EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

PA to the Director
Esther Liebig

Room: ATC B2303
Tel: +49 6221 387-8914
Administrative Assistant
Christine Georgi-Turcotte

Room: ATC B2303
Tel: +49 6221 387-8766
E-mail: director@embl.org
Project Officer / Executive Assistant
Niki Pham

Room: ATC B2303
Tel: +49 6221-387 8909
E-mail: director@embl.org


  • MD 1984, University of Münster.
    Postdoctoral training at the NIH, Bethesda.
    Group Leader at EMBL since 1989. Senior Scientist since 1998. Associate Director 2005-2013. Director since 2013.
    Co-Director of the EMBL/University of Heidelberg Molecular Medicine Partnership Unit since 2002.
    ERC Advanced Investigator from 2011 to 2017.


Total: 283 publication(s)


Ivanov PV, Gehring NH, Kunz JB, Hentze MW, Kulozik AE. (2008)

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

EMBO J. 27(5):736-747. doi: 10.1038/emboj.2008.17
Europe PMC | doi

Danckwardt S, Hentze MW, Kulozik AE. (2008)

3' end mRNA processing: molecular mechanisms and implications for health and disease

EMBO J. 27(3):482-498. doi: 10.1038/sj.emboj.7601932
Europe PMC | doi

Vujić Spasić M, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, Gröne HJ, Stremmel W, Hentze MW, Muckenthaler MU. (2008)

Hfe acts in hepatocytes to prevent hemochromatosis

Cell Metab. 7(2):173-178. doi: 10.1016/j.cmet.2007.11.014
Europe PMC | doi

Castoldi M, Schmidt S, Benes V, Hentze MW, Muckenthaler MU. (2008)

miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes

Nat Protoc 3(2):321-329. doi: 10.1038/nprot.2008.4
Europe PMC | doi

Galy B, Ferring-Appel D, Kaden S, Gröne HJ, Hentze MW. (2008)

Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum

Cell Metab. 7(1):79-85. doi: 10.1016/j.cmet.2007.10.006
Europe PMC | doi

Gehring NH, Hentze MW, Kulozik AE. (2008)

Tethering assays to investigate nonsense-mediated mRNA decay activating proteins

Meth. Enzymol. 448:467-482. doi: 10.1016/s0076-6879(08)02623-2
Europe PMC | doi

Muckenthaler MU, Galy B, Hentze MW. (2008)

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

Annu. Rev. Nutr. 28:197-213. doi: 10.1146/annurev.nutr.28.061807.155521
Europe PMC | doi

Pantopoulos K, Hentze MW. (2008)

Regulation of iron metabolism in higher eukaryotes: iron-sulfur centers as genetic switches

In: Ferreira GC, Moura JJG, Franco R (eds.), Inorganic biochemistry and regulatory mechanisms of iron metabolism. Wiley-VCH Verlag GmbH. pp 131-152.doi: 10.1002/9783527613700.ch08
Europe PMC | doi


Castoldi M, Benes V, Hentze MW, Muckenthaler MU. (2007)

miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes

Methods 43(2):146-152. doi: 10.1016/j.ymeth.2007.04.009
Europe PMC | doi

Percy MJ, Sanchez M, Swierczek S, McMullin MF, Mojica-Henshaw MP, Muckenthaler MU, Prchal JT, Hentze MW. (2007)

Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?

Blood 110(7):2776-2777. doi: 10.1182/blood-2007-03-082503
Europe PMC | doi

Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG. (2007)

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

Nat. Struct. Mol. Biol. 14(10):897-903. doi: 10.1038/nsmb1302
Europe PMC | doi

Fillebeen C, Muckenthaler M, Andriopoulos B, Bisaillon M, Mounir Z, Hentze MW, Koromilas AE, Pantopoulos K. (2007)

Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells

J. Hepatol. 47(1):12-22. doi: 10.1016/j.jhep.2007.01.035
Europe PMC | doi

Danckwardt S, Kaufmann I, Gentzel M, Foerstner KU, Gantzert AS, Gehring NH, Neu-Yilik G, Bork P, Keller W, Wilm M, Hentze MW, Kulozik AE. (2007)

Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals

EMBO J. 26(11):2658-2669. doi: 10.1038/sj.emboj.7601699
Europe PMC | doi

Thermann R, Hentze MW. (2007)

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Nature 447(7146):875-878. doi: 10.1038/nature05878
Europe PMC | doi

Sanchez M, Galy B, Muckenthaler MU, Hentze MW. (2007)

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

Nat. Struct. Mol. Biol. 14(5):420-426. doi: 10.1038/nsmb1222
Europe PMC | doi

Vujic Spasic M, Kiss J, Herrmann T, Kessler R, Stolte J, Galy B, Rathkolb B, Wolf E, Stremmel W, Hentze MW, Muckenthaler MU. (2007)

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

Blood 109(10):4511-4517. doi: 10.1182/blood-2006-07-036186
Europe PMC | doi

Ludwiczek S, Theurl I, Muckenthaler MU, Jakab M, Mair SM, Theurl M, Kiss J, Paulmichl M, Hentze MW, Ritter M, Weiss G. (2007)

Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1

Nat. Med. 13(4):448-454. doi: 10.1038/nm1542
Europe PMC | doi

Gebauer F, Hentze MW. (2007)

Studying translational control in Drosophila cell-free systems

Meth. Enzymol. 429:23-33. doi: 10.1016/s0076-6879(07)29002-0
Europe PMC | doi

Mihailovich M, Thermann R, Grohovaz F, Hentze MW, Zacchetti D. (2007)

Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region

Nucleic Acids Res. 35(9):2975-2985. doi: 10.1093/nar/gkm191
Europe PMC | doi

Sanchez M, Galy B, Hentze MW, Muckenthaler MU. (2007)

Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays

Nat Protoc 2(8):2033-2042. doi: 10.1038/nprot.2007.293
Europe PMC | doi

Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. (2007)

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Blood 109(1):353-358. doi: 10.1182/blood-2006-07-033969
Europe PMC | doi

Viegas MH, Gehring NH, Breit S, Hentze MW, Kulozik AE. (2007)

The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway

Nucleic Acids Res. 35(13):4542-4551. doi: 10.1093/nar/gkm461
Europe PMC | doi


Boelz S, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2006)

A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay

Biochem. Biophys. Res. Commun. 349(1):186-191. doi: 10.1016/j.bbrc.2006.08.017
Europe PMC | doi

Galy B, Hölter SM, Klopstock T, Ferring D, Becker L, Kaden S, Wurst W, Gröne HJ, Hentze MW. (2006)

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

Nat. Genet. 38(9):967-9; discussion 969-70. doi: 10.1038/ng0906-967
Europe PMC | doi

Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stolte J, Muckenthaler MU, Hentze MW. (2006)

Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy

J. Biol. Chem. 281(32):22865-22874. doi: 10.1074/jbc.m603876200
Europe PMC | doi

Corna G, Galy B, Hentze MW, Cairo G. (2006)

IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice

J. Mol. Med. 84(7):551-560. doi: 10.1007/s00109-006-0068-y
Europe PMC | doi

Holbrook JA, Neu-Yilik G, Gehring NH, Kulozik AE, Hentze MW. (2006)

Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay

EMBO Rep. 7(7):722-726. doi: 10.1038/sj.embor.7400721
Europe PMC | doi

Kunz JB, Neu-Yilik G, Hentze MW, Kulozik AE, Gehring NH. (2006)

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

RNA 12(6):1015-1022. doi: 10.1261/rna.12506
Europe PMC | doi

Castoldi M, Schmidt S, Benes V, Noerholm M, Kulozik AE, Hentze MW, Muckenthaler MU. (2006)

A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA)

RNA 12(5):913-920. doi: 10.1261/rna.2332406
Europe PMC | doi

Danckwardt S, Hartmann K, Katz B, Hentze MW, Levy Y, Eichele R, Deutsch V, Kulozik AE, Ben-Tal O. (2006)

The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing

J. Thromb. Haemost. 4(5):1078-1085. doi: 10.1111/j.1538-7836.2006.01885.x
Europe PMC | doi

Mok H, Mlodnicka AE, Hentze MW, Muckenthaler M, Schumacher A. (2006)

The molecular circuitry regulating the switch between iron deficiency and overload in mice

J. Biol. Chem. 281(12):7946-7951. doi: 10.1074/jbc.m509857200
Europe PMC | doi

Chekulaeva M, Hentze MW, Ephrussi A. (2006)

Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.

