EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

ORCID iD: iD icon0000-0002-1643-0780

Publications

Total: 26 publication(s)

2020

Fuqua T, Jordan J, van Breugel ME, Halavatyi A, Tischer C, Polidoro P, Abe N, Tsai A, Mann RS, Stern DL, Crocker J. (2020)

Dense and pleiotropic regulatory information in a developmental enhancer.

Nature 587(7833):235-239. doi: 10.1038/s41586-020-2816-5
Europe PMC | doi

Tsai A, Galupa R, Crocker J. (2020)

Robust and efficient gene regulation through localized nuclear microenvironments.

Development 147(19) doi: 10.1242/dev.161430
Europe PMC | doi


2019

Tsai A, Alves MRP, Crocker J. (2019)

Multi-enhancer transcriptional hubs confer phenotypic robustness.

Elife 8 doi: 10.7554/eLife.45325
Europe PMC | doi


2018

Tsai A, Crocker J. (2018)

Visualizing long-range enhancer-promoter interaction.

Nat. Genet. 50(9):1205-1206. doi: 10.1038/s41588-018-0198-5
Europe PMC | doi

Tsai A, Singer RH, Crocker J. (2018)

Transvection Goes Live-Visualizing Enhancer-Promoter Communication between Chromosomes.

Mol Cell 70(2):195-196. doi: 10.1016/j.molcel.2018.04.004
Europe PMC | doi


2017

Tsai A, Muthusamy AK, Alves MR, Lavis LD, Singer RH, Stern DL, Crocker J. (2017)

Nuclear microenvironments modulate transcription from low-affinity enhancers.

Elife 6 doi: 10.7554/elife.28975
Europe PMC | doi

Crocker J, Tsai A, Stern DL. (2017)

A Fully Synthetic Transcriptional Platform for a Multicellular Eukaryote

Cell Rep 18(1):287-296. doi: 10.1016/j.celrep.2016.12.025
Europe PMC | doi


2016

Navon SP, Kornberg G, Chen J, Schwartzman T, Tsai A, Puglisi EV, Puglisi JD, Adir N. (2016)

Amino acid sequence repertoire of the bacterial proteome and the occurrence of untranslatable sequences

Proceedings of the National Academy of Sciences 113(26) doi: 10.1073/pnas.1606518113
Europe PMC | doi

Tsai A, Puglisi JD, Uemura S. (2016)

Probing the Translation Dynamics of Ribosomes Using Zero-Mode Waveguides

Prog Mol Biol Transl Sci 139 doi: 10.1016/bs.pmbts.2015.10.006
Europe PMC | doi

Yoon YJ, Wu B, Buxbaum AR, Das S, Tsai A, English BP, Grimm JB, Lavis LD, Singer RH. (2016)

Glutamate-induced RNA localization and translation in neurons

Proceedings of the National Academy of Sciences 113(44) doi: 10.1073/pnas.1614267113
Europe PMC | doi

Zhang Z, English BP, Grimm JB, Kazane SA, Hu W, Tsai A, Inouye C, You C, Piehler J, Schultz PG, Lavis LD, Revyakin A, Tjian R. (2016)

Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis

Genes {&} Development 30(18) doi: 10.1101/gad.285395.116
Europe PMC | doi


2014

Chen J, Petrov A, Johansson M, Tsai A, O'Leary SE, Puglisi JD. (2014)

Dynamic pathways of −1 translational frameshifting

Nature 512(7514) doi: 10.1038/nature13428
Europe PMC | doi

Noriega TR, Tsai A, Elvekrog MM, Petrov A, Neher SB, Chen J, Bradshaw N, Puglisi JD, Walter P. (2014)

Signal Recognition Particle-ribosome Binding Is Sensitive to Nascent Chain Length

Journal of Biological Chemistry 289(28) doi: 10.1074/jbc.m114.563239
Europe PMC | doi

Chen J, Dalal RV, Petrov AN, Tsai A, O'Leary SE, Chapin K, Cheng J, Ewan M, Hsiung PL, Lundquist P, Turner SW, Hsu DR, Puglisi JD.. (2014)

High-throughput platform for real-time monitoring of biological processes by multicolor single-molecule fluorescence.

