Total: 47 publication(s)


Fischer TH, Eiringhaus J, Dybkova N, Saadatmand A, Pabel S, Weber S, Wang Y, Köhn M, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Maier LS, Hasenfuß G, El-Armouche A, Sossalla S. (2018)

Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.

Eur. J. Heart Fail. doi: 10.1002/ejhf.1297
Europe PMC | doi

Fontanillo M, Köhn M. (2018)

Microcystins: Synthesis and structure-activity relationship studies toward PP1 and PP2A.

Bioorg Med Chem 26(6) doi: 10.1016/j.bmc.2017.08.040
Europe PMC | doi


Hoeger B, Rios P, Berteotti A, Hoermann B, Duan G, Köhn M. (2017)

Mutational Analysis of a Conserved Glutamate Reveals Unique Mechanistic and Structural Features of the Phosphatase PRL-3.

ACS Omega 2(12):9171-9180. doi: 10.1021/acsomega.7b01208
Europe PMC | doi

Lujan P, Rubio T, Varsano G, Köhn M. (2017)

Keep it on the edge: The post-mitotic midbody as a polarity signal unit.

Commun Integr Biol 10(4) doi: 10.1080/19420889.2017.1338990
Europe PMC | doi

Sukackaite R, Cornacchia D, Jensen MR, Mas PJ, Blackledge M, Enervald E, Duan G, Auchynnikava T, Köhn M, Hart DJ, Buonomo SBC. (2017)

Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1).

Sci Rep 7(1):2119. doi: 10.1038/s41598-017-01910-1
Europe PMC | doi


Luján P, Varsano G, Rubio T, Hennrich ML, Sachsenheimer T, Gálvez-Santisteban M, Martín-Belmonte F, Gavin AC, Brügger B, Köhn M. (2016)

PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position.

J. Cell. Sci. 129(21):4130-4142. doi: 10.1242/jcs.190215
Europe PMC | doi

Rubio T, Köhn M. (2016)

Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3.

Biochem. Soc. Trans. 44(5):1305-1312. doi: 10.1042/bst20160146
Europe PMC | doi

Fahs S, Lujan P, Köhn M. (2016)

Approaches to Study Phosphatases.

ACS Chem. Biol. 11(11):2944-2961. doi: 10.1021/acschembio.6b00570
Europe PMC | doi

Fontanillo M, Zemskov I, Häfner M, Uhrig U, Salvi F, Simon B, Wittmann V, Köhn M. (2016)

Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1.

Angew. Chem. Int. Ed. Engl. 55(45):13985-13989. doi: 10.1002/anie.201606449
Europe PMC | doi

Madroñal N, Delgado-García JM, Fernández-Guizán A, Chatterjee J, Köhn M, Mattucci C, Jain A, Tsetsenis T, Illarionova A, Grinevich V, Gross CT, Gruart A. (2016)

Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells.

Nat Commun 7 doi: 10.1038/ncomms10923
Europe PMC | doi

Li X, Köhn M. (2016)

Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B.

Bioorg. Med. Chem. 24(15) doi: 10.1016/j.bmc.2016.03.030
Europe PMC | doi


Stadlbauer S, Rios P, Ohmori K, Suzuki K, Kohn M. (2015)

Procyanidins Negatively Affect the Activity of the Phosphatases of Regenerating Liver

PLoS One 10(7) doi: 10.1371/journal.pone.0134336
Europe PMC | doi

Knobloch G, Jabari N, Stadlbauer S, Schindelin H, Köhn M, Gohla A. (2015)

Synthesis of hydrolysis-resistant pyridoxal 5'-phosphate analogs and their biochemical and X-ray crystallographic characterization with the pyridoxal phosphatase chronophin.

Bioorg. Med. Chem. 23(12) doi: 10.1016/j.bmc.2015.02.049
Europe PMC | doi

Meyer C, Hoeger B, Chatterjee J, Köhn M. (2015)

Azide-alkyne cycloaddition-mediated cyclization of phosphonopeptides and their evaluation as PTP1B binders and enrichment tools.

Bioorg. Med. Chem. 23(12) doi: 10.1016/j.bmc.2015.03.015
Europe PMC | doi

Köhn M. (2015)

Chemistry and biology of protein and inositol phosphorylation.

Bioorg. Med. Chem. 23(12) doi: 10.1016/j.bmc.2015.04.076
Europe PMC | doi

Pavic K, Duan G, Köhn M. (2015)

VHR/DUSP3 phosphatase: Structure, function and regulation.

