EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
PA to the Director Esther Liebig Room: >ATC B2303 Tel: +49 6221 387-8914 E-mail:director@embl.org | Administrative Assistant Christine Georgi-Turcotte Room: ATC B2303 Tel: +49 6221 387-8766 E-mail: director@embl.org | Project Officer / Executive Assistant Niki Pham Room: ATC B2303 Tel: +49 6221-387 8909 E-mail: director@embl.org |
Biography
MD 1984, University of Münster.
Postdoctoral training at the NIH, Bethesda.
Group Leader at EMBL since 1989. Senior Scientist since 1998. Associate Director 2005-2013. Director since 2013.
Co-Director of the EMBL/University of Heidelberg Molecular Medicine Partnership Unit since 2002.
ERC Advanced Investigator from 2011 to 2017.
Publications
Total: 283 publication(s)
2008
Ivanov PV, Gehring NH, Kunz JB, Hentze MW, Kulozik AE. (2008)
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
EMBO J. 27(5):736-747. doi: 10.1038/emboj.2008.17
Europe PMC | doi
Danckwardt S, Hentze MW, Kulozik AE. (2008)
3' end mRNA processing: molecular mechanisms and implications for health and disease
EMBO J. 27(3):482-498. doi: 10.1038/sj.emboj.7601932
Europe PMC | doi
Vujić Spasić M, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, Gröne HJ, Stremmel W, Hentze MW, Muckenthaler MU. (2008)
Hfe acts in hepatocytes to prevent hemochromatosis
Cell Metab. 7(2):173-178. doi: 10.1016/j.cmet.2007.11.014
Europe PMC | doi
Castoldi M, Schmidt S, Benes V, Hentze MW, Muckenthaler MU. (2008)
miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes
Nat Protoc 3(2):321-329. doi: 10.1038/nprot.2008.4
Europe PMC | doi
Galy B, Ferring-Appel D, Kaden S, Gröne HJ, Hentze MW. (2008)
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum
Cell Metab. 7(1):79-85. doi: 10.1016/j.cmet.2007.10.006
Europe PMC | doi
Gehring NH, Hentze MW, Kulozik AE. (2008)
Tethering assays to investigate nonsense-mediated mRNA decay activating proteins
Meth. Enzymol. 448:467-482. doi: 10.1016/s0076-6879(08)02623-2
Europe PMC | doi
Muckenthaler MU, Galy B, Hentze MW. (2008)
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network
Annu. Rev. Nutr. 28:197-213. doi: 10.1146/annurev.nutr.28.061807.155521
Europe PMC | doi
Pantopoulos K, Hentze MW. (2008)
Regulation of iron metabolism in higher eukaryotes: iron-sulfur centers as genetic switches
In: Ferreira GC, Moura JJG, Franco R (eds.), Inorganic biochemistry and regulatory mechanisms of iron metabolism. Wiley-VCH Verlag GmbH. pp 131-152.doi: 10.1002/9783527613700.ch08
Europe PMC | doi
2007
Castoldi M, Benes V, Hentze MW, Muckenthaler MU. (2007)
miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes
Methods 43(2):146-152. doi: 10.1016/j.ymeth.2007.04.009
Europe PMC | doi
Percy MJ, Sanchez M, Swierczek S, McMullin MF, Mojica-Henshaw MP, Muckenthaler MU, Prchal JT, Hentze MW. (2007)
Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?
