EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: Send a mail


  • PhD 1999, University of Amsterdam, The Netherlands.

  • Postdoc at Utrecht University, The Netherlands and Harvard Medical School, Boston, USA.

  • Assistant Professor, Utrecht University, The Netherlands.

  • Team leader at EMBL since 2008.


Total: 94 publication(s)


Castello A, Fischer B, Frese CK, Horos R, Alleaume AM, Foehr S, Curk T, Krijgsveld J, Hentze MW. (2016)

Comprehensive Identification of RNA-Binding Domains in Human Cells.

MOL CELL 63(4):696-710. doi: 10.1016/j.molcel.2016.06.029
Europe PMC | doi

Sysoev VO, Fischer B, Frese CK, Gupta I, Krijgsveld J, Hentze MW, Castello A, Ephrussi A. (2016)

Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila.

Nat Commun 7:12128. doi: 10.1038/ncomms12128
Europe PMC | doi

Liepelt A, Naarmann-de Vries IS, Simons N, Eichelbaum K, Foehr S, Archer SK, Castello A, Usadel B, Krijgsveld J, Preiss T, Marx G, Hentze MW, Ostareck DH, Ostareck-Lederer A. (2016)

Identification of RNA-binding proteins in macrophages by interactome capture.

Mol. Cell Proteomics doi: 10.1074/mcp.M115.056564
Europe PMC | doi

Virant-Klun I, Leicht S, Hughes C, Krijgsveld J. (2016)

Identification of maturation-specific proteins by single-cell proteomics of human oocytes.

Mol. Cell Proteomics (15):2616-2627. doi: 10.1074/mcp.M115.056887
Europe PMC | doi

Sieber J, Hauer C, Bhuvanagiri M, Leicht S, Krijgsveld J, Neu-Yilik G, Hentze MW, Kulozik AE. (2016)

Proteomic analysis reveals branch-specific regulation of the unfolded protein response by nonsense-mediated mRNA decay.

Mol. Cell Proteomics
Europe PMC

Vargel O, Zhang Y, Kosim K, Ganter K, Foehr S, Mardenborough Y, Shvartsman M, Enright AJ, Krijgsveld J, Lancrin C. (2016)

Activation of the TGF beta pathway impairs endothelial to haematopoietic transition

SCI REP-UK 6 doi: 10.1038/srep21518

Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW. (2016)

Comprehensive Identification of RNA-Binding Proteins by RNA Interactome Capture.

Methods Mol. Biol. 1358:131-139. doi: 10.1007/978-1-4939-3067-8_8
Europe PMC | doi


Dunne M, Leicht S, Krichel B, Mertens HD, Thompson A, Krijgsveld J, Svergun DI, Gómez-Torres N, Garde S, Uetrecht C, Narbad A, Mayer MJ, Meijers R. (2015)

Crystal structure of the CTP1L endolysin reveals how its activity is regulated by a secondary translation product.

J. Biol. Chem. doi: 10.1074/jbc.M115.671172
Europe PMC | doi

Beckmann BM, Horos R, Fischer B, Castello A, Eichelbaum K, Alleaume AM, Schwarzl T, Curk T, Foehr S, Huber W, Krijgsveld J, Hentze MW. (2015)

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs.

Nat Commun 6 doi: 10.1038/ncomms10127
Europe PMC | doi

Schäfer M, Oeing CU, Rohm M, Baysal-Temel E, Lehmann LH, Bauer R, Volz HC, Boutros M, Sohn D, Sticht C, Gretz N, Eichelbaum K, Werner T, Hirt MN, Eschenhagen T, Müller-Decker K, Strobel O, Hackert T, Krijgsveld J, Katus HA, Berriel Diaz M, Backs J, Herzig S. (2015)

Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia.