Cell 124(3):521-533. doi: 10.1016/j.cell.2006.01.031
Europe PMC | doi

Duncan K, Grskovic M, Strein C, Beckmann K, Niggeweg R, Abaza I, Gebauer F, Wilm M, Hentze MW. (2006)

Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation

Genes Dev. 20(3):368-379. doi: 10.1101/gad.371406
Europe PMC | doi

Danckwardt S, Hartmann K, Gehring NH, Hentze MW, Kulozik AE. (2006)

3' end processing of the prothrombin mRNA in thrombophilia

Acta Haematol. 115(3-4):192-197. doi: 10.1159/000090934
Europe PMC | doi

Stockklausner C, Breit S, Neu-Yilik G, Echner N, Hentze MW, Kulozik AE, Gehring NH. (2006)

The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)

Nucleic Acids Res. 34(8):2355-2363. doi: 10.1093/nar/gkl277
Europe PMC | doi


Galy B, Ferring D, Hentze MW. (2005)

Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes

Genesis 43(4):181-188. doi: 10.1002/gene.20169
Europe PMC | doi

Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW. (2005)

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Blood 106(7):2580-2589. doi: 10.1182/blood-2005-04-1365
Europe PMC | doi

Gehring NH, Kunz JB, Neu-Yilik G, Breit S, Viegas MH, Hentze MW, Kulozik AE. (2005)

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements

Mol. Cell 20(1):65-75. doi: 10.1016/j.molcel.2005.08.012
Europe PMC | doi

Hundsdoerfer P, Thoma C, Hentze MW. (2005)

Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation

Proc. Natl. Acad. Sci. U.S.A. 102(38):13421-13426. doi: 10.1073/pnas.0506536102
Europe PMC | doi

Beckmann K, Grskovic M, Gebauer F, Hentze MW. (2005)

A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila

Cell 122(4):529-540. doi: 10.1016/j.cell.2005.06.011
Europe PMC | doi

Fillebeen C, Rivas-Estilla AM, Bisaillon M, Ponka P, Muckenthaler M, Hentze MW, Koromilas AE, Pantopoulos K. (2005)

Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus

J. Biol. Chem. 280(10):9049-9057. doi: 10.1074/jbc.m412687200
Europe PMC | doi


Gebauer F, Hentze MW. (2004)

Molecular mechanisms of translational control

Nat. Rev. Mol. Cell Biol. 5(10):827-835. doi: 10.1038/nrm1488
Europe PMC | doi

Thoma C, Bergamini G, Galy B, Hundsdoerfer P, Hentze MW. (2004)

Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP

Mol. Cell 15(6):925-935. doi: 10.1016/j.molcel.2004.08.021
Europe PMC | doi

Holbrook JA, Neu-Yilik G, Hentze MW, Kulozik AE. (2004)

Nonsense-mediated decay approaches the clinic

Nat. Genet. 36(8):801-808. doi: 10.1038/ng1403
Europe PMC | doi

Danckwardt S, Gehring NH, Neu-Yilik G, Hundsdoerfer P, Pforsich M, Frede U, Hentze MW, Kulozik AE. (2004)

The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations

Blood 104(2):428-435. doi: 10.1182/blood-2003-08-2894
Europe PMC | doi

Galy B, Ferring D, Benesova M, Benes V, Hentze MW. (2004)

Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo

RNA 10(7):1019-1025. doi: 10.1261/rna.7220704
Europe PMC | doi

Bonnah RA, Muckenthaler MU, Carlson H, Minana B, Enns CA, Hentze MW, So M. (2004)

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

Cell. Microbiol. 6(5):473-484. doi: 10.1111/j.1462-5822.2004.00376.x
Europe PMC | doi

Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, Sanchez M, Gaudino A, Hentze MW, Andrews NC, Muckenthaler MU. (2004)

An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice

Nat. Genet. 36(5):481-485. doi: 10.1038/ng1350
Europe PMC | doi

Hentze MW, Muckenthaler MU, Andrews NC. (2004)