Blood 110(7):2776-2777. doi: 10.1182/blood-2007-03-082503
Europe PMC | doi
Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG. (2007)
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain
Nat. Struct. Mol. Biol. 14(10):897-903. doi: 10.1038/nsmb1302
Europe PMC | doi
Fillebeen C, Muckenthaler M, Andriopoulos B, Bisaillon M, Mounir Z, Hentze MW, Koromilas AE, Pantopoulos K. (2007)
Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells
J. Hepatol. 47(1):12-22. doi: 10.1016/j.jhep.2007.01.035
Europe PMC | doi
Danckwardt S, Kaufmann I, Gentzel M, Foerstner KU, Gantzert AS, Gehring NH, Neu-Yilik G, Bork P, Keller W, Wilm M, Hentze MW, Kulozik AE. (2007)
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals
EMBO J. 26(11):2658-2669. doi: 10.1038/sj.emboj.7601699
Europe PMC | doi
Thermann R, Hentze MW. (2007)
Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation
Nature 447(7146):875-878. doi: 10.1038/nature05878
Europe PMC | doi
Sanchez M, Galy B, Muckenthaler MU, Hentze MW. (2007)
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency
Nat. Struct. Mol. Biol. 14(5):420-426. doi: 10.1038/nsmb1222
Europe PMC | doi
Vujic Spasic M, Kiss J, Herrmann T, Kessler R, Stolte J, Galy B, Rathkolb B, Wolf E, Stremmel W, Hentze MW, Muckenthaler MU. (2007)
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe
Blood 109(10):4511-4517. doi: 10.1182/blood-2006-07-036186
Europe PMC | doi
Ludwiczek S, Theurl I, Muckenthaler MU, Jakab M, Mair SM, Theurl M, Kiss J, Paulmichl M, Hentze MW, Ritter M, Weiss G. (2007)
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
Nat. Med. 13(4):448-454. doi: 10.1038/nm1542
Europe PMC | doi
Gebauer F, Hentze MW. (2007)
Studying translational control in Drosophila cell-free systems
Meth. Enzymol. 429:23-33. doi: 10.1016/s0076-6879(07)29002-0
Europe PMC | doi
Mihailovich M, Thermann R, Grohovaz F, Hentze MW, Zacchetti D. (2007)
Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region
Nucleic Acids Res. 35(9):2975-2985. doi: 10.1093/nar/gkm191
Europe PMC | doi
Sanchez M, Galy B, Hentze MW, Muckenthaler MU. (2007)
Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays
Nat Protoc 2(8):2033-2042. doi: 10.1038/nprot.2007.293
Europe PMC | doi
Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. (2007)
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
Blood 109(1):353-358. doi: 10.1182/blood-2006-07-033969
Europe PMC | doi
Viegas MH, Gehring NH, Breit S, Hentze MW, Kulozik AE. (2007)
The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway
Nucleic Acids Res. 35(13):4542-4551. doi: 10.1093/nar/gkm461
Europe PMC | doi
2006
Boelz S, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2006)
A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay
Biochem. Biophys. Res. Commun. 349(1):186-191. doi: 10.1016/j.bbrc.2006.08.017
Europe PMC | doi
Galy B, Hölter SM, Klopstock T, Ferring D, Becker L, Kaden S, Wurst W, Gröne HJ, Hentze MW. (2006)
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse
Nat. Genet. 38(9):967-9; discussion 969-70. doi: 10.1038/ng0906-967
Europe PMC | doi
Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stolte J, Muckenthaler MU, Hentze MW. (2006)
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy
J. Biol. Chem. 281(32):22865-22874. doi: 10.1074/jbc.m603876200
Europe PMC | doi
Corna G, Galy B, Hentze MW, Cairo G. (2006)
IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice
J. Mol. Med. 84(7):551-560. doi: 10.1007/s00109-006-0068-y
Europe PMC | doi
Holbrook JA, Neu-Yilik G, Gehring NH, Kulozik AE, Hentze MW. (2006)
Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay
EMBO Rep. 7(7):722-726. doi: 10.1038/sj.embor.7400721
Europe PMC | doi
Kunz JB, Neu-Yilik G, Hentze MW, Kulozik AE, Gehring NH. (2006)
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
RNA 12(6):1015-1022. doi: 10.1261/rna.12506
Europe PMC | doi
Castoldi M, Schmidt S, Benes V, Noerholm M, Kulozik AE, Hentze MW, Muckenthaler MU. (2006)
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA)
RNA 12(5):913-920. doi: 10.1261/rna.2332406
Europe PMC | doi
Danckwardt S, Hartmann K, Katz B, Hentze MW, Levy Y, Eichele R, Deutsch V, Kulozik AE, Ben-Tal O. (2006)
The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing
J. Thromb. Haemost. 4(5):1078-1085. doi: 10.1111/j.1538-7836.2006.01885.x
Europe PMC | doi
Mok H, Mlodnicka AE, Hentze MW, Muckenthaler M, Schumacher A. (2006)
The molecular circuitry regulating the switch between iron deficiency and overload in mice
J. Biol. Chem. 281(12):7946-7951. doi: 10.1074/jbc.m509857200
Europe PMC | doi
Chekulaeva M, Hentze MW, Ephrussi A. (2006)
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.