Mol Metab 5(2):67-78. doi: 10.1016/j.molmet.2015.11.004
Europe PMC | doi

Haberkant P, Stein F, Höglinger D, Gerl MJ, Brügger B, Van Veldhoven PP, Krijgsveld J, Gavin AC, Schultz C. (2015)

Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions.

ACS Chem Biol 11(1):222-230. doi: 10.1021/acschembio.5b00810
Europe PMC | doi

Barra MM, Richards DM, Hansson J, Hofer AC, Delacher M, Hettinger J, Krijgsveld J, Feuerer M. (2015)

Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus.

J Immunol 195(7):3058-3070. doi: 10.4049/jimmunol.1500821
Europe PMC | doi

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA. (2015)

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

Cell Stem Cell 17(4):422-434. doi: 10.1016/j.stem.2015.07.007
Europe PMC | doi


Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE. (2014)

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.

EMBO Mol Med 6(12):1509-1639. doi: 10.15252/emmm.201404461
Europe PMC | doi

Klimmeck D, Cabezas-Wallscheid N, Reyes A, von Paleske L, Renders S, Hansson J, Krijgsveld J, Huber W, Trumpp A. (2014)

Transcriptome-wide Profiling and Posttranscriptional Analysis of Hematopoietic Stem/Progenitor Cell Differentiation toward Myeloid Commitment.

Stem Cell Reports 3(5):858-875. doi: 10.1016/j.stemcr.2014.08.012
Europe PMC | doi

Hughes CS, Foehr S, Garfield DA, Furlong EE, Steinmetz LM, Krijgsveld J. (2014)

Ultrasensitive proteome analysis using paramagnetic bead technology.

Mol. Syst. Biol. 10(10) doi: 10.15252/msb.20145625
Europe PMC | doi

Kronja I, Whitfield ZJ, Yuan B, Dzeyk K, Kirkpatrick J, Krijgsveld J, Orr-Weaver TL. (2014)

Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition.

Proc. Natl. Acad. Sci. U.S.A. 111(45):16023-16028. doi: 10.1073/pnas.1418657111
Europe PMC | doi

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A. (2014)

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

Cell Stem Cell 15(4):507-522. doi: 10.1016/j.stem.2014.07.005
Europe PMC | doi

Haas S, Hansson J, Klimmeck D, Loffler D, Velten L, Uckelmann H, Wurzer S, Prendergast A, Schroeder T, Trumpp A, Krijgsveld J, Essers M. (2014)

Inflammation-driven fast-track differentiation of HSCs into the megakaryocytic lineage

EXP HEMATOL 42(8):S14. doi: 10.1016/j.exphem.2014.07.047

Virant-Klun I, Krijgsveld J, Huntriss J, Rodgers RJ. (2014)

New advances in reproductive biomedicine

Biomed Res Int 2014 doi: 10.1155/2014/529170
Europe PMC | doi

Kronja I, Yuan B, Eichhorn SW, Dzeyk K, Krijgsveld J, Bartel DP, Orr-Weaver TL. (2014)

Widespread Changes in the Posttranscriptional Landscape at the Drosophila Oocyte-to-Embryo Transition

Cell Rep 7(5):1495-1508. doi: 10.1016/j.celrep.2014.05.002
Europe PMC | doi

Eichelbaum K, Krijgsveld J. (2014)

Combining Pulsed SILAC Labeling and Click-Chemistry for Quantitative Secretome Analysis

Methods Mol. Biol. 1174:101-114. doi: 10.1007/978-1-4939-0944-5_7
Europe PMC | doi

Eichelbaum K, Krijgsveld J. (2014)

Rapid temporal dynamics of transcription, protein synthesis, and secretion during macrophage activation

Mol. Cell Proteomics 13:792-810. doi: 10.1074/mcp.m113.030916
Europe PMC | doi

Gonzalez D, Hamidi N, Del Sol R, Benschop JJ, Nancy T, Li C, Francis L, Tzouros M, Krijgsveld J, Holstege FC, Conlan RS. (2014)

Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator

Proc. Natl. Acad. Sci. U.S.A. 111(7):2500-2505. doi: 10.1073/pnas.1307525111
Europe PMC | doi

Polonio-Vallon T, Kirkpatrick J, Krijgsveld J, Hofmann TG. (2014)

Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization

Cell Cycle 13(1):115-125. doi: 10.4161/cc.26857
Europe PMC | doi

Virant-Klun I, Krijgsveld J. (2014)

Proteomes of animal oocytes: what can we learn for human oocytes in the in vitro fertilization programme?

