EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

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  • PhD 1997, Institut Cochin de Génétique Moléculaire, Paris.
    Postdoctoral research at the University of Geneva.
    Group leader at EMBL since 2006.


Total: 35 publication(s)


Symmons O, Pan L, Remeseiro S, Aktas T, Klein F, Huber W, Spitz F. (2016)

The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances.

Dev. Cell 39(5):529-543. doi: 10.1016/j.devcel.2016.10.015
Europe PMC | doi

Franke M, Ibrahim DM, Andrey G, Schwarzer W, Heinrich V, Schöpflin R, Kraft K, Kempfer R, Jerković I, Chan WL, Spielmann M, Timmermann B, Wittler L, Kurth I, Cambiaso P, Zuffardi O, Houge G, Lambie L, Brancati F, Pombo A, Vingron M, Spitz F, Mundlos S. (2016)

Formation of new chromatin domains determines pathogenicity of genomic duplications.

Nature 538:265-269. doi: 10.1038/nature19800
Europe PMC | doi

Spitz F. (2016)

Gene regulation at a distance: from remote enhancers to 3D regulatory ensembles.

Semin. Cell Dev. Biol. doi: 10.1016/j.semcdb.2016.06.017
Europe PMC | doi

Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ. (2016)

Cis-regulatory architecture of a brain signaling center predates the origin of chordates.

Nat. Genet. doi: 10.1038/ng.3542
Europe PMC | doi


Remeseiro S, Hörnblad A, Spitz F. (2015)

Gene regulation during development in the light of topologically associating domains.

Wiley Interdiscip Rev Dev Biol doi: 10.1002/wdev.218
Europe PMC | doi

Liu X, Tamada K, Kishimoto R, Okubo H, Ise S, Ohta H, Ruf S, Nakatani J, Kohno N, Spitz F, Takumi T. (2015)

Transcriptome profiling of white adipose tissue in a mouse model for 15q duplication syndrome.

Genom Data 5:394-396. doi: 10.1016/j.gdata.2015.06.035
Europe PMC | doi

Kishimoto R, Tamada K, Liu X, Okubo H, Ise S, Ohta H, Ruf S, Nakatani J, Kohno N, Spitz F, Takumi T. (2015)

Model mice for 15q11-13 duplication syndrome exhibit late onset obesity and altered lipid metabolism.

Hum. Mol. Genet. 24(16):4559-4572. doi: 10.1093/hmg/ddv187
Europe PMC | doi

Amin S, Donaldson IJ, Zannino DA, Hensman J, Rattray M, Losa M, Spitz F, Ladam F, Sagerström C, Bobola N. (2015)

Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State.

Dev. Cell 32(3):265-277. doi: 10.1016/j.devcel.2014.12.024
Europe PMC | doi

Tsujimura T, Klein FA, Langenfeld K, Glaser J, Huber W, Spitz F. (2015)

A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes.

PLoS Genet. 11(1) doi: 10.1371/journal.pgen.1004897
Europe PMC | doi


Uslu VV, Petretich M, Ruf S, Langenfeld K, Fonseca NA, Marioni JC, Spitz F. (2014)

Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.

Nat. Genet. 46(7):753-758. doi: 10.1038/ng.2971
Europe PMC | doi

Schwarzer W, Spitz F. (2014)

The architecture of gene expression: integrating dispersed cis-regulatory modules into coherent regulatory domains

Curr. Opin. Genet. Dev. 27C:74-82. doi: 10.1016/j.gde.2014.03.014
Europe PMC | doi

Symmons O, Uslu VV, Tsujimura T, Ruf S, Nassari S, Schwarzer W, Ettwiller L, Spitz F. (2014)

Functional and topological characteristics of mammalian regulatory domains

Genome Res. 24(3):390-400. doi: 10.1101/gr.163519.113
Europe PMC | doi


Kirchmaier S, Höckendorf B, Möller EK, Bornhorst D, Spitz F, Wittbrodt J. (2013)

Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase

Development 140(20):4287-4295. doi: 10.1242/dev.096081
Europe PMC | doi

Andrey G, Montavon T, Mascrez B, Gonzalez F, Noordermeer D, Leleu M, Trono D, Spitz F, Duboule D. (2013)

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Science 340(6137):1234167. doi: 10.1126/science.1234167
Europe PMC | doi

Marinić M, Aktas T, Ruf S, Spitz F. (2013)

An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape

Dev. Cell 24(5):530-542. doi: 10.1016/j.devcel.2013.01.025
Europe PMC | doi

Weischenfeldt J, Symmons O, Spitz F, Korbel JO. (2013)

Phenotypic impact of genomic structural variation: insights from and for human disease