Balancing acts: molecular control of mammalian iron metabolism

Cell 117(3):285-297. doi: 10.1016/s0092-8674(04)00343-5
Europe PMC | doi

Schümann K, Brennan K, Weiss M, Pantopoulos K, Hentze MW. (2004)

Rat duodenal IRP1 activity and iron absorption in iron deficiency and after H2O2 perfusion

Eur. J. Clin. Invest. 34(4):275-282. doi: 10.1111/j.1365-2362.2004.01335.x
Europe PMC | doi

Wang J, Chen G, Muckenthaler M, Galy B, Hentze MW, Pantopoulos K. (2004)

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

Mol. Cell. Biol. 24(3):954-965. doi: 10.1128/mcb.24.3.954-965.2004
Europe PMC | doi

Baron-Benhamou J, Gehring NH, Kulozik AE, Hentze MW. (2004)

Using the lambdaN peptide to tether proteins to RNAs

Methods Mol. Biol. 257:135-154. doi: 10.1385/1-59259-750-5:135
Europe PMC | doi

Herrmann T, Muckenthaler M, van der Hoeven F, Brennan K, Gehrke SG, Hubert N, Sergi C, Gröne HJ, Kaiser I, Gosch I, Volkmann M, Riedel HD, Hentze MW, Stewart AF, Stremmel W. (2004)

Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin

J. Mol. Med. 82(1):39-48. doi: 10.1007/s00109-003-0508-x
Europe PMC | doi

Muckenthaler MU, Rodrigues P, Macedo MG, Minana B, Brennan K, Cardoso EM, Hentze MW, de Sousa M. (2004)

Molecular analysis of iron overload in beta2-microglobulin-deficient mice

Blood Cells Mol. Dis. 33(2):125-131. doi: 10.1016/j.bcmd.2004.05.003
Europe PMC | doi

Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2004)

Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

Genome Biol. 5(4):218. doi: 10.1186/gb-2004-5-4-218
Europe PMC | doi

Thoma C, Ostareck-Lederer A, Hentze MW. (2004)

A poly(A) tail-responsive in vitro system for cap- or IRES-driven translation from HeLa cells

Methods Mol. Biol. 257:171-180. doi: 10.1385/1-59259-750-5:171
Europe PMC | doi


Preiss T, Baron-Benhamou J, Ansorge W, Hentze MW. (2003)

Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock

Nat. Struct. Biol. 10(12):1039-1047. doi: 10.1038/nsb1015
Europe PMC | doi

Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S. (2003)

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

Mol. Cell 12(5):1187-1200. doi: 10.1016/s1097-2765(03)00443-x
Europe PMC | doi

Grskovic M, Hentze MW, Gebauer F. (2003)

A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA

EMBO J. 22(20):5571-5581. doi: 10.1093/emboj/cdg539
Europe PMC | doi

Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW. (2003)

Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells

Biochem. J. 373(Pt 3):775-783. doi: 10.1042/bj20021920
Europe PMC | doi

Baron-Benhamou J, Fortes P, Inada T, Preiss T, Hentze MW. (2003)

The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast

RNA 9(6):654-662. doi: 10.1261/rna.5100903
Europe PMC | doi

Gebauer F, Grskovic M, Hentze MW. (2003)

Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA

Mol. Cell 11(5):1397-1404. doi: 10.1016/s1097-2765(03)00176-x
Europe PMC | doi

Muckenthaler M, Richter A, Gunkel N, Riedel D, Polycarpou-Schwarz M, Hentze S, Falkenhahn M, Stremmel W, Ansorge W, Hentze MW. (2003)

Relationships and distinctions in iron-regulatory networks responding to interrelated signals

Blood 101(9):3690-3698. doi: 10.1182/blood-2002-07-2140
Europe PMC | doi

Muckenthaler M, Roy CN, Custodio AO, Miñana B, deGraaf J, Montross LK, Andrews NC, Hentze MW. (2003)

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

Nat. Genet. 34(1):102-107. doi: 10.1038/ng1152
Europe PMC | doi

Gehring NH, Neu-Yilik G, Schell T, Hentze MW, Kulozik AE. (2003)