Biomed Res Int 2014:856907. doi: 10.1155/2014/856907
Europe PMC | doi


Yokoyama H, Nakos K, Santarella-Mellwig R, Rybina S, Krijgsveld J, Koffa MD, Mattaj IW. (2013)

CHD4 is a RanGTP-dependent MAP that stabilizes microtubules and regulates bipolar spindle formation

Curr. Biol. 23(24):2443-2451. doi: 10.1016/j.cub.2013.09.062
Europe PMC | doi

Hansson J, Krijgsveld J. (2013)

Proteomic analysis of cell fate decision

Curr. Opin. Genet. Dev. 23(5):540-547. doi: 10.1016/j.gde.2013.06.004
Europe PMC | doi

Kwon SC, Yi H, Eichelbaum K, Föhr S, Fischer B, You KT, Castello A, Krijgsveld J, Hentze MW, Kim VN. (2013)

The RNA-binding protein repertoire of embryonic stem cells

Nat. Struct. Mol. Biol. 20(9):1122-1130. doi: 10.1038/nsmb.2638
Europe PMC | doi

Hettinger J, Richards DM, Hansson J, Barra MM, Joschko AC, Krijgsveld J, Feuerer M. (2013)

Origin of monocytes and macrophages in a committed progenitor

Nat. Immunol. 14(8):821-830. doi: 10.1038/ni.2638
Europe PMC | doi

Okawa S, Fischer B, Krijgsveld J. (2013)

Properties of isotope patterns and their utility for peptide identification in large-scale proteomic experiments

Rapid Commun. Mass Spectrom. 27(9):1067-1075. doi: 10.1002/rcm.6551
Europe PMC | doi

Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW. (2013)

System-wide identification of RNA-binding proteins by interactome capture

Nat Protoc 8(3):491-500. doi: 10.1038/nprot.2013.020
Europe PMC | doi

Dastidar EG, Dzeyk K, Krijgsveld J, Malmquist NA, Doerig C, Scherf A, Lopez-Rubio JJ. (2013)

Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites

PLoS ONE 8(1):e53179. doi: 10.1371/journal.pone.0053179
Europe PMC | doi


Hansson J, Rafiee MR, Reiland S, Polo JM, Gehring J, Okawa S, Huber W, Hochedlinger K, Krijgsveld J. (2012)

Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency

Cell Rep 2(6):1579-1592. doi: 10.1016/j.celrep.2012.10.014
Europe PMC | doi

Hughes C, Krijgsveld J. (2012)

Developments in quantitative mass spectrometry for the analysis of proteome dynamics

Trends Biotechnol. 30(12):668-676. doi: 10.1016/j.tibtech.2012.09.007
Europe PMC | doi

Eichelbaum K, Winter M, Berriel Diaz M, Herzig S, Krijgsveld J. (2012)

Selective enrichment of newly synthesized proteins for quantitative secretome analysis

Nat. Biotechnol. 30(10):984-990. doi: 10.1038/nbt.2356
Europe PMC | doi

Klimmeck D, Hansson J, Raffel S, Vakhrushev SY, Trumpp A, Krijgsveld J. (2012)

Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells

Mol. Cell Proteomics 11(8):286-302. doi: 10.1074/mcp.m111.016790
Europe PMC | doi

Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW. (2012)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

