EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • MDPhD 2000, Kyoto University, Japan.
    Postdoctoral research at the Max Planck Institute of Immunobiology, Freiburg, Germany.
    Group leader at the MPI of Immunobiology 2002-7.
    Independent group leader at the MPI for Molecular Biomedicine, Münster, 2007-11.
    Group leader at EMBL since 2011.
    ERC Investigator.


Total: 38 publication(s)


Roffay C, Chan CJ, Guirao B, Hiiragi T, Graner F. (2021)

Inferring cell junction tension and pressure from cell geometry.

Development 148(18) doi: 10.1242/dev.192773
Europe PMC | doi


Chan CJ, Hiiragi T. (2020)

Integration of luminal pressure and signalling in tissue self-organization.

Development 147(5) doi: 10.1242/dev.181297
Europe PMC | doi

Yang Q, Xue S-L, Chan CJ, Rempfler M, Vischi D, Mauer Gutierrez F, Hiiragi T, Hannezo E, Liberali P. (2020)

Cell fate coordinates mechano-osmotic forces in intestinal crypt morphogenesis.

bioRxivorg doi: 10.1101/2020.05.13.094359


Niwayama R, Moghe P, Liu YJ, Fabrèges D, Buchholz F, Piel M, Hiiragi T. (2019)

A tug-of-war between cell shape and polarity controls division orientation to ensure robust patterning in the mouse blastocyst.

Dev. Cell 51(5):564-574.e6. doi: 10.1016/j.devcel.2019.10.012
Europe PMC | doi

Ryan AQ, Chan CJ, Graner F, Hiiragi T. (2019)

Lumen expansion facilitates epiblast-primitive endoderm fate specification during mouse blastocyst formation.

Dev. Cell 51(6):684-697.e4. doi: 10.1016/j.devcel.2019.10.011
Europe PMC | doi

Chan CJ, Costanzo M, Ruiz-Herrero T, Mönke G, Petrie RJ, Bergert M, Diz-Muñoz A, Mahadevan L, Hiiragi T. (2019)

Hydraulic control of mammalian embryo size and cell fate.

Nature 571(7763) doi: 10.1038/s41586-019-1309-x
Europe PMC | doi

Ryan AQ, Chan CJ, Graner F, Hiiragi T. (2019)

Lumen expansion facilitates epiblast-primitive endoderm fate specification in the mouse blastocyst formation.

bioRxivorg doi: 10.1101/575282
Europe PMC | doi


Zhang HT, Hiiragi T. (2018)

Symmetry Breaking in the Mammalian Embryo.

Annu. Rev. Cell Dev. Biol. 34 doi: 10.1146/annurev-cellbio-100617-062616
Europe PMC | doi

Chan CJ, Costanzo M, Ruiz-Herrero T, Mönke G, Petrie R, Mahadevan L, Hiiragi T. (2018)

Hydraulic control of embryo size, tissue shape and cell fate.

bioRxivorg doi: 10.1101/389619

Reichmann J, Nijmeijer B, Hossain MJ, Eguren M, Schneider I, Politi AZ, Roberti MJ, Hufnagel L, Hiiragi T, Ellenberg J. (2018)

Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos.

Science 361(6398):189-193. doi: 10.1126/science.aar7462
Europe PMC | doi

Kim EJY, Korotkevich E, Hiiragi T. (2018)

Coordination of Cell Polarity, Mechanics and Fate in Tissue Self-organization.

Trends Cell Biol 28(7) doi: 10.1016/j.tcb.2018.02.008
Europe PMC | doi


Chan CJ, Hiiragi T. (2017)

Keeping in touch to differentiate.

Dev. Cell 43(2):113-114. doi: 10.1016/j.devcel.2017.10.006
Europe PMC | doi

Chan CJ, Heisenberg CP, Hiiragi T. (2017)

Coordination of morphogenesis and cell-fate specification in development.

Curr. Biol. 27(18):R1024-R1035. doi: 10.1016/j.cub.2017.07.010
Europe PMC | doi

Veldhuis JH, Ehsandar A, Maître JL, Hiiragi T, Cox S, Brodland GW. (2017)

Inferring cellular forces from image stacks

Philos Trans R Soc Lond B Biol Sci 372(1720) doi: 10.1098/rstb.2016.0261
Europe PMC | doi

Korotkevich E, Niwayama R, Courtois A, Friese S, Berger N, Buchholz F, Hiiragi T. (2017)

The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo

Dev Cell 40(3):235-247.e7. doi: 10.1016/j.devcel.2017.01.006
Europe PMC | doi


Maître JL, Turlier H, Illukkumbura R, Eismann B, Niwayama R, Nédélec F, Hiiragi T. (2016)

Asymmetric division of contractile domains couples cell positioning and fate specification

Nature 536(7616):344-348. doi: 10.1038/nature18958
Europe PMC | doi

Strnad P, Gunther S, Reichmann J, Krzic U, Balazs B, de Medeiros G, Norlin N, Hiiragi T, Hufnagel L, Ellenberg J. (2016)

Inverted light-sheet microscope for imaging mouse pre-implantation development.

Nat. Methods 13(2):139-142. doi: 10.1038/nmeth.3690
Europe PMC | doi


Medeiros Gd, Norlin N, Günther S, Albert M, Panavaite L, Fiuza UM, Peri F, Hiiragi T, Krzic U, Hufnagel L. (2015)

Confocal multiview light-sheet microscopy.

Nat Commun 6 doi: 10.1038/ncomms9881
Europe PMC | doi

Dietrich JE, Panavaite L, Gunther S, Wennekamp S, Groner AC, Pigge A, Salvenmoser S, Trono D, Hufnagel L, Hiiragi T. (2015)

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.