Nat. Rev. Genet. 14(2):125-138. doi: 10.1038/nrg3373
Europe PMC | doi

Chen CK, Symmons O, Uslu VV, Tsujimura T, Ruf S, Smedley D, Spitz F. (2013)

TRACER: a resource to study the regulatory architecture of the mouse genome

BMC Genomics 14:215. doi: 10.1186/1471-2164-14-215
Europe PMC | doi

Symmons O, Spitz F. (2013)

From remote enhancers to gene regulation: charting the genome's regulatory landscapes

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 368(1620):20120358. doi: 10.1098/rstb.2012.0358
Europe PMC | doi


Spitz F, Furlong EE. (2012)

Transcription factors: from enhancer binding to developmental control

Nat. Rev. Genet. 13(9):613-626. doi: 10.1038/nrg3207
Europe PMC | doi


Montavon T, Soshnikova N, Mascrez B, Joye E, Thevenet L, Splinter E, de Laat W, Spitz F, Duboule D. (2011)

A regulatory archipelago controls Hox genes transcription in digits

Cell 147(5):1132-1145. doi: 10.1016/j.cell.2011.10.023
Europe PMC | doi

Ruf S, Symmons O, Uslu VV, Dolle D, Hot C, Ettwiller L, Spitz F. (2011)

Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor

Nat. Genet. 43(4):379-386. doi: 10.1038/ng.790
Europe PMC | doi


Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D. (2010)

KAP1 controls endogenous retroviruses in embryonic stem cells

Nature 463(7278):237-240. doi: 10.1038/nature08674
Europe PMC | doi


Tschopp P, Tarchini B, Spitz F, Zakany J, Duboule D. (2009)

Uncoupling time and space in the collinear regulation of Hox genes

PLoS Genet. 5(3):e1000398. doi: 10.1371/journal.pgen.1000398
Europe PMC | doi


Sauvain MO, Dorr AP, Stevenson B, Quazzola A, Naef F, Wiznerowicz M, Schütz F, Jongeneel V, Duboule D, Spitz F, Trono D. (2008)

Genotypic features of lentivirus transgenic mice

J. Virol. 82(14):7111-7119. doi: 10.1128/jvi.00623-08
Europe PMC | doi

Friedli M, Nikolaev S, Lyle R, Arcangeli M, Duboule D, Spitz F, Antonarakis SE. (2008)

Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3

Mamm. Genome 19(4):272-278. doi: 10.1007/s00335-008-9106-0
Europe PMC | doi

Ettwiller L, Budd A, Spitz F, Wittbrodt J. (2008)

Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences

Genome Biol. 9(12):R172. doi: 10.1186/gb-2008-9-12-r172
Europe PMC | doi

Spitz F, Duboule D. (2008)

Global control regions and regulatory landscapes in vertebrate development and evolution

Adv. Genet. 61:175-205. doi: 10.1016/s0065-2660(07)00006-5
Europe PMC | doi


Gonzalez F, Duboule D, Spitz F. (2007)

Transgenic analysis of Hoxd gene regulation during digit development

Dev. Biol. 306(2):847-859. doi: 10.1016/j.ydbio.2007.03.020
Europe PMC | doi


Spitz F, Furlong EE. (2006)

Genomics and development: Taking developmental biology to new heights

Dev. Cell 11(4):451-457. doi: 10.1016/j.devcel.2006.09.013
Europe PMC | doi


Spitz F, Herkenne C, Morris MA, Duboule D. (2005)

Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes

Nat. Genet. 37(8):889-893. doi: 10.1038/ng1597
Europe PMC | doi

Spitz F, Duboule D. (2005)

Developmental biology: reproduction in clusters

Nature 434(7034):715-716. doi: 10.1038/434715a
Europe PMC | doi


Zuniga A, Michos O, Spitz F, Haramis AP, Panman L, Galli A, Vintersten K, Klasen C, Mansfield W, Kuc S, Duboule D, Dono R, Zeller R. (2004)

Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression

Genes Dev. 18(13):1553-1564. doi: 10.1101/gad.299904
Europe PMC | doi

Spitz F. (2004)

[Genes without borders: global control of transcription activity at the level of several genes]

Med Sci (Paris) 20(1):9-10. doi: 10.1051/medsci/20042019
Europe PMC | doi


Spitz F, Gonzalez F, Duboule D. (2003)

A global control region defines a chromosomal regulatory landscape containing the HoxD cluster

Cell 113(3):405-417. doi: 10.1016/s0092-8674(03)00310-6
Europe PMC | doi


Spitz F, Benbacer L, Sabourin JC, Salminen M, Chen F, Cywiner C, Kahn A, Chatelet F, Maire P, Daegelen D. (2002)

Fiber-type specific and position-dependent expression of a transgene in limb muscles

Differentiation 70(8):457-467. doi: 10.1046/j.1432-0436.2002.700808.x
Europe PMC | doi