Cell 149(6):1393-1406. doi: 10.1016/j.cell.2012.04.031
Europe PMC | doi

van Hoof D, Krijgsveld J, Mummery C. (2012)

Proteomic analysis of stem cell differentiation and early development

Cold Spring Harb Perspect Biol 4(3):500-501. doi: 10.1101/cshperspect.a008177
Europe PMC | doi

Gouw JW, Krijgsveld J. (2012)

MSQuant: a platform for stable isotope-based quantitative proteomics

Methods Mol. Biol. 893:511-522. doi: 10.1007/978-1-61779-885-6_31
Europe PMC | doi


Kwakman PH, Krijgsveld J, de Boer L, Nguyen LT, Boszhard L, Vreede J, Dekker HL, Speijer D, Drijfhout JW, te Velde AA, Crielaard W, Vogel HJ, Vandenbroucke-Grauls CM, Zaat SA. (2011)

Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements

J. Biol. Chem. 286(50):43506-43514. doi: 10.1074/jbc.m111.248641
Europe PMC | doi

De Vos D, Frederiks F, Terweij M, van Welsem T, Verzijlbergen KF, Iachina E, de Graaf EL, Altelaar AF, Oudgenoeg G, Heck AJ, Krijgsveld J, Bakker BM, van Leeuwen F. (2011)

Progressive methylation of ageing histones by Dot1 functions as a timer

EMBO Rep. 12(9):956-962. doi: 10.1038/embor.2011.131
Europe PMC | doi

Huang HY, Houwing S, Kaaij LJ, Meppelink A, Redl S, Gauci S, Vos H, Draper BW, Moens CB, Burgering BM, Ladurner P, Krijgsveld J, Berezikov E, Ketting RF. (2011)

Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish

EMBO J. 30(16):3298-3308. doi: 10.1038/emboj.2011.228
Europe PMC | doi

Friedman DB, Andacht TM, Bunger MK, Chien AS, Hawke DH, Krijgsveld J, Lane WS, Lilley KS, MacCoss MJ, Moritz RL, Settlage RE, Sherman NE, Weintraub ST, Witkowska HE, Yates NA, Turck CW. (2011)

The ABRF Proteomics Research Group studies: educational exercises for qualitative and quantitative proteomic analyses

Proteomics 11(8):1371-1381. doi: 10.1002/pmic.201000736
Europe PMC | doi

Colbourne JK, Pfrender ME, Gilbert D, Thomas WK, Tucker A, Oakley TH, Tokishita S, Aerts A, Arnold GJ, Basu MK, Bauer DJ, Cáceres CE, Carmel L, Casola C, Choi JH, Detter JC, Dong Q, Dusheyko S, Eads BD, Fröhlich T, Geiler-Samerotte KA, Gerlach D, Hatcher P, Jogdeo S, Krijgsveld J, Kriventseva EV, Kültz D, Laforsch C, Lindquist E, Lopez J, Manak JR, Muller J, Pangilinan J, Patwardhan RP, Pitluck S, Pritham EJ, Rechtsteiner A, Rho M, Rogozin IB, Sakarya O, Salamov A, Schaack S, Shapiro H, Shiga Y, Skalitzky C, Smith Z, Souvorov A, Sung W, Tang Z, Tsuchiya D, Tu H, Vos H, Wang M, Wolf YI, Yamagata H, Yamada T, Ye Y, Shaw JR, Andrews J, Crease TJ, Tang H, Lucas SM, Robertson HM, Bork P, Koonin EV, Zdobnov EM, Grigoriev IV, Lynch M, Boore JL. (2011)

The ecoresponsive genome of Daphnia pulex

Science 331(6017):555-561. doi: 10.1126/science.1197761
Europe PMC | doi

Reiland S, Salekdeh GH, Krijgsveld J. (2011)

