EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Phone: +49 6221 387-8256


  • PhD 2001, Louis Pasteur University, Strasbourg.
    Postdoctoral research at the University of Calgary, Canada and at the IGBMC, Illkirch, France.
    Head of Electron Microscopy at the Imaging Center, IGBMC, Illkirch, France.
    Facility head and team leader at EMBL since 2012.


Total: 59 publication(s)


Fermie J, Liv N, Ten Brink C, van Donselaar EG, Müller WH, Schieber NL, Schwab Y, Gerritsen HC, Klumperman J. (2019)

Single organelle dynamics linked to 3D structure by correlative live-cell - 3D electron microscopy.

Traffic 19(5) doi: 10.1111/tra.12557
Europe PMC | doi


Bussi C, Peralta Ramos JM, Arroyo DS, Gallea JI, Ronchi P, Kolovou A, Wang JM, Florey O, Celej MS, Schwab Y, Ktistakis NT, Iribarren P. (2018)

Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells.

J. Cell. Sci. 131(23) doi: 10.1242/jcs.226241
Europe PMC | doi

Santarella-Mellwig R, Haselmann U, Schieber NL, Walther P, Schwab Y, Antony C, Bartenschlager R, Romero-Brey I. (2018)

Correlative Light Electron Microscopy (CLEM) for Tracking and Imaging Viral Protein Associated Structures in Cryo-immobilized Cells.

J Vis Exp (139) doi: 10.3791/58154
Europe PMC | doi

Burdyniuk M, Wesolowska N, Fleszar M, Karreman MA, Machado P, Borrego-Pinto J, Ruthensteiner B, Schwab Y, Lénárt P. (2018)

Correlated light and electron microscopy of cell division in large marine oocytes, eggs, and embryos.

Methods Cell Biol. 145:293-313. doi: 10.1016/bs.mcb.2018.03.031
Europe PMC | doi

Follain G, Osmani N, Azevedo AS, Allio G, Mercier L, Karreman MA, Solecki G, Garcia Leòn MJ, Lefebvre O, Fekonja N, Hille C, Chabannes V, Dollé G, Metivet T, Hovsepian F, Pichot A, Prudhomme C, Carapito R, Paul N, Ruthensteiner B, Bahram S, Siemonsen S, Kemmling A, Fiehler J, Schneider T, Winkler F, Glatzel M, Pantel K, Schwab Y, Goetz JG, Harlepp S. (2018)

Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells.

Dev Cell 45(1):33-52.e12. doi: 10.1016/j.devcel.2018.02.015
Europe PMC | doi

Weinhard L, di Bartolomei G, Bolasco G, Machado P, Schieber NL, Neniskyte U, Exiga M, Vadisiute A, Raggioli A, Schertel A, Schwab Y, Gross CT. (2018)

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction.

Nat Commun 9(1) doi: 10.1038/s41467-018-03566-5
Europe PMC | doi

Otsuka S, Steyer AM, Schorb M, Hériché JK, Hossain MJ, Sethi S, Kueblbeck M, Schwab Y, Beck M, Ellenberg J. (2018)

Postmitotic nuclear pore assembly proceeds by radial dilation of small membrane openings

Nat. Struct. Mol. Biol. 25(1):21-28. doi: 10.1038/s41594-017-0001-9
Europe PMC | doi


Kuri P, Schieber NL, Thumberger T, Wittbrodt J, Schwab Y, Leptin M. (2017)

Dynamics of in vivo ASC speck formation.

J Cell Biol 216(9) doi: 10.1083/jcb.201703103
Europe PMC | doi

Cosenza MR, Cazzola A, Rossberg A, Schieber NL, Konotop G, Bausch E, Slynko A, Holland-Letz T, Raab MS, Dubash T, Glimm H, Poppelreuther S, Herold-Mende C, Schwab Y, Krämer A. (2017)

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer.

Cell Rep 20(8):1906-1920. doi: 10.1016/j.celrep.2017.08.005
Europe PMC | doi

Ferguson S, Steyer AM, Mayhew TM, Schwab Y, Lucocq JM. (2017)

Quantifying Golgi structure using EM: combining volume-SEM and stereology for higher throughput.