FEBS J. 282(10) doi: 10.1111/febs.13263
Europe PMC | doi


Hoeger B, Diether M, Ballester PJ, Köhn M. (2014)

Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver

Eur J Med Chem 88:89-100. doi: 10.1016/j.ejmech.2014.08.060
Europe PMC | doi

Duan G, Li X, Köhn M. (2014)

The human DEPhOsphorylation database DEPOD: a 2015 update.

Nucleic Acids Res. 43(D1) doi: 10.1093/nar/gku1009
Europe PMC | doi

Köhn M, Meijler MM, Kaiser M. (2014)

Building up a chemical proteomics network in europe and beyond

ACS Chem. Biol. 9(8):1647-1648. doi: 10.1021/cb5005299
Europe PMC | doi

Pavic K, Rios P, Dzeyk K, Koehler C, Lemke EA, Köhn M. (2014)

Unnatural Amino Acid Mutagenesis Reveals Dimerization As a Negative Regulatory Mechanism of VHR's Phosphatase Activity

ACS Chem. Biol. 9(7):1451-1459. doi: 10.1021/cb500240n
Europe PMC | doi

Ríos P, Nunes-Xavier CE, Tabernero L, Köhn M, Pulido R. (2014)

Dual-specificity phosphatases as molecular targets for inhibition in human disease

Antioxid. Redox Signal. 20(14):2251-2273. doi: 10.1089/ars.2013.5709
Europe PMC | doi

Meyer C, Hoeger B, Temmerman K, Tatarek-Nossol M, Pogenberg V, Bernhagen J, Wilmanns M, Kapurniotu A, Köhn M. (2014)

Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells

ACS Chem. Biol. 9(3):769-776. doi: 10.1021/cb400903u
Europe PMC | doi


Reither G, Chatterjee J, Beullens M, Bollen M, Schultz C, Köhn M. (2013)

Chemical activators of protein phosphatase-1 induce calcium release inside intact cells

Chem. Biol. 20(9):1179-1186. doi: 10.1016/j.chembiol.2013.07.008
Europe PMC | doi

Chatterjee J, Köhn M. (2013)

Targeting the untargetable: recent advances in the selective chemical modulation of protein phosphatase-1 activity

Curr Opin Chem Biol 17(3):361-368. doi: 10.1016/j.cbpa.2013.04.008
Europe PMC | doi

Li X, Wilmanns M, Thornton J, Köhn M. (2013)

Elucidating human phosphatase-substrate networks

Sci Signal 6(275):rs10. doi: 10.1126/scisignal.2003203
Europe PMC | doi

De Munter S, Köhn M, Bollen M. (2013)

Challenges and opportunities in the development of protein phosphatase-directed therapeutics

ACS Chem. Biol. 8(1):36-45. doi: 10.1021/cb300597g
Europe PMC | doi

Rios P, Li X, Köhn M. (2013)

Molecular mechanisms of the PRL phosphatases

FEBS J. 280(2):505-524. doi: 10.1111/j.1742-4658.2012.08565.x
Europe PMC | doi


Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M, Köhn M. (2012)

Development of a peptide that selectively activates protein phosphatase-1 in living cells

Angew. Chem. Int. Ed. Engl. 51(40):10054-10059. doi: 10.1002/anie.201204308
Europe PMC | doi

Meyer C, Köhn M. (2012)

A molecular tete-a-tete arranged by a designed adaptor protein

Angew. Chem. Int. Ed. Engl. 51(33):8160-8162. doi: 10.1002/anie.201203345
Europe PMC | doi

Pavic K, Köhn M. (2012)

Chemical biology techniques unlock the secrets of casein kinase 2 regulation by phosphorylation and glycosylation

Chembiochem 13(9):1253-1255. doi: 10.1002/cbic.201200235
Europe PMC | doi

Köhn M. (2012)

Omics and chemical biology--a powerful synergism

Curr Opin Chem Biol 16(1-2):204-205. doi: 10.1016/j.cbpa.2012.03.001
Europe PMC | doi

Bru M, Kotkar SP, Kar N, Köhn M. (2012)

Development of a solid phase synthesis strategy for soluble phosphoinositide analogues

Chem Sci 3(6):1893-1902. doi: 10.1039/c2sc01061e
Europe PMC | doi


McParland V, Varsano G, Li X, Thornton J, Baby J, Aravind A, Meyer C, Pavic K, Rios P, Köhn M. (2011)