Defining pluripotent stem cells through quantitative proteomic analysis

Expert Rev Proteomics 8(1):29-42. doi: 10.1586/epr.10.100
Europe PMC | doi

Gouw JW, Tops BB, Krijgsveld J. (2011)

Metabolic labeling of model organisms using heavy nitrogen (15N)

Methods Mol. Biol. 753:29-42. doi: 10.1007/978-1-61779-148-2_2
Europe PMC | doi


Van Hoof D, Dormeyer W, Braam SR, Passier R, Monshouwer-Kloots J, Ward-van Oostwaard D, Heck AJ, Krijgsveld J, Mummery CL. (2010)

Identification of cell surface proteins for antibody-based selection of human embryonic stem cell-derived cardiomyocytes

J. Proteome Res. 9(3):1610-1618. doi: 10.1021/pr901138a
Europe PMC | doi

Puts CF, Lenoir G, Krijgsveld J, Williamson P, Holthuis JC. (2010)

A P4-ATPase protein interaction network reveals a link between aminophospholipid transport and phosphoinositide metabolism

J. Proteome Res. 9(2):833-842. doi: 10.1021/pr900743b
Europe PMC | doi

Barbu IM, Smith DF, van Breukelen B, van der Burgt YE, Duursma MC, Heck AJ, Heeren RM, Krijgsveld J. (2010)

On-the-fly targeted selection of labeled peptides in liquid chromatography/mass spectrometry based quantitative proteomics

Rapid Commun. Mass Spectrom. 24(2):239-241. doi: 10.1002/rcm.4385
Europe PMC | doi

Gouw JW, Krijgsveld J, Heck AJ. (2010)

Quantitative proteomics by metabolic labeling of model organisms

Mol. Cell Proteomics 9(1):11-24. doi: 10.1074/mcp.r900001-mcp200
Europe PMC | doi

Tops BB, Gauci S, Heck AJ, Krijgsveld J. (2010)

Worms from venus and mars: proteomics profiling of sexual differences in Caenorhabditis elegans using in vivo 15N isotope labeling

J. Proteome Res. 9(1):341-351. doi: 10.1021/pr900678j
Europe PMC | doi


Tsaytler PA, Krijgsveld J, Goerdayal SS, Rüdiger S, Egmond MR. (2009)

Novel Hsp90 partners discovered using complementary proteomic approaches

Cell Stress Chaperones 14(6):629-638. doi: 10.1007/s12192-009-0115-z
Europe PMC | doi

Morinière J, Rousseaux S, Steuerwald U, Soler-López M, Curtet S, Vitte AL, Govin J, Gaucher J, Sadoul K, Hart DJ, Krijgsveld J, Khochbin S, Müller CW, Petosa C. (2009)

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

Nature 461(7264):664-668. doi: 10.1038/nature08397
Europe PMC | doi

Van Hoof D, Muñoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J. (2009)

Phosphorylation dynamics during early differentiation of human embryonic stem cells

Cell Stem Cell 5(2):214-226. doi: 10.1016/j.stem.2009.05.021
Europe PMC | doi

Gauci S, Veenhoff LM, Heck AJ, Krijgsveld J. (2009)

Orthogonal separation techniques for the characterization of the yeast nuclear proteome

J. Proteome Res. 8(7):3451-3463. doi: 10.1021/pr9000948
Europe PMC | doi

Gouw JW, Pinkse MW, Vos HR, Moshkin Y, Verrijzer CP, Heck AJ, Krijgsveld J. (2009)

In vivo stable isotope labeling of fruit flies reveals post-transcriptional regulation in the maternal-to-zygotic transition

Mol. Cell Proteomics 8(7):1566-1578. doi: 10.1074/mcp.m900114-mcp200
Europe PMC | doi

Santema W, Overdijk M, Barends J, Krijgsveld J, Rutten V, Koets A. (2009)

Searching for proteins of Mycobacterium avium subspecies paratuberculosis with diagnostic potential by comparative qualitative proteomic analysis of mycobacterial tuberculins.