Histochem. Cell Biol. 147(6):653-669. doi: 10.1007/s00418-017-1564-6
Europe PMC | doi

Karreman MA, Ruthensteiner B, Mercier L, Schieber NL, Solecki G, Winkler F, Goetz JG, Schwab Y. (2017)

Find your way with X-Ray: Using microCT to correlate in vivo imaging with 3D electron microscopy.

Methods Cell Biol 140:277-301. doi: 10.1016/bs.mcb.2017.03.006
Europe PMC | doi

Gonzalez-Moragas L, Berto P, Vilches C, Quidant R, Kolovou A, Santarella-Mellwig R, Schwab Y, Stürzenbaum S, Roig A, Laromaine A. (2017)

In vivo testing of gold nanoparticles using the Caenorhabditis elegans model organism.

Acta Biomater S1742-7061(17):30090-30099. doi: 10.1016/j.actbio.2017.01.080
Europe PMC | doi

Kolovou A, Schorb M, Tarafder A, Sachse C, Schwab Y, Santarella-Mellwig R. (2017)

A new method for cryo-sectioning cell monolayers using a correlative workflow.

Methods Cell Biol 140:85-103. doi: 10.1016/bs.mcb.2017.03.011
Europe PMC | doi

Schieber NL, Machado P, Markert SM, Stigloher C, Schwab Y, Steyer AM. (2017)

Minimal resin embedding of multicellular specimens for targeted FIB-SEM imaging.

Methods Cell Biol 140:69-83. doi: 10.1016/bs.mcb.2017.03.005
Europe PMC | doi

Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Funaya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R. (2017)

Ultrastructural Characterization of Zika Virus Replication Factories.

Cell Rep 18(9):2113-2123. doi: 10.1016/j.celrep.2017.02.014
Europe PMC | doi


Morley SJ, Qi YM, Iovino L, Andolfi L, Guo D, Kalebic N, Castaldi L, Tischer C, Portulano C, Bolasco G, Shirlekar K, Fusco CM, Asaro A, Fermani F, Sundukova M, Matti U, Reymond L, De Ninno A, Businaro L, Johnsson K, Lazzarino M, Ries J, Schwab Y, Hu J, Heppenstall PA. (2016)

Acetylated tubulin is essential for touch sensation in mice

ELIFE 5 doi: 10.7554/eLife.20813
Europe PMC | doi

Karreman MA, Hyenne V, Schwab Y, Goetz JG. (2016)

Intravital Correlative Microscopy: Imaging Life at the Nanoscale.

Trends Cell Biol. 26(11):848-863. doi: 10.1016/j.tcb.2016.07.003
Europe PMC | doi

Yu SM, Gonzalez-Moragas L, Milla M, Kolovou A, Mellwig-Santarella R, Schwab Y, Laromaine A, Roig A. (2016)

Bio-identity and fate of albumin-coated SPIONs evaluated in cells and by the C. elegans model.

Acta Biomater 43:348-357. doi: 10.1016/j.actbio.2016.07.024
Europe PMC | doi

Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R. (2016)

Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses.

Cell Host Microbe 20(3):342-356. doi: 10.1016/j.chom.2016.07.008
Europe PMC | doi

Hampoelz B, Mackmull MT, Machado P, Ronchi P, Bui KH, Schieber N, Santarella-Mellwig R, Necakov A, Andrés-Pons A, Philippe JM, Lecuit T, Schwab Y, Beck M. (2016)

Pre-assembled Nuclear Pores Insert into the Nuclear Envelope during Early Development.

Cell 166(3):664-678. doi: 10.1016/j.cell.2016.06.015
Europe PMC | doi

Borrego-Pinto J, Somogyi K, Karreman MA, König J, Müller-Reichert T, Bettencourt-Dias M, Gönczy P, Schwab Y, Lénárt P. (2016)

Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes.

J. Cell Biol. 212(7):815-827. doi: 10.1083/jcb.201510083
Europe PMC | doi

Karreman MA, Mercier L, Schieber NL, Solecki G, Allio G, Winkler F, Ruthensteiner B, Goetz JG, Schwab Y. (2016)

Fast and precise targeting of single tumor cells in vivo by multimodal correlative microscopy.

