EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
|PA to the Director|
Room: >ATC B2303
Tel: +49 6221 387-8914
Room: ATC B2303
Tel: +49 6221 387-8766
|Project Officer / Executive Assistant|
Room: ATC B2303
Tel: +49 6221-387 8909
MD 1984, University of Münster.
Postdoctoral training at the NIH, Bethesda.
Group Leader at EMBL since 1989. Senior Scientist since 1998. Associate Director 2005-2013. Director since 2013.
Co-Director of the EMBL/University of Heidelberg Molecular Medicine Partnership Unit since 2002.
ERC Advanced Investigator from 2011 to 2017.
Total: 283 publication(s)
Gegout V, Schlegl J, Schläger B, Hentze MW, Reinbolt J, Ehresmann B, Ehresmann C, Romby P. (1999)
Ligand-induced structural alterations in human iron regulatory protein-1 revealed by protein footprinting
Gehring NH, Hentze MW, Pantopoulos K. (1999)
Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress
Hentze MW, Kulozik AE. (1999)
A perfect message: RNA surveillance and nonsense-mediated decay
Paraskeva E, Gray NK, Schläger B, Wehr K, Hentze MW. (1999)
Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements
Mol. Cell. Biol. 19(1):807-816.
Ostareck-Lederer A, Ostareck DH, Hentze MW. (1998)
Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2
Preiss T, Muckenthaler M, Hentze MW. (1998)
Poly(A)-tail-promoted translation in yeast: implications for translational control
Muckenthaler M, Gray NK, Hentze MW. (1998)
IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F
Pantopoulos K, Hentze MW. (1998)
Activation of iron regulatory protein-1 by oxidative stress in vitro
McKie AT, Wehr K, Simpson RJ, Peters TJ, Hentze MW, Farzaneh F. (1998)
Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption
Paper presented at the 665th Meeting of the Royal-Irish-Academy-Lecture on Peptide Metabolism in Cytoplasm of Brain Cells, HANTS, ENGLAND, MAR 31-APR 02, 1998.Biochem. Soc. Trans. 26(3):S264. doi: 10.1042/bst026s264
Europe PMC | doi
De Gregorio E, Preiss T, Hentze MW. (1998)
Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent
Muckenthaler M, Gunkel N, Frishman D, Cyrklaff A, Tomancak P, Hentze MW. (1998)
Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans
Thermann R, Neu-Yilik G, Deters A, Frede U, Wehr K, Hagemeier C, Hentze MW, Kulozik AE. (1998)
Binary specification of nonsense codons by splicing and cytoplasmic translation
Preiss T, Hentze MW. (1998)
Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast
Gebauer F, Merendino L, Hentze MW, Valcárcel J. (1998)
The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA
Paraskeva E, Atzberger A, Hentze MW. (1998)
A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo
Dandekar T, Beyer K, Bork P, Kenealy MR, Pantopoulos K, Hentze M, Sonntag-Buck V, Flouriot G, Gannon F, Schreiber S. (1998)
Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: combining experimental and computational approaches
Gebauer F, Merendino L, Hentze MW, Valcárcel J. (1997)
Novel functions for 'nuclear factors' in the cytoplasm: the Sex-lethal paradigm
Schlegl J, Gegout V, Schläger B, Hentze MW, Westhof E, Ehresmann C, Ehresmann B, Romby P. (1997)
Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1
Muckenthaler M, Gunkel N, Stripecke R, Hentze MW. (1997)
Regulated poly(A) tail shortening in somatic cells mediated by cap-proximal translational repressor proteins and ribosome association
Sachs AB, Sarnow P, Hentze MW. (1997)
Starting at the beginning, middle, and end: translation initiation in eukaryotes
Ostareck DH, Ostareck-Lederer A, Wilm M, Thiele BJ, Mann M, Hentze MW. (1997)
mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end
Pantopoulos K, Mueller S, Atzberger A, Ansorge W, Stremmel W, Hentze MW. (1997)
Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress
Hentze MW. (1997)
eIF4G: a multipurpose ribosome adapter?