Y14 and hUpf3b form an NMD-activating complex

Mol. Cell 11(4):939-949. doi: 10.1016/s1097-2765(03)00142-4
Europe PMC | doi

Thompson K, Menzies S, Muckenthaler M, Torti FM, Wood T, Torti SV, Hentze MW, Beard J, Connor J. (2003)

Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress

J. Neurosci. Res. 71(1):46-63. doi: 10.1002/jnr.10463
Europe PMC | doi


Hubert N, Hentze MW. (2002)

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function

Proc. Natl. Acad. Sci. U.S.A. 99(19):12345-12350. doi: 10.1073/pnas.192423399
Europe PMC | doi

Richter A, Schwager C, Hentze S, Ansorge W, Hentze MW, Muckenthaler M. (2002)

Comparison of fluorescent tag DNA labeling methods used for expression analysis by DNA microarrays

BioTechniques 33(3):620-8, 630. doi: 10.2144/02333rr05_11834a
Europe PMC | doi

Schümann K, Borch-Iohnsen B, Hentze MW, Marx JJ. (2002)

Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board

Am. J. Clin. Nutr. 76(3):499-500.
Europe PMC

Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW. (2002)

c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs

Mol. Cell. Biol. 22(13):4535-4543. doi: 10.1128/mcb.22.13.4535-4543.2002
Europe PMC | doi

Danckwardt S, Neu-Yilik G, Thermann R, Frede U, Hentze MW, Kulozik AE. (2002)

Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay

Blood 99(5):1811-1816. doi: 10.1182/blood.v99.5.1811
Europe PMC | doi

Brocke KS, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2002)

The human intronless melanocortin 4-receptor gene is NMD insensitive

Hum. Mol. Genet. 11(3):331-335. doi: 10.1093/hmg/11.3.331
Europe PMC | doi

Schell T, Kulozik AE, Hentze MW. (2002)

Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway

Genome Biol. 3(3):REVIEWS1006. doi: 10.1186/gb-2002-3-3-reviews1006
Europe PMC | doi


Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA. (2001)

Iron-dependent regulation of the divalent metal ion transporter

FEBS Lett. 509(2):309-316. doi: 10.1016/s0014-5793(01)03189-1
Europe PMC | doi

Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M Jr, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. (2001)

New ways of initiating translation in eukaryotes.

Mol. Cell. Biol. 21(23):8238-8246. doi: 10.1128/mcb.21.23.8238-8246.2001
Europe PMC | doi

Thoma C, Hasselblatt P, Köck J, Chang SF, Hockenjos B, Will H, Hentze MW, Blum HE, von Weizsäcker F, Offensperger WB. (2001)

Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides

Mol. Cell 8(4):865-872. doi: 10.1016/s1097-2765(01)00364-1
Europe PMC | doi

Gebauer F, Hentze MW. (2001)

Fertility facts: male and female germ cell development requires translational control by CPEB

Mol. Cell 8(2):247-249. doi: 10.1016/s1097-2765(01)00326-4
Europe PMC | doi

Gehring NH, Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, Hentze MW, Kulozik AE. (2001)

Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia

Nat. Genet. 28(4):389-392. doi: 10.1038/ng578
Europe PMC | doi

Hentze MW. (2001)

Protein synthesis. Believe it or not-translation in the nucleus

Science 293(5532):1058-1059. doi: 10.1126/science.1063290
Europe PMC | doi

Mueller S, Pantopoulos K, Hübner CA, Stremmel W, Hentze MW. (2001)

IRP1 activation by extracellular oxidative stress in the perfused rat liver

J. Biol. Chem. 276(25):23192-23196. doi: 10.1074/jbc.m100654200
Europe PMC | doi

Pöyry TA, Hentze MW, Jackson RJ. (2001)

Construction of regulatable picornavirus IRESes as a test of current models of the mechanism of internal translation initiation

RNA 7(5):647-660. doi: 10.1017/s1355838201001911
Europe PMC | doi

Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z. (2001)

ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

Nat. Cell Biol. 3(3):325-330. doi: 10.1038/35060131
Europe PMC | doi

Neu-Yilik G, Gehring NH, Thermann R, Frede U, Hentze MW, Kulozik AE. (2001)

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs

EMBO J. 20(3):532-540. doi: 10.1093/emboj/20.3.532
Europe PMC | doi

De Gregorio E, Baron J, Preiss T, Hentze MW. (2001)

Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure

RNA 7(1):106-113. doi: 10.1017/s1355838201000577
Europe PMC | doi

Gebauer F, Ostareck DH, Ostareck-Lederer A, Grskovic M, Hentze MW. (2001)

Translational control of 15-lipoxygenase and msl-2 mRNAs: single regulators or corepressor assemblies?