J. Cell. Sci. 129(2):444-456. doi: 10.1242/jcs.181842
Europe PMC | doi


D'Alessandro M, Hnia K, Gache V, Koch C, Gavriilidis C, Rodriguez D, Nicot AS, Romero NB, Schwab Y, Gomes E, Labouesse M, Laporte J. (2015)

Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton.

Dev Cell 35(2):186-198. doi: 10.1016/j.devcel.2015.09.018
Europe PMC | doi

Hyenne V, Apaydin A, Rodriguez D, Spiegelhalter C, Hoff-Yoessle S, Diem M, Tak S, Lefebvre O, Schwab Y, Goetz JG, Labouesse M. (2015)

RAL-1 controls multivesicular body biogenesis and exosome secretion.

J Cell Biol 211(1):27-37. doi: 10.1083/jcb.201504136
Europe PMC | doi

Echbarthi M, Zonca M, Mellwig R, Schwab Y, Kaplan G, DeKruyff RH, Roda-Navarro P, Casasnovas JM. (2015)

Distinct Trafficking of Cell Surface and Endosomal TIM-1 to the Immune Synapse.

Traffic 16(11):1193-1207. doi: 10.1111/tra.12329
Europe PMC | doi

Goginashvili A, Zhang Z, Erbs E, Spiegelhalter C, Kessler P, Mihlan M, Pasquier A, Krupina K, Schieber N, Cinque L, Morvan J, Sumara I, Schwab Y, Settembre C, Ricci R. (2015)

Insulin granules. Insulin secretory granules control autophagy in pancreatic β cells.

Science 347(6224):878-882. doi: 10.1126/science.aaa2628
Europe PMC | doi

Lucocq JM, Mayhew TM, Schwab Y, Steyer AM, Hacker C. (2015)

Systems biology in 3D space - enter the morphome.

Trends Cell Biol. 25(2):59-64. doi: 10.1016/j.tcb.2014.09.008
Europe PMC | doi


Karreman MA, Mercier L, Schieber NL, Shibue T, Schwab Y, Goetz JG. (2014)

Correlating Intravital Multi-Photon Microscopy to 3D Electron Microscopy of Invading Tumor Cells Using Anatomical Reference Points.

PLoS ONE 9(12) doi: 10.1371/journal.pone.0114448
Europe PMC | doi

Durdu S, Iskar M, Revenu C, Schieber N, Kunze A, Bork P, Schwab Y, Gilmour D. (2014)

Luminal signalling links cell communication to tissue architecture during organogenesis.

Nature 515(7525):120-124. doi: 10.1038/nature13852
Europe PMC | doi

Becker JA, Clesse D, Spiegelhalter C, Schwab Y, Le Merrer J, Kieffer BL. (2014)

Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.

Neuropsychopharmacology 39(9):2049-2060. doi: 10.1038/npp.2014.59
Europe PMC | doi

Goetz JG, Steed E, Ferreira RR, Roth S, Ramspacher C, Boselli F, Charvin G, Liebling M, Wyart C, Schwab Y, Vermot J. (2014)

Endothelial cilia mediate low flow sensing during zebrafish vascular development

Cell Rep 6(5):799-808. doi: 10.1016/j.celrep.2014.01.032
Europe PMC | doi

Spiegelhalter C, Laporte JF, Schwab Y. (2014)

Correlative light and electron microscopy: from live cell dynamic to 3D ultrastructure

In: John Kuo, Electron Microscopy, vol 1117. Correlative Light and Electron Microscopy: From Live Cell Dynamic to 3D Ultrastructure edn. Humana Press. pp 485-501.Methods Mol. Biol. 1117:485-501. doi: 10.1007/978-1-62703-776-1_21
Europe PMC | doi


Amoasii L, Hnia K, Chicanne G, Brech A, Cowling BS, Müller MM, Schwab Y, Koebel P, Ferry A, Payrastre B, Laporte J. (2013)

Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo

J. Cell. Sci. 126(Pt 8):1806-1819. doi: 10.1242/jcs.118505
Europe PMC | doi

Kolotuev I, Hyenne V, Schwab Y, Rodriguez D, Labouesse M. (2013)