Vet. Microbiol. 138(1-2):191-196. doi: 10.1016/j.vetmic.2009.03.021
Europe PMC | doi

Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S. (2009)

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach

Anal. Chem. 81(11):4493-4501. doi: 10.1021/ac9004309
Europe PMC | doi

Jansen FH, Krijgsveld J, van Rijswijk A, van den Bemd GJ, van den Berg MS, van Weerden WM, Willemsen R, Dekker LJ, Luider TM, Jenster G. (2009)

Exosomal secretion of cytoplasmic prostate cancer xenograft-derived proteins

Mol. Cell Proteomics 8(6):1192-1205. doi: 10.1074/mcp.m800443-mcp200
Europe PMC | doi

De Vries E, Bakker N, Krijgsveld J, Knox DP, Heck AJ, Yatsuda AP. (2009)

An AC-5 cathepsin B-like protease purified from Haemonchus contortus excretory secretory products shows protective antigen potential for lambs

Vet. Res. 40(4):41. doi: 10.1051/vetres/2009025
Europe PMC | doi


Gauci S, van Breukelen B, Lemeer SM, Krijgsveld J, Heck AJ. (2008)

A versatile peptide pI calculator for phosphorylated and N-terminal acetylated peptides experimentally tested using peptide isoelectric focusing

Proteomics 8(23-24):4898-4906. doi: 10.1002/pmic.200800295
Europe PMC | doi

Krijgsveld J. (2008)

Human Proteome Organisation's 7th World Congress, 2008

Expert Rev Proteomics 5(6):775-777. doi: 10.1586/14789450.5.6.775
Europe PMC | doi

Van Hoof D, Braam SR, Dormeyer W, Ward-van Oostwaard D, Heck AJ, Krijgsveld J, Mummery CL. (2008)

Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile

Stem Cells 26(11):2777-2781. doi: 10.1634/stemcells.2008-0365
Europe PMC | doi

Dormeyer W, van Hoof D, Mummery CL, Krijgsveld J, Heck AJ. (2008)

A practical guide for the identification of membrane and plasma membrane proteins in human embryonic stem cells and human embryonal carcinoma cells

Proteomics 8(19):4036-4053. doi: 10.1002/pmic.200800143
Europe PMC | doi

Gouw JW, Tops BB, Mortensen P, Heck AJ, Krijgsveld J. (2008)

Optimizing identification and quantitation of 15N-labeled proteins in comparative proteomics

Anal. Chem. 80(20):7796-7803. doi: 10.1021/ac801249v
Europe PMC | doi

Tsaytler PA, C O'Flaherty M, Sakharov DV, Krijgsveld J, Egmond MR. (2008)

Immediate protein targets of photodynamic treatment in carcinoma cells

J. Proteome Res. 7(9):3868-3878. doi: 10.1021/pr800189q
Europe PMC | doi

Van Hoof D, Heck AJ, Krijgsveld J, Mummery CL. (2008)

Proteomics and human embryonic stem cells

Stem Cell Res 1(3):169-182. doi: 10.1016/j.scr.2008.05.003
Europe PMC | doi

Dormeyer W, van Hoof D, Braam SR, Heck AJ, Mummery CL, Krijgsveld J. (2008)

Plasma membrane proteomics of human embryonic stem cells and human embryonal carcinoma cells

J. Proteome Res. 7(7):2936-2951. doi: 10.1021/pr800056j
Europe PMC | doi

Frederiks F, Tzouros M, Oudgenoeg G, van Welsem T, Fornerod M, Krijgsveld J, van Leeuwen F. (2008)

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states

Nat. Struct. Mol. Biol. 15(6):550-557. doi: 10.1038/nsmb.1432
Europe PMC | doi

Whetton AD, Williamson AJ, Krijgsveld J, Lee BH, Lemischka I, Oh S, Pera M, Mummery C, Heck AJ. (2008)