Cold Spring Harb. Symp. Quant. Biol. 66:329-336. doi: 10.1101/sqb.2001.66.329
Europe PMC | doi

Ostareck DH, Ostareck-Lederer A, Shatsky IN, Hentze MW. (2001)

Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining

Cell 104(2):281-290. doi: 10.1016/s0092-8674(01)00212-4
Europe PMC | doi


Bergamini G, Preiss T, Hentze MW. (2000)

Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system

RNA 6(12):1781-1790. doi: 10.1017/s1355838200001679
Europe PMC | doi

Hentze MW, Izaurralde E, Séraphin B. (2000)

A new era for the RNA world. Conference: RNA 2000

EMBO Rep. 1(5):394-398. doi: 10.1093/embo-reports/kvd100
Europe PMC | doi

Fortes P, Inada T, Preiss T, Hentze MW, Mattaj IW, Sachs AB. (2000)

The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation

Mol. Cell 6(1):191-196. doi: 10.1016/s1097-2765(00)00020-4
Europe PMC | doi

Volkmann M, Schiff JH, Hör M, Hentze MW, Fiehn W, Merkt J. (2000)

[Pair of siblings of Italian ethnicity with hyperferritinemia and cataract]

Internist (Berl) 41(4):381-384. doi: 10.1007/s001080050521
Europe PMC | doi

Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. (2000)

Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries.

Development 127(5):1063-1068.
Europe PMC

McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ. (2000)

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

Mol. Cell 5(2):299-309. doi: 10.1016/s1097-2765(00)80425-6
Europe PMC | doi

Pantopoulos K, Hentze MW. (2000)

Nitric oxide, oxygen radicals, and iron metabolism

In: L.J. Ignarro, (ed.). Academic Press, Nitric Oxide: Biology and Pathobiology. pp 293-313.
Europe PMC

Paraskeva E, Hentze MW. (2000)

Translational repression assay procedure: a method to study RNA-protein interactions in yeast

Meth. Enzymol. 318:374-384. doi: 10.1016/s0076-6879(00)18064-4
Europe PMC | doi

Wickens M, Goodwin EB, Kimble J, Strickland S, Hentze MW. (2000)

Translational Control of Developmental Decisions

In: N. Sonenberg, J. W.B. Hershey, M.B. Mathews, (eds.), Cold Spring Harbor Press, Translational Control. pp 295-370.
Europe PMC


Riedel HD, Muckenthaler MU, Gehrke SG, Mohr I, Brennan K, Herrmann T, Fitscher BA, Hentze MW, Stremmel W. (1999)

HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells

Blood 94(11):3915-3921. doi: 10.1182/blood.V94.11.3915.423k27_3915_3921
Europe PMC | doi

Gebauer F, Corona DF, Preiss T, Becker PB, Hentze MW. (1999)

Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail

EMBO J. 18(21):6146-6154. doi: 10.1093/emboj/18.21.6146
Europe PMC | doi

Preiss T, Hentze MW. (1999)

From factors to mechanisms: translation and translational control in eukaryotes

Curr. Opin. Genet. Dev. 9(5):515-521. doi: 10.1016/s0959-437x(99)00005-2
Europe PMC | doi

De Gregorio E, Preiss T, Hentze MW. (1999)

Translation driven by an eIF4G core domain in vivo

EMBO J. 18(17):4865-4874. doi: 10.1093/emboj/18.17.4865
Europe PMC | doi

Brazzolotto X, Gaillard J, Pantopoulos K, Hentze MW, Moulis JM. (1999)

Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding

J. Biol. Chem. 274(31):21625-21630. doi: 10.1074/jbc.274.31.21625
Europe PMC | doi