A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation

Nat. Cell Biol. 15(2):157-168. doi: 10.1038/ncb2662
Europe PMC | doi

Lenormand C, Spiegelhalter C, Cinquin B, Bardin S, Bausinger H, Angénieux C, Eckly A, Proamer F, Wall D, Lich B, Tourne S, Hanau D, Schwab Y, Salamero J, de la Salle H. (2013)

Birbeck granule-like "organized smooth endoplasmic reticulum" resulting from the expression of a cytoplasmic YFP-tagged langerin

PLoS ONE 8(4):e60813. doi: 10.1371/journal.pone.0060813
Europe PMC | doi


Gibbings D, Mostowy S, Jay F, Schwab Y, Cossart P, Voinnet O. (2012)

Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

Nat. Cell Biol. 14(12):1314-1321. doi: 10.1038/ncb2611
Europe PMC | doi

Gehart H, Goginashvili A, Beck R, Morvan J, Erbs E, Formentini I, De Matteis MA, Schwab Y, Wieland FT, Ricci R. (2012)

The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network

Dev. Cell 23(4):756-768. doi: 10.1016/j.devcel.2012.07.019
Europe PMC | doi

Faget L, Erbs E, Le Merrer J, Scherrer G, Matifas A, Benturquia N, Noble F, Decossas M, Koch M, Kessler P, Vonesch JL, Schwab Y, Kieffer BL, Massotte D. (2012)

In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile

J. Neurosci. 32(21):7301-7310. doi: 10.1523/jneurosci.0185-12.2012
Europe PMC | doi

Gibbings D, Leblanc P, Jay F, Pontier D, Michel F, Schwab Y, Alais S, Lagrange T, Voinnet O. (2012)

Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes

Nat. Struct. Mol. Biol. 19(5):517-24, S1. doi: 10.1038/nsmb.2273
Europe PMC | doi

Rezaï X, Faget L, Bednarek E, Schwab Y, Kieffer BL, Massotte D. (2012)

Mouse δ opioid receptors are located on presynaptic afferents to hippocampal pyramidal cells

Cell. Mol. Neurobiol. 32(4):509-516. doi: 10.1007/s10571-011-9791-1
Europe PMC | doi

Tobin V, Schwab Y, Lelos N, Onaka T, Pittman QJ, Ludwig M. (2012)

Expression of exocytosis proteins in rat supraoptic nucleus neurones

J. Neuroendocrinol. 24(4):629-641. doi: 10.1111/j.1365-2826.2011.02237.x
Europe PMC | doi

Kolotuev I, Bumbarger DJ, Labouesse M, Schwab Y. (2012)

Targeted ultramicrotomy: a valuable tool for correlated light and electron microscopy of small model organisms

Methods Cell Biol. 111:203-222. doi: 10.1016/b978-0-12-416026-2.00011-x
Europe PMC | doi


Wagner N, Morrison H, Pagnotta S, Michiels JF, Schwab Y, Tryggvason K, Schedl A, Wagner KD. (2011)

The podocyte protein nephrin is required for cardiac vessel formation

Hum. Mol. Genet. 20(11):2182-2194. doi: 10.1093/hmg/ddr106
Europe PMC | doi

Deniz S, Wersinger E, Schwab Y, Mura C, Erdelyi F, Szabó G, Rendon A, Sahel JA, Picaud S, Roux MJ. (2011)

Mammalian retinal horizontal cells are unconventional GABAergic neurons

J. Neurochem. 116(3):350-362. doi: 10.1111/j.1471-4159.2010.07114.x
Europe PMC | doi

Hetherington S, Gally C, Fritz JA, Polanowska J, Reboul J, Schwab Y, Zahreddine H, Behm C, Labouesse M. (2011)

PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis

Dev. Biol. 350(2):267-278. doi: 10.1016/j.ydbio.2010.11.025
Europe PMC | doi

Toussaint A, Cowling BS, Hnia K, Mohr M, Oldfors A, Schwab Y, Yis U, Maisonobe T, Stojkovic T, Wallgren-Pettersson C, Laugel V, Echaniz-Laguna A, Mandel JL, Nishino I, Laporte J. (2011)

Defects in amphiphysin 2 (BIN1) and triads in several forms of centronuclear myopathies

Acta Neuropathol. 121(2):253-266. doi: 10.1007/s00401-010-0754-2
Europe PMC | doi