The time is right: proteome biology of stem cells

Cell Stem Cell 2(3):215-217. doi: 10.1016/j.stem.2008.02.003
Europe PMC | doi

Krijgsveld J, Whetton AD, Lee B, Lemischka I, Oh S, Pera M, Mummery C, Heck AJ. (2008)

Proteome biology of stem cells: a new joint HUPO and ISSCR initiative

Mol. Cell Proteomics 7(1):204-205. doi: 10.1074/mcp.h800001-mcp200
Europe PMC | doi


Dormeyer W, Mohammed S, Breukelen Bv, Krijgsveld J, Heck AJ. (2007)

Targeted analysis of protein termini

J. Proteome Res. 6(12):4634-4645. doi: 10.1021/pr070375k
Europe PMC | doi

Heck AJ, Mummery C, Whetton A, Oh S, Lee B, Pera M, Lemischka I, Krijgsveld J. (2007)

Proteome biology of stem cells

Stem Cell Res 1(1):7-8. doi: 10.1016/j.scr.2007.08.001
Europe PMC | doi

Van Hoof D, Pinkse MW, Oostwaard DW, Mummery CL, Heck AJ, Krijgsveld J. (2007)

An experimental correction for arginine-to-proline conversion artifacts in SILAC-based quantitative proteomics

Nat. Methods 4(9):677-678. doi: 10.1038/nmeth0907-677
Europe PMC | doi

Brunner E, Ahrens CH, Mohanty S, Baetschmann H, Loevenich S, Potthast F, Deutsch EW, Panse C, de Lichtenberg U, Rinner O, Lee H, Pedrioli PG, Malmstrom J, Koehler K, Schrimpf S, Krijgsveld J, Kregenow F, Heck AJ, Hafen E, Schlapbach R, Aebersold R. (2007)

A high-quality catalog of the Drosophila melanogaster proteome

Nat. Biotechnol. 25(5):576-583. doi: 10.1038/nbt1300
Europe PMC | doi


Meier N, Krpic S, Rodriguez P, Strouboulis J, Monti M, Krijgsveld J, Gering M, Patient R, Hostert A, Grosveld F. (2006)

Novel binding partners of Ldb1 are required for haematopoietic development

Development 133(24):4913-4923. doi: 10.1242/dev.02656
Europe PMC | doi

van den Bemd GJ, Krijgsveld J, Luider TM, van Rijswijk AL, Demmers JA, Jenster G. (2006)

Mass spectrometric identification of human prostate cancer-derived proteins in serum of xenograft-bearing mice

Mol. Cell Proteomics 5(10):1830-1839. doi: 10.1074/mcp.m500371-mcp200
Europe PMC | doi

Van Hoof D, Mummery CL, Heck AJ, Krijgsveld J. (2006)

Embryonic stem cell proteomics

Expert Rev Proteomics 3(4):427-437. doi: 10.1586/14789450.3.4.427
Europe PMC | doi

Krijgsveld J, Gauci S, Dormeyer W, Heck AJ. (2006)

In-gel isoelectric focusing of peptides as a tool for improved protein identification

J. Proteome Res. 5(7):1721-1730. doi: 10.1021/pr0601180
Europe PMC | doi

Van Hoof D, Passier R, Ward-Van Oostwaard D, Pinkse MW, Heck AJ, Mummery CL, Krijgsveld J. (2006)

A quest for human and mouse embryonic stem cell-specific proteins

Mol. Cell Proteomics 5(7):1261-1273. doi: 10.1074/mcp.m500405-mcp200
Europe PMC | doi

Yatsuda AP, Bakker N, Krijgsveld J, Knox DP, Heck AJ, de Vries E. (2006)

Identification of secreted cysteine proteases from the parasitic nematode Haemonchus contortus detected by biotinylated inhibitors