EMBO Rep. 16(8):1005-1021. doi: 10.15252/embr.201540162
Europe PMC | doi

Maître JL, Niwayama R, Turlier H, Nédélec F, Hiiragi T. (2015)

Pulsatile cell-autonomous contractility drives compaction in the mouse embryo.

Nat. Cell Biol. 17(7):849-855. doi: 10.1038/ncb3185
Europe PMC | doi


Ohnishi Y, Huber W, Tsumura A, Kang M, Xenopoulos P, Kurimoto K, Oleś AK, Araúzo-Bravo MJ, Saitou M, Hadjantonakis AK, Hiiragi T. (2014)

Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages

Nat. Cell Biol. 16(1):27-37. doi: 10.1038/ncb2881
Europe PMC | doi


Wennekamp S, Mesecke S, Nédélec F, Hiiragi T. (2013)

A self-organization framework for symmetry breaking in the mammalian embryo

Nat. Rev. Mol. Cell Biol. 14(7):452-459. doi: 10.1038/nrm3602
Europe PMC | doi


Courtois A, Schuh M, Ellenberg J, Hiiragi T. (2012)

The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development

J. Cell Biol. 198(3):357-370. doi: 10.1083/jcb.201202135
Europe PMC | doi

Groner AC, Tschopp P, Challet L, Dietrich JE, Verp S, Offner S, Barde I, Rodriguez I, Hiiragi T, Trono D. (2012)

The Kruppel-associated box repressor domain can induce reversible heterochromatization of a mouse locus in vivo

J. Biol. Chem. 287(30):25361-25369. doi: 10.1074/jbc.m112.350884
Europe PMC | doi

Lavial F, Bessonnard S, Ohnishi Y, Tsumura A, Chandrashekran A, Fenwick MA, Tomaz RA, Hosokawa H, Nakayama T, Chambers I, Hiiragi T, Chazaud C, Azuara V. (2012)

Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development

Genes Dev. 26(13):1445-1458. doi: 10.1101/gad.188193.112
Europe PMC | doi

Wennekamp S, Hiiragi T. (2012)

Stochastic processes in the development of pluripotency in vivo

Biotechnol J 7(6):737-744. doi: 10.1002/biot.201100357
Europe PMC | doi


Honda H, Motosugi N, Nagai T, Tanemura M, Hiiragi T. (2008)

Computer simulation of emerging asymmetry in the mouse blastocyst

Development 135(8):1407-1414. doi: 10.1242/dev.014555
Europe PMC | doi

Bauer T, Motosugi N, Miura K, Sabe H, Hiiragi T. (2008)

Dynamic rearrangement of surface proteins is essential for cytokinesis

Genesis 46(3):152-162. doi: 10.1002/dvg.20377
Europe PMC | doi

Dietrich JE, Hiiragi T. (2008)

Stochastic processes during mouse blastocyst patterning

Paper presented at the 1st International Conference on Stem Cells and Tissue Formation, Dresden, GERMANY, SEP, 2006.Cells Tissues Organs (Print) 188(1-2):46-51. doi: 10.1159/000118783
Europe PMC | doi

Polanski Z, Motosugi N, Tsurumi C, Hiiragi T, Hoffmann S. (2008)

Hypomethylation of paternal DNA in the late mouse zygote is not essential for development

Int. J. Dev. Biol. 52(2-3):295-298. doi: 10.1387/ijdb.072347zp
Europe PMC | doi


Dietrich JE, Hiiragi T. (2007)

Stochastic patterning in the mouse pre-implantation embryo

Development 134(23):4219-4231. doi: 10.1242/dev.003798
Europe PMC | doi


Hiiragi T, Louvet-Vallée S, Solter D, Maro B. (2006)

Embryology: does prepatterning occur in the mouse egg?

Nature 442(7099):E3-4; discussion E4. doi: 10.1038/nature04907
Europe PMC | doi

Motosugi N, Dietrich JE, Polanski Z, Solter D, Hiiragi T. (2006)

Space asymmetry directs preferential sperm entry in the absence of polarity in the mouse oocyte

PLoS Biol. 4(5):e135. doi: 10.1371/journal.pbio.0040135
Europe PMC | doi

Hiiragi T, Solter D. (2006)

Fatal flaws in the case for prepatterning in the mouse egg

Reprod. Biomed. Online 12(2):150-152. doi: 10.1016/s1472-6483(10)60854-1
Europe PMC | doi

Hiiragi T, Alarcon VB, Fujimori T, Louvet-Vallee S, Maleszewski M, Marikawa Y, Maro B, Solter D. (2006)

Where do we stand now? Mouse early embryo patterning meeting in Freiburg, Germany (2005)

Int. J. Dev. Biol. 50(7):581-6; discussion 586-7. doi: 10.1387/ijdb.062181th
Europe PMC | doi


Hiiragi T, Solter D. (2005)

Mechanism of first cleavage specification in the mouse egg: is our body plan set at day 0?

Cell Cycle 4(5):661-664. doi: 10.4161/cc.4.5.1680
Europe PMC | doi

Motosugi N, Bauer T, Polanski Z, Solter D, Hiiragi T. (2005)

Polarity of the mouse embryo is established at blastocyst and is not prepatterned

Genes Dev. 19(9):1081-1092. doi: 10.1101/gad.1304805
Europe PMC | doi


Hiiragi T, Solter D. (2004)

First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei

Nature 430(6997):360-364. doi: 10.1038/nature02595
Europe PMC | doi