Proceedings of the National Academy of Sciences of the United States of America 111(2) doi: 10.1073/pnas.1315735111
Europe PMC | doi

Chen J, Petrov A, Johansson M, Tsai A, O'Leary SE, Puglisi JD. (2014)

Single-Molecule Profiling of Ribosome Translational Phenomena

Biophys. J. 106(2) doi: 10.1016/j.bpj.2013.11.1402
doi

Johansson M, Chen J, Tsai A, Kornberg G, Puglisi J. (2014)

Sequence-Dependent Elongation Dynamics on Macrolide-Bound Ribosomes

Cell Reports 7(5) doi: 10.1016/j.celrep.2014.04.034
Europe PMC | doi

Tsai A, Kornberg G, Johansson M, Chen J, Puglisi J. (2014)

The Dynamics of SecM-Induced Translational Stalling

Cell Reports 7(5) doi: 10.1016/j.celrep.2014.04.033
Europe PMC | doi


2013

Chen J, Petrov A, Seán AT, O'Leary E, Puglisi JD. (2013)

Coordinated conformational and compositional dynamics drive ribosome translocation.

Biophys. J. 104(2) doi: 10.1016/j.bpj.2012.11.1457
doi

Chen J, Petrov A, Tsai A, O'Leary SE, Puglisi JD. (2013)

Coordinated conformational and compositional dynamics drive ribosome translocation.

Nat. Struct. Mol. Biol. 20(6) doi: 10.1038/nsmb.2567
Europe PMC | doi

Simonetti A, Marzi S, Billas IM, Tsai A, Fabbretti A, Myasnikov AG, Roblin P, Vaiana AC, Hazemann I, Eiler D, Steitz TA, Puglisi JD, Gualerzi CO, Klaholz BP. (2013)

Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.

Proc. Natl. Acad. Sci. U.S.A. 110(39) doi: 10.1073/pnas.1309578110
Europe PMC | doi

Tsai A, Uemura S, Johansson M, Puglisi E, Marshall R, Aitken C, Korlach J, Ehrenberg M, Puglisi J. (2013)

The impact of aminoglycosides on the dynamics of translation elongation.

Cell Reports 3(2) doi: 10.1016/j.celrep.2013.01.027
Europe PMC | doi


2012

Chen J, Tsai A, Petrov A, Puglisi JD. (2012)

Nonfluorescent quenchers to correlate single-molecule conformational and compositional dynamics.

J. Am. Chem. Soc. 134(13) doi: 10.1021/ja2119964
Europe PMC | doi

Chen J, Tsai A, O'Leary SE, Petrov A, Puglisi JD. (2012)

Unraveling the dynamics of ribosome translocation.

Curr. Opin. Struct. Biol. 22(6) doi: 10.1016/j.sbi.2012.09.004
Europe PMC | doi

Petrov A, Chen J, O'Leary S, Tsai A, Puglisi JD. (2012)

Single-molecule analysis of translational dynamics.

Cold Spring Harb Perspect Biol 4(9) doi: 10.1101/cshperspect.a011551
Europe PMC | doi

Tsai A, Petrov A, Marshall RA, Korlach J, Uemura S, Puglisi JD. (2012)

Heterogeneous pathways and timing of factor departure during translation initiation.

Nature 487(7407) doi: 10.1038/nature11172
Europe PMC | doi


2011

Petrov A, Kornberg G, O'Leary S, Tsai A, Uemura S, Puglisi JD. (2011)

Dynamics of the translational machinery.

Curr. Opin. Struct. Biol. 21(1) doi: 10.1016/j.sbi.2010.11.007
Europe PMC | doi