Infect. Immun. 74(3):1989-1993. doi: 10.1128/iai.74.3.1989-1993.2006
Europe PMC | doi


Rodriguez P, Bonte E, Krijgsveld J, Kolodziej KE, Guyot B, Heck AJ, Vyas P, de Boer E, Grosveld F, Strouboulis J. (2005)

GATA-1 forms distinct activating and repressive complexes in erythroid cells

EMBO J. 24(13):2354-2366. doi: 10.1038/sj.emboj.7600702
Europe PMC | doi

van der Knaap JA, Kumar BR, Moshkin YM, Langenberg K, Krijgsveld J, Heck AJ, Karch F, Verrijzer CP. (2005)

GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7

Mol. Cell 17(5):695-707. doi: 10.1016/j.molcel.2005.02.013
Europe PMC | doi

Neeft M, Wieffer M, de Jong AS, Negroiu G, Metz CH, van Loon A, Griffith J, Krijgsveld J, Wulffraat N, Koch H, Heck AJ, Brose N, Kleijmeer M, van der Sluijs P. (2005)

Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells

Mol. Biol. Cell 16(2):731-741. doi: 10.1091/mbc.e04-10-0923
Europe PMC | doi

van Balkom BW, van Gestel RA, Brouwers JF, Krijgsveld J, Tielens AG, Heck AJ, van Hellemond JJ. (2005)

Mass spectrometric analysis of the Schistosoma mansoni tegumental sub-proteome

J. Proteome Res. 4(3):958-966. doi: 10.1021/pr050036w
Europe PMC | doi


Heck AJ, Krijgsveld J. (2004)

Mass spectrometry-based quantitative proteomics

Expert Rev Proteomics 1(3):317-326. doi: 10.1586/14789450.1.3.317
Europe PMC | doi

Everley PA, Krijgsveld J, Zetter BR, Gygi SP. (2004)

Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research

Mol. Cell Proteomics 3(7):729-735. doi: 10.1074/mcp.m400021-mcp200
Europe PMC | doi

Mohrmann L, Langenberg K, Krijgsveld J, Kal AJ, Heck AJ, Verrijzer CP. (2004)

Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes

Mol. Cell. Biol. 24(8):3077-3088. doi: 10.1128/mcb.24.8.3077-3088.2004
Europe PMC | doi


Houtman R, Krijgsveld J, Kool M, Romijn EP, Redegeld FA, Nijkamp FP, Heck AJ, Humphery-Smith I. (2003)

Lung proteome alterations in a mouse model for nonallergic asthma

Proteomics 3(10):2008-2018. doi: 10.1002/pmic.200300469
Europe PMC | doi

Krijgsveld J, Ketting RF, Mahmoudi T, Johansen J, Artal-Sanz M, Verrijzer CP, Plasterk RH, Heck AJ. (2003)

Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics

Nat. Biotechnol. 21(8):927-931. doi: 10.1038/nbt848
Europe PMC | doi

de Boer E, Rodriguez P, Bonte E, Krijgsveld J, Katsantoni E, Heck A, Grosveld F, Strouboulis J. (2003)

Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice

Proc. Natl. Acad. Sci. U.S.A. 100(13):7480-7485. doi: 10.1073/pnas.1332608100
Europe PMC | doi

Romijn EP, Krijgsveld J, Heck AJ. (2003)

Recent liquid chromatographic-(tandem) mass spectrometric applications in proteomics

J Chromatogr A 1000(1-2):589-608. doi: 10.1016/s0021-9673(03)00178-x
Europe PMC | doi

Yatsuda AP, Krijgsveld J, Cornelissen AW, Heck AJ, de Vries E. (2003)

Comprehensive analysis of the secreted proteins of the parasite Haemonchus contortus reveals extensive sequence variation and differential immune recognition

J. Biol. Chem. 278(19):16941-16951. doi: 10.1074/jbc.m212453200
Europe PMC | doi