Muckenthaler M, Hentze MW. (1997)
Mechanisms for posttranscriptional regulation by iron-responsive elements and iron regulatory proteins
Prog. Mol. Subcell. Biol. 18:93-115.
Weiss G, Bogdan C, Hentze MW. (1997)
Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13
J. Immunol. 158(1):420-425.
Hentze MW. (1996)
Iron-sulfur clusters and oxidant stress responses
Hentze MW, Kühn LC. (1996)
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
Frishman D, Hentze MW. (1996)
Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships
Pantopoulos K, Weiss G, Hentze MW. (1996)
Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways
Mol. Cell. Biol. 16(7):3781-3788.
Paraskeva E, Hentze MW. (1996)
Iron-sulphur clusters as genetic regulatory switches: the bifunctional iron regulatory protein-1
Gray NK, Pantopoulos K, Dandekar T, Ackrell BA, Hentze MW. (1996)
Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements
Kollmus H, Hentze MW, Hauser H. (1996)
Regulated ribosomal frameshifting by an RNA-protein interaction
Picard V, Renaudie F, Porcher C, Hentze MW, Grandchamp B, Beaumont C. (1996)
Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution
Hentze MW. (1995)
Translational regulation: versatile mechanisms for metabolic and developmental control.
Pantopoulos K, Hentze MW. (1995)
Rapid responses to oxidative stress mediated by iron regulatory protein
Oria R, Sánchez L, Houston T, Hentze MW, Liew FY, Brock JH. (1995)
Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells.
Pantopoulos K, Gray NK, Hentze MW. (1995)
Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB.
Dandekar T, Hentze MW. (1995)
Finding the hairpin in the haystack: searching for RNA motifs.
Kugler W, Enssle J, Hentze MW, Kulozik AE. (1995)
Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?
Pantopoulos K, Hentze MW. (1995)
Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts
Johansson HE, Belsham GJ, Sproat BS, Hentze MW. (1994)
Target-specific arrest of mRNA translation by antisense 2'-O-alkyloligoribonucleotides
Stripecke R, Oliveira CC, McCarthy JE, Hentze MW. (1994)
Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells.
Weiss G, Werner-Felmayer G, Werner ER, Grünewald K, Wachter H, Hentze MW. (1994)
Iron regulates nitric oxide synthase activity by controlling nuclear transcription
Gray NK, Hentze MW. (1994)
Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.
Gray NK, Hentze MW. (1994)
Regulation of protein synthesis by mRNA structure.
Hentze MW. (1994)
Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains?
Pantopoulos K, Weiss G, Hentze MW. (1994)
Nitric oxide and the post-transcriptional control of cellular iron traffic.
Gray NK, Quick S, Goossen B, Constable A, Hirling H, Kühn LC, Hentze MW. (1993)
Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational repressor and an aconitase. A functional assay for translational repression and direct demonstration of the iron switch
Hentze MW. (1993)
Translational control by iron-responsive elements.
Adv. Exp. Med. Biol. 356:119-126.
Melefors O, Hentze MW. (1993)
Iron regulatory factor--the conductor of cellular iron regulation.
Pantopoulos K, Johansson HE, Hentze MW. (1993)
The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies.
Weiss G, Goossen B, Doppler W, Fuchs D, Pantopoulos K, Werner-Felmayer G, Grünewald K, Wachter H, Hentze MW. (1993)
Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase.
Adv. Exp. Med. Biol. 356:133-139.
Enssle J, Kugler W, Hentze MW, Kulozik AE. (1993)
Determination of mRNA fate by different RNA polymerase II promoters
Oliveira CC, Goossen B, Zanchin NI, McCarthy JE, Hentze MW, Stripecke R. (1993)
Translational repression by the human iron-regulatory factor (IRF) in Saccharomyces cerevisiae
Weiss G, Goossen B, Doppler W, Fuchs D, Pantopoulos K, Werner-Felmayer G, Wachter H, Hentze MW. (1993)
Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.