Cell 124(3):521-533. doi: 10.1016/j.cell.2006.01.031
Europe PMC | doi
Duncan K, Grskovic M, Strein C, Beckmann K, Niggeweg R, Abaza I, Gebauer F, Wilm M, Hentze MW. (2006)
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation
Genes Dev. 20(3):368-379. doi: 10.1101/gad.371406
Europe PMC | doi
Danckwardt S, Hartmann K, Gehring NH, Hentze MW, Kulozik AE. (2006)
3' end processing of the prothrombin mRNA in thrombophilia
Acta Haematol. 115(3-4):192-197. doi: 10.1159/000090934
Europe PMC | doi
Stockklausner C, Breit S, Neu-Yilik G, Echner N, Hentze MW, Kulozik AE, Gehring NH. (2006)
The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)
Nucleic Acids Res. 34(8):2355-2363. doi: 10.1093/nar/gkl277
Europe PMC | doi
2005
Galy B, Ferring D, Hentze MW. (2005)
Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes
Genesis 43(4):181-188. doi: 10.1002/gene.20169
Europe PMC | doi
Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW. (2005)
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
Blood 106(7):2580-2589. doi: 10.1182/blood-2005-04-1365
Europe PMC | doi
Gehring NH, Kunz JB, Neu-Yilik G, Breit S, Viegas MH, Hentze MW, Kulozik AE. (2005)
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
Mol. Cell 20(1):65-75. doi: 10.1016/j.molcel.2005.08.012
Europe PMC | doi
Hundsdoerfer P, Thoma C, Hentze MW. (2005)
Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation
Proc. Natl. Acad. Sci. U.S.A. 102(38):13421-13426. doi: 10.1073/pnas.0506536102
Europe PMC | doi
Beckmann K, Grskovic M, Gebauer F, Hentze MW. (2005)
A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila
Cell 122(4):529-540. doi: 10.1016/j.cell.2005.06.011
Europe PMC | doi
Fillebeen C, Rivas-Estilla AM, Bisaillon M, Ponka P, Muckenthaler M, Hentze MW, Koromilas AE, Pantopoulos K. (2005)
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus
J. Biol. Chem. 280(10):9049-9057. doi: 10.1074/jbc.m412687200
Europe PMC | doi
2004
Gebauer F, Hentze MW. (2004)
Molecular mechanisms of translational control
Nat. Rev. Mol. Cell Biol. 5(10):827-835. doi: 10.1038/nrm1488
Europe PMC | doi
Thoma C, Bergamini G, Galy B, Hundsdoerfer P, Hentze MW. (2004)
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP
Mol. Cell 15(6):925-935. doi: 10.1016/j.molcel.2004.08.021
Europe PMC | doi
Holbrook JA, Neu-Yilik G, Hentze MW, Kulozik AE. (2004)
Nonsense-mediated decay approaches the clinic
Nat. Genet. 36(8):801-808. doi: 10.1038/ng1403
Europe PMC | doi
Danckwardt S, Gehring NH, Neu-Yilik G, Hundsdoerfer P, Pforsich M, Frede U, Hentze MW, Kulozik AE. (2004)
The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations
Blood 104(2):428-435. doi: 10.1182/blood-2003-08-2894
Europe PMC | doi
Galy B, Ferring D, Benesova M, Benes V, Hentze MW. (2004)
Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo
RNA 10(7):1019-1025. doi: 10.1261/rna.7220704
Europe PMC | doi
Bonnah RA, Muckenthaler MU, Carlson H, Minana B, Enns CA, Hentze MW, So M. (2004)
Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis
Cell. Microbiol. 6(5):473-484. doi: 10.1111/j.1462-5822.2004.00376.x
Europe PMC | doi
Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, Sanchez M, Gaudino A, Hentze MW, Andrews NC, Muckenthaler MU. (2004)
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
Nat. Genet. 36(5):481-485. doi: 10.1038/ng1350
Europe PMC | doi
Hentze MW, Muckenthaler MU, Andrews NC. (2004)
Balancing acts: molecular control of mammalian iron metabolism
Cell 117(3):285-297. doi: 10.1016/s0092-8674(04)00343-5
Europe PMC | doi
Schümann K, Brennan K, Weiss M, Pantopoulos K, Hentze MW. (2004)
Rat duodenal IRP1 activity and iron absorption in iron deficiency and after H2O2 perfusion
Eur. J. Clin. Invest. 34(4):275-282. doi: 10.1111/j.1365-2362.2004.01335.x
Europe PMC | doi
Wang J, Chen G, Muckenthaler M, Galy B, Hentze MW, Pantopoulos K. (2004)
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity
Mol. Cell. Biol. 24(3):954-965. doi: 10.1128/mcb.24.3.954-965.2004
Europe PMC | doi
Baron-Benhamou J, Gehring NH, Kulozik AE, Hentze MW. (2004)
Using the lambdaN peptide to tether proteins to RNAs
Methods Mol. Biol. 257:135-154. doi: 10.1385/1-59259-750-5:135
Europe PMC | doi
Herrmann T, Muckenthaler M, van der Hoeven F, Brennan K, Gehrke SG, Hubert N, Sergi C, Gröne HJ, Kaiser I, Gosch I, Volkmann M, Riedel HD, Hentze MW, Stewart AF, Stremmel W. (2004)
Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin
J. Mol. Med. 82(1):39-48. doi: 10.1007/s00109-003-0508-x
Europe PMC | doi
Muckenthaler MU, Rodrigues P, Macedo MG, Minana B, Brennan K, Cardoso EM, Hentze MW, de Sousa M. (2004)
Molecular analysis of iron overload in beta2-microglobulin-deficient mice
Blood Cells Mol. Dis. 33(2):125-131. doi: 10.1016/j.bcmd.2004.05.003
Europe PMC | doi
Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2004)
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife
Genome Biol. 5(4):218. doi: 10.1186/gb-2004-5-4-218
Europe PMC | doi
Thoma C, Ostareck-Lederer A, Hentze MW. (2004)
A poly(A) tail-responsive in vitro system for cap- or IRES-driven translation from HeLa cells
Methods Mol. Biol. 257:171-180. doi: 10.1385/1-59259-750-5:171
Europe PMC | doi
2003
Preiss T, Baron-Benhamou J, Ansorge W, Hentze MW. (2003)
Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock
Nat. Struct. Biol. 10(12):1039-1047. doi: 10.1038/nsb1015
Europe PMC | doi
Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S. (2003)
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7
Mol. Cell 12(5):1187-1200. doi: 10.1016/s1097-2765(03)00443-x
Europe PMC | doi
Grskovic M, Hentze MW, Gebauer F. (2003)
A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA
EMBO J. 22(20):5571-5581. doi: 10.1093/emboj/cdg539
Europe PMC | doi
Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW. (2003)
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells
Biochem. J. 373(Pt 3):775-783. doi: 10.1042/bj20021920
Europe PMC | doi
Baron-Benhamou J, Fortes P, Inada T, Preiss T, Hentze MW. (2003)
The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast
RNA 9(6):654-662. doi: 10.1261/rna.5100903
Europe PMC | doi
Gebauer F, Grskovic M, Hentze MW. (2003)
Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA
Mol. Cell 11(5):1397-1404. doi: 10.1016/s1097-2765(03)00176-x
Europe PMC | doi
Muckenthaler M, Richter A, Gunkel N, Riedel D, Polycarpou-Schwarz M, Hentze S, Falkenhahn M, Stremmel W, Ansorge W, Hentze MW. (2003)
Relationships and distinctions in iron-regulatory networks responding to interrelated signals
Blood 101(9):3690-3698. doi: 10.1182/blood-2002-07-2140
Europe PMC | doi
Muckenthaler M, Roy CN, Custodio AO, Miñana B, deGraaf J, Montross LK, Andrews NC, Hentze MW. (2003)
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
Nat. Genet. 34(1):102-107. doi: 10.1038/ng1152
Europe PMC | doi
Gehring NH, Neu-Yilik G, Schell T, Hentze MW, Kulozik AE. (2003)
Y14 and hUpf3b form an NMD-activating complex
Mol. Cell 11(4):939-949. doi: 10.1016/s1097-2765(03)00142-4
Europe PMC | doi
Thompson K, Menzies S, Muckenthaler M, Torti FM, Wood T, Torti SV, Hentze MW, Beard J, Connor J. (2003)
Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress
J. Neurosci. Res. 71(1):46-63. doi: 10.1002/jnr.10463
Europe PMC | doi
2002
Hubert N, Hentze MW. (2002)
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function
Proc. Natl. Acad. Sci. U.S.A. 99(19):12345-12350. doi: 10.1073/pnas.192423399
Europe PMC | doi
Richter A, Schwager C, Hentze S, Ansorge W, Hentze MW, Muckenthaler M. (2002)
Comparison of fluorescent tag DNA labeling methods used for expression analysis by DNA microarrays
BioTechniques 33(3):620-8, 630. doi: 10.2144/02333rr05_11834a
Europe PMC | doi
Schümann K, Borch-Iohnsen B, Hentze MW, Marx JJ. (2002)
Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board
Am. J. Clin. Nutr. 76(3):499-500.