The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides

Biochemistry 50(35):7579-7590. doi: 10.1021/bi201095z
Europe PMC | doi

Meyer C, Köhn M. (2011)

Efficient scaled-up synthesis of N-alpha-Fmoc-4-Phosphono(difluoromethyl)-L-phenylalanine and its incorporation into peptides

Synthesis (Stuttg) 2011(20):3255-3260. doi: 10.1055/s-0030-1260206
Europe PMC | doi


Weinrich D, Köhn M, Jonkheijm P, Westerlind U, Dehmelt L, Engelkamp H, Christianen PC, Kuhlmann J, Maan JC, Nüsse D, Schröder H, Wacker R, Voges E, Breinbauer R, Kunz H, Niemeyer CM, Waldmann H. (2010)

Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization

Chembiochem 11(2):235-247. doi: 10.1002/cbic.200900559
Europe PMC | doi


McGinty RK, Köhn M, Chatterjee C, Chiang KP, Pratt MR, Muir TW. (2009)

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B

ACS Chem. Biol. 4(11):958-968. doi: 10.1021/cb9002255
Europe PMC | doi

Köhn M. (2009)

Immobilization strategies for small molecule, peptide and protein microarrays

J. Pept. Sci. 15(6):393-397. doi: 10.1002/psc.1130
Europe PMC | doi

Köhn M, Schultz C. (2009)

Chemical biologists gather in Heidelberg

Nat. Chem. Biol. 5(2):66-69. doi: 10.1038/nchembio0209-66
Europe PMC | doi


Schultz C, Köhn M. (2008)

Simultaneous protein tagging in two colors

Chem. Biol. 15(2):91-92. doi: 10.1016/j.chembiol.2008.02.004
Europe PMC | doi

Jonkheijm P, Weinrich D, Köhn M, Engelkamp H, Christianen PC, Kuhlmann J, Maan JC, Nüsse D, Schroeder H, Wacker R, Breinbauer R, Niemeyer CM, Waldmann H. (2008)

Photochemical surface patterning by the thiol-ene reaction

Angew. Chem. Int. Ed. Engl. 47(23):4421-4424. doi: 10.1002/anie.200800101
Europe PMC | doi


Köhn M, Gutierrez-Rodriguez M, Jonkheijm P, Wetzel S, Wacker R, Schroeder H, Prinz H, Niemeyer CM, Breinbauer R, Szedlacsek SE, Waldmann H. (2007)

A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase

Angew. Chem. Int. Ed. Engl. 46(40):7700-7703. doi: 10.1002/anie.200701601
Europe PMC | doi


Watzke A, Köhn M, Gutierrez-Rodriguez M, Wacker R, Schröder H, Breinbauer R, Kuhlmann J, Alexandrov K, Niemeyer CM, Goody RS, Waldmann H. (2006)

Site-selective protein immobilization by Staudinger ligation

Angew. Chem. Int. Ed. Engl. 45(9):1408-1412. doi: 10.1002/anie.200502057
Europe PMC | doi


de Araújo AD, Palomo JM, Cramer J, Köhn M, Schröder H, Wacker R, Niemeyer C, Alexandrov K, Waldmann H. (2005)

Diels-Alder ligation and surface immobilization of proteins

Angew. Chem. Int. Ed. Engl. 45(2):296-301. doi: 10.1002/anie.200502266
Europe PMC | doi


Köhn M, Benito JM, Ortiz Mellet C, Lindhorst TK, García Fernández JM. (2004)

Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: ligands for concanavalin A

Chembiochem 5(6):771-777. doi: 10.1002/cbic.200300807
Europe PMC | doi

Köhn M, Breinbauer R. (2004)

The Staudinger ligation-a gift to chemical biology

Angew. Chem. Int. Ed. Engl. 43(24):3106-3116. doi: 10.1002/anie.200401744
Europe PMC | doi


Breinbauer R, Köhn M. (2003)

Azide-alkyne coupling: a powerful reaction for bioconjugate chemistry

Chembiochem 4(11):1147-1149. doi: 10.1002/cbic.200300705
Europe PMC | doi

Köhn M, Wacker R, Peters C, Schröder H, Soulère L, Breinbauer R, Niemeyer CM, Waldmann H. (2003)

Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays

Angew. Chem. Int. Ed. Engl. 42(47):5830-5834. doi: 10.1002/anie.200352877
Europe PMC | doi