Melefors O, Goossen B, Johansson HE, Stripecke R, Gray NK, Hentze MW. (1993)
Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells.
J. Biol. Chem. 268(8):5974-5978.
Melefors O, Hentze MW. (1993)
Translational regulation by mRNA/protein interactions in eukaryotic cells: ferritin and beyond.
Stripecke R, Hentze MW. (1992)
Bacteriophage and spliceosomal proteins function as position-dependent cis/trans repressors of mRNA translation in vitro
Coccia EM, Profita V, Fiorucci G, Romeo G, Affabris E, Testa U, Hentze MW, Battistini A. (1992)
Modulation of ferritin H-chain expression in Friend erythroleukemia cells: transcriptional and translational regulation by hemin.
Constable A, Quick S, Gray NK, Hentze MW. (1992)
Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?
Goossen B, Hentze MW. (1992)
Position is the critical determinant for function of iron-responsive elements as translational regulators.
Kühn LC, Hentze MW. (1991)
Coordination of cellular iron metabolism by post-transcriptional gene regulation.
Hentze MW. (1991)
Determinants and regulation of cytoplasmic mRNA stability in eukaryotic cells.
Dandekar T, Stripecke R, Gray NK, Goossen B, Constable A, Johansson HE, Hentze MW. (1991)
Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.
Hentze MW, Argos P. (1991)
Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase
Johansson HE, De Groot N, Hochberg AA, Hentze MW. (1991)
Effect of heparin contained in preparations of small cytoplasmic RNAs on cell-free translation.
J. Biol. Chem. 266(3):1921-1925.
Goossen B, Caughman SW, Harford JB, Klausner RD, Hentze MW. (1990)
Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo.
Hentze MW. (1990)
Translational regulation of ferritin biosynthesis by iron: a review.
Curr Stud Hematol Blood Transfus 58(58):115-126.
Hentze MW. (1990)
In: sponsored by the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, September 13-17, 1989., Translational Control, vol 2. pp 33-36.New Biol. 2(1):33-36.
Hentze MW, Goossen B, Caughman SW. (1989)
Complex formation between a cytoplasmic protein and the ferritin mRNA regulates translation initiation.
Haile DJ, Hentze MW, Rouault TA, Harford JB, Klausner RD. (1989)
Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements.
Hentze MW, Seuanez HN, O'Brien SJ, Harford JB, Klausner RD. (1989)
Chromosomal localization of nucleic acid-binding proteins by affinity mapping: assignment of the IRE-binding protein gene to human chromosome 9.
Rouault TA, Hentze MW, Haile DJ, Harford JB, Klausner RD. (1989)
The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.
Koeller DM, Casey JL, Hentze MW, Gerhardt EM, Chan LN, Klausner RD, Harford JB. (1989)
A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.
Hentze MW, Rouault TA, Harford JB, Klausner RD. (1989)
Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.
Caughman SW, Hentze MW, Rouault TA, Harford JB, Klausner RD. (1988)
The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.
J. Biol. Chem. 263(35):19048-19052.
Hentze MW, Caughman SW, Casey JL, Koeller DM, Rouault TA, Harford JB, Klausner RD. (1988)
A model for the structure and functions of iron-responsive elements.
Rouault TA, Hentze MW, Caughman SW, Harford JB, Klausner RD. (1988)
Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA.
Casey JL, Hentze MW, Koeller DM, Caughman SW, Rouault TA, Klausner RD, Harford JB. (1988)
Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.
Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB, Klausner RD. (1987)
Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.
Hentze MW, Rouault TA, Caughman SW, Dancis A, Harford JB, Klausner RD. (1987)
A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.
Rouault TA, Hentze MW, Dancis A, Caughman W, Harford JB, Klausner RD. (1987)
Influence of altered transcription on the translational control of human ferritin expression.
Hentze MW, Keim S, Papadopoulos P, O'Brien S, Modi W, Drysdale J, Leonard WJ, Harford JB, Klausner RD. (1986)
Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.