Europe PMC
Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW. (2002)
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs
Mol. Cell. Biol. 22(13):4535-4543. doi: 10.1128/mcb.22.13.4535-4543.2002
Europe PMC | doi
Danckwardt S, Neu-Yilik G, Thermann R, Frede U, Hentze MW, Kulozik AE. (2002)
Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay
Blood 99(5):1811-1816. doi: 10.1182/blood.v99.5.1811
Europe PMC | doi
Brocke KS, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2002)
The human intronless melanocortin 4-receptor gene is NMD insensitive
Hum. Mol. Genet. 11(3):331-335. doi: 10.1093/hmg/11.3.331
Europe PMC | doi
Schell T, Kulozik AE, Hentze MW. (2002)
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
Genome Biol. 3(3):REVIEWS1006. doi: 10.1186/gb-2002-3-3-reviews1006
Europe PMC | doi
2001
Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA. (2001)
Iron-dependent regulation of the divalent metal ion transporter
FEBS Lett. 509(2):309-316. doi: 10.1016/s0014-5793(01)03189-1
Europe PMC | doi
Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M Jr, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. (2001)
New ways of initiating translation in eukaryotes.
Mol. Cell. Biol. 21(23):8238-8246. doi: 10.1128/mcb.21.23.8238-8246.2001
Europe PMC | doi
Thoma C, Hasselblatt P, Köck J, Chang SF, Hockenjos B, Will H, Hentze MW, Blum HE, von Weizsäcker F, Offensperger WB. (2001)
Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides
Mol. Cell 8(4):865-872. doi: 10.1016/s1097-2765(01)00364-1
Europe PMC | doi
Gebauer F, Hentze MW. (2001)
Fertility facts: male and female germ cell development requires translational control by CPEB
Mol. Cell 8(2):247-249. doi: 10.1016/s1097-2765(01)00326-4
Europe PMC | doi
Gehring NH, Frede U, Neu-Yilik G, Hundsdoerfer P, Vetter B, Hentze MW, Kulozik AE. (2001)
Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia
Nat. Genet. 28(4):389-392. doi: 10.1038/ng578
Europe PMC | doi
Hentze MW. (2001)
Protein synthesis. Believe it or not-translation in the nucleus
Science 293(5532):1058-1059. doi: 10.1126/science.1063290
Europe PMC | doi
Mueller S, Pantopoulos K, Hübner CA, Stremmel W, Hentze MW. (2001)
IRP1 activation by extracellular oxidative stress in the perfused rat liver
J. Biol. Chem. 276(25):23192-23196. doi: 10.1074/jbc.m100654200
Europe PMC | doi
Pöyry TA, Hentze MW, Jackson RJ. (2001)
Construction of regulatable picornavirus IRESes as a test of current models of the mechanism of internal translation initiation
RNA 7(5):647-660. doi: 10.1017/s1355838201001911
Europe PMC | doi
Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z. (2001)
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation
Nat. Cell Biol. 3(3):325-330. doi: 10.1038/35060131
Europe PMC | doi
Neu-Yilik G, Gehring NH, Thermann R, Frede U, Hentze MW, Kulozik AE. (2001)
Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs
EMBO J. 20(3):532-540. doi: 10.1093/emboj/20.3.532
Europe PMC | doi
De Gregorio E, Baron J, Preiss T, Hentze MW. (2001)
Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure
RNA 7(1):106-113. doi: 10.1017/s1355838201000577
Europe PMC | doi
Gebauer F, Ostareck DH, Ostareck-Lederer A, Grskovic M, Hentze MW. (2001)
Translational control of 15-lipoxygenase and msl-2 mRNAs: single regulators or corepressor assemblies?