Wersinger E, Bordais A, Schwab Y, Sene A, Bénard R, Alunni V, Sahel JA, Rendon A, Roux MJ. (2011)

Reevaluation of dystrophin localization in the mouse retina

Invest. Ophthalmol. Vis. Sci. 52(11):7901-7908. doi: 10.1167/iovs.11-7519
Europe PMC | doi


Kolotuev I, Schwab Y, Labouesse M. (2010)

A precise and rapid mapping protocol for correlative light and electron microscopy of small invertebrate organisms

Biol. Cell 102(2):121-132. doi: 10.1042/bc20090096
Europe PMC | doi

Spiegelhalter C, Tosch V, Hentsch D, Koch M, Kessler P, Schwab Y, Laporte J. (2010)

From dynamic live cell imaging to 3D ultrastructure: novel integrated methods for high pressure freezing and correlative light-electron microscopy

PLoS ONE 5(2):e9014. doi: 10.1371/journal.pone.0009014
Europe PMC | doi


Buj-Bello A, Fougerousse F, Schwab Y, Messaddeq N, Spehner D, Pierson CR, Durand M, Kretz C, Danos O, Douar AM, Beggs AH, Schultz P, Montus M, Denèfle P, Mandel JL. (2008)

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis

Hum. Mol. Genet. 17(14):2132-2143. doi: 10.1093/hmg/ddn112
Europe PMC | doi

Jarriault S, Schwab Y, Greenwald I. (2008)

A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation

Proc. Natl. Acad. Sci. U.S.A. 105(10):3790-3795. doi: 10.1073/pnas.0712159105
Europe PMC | doi

Lecroisey C, Martin E, Mariol MC, Granger L, Schwab Y, Labouesse M, Ségalat L, Gieseler K. (2008)

DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1

Mol. Biol. Cell 19(3):785-796. doi: 10.1091/mbc.e07-05-0497
Europe PMC | doi

McDonald NA, Kuzmiski JB, Naderi N, Schwab Y, Pittman QJ. (2008)

Endogenous modulators of synaptic transmission: cannabinoid regulation in the supraoptic nucleus

Paper presented at the 7th World Congress on Neurohypophysial Hormones, Regensburg, GERMANY, SEP 18-22, 2007.Prog. Brain Res. 170:129-136. doi: 10.1016/s0079-6123(08)00412-3
Europe PMC | doi


Wersinger E, Schwab Y, Sahel JA, Rendon A, Pow DV, Picaud S, Roux MJ. (2006)

The glutamate transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cells

J. Physiol. (Lond.) 577(Pt 1):221-234. doi: 10.1113/jphysiol.2006.118281
Europe PMC | doi

Liégeois S, Benedetto A, Garnier JM, Schwab Y, Labouesse M. (2006)

The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans

J. Cell Biol. 173(6):949-961. doi: 10.1083/jcb.200511072
Europe PMC | doi


Côté PD, De Repentigny Y, Coupland SG, Schwab Y, Roux MJ, Levinson SR, Kothary R. (2005)

Physiological maturation of photoreceptors depends on the voltage-gated sodium channel NaV1.6 (Scn8a)

J. Neurosci. 25(20):5046-5050. doi: 10.1523/jneurosci.4692-04.2005
Europe PMC | doi


Hirasawa M, Schwab Y, Natah S, Hillard CJ, Mackie K, Sharkey KA, Pittman QJ. (2004)

Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain

J. Physiol. (Lond.) 559(Pt 2):611-624. doi: 10.1113/jphysiol.2004.066159
Europe PMC | doi

Schwab Y, Jahke R, Jover E. (2004)

Expression of tetrodotoxin-sensitive and resistant sodium channels by rat melanotrophs

Neuroreport 15(7):1219-1223. doi: 10.1097/00001756-200405190-00028
Europe PMC | doi


Schwab Y, Mouton J, Chasserot-Golaz S, Marty I, Maulet Y, Jover E. (2001)

Calcium-dependent translocation of synaptotagmin to the plasma membrane in the dendrites of developing neurones

Brain Res. Mol. Brain Res. 96(1-2):1-13. doi: 10.1016/s0169-328x(01)00244-3
Europe PMC | doi