug J. (2019)

An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1.

J Cell Sci 132(6) doi: 10.1242/jcs.223016
Europe PMC | doi


2018

Romero-Brey I. (2018)

3D electron microscopy (EM) and correlative light electron microscopy (CLEM) methods to study virus-host interactions.

Methods Mol Biol 1836:213-236. doi: 10.1007/978-1-4939-8678-1_11
Europe PMC | doi

Santarella-Mellwig R, Haselmann U, Schieber NL, Walther P, Schwab Y, Antony C, Bartenschlager R, Romero-Brey I. (2018)

Correlative light electron microscopy (CLEM) for tracking and imaging viral protein associated structures in cryo-immobilized cells.

J Vis Exp (139) doi: 10.3791/58154
Europe PMC | doi

Stoeck IK, Lee JY, Tabata K, Romero-Brey I, Paul D, Schult P, Lohmann V, Kaderali L, Bartenschlager R. (2018)

Hepatitis C virus replication depends on endosomal cholesterol homeostasis.

J Virol 92(1) doi: 10.1128/JVI.01196-17
Europe PMC | doi


2017

Doerflinger SY, Cortese M, Romero-Brey I, Menne Z, Tubiana T, Schenk C, White PA, Bartenschlager R, Bressanelli S, Hansman GS, Lohmann V. (2017)

Membrane alterations induced by nonstructural proteins of human norovirus.

PLoS Pathog 13(10) doi: 10.1371/journal.ppat.1006705
Europe PMC | doi

Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJ, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Wagner B, Kalinke U, Baumgärtner W, Bartenschlager R, Pietschmann T, Feige K, Steinmann E, Cavalleri JM. (2017)

Immune protection against reinfection with nonprimate hepacivirus.

Proc. Natl. Acad. Sci. U.S.A. 114(12):E2430-E2439. doi: 10.1073/pnas.1619380114
Europe PMC | doi

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, De Francesco R, Florian WR, Bartenschlager R, Rice CM, Lohmann V. (2017)

Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Nat Microbiol 2 doi: 10.1038/nmicrobiol.2017.12
Europe PMC | doi

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, De Francesco R, Vondran FW, Bartenschlager R, Rice CM, Lohmann V. (2017)

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Nat Microbiol 2(3) doi: 10.1038/nmicrobiol.2016.247
Europe PMC | doi


2016

Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R. (2016)

Dengue virus perturbs mitochondrial morphodynamics to dampen innate immune responses.

Cell Host Microbe 20(3):342-356. doi: 10.1016/j.chom.2016.07.008
Europe PMC | doi

Romero-Brey I, Bartenschlager R. (2016)

Endoplasmic reticulum: The favorite intracellular niche for viral replication and assembly.

Viruses 8(6) doi: 10.3390/v8060160
Europe PMC | doi


2015

Romero-Brey I, Bartenschlager R. (2015)

Viral infection at high magnification: 3D electron microscopy methods to analyze the architecture of infected cells.

Viruses 7(12):6316-45. doi: 10.3390/v7122940
Europe PMC | doi

Koutsoudakis G, Romero-Brey I, Berger C, Pérez-Vilaró G, Monteiro Perin P, Vondran FW, Kalesse M, Harmrolfs K, Müller R, Martinez JP, Pietschmann T, Bartenschlager R, Brönstrup M, Meyerhans A, Díez J. (2015)

Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity.

J Hepatol 63(4):813-21. doi: 10.1016/j.jhep.2015.06.002
Europe PMC | doi

Anggakusuma, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Steinmann E, Pietschmann T. (2015)

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.

Hepatology 62(3):702-14. doi: 10.1002/hep.27913
Europe PMC | doi

Romero-Brey I, Berger C, Kallis S, Kolovou A, Paul D, Lohmann V, Bartenschlager R. (2015)

NS5A domain 1 and polyprotein cleavage kinetics are critical for induction of double-membrane vesicles associated with hepatitis C virus replication.

mBio 6(4) doi: 10.1128/mBio.00759-15
Europe PMC | doi


2014

Berger C, Romero-Brey I, Radujkovic D, Terreux R, Zayas M, Paul D, Harak C, Hoppe S, Gao M, Penin F, Lohmann V, Bartenschlager R. (2014)

Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication.

Gastroenterology 147(5):1094-105.e25. doi: 10.1053/j.gastro.2014.07.019
Europe PMC | doi

Romero-Brey I, Bartenschlager R. (2014)

Membranous replication factories induced by plus-strand RNA viruses.

Viruses 6(7):2826-57. doi: 10.3390/v6072826
Europe PMC | doi


2013

Miorin L, Romero-Brey I, Maiuri P, Hoppe S, Krijnse-Locker J, Bartenschlager R, Marcello A. (2013)

Three-dimensional architecture of tick-borne encephalitis virus replication sites and trafficking of the replicated RNA.

J Virol 87(11):6469-81. doi: 10.1128/JVI.03456-12
Europe PMC | doi

Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V. (2013)

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.

PLoS Pathog 9(5) doi: 10.1371/journal.ppat.1003359
Europe PMC | doi

Esser-Nobis K, Romero-Brey I, Ganten TM, Gouttenoire J, Harak C, Klein R, Schemmer P, Binder M, Schnitzler P, Moradpour D, Bartenschlager R, Polyak SJ, Stremmel W, Penin F, Eisenbach C, Lohmann V. (2013)

Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.

Hepatology 57(3):953-63. doi: 10.1002/hep.26260
Europe PMC | doi


2012

Romero-Brey I, Merz A, Chiramel A, Lee JY, Chlanda P, Haselman U, Santarella-Mellwig R, Habermann A, Hoppe S, Kallis S, Walther P, Antony C, Krijnse-Locker J, Bartenschlager R. (2012)

Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication.

PLoS Pathog. 8(12):e1003056. doi: 10.1371/journal.ppat.1003056
Europe PMC | doi


2011

Paul D, Romero-Brey I, Gouttenoire J, Stoitsova S, Krijnse-Locker J, Moradpour D, Bartenschlager R. (2011)

NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes.

J Virol 85(14):6963-76. doi: 10.1128/JVI.00502-11
Europe PMC | doi

Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R. (2011)

Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.

Cell Host Microbe 9(1):32-45. doi: 10.1016/j.chom.2010.12.002
Europe PMC | doi


2009

Romero-Brey I, Bandín I, Cutrín JM, Vakharia VN, Dopazo CP. (2009)

Genetic analysis of aquabirnaviruses isolated from wild fish reveals occurrence of natural reassortment of infectious pancreatic necrosis virus.

J Fish Dis 32(7):585-95. doi: 10.1111/j.1365-2761.2009.01020.x
Europe PMC | doi

Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CK, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R. (2009)

Composition and three-dimensional architecture of the dengue virus replication and assembly sites.

Cell Host Microbe 5(4):365-375. doi: 10.1016/j.chom.2009.03.007
Europe PMC | doi


2004

Romero-Brey I, Batts WN, Bandín I, Winton JR, Dopazo CP. (2004)

Molecular characterization of birnaviruses isolated from wild marine fishes at the Flemish Cap (Newfoundland).

Dis Aquat Organ 61(1-2):1-10. doi: 10.3354/dao061001
Europe PMC | doi