Cold Spring Harb. Symp. Quant. Biol. 66:329-336. doi: 10.1101/sqb.2001.66.329
Europe PMC | doi
Ostareck DH, Ostareck-Lederer A, Shatsky IN, Hentze MW. (2001)
Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining
Cell 104(2):281-290. doi: 10.1016/s0092-8674(01)00212-4
Europe PMC | doi
2000
Bergamini G, Preiss T, Hentze MW. (2000)
Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system
RNA 6(12):1781-1790. doi: 10.1017/s1355838200001679
Europe PMC | doi
Hentze MW, Izaurralde E, Séraphin B. (2000)
A new era for the RNA world. Conference: RNA 2000
EMBO Rep. 1(5):394-398. doi: 10.1093/embo-reports/kvd100
Europe PMC | doi
Fortes P, Inada T, Preiss T, Hentze MW, Mattaj IW, Sachs AB. (2000)
The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation
Mol. Cell 6(1):191-196. doi: 10.1016/s1097-2765(00)00020-4
Europe PMC | doi
Volkmann M, Schiff JH, Hör M, Hentze MW, Fiehn W, Merkt J. (2000)
[Pair of siblings of Italian ethnicity with hyperferritinemia and cataract]
Internist (Berl) 41(4):381-384. doi: 10.1007/s001080050521
Europe PMC | doi
Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. (2000)
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries.
Development 127(5):1063-1068.
Europe PMC
McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ. (2000)
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
Mol. Cell 5(2):299-309. doi: 10.1016/s1097-2765(00)80425-6
Europe PMC | doi
Pantopoulos K, Hentze MW. (2000)
Nitric oxide, oxygen radicals, and iron metabolism
In: L.J. Ignarro, (ed.). Academic Press, Nitric Oxide: Biology and Pathobiology. pp 293-313.
Europe PMC
Paraskeva E, Hentze MW. (2000)
Translational repression assay procedure: a method to study RNA-protein interactions in yeast
Meth. Enzymol. 318:374-384. doi: 10.1016/s0076-6879(00)18064-4
Europe PMC | doi
Wickens M, Goodwin EB, Kimble J, Strickland S, Hentze MW. (2000)
Translational Control of Developmental Decisions
In: N. Sonenberg, J. W.B. Hershey, M.B. Mathews, (eds.), Cold Spring Harbor Press, Translational Control. pp 295-370.
Europe PMC
1999
Riedel HD, Muckenthaler MU, Gehrke SG, Mohr I, Brennan K, Herrmann T, Fitscher BA, Hentze MW, Stremmel W. (1999)
HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells
Blood 94(11):3915-3921. doi: 10.1182/blood.V94.11.3915.423k27_3915_3921
Europe PMC | doi
Gebauer F, Corona DF, Preiss T, Becker PB, Hentze MW. (1999)
Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail
EMBO J. 18(21):6146-6154. doi: 10.1093/emboj/18.21.6146
Europe PMC | doi
Preiss T, Hentze MW. (1999)
From factors to mechanisms: translation and translational control in eukaryotes
Curr. Opin. Genet. Dev. 9(5):515-521. doi: 10.1016/s0959-437x(99)00005-2
Europe PMC | doi
De Gregorio E, Preiss T, Hentze MW. (1999)
Translation driven by an eIF4G core domain in vivo
EMBO J. 18(17):4865-4874. doi: 10.1093/emboj/18.17.4865
Europe PMC | doi
Brazzolotto X, Gaillard J, Pantopoulos K, Hentze MW, Moulis JM. (1999)
Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding
J. Biol. Chem. 274(31):21625-21630. doi: 10.1074/jbc.274.31.21625
Europe PMC | doi