EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • PhD in Neuroscience 2008, Albert Einstein College of Medicine, New York, USA
    Postdoctoral research in epigenetics at The Rockefeller University, New York, USA
    Group leader at EMBL since 2014.


Total: 33 publication(s)


Trovato M, Patil V, Gehre M, Noh KM. (2020)

Histone variant H3.3 mutations in defining the chromatin function in mammals.

Cells 9(12) doi: 10.3390/cells9122716
Europe PMC | doi

Bunina D, Abazova N, Diaz N, Noh KM, Krijgsveld J, Zaugg JB. (2020)

Genomic Rewiring of SOX2 Chromatin Interaction Network during Differentiation of ESCs to Postmitotic Neurons.

Cell Syst 10(6):480-494.e8. doi: 10.1016/j.cels.2020.05.003
Europe PMC | doi

Gehre M, Bunina D, Sidoli S, Lübke MJ, Diaz N, Trovato M, Garcia BA, Zaugg JB, Noh KM. (2020)

Lysine 4 of histone H3.3 is required for embryonic stem cell differentiation, histone enrichment at regulatory regions and transcription accuracy.

Nat. Genet. 52(3):273-282. doi: 10.1038/s41588-020-0586-5
Europe PMC | doi


Ochoa D, Jarnuczak AF, Viéitez C, Gehre M, Soucheray M, Mateus A, Kleefeldt AA, Hill A, Garcia-Alonso L, Stein F, Krogan NJ, Savitski MM, Swaney DL, Vizcaíno JA, Noh KM, Beltrao P. (2019)

The functional landscape of the human phosphoproteome.

Nat. Biotechnol. 38(3):365-373. doi: 10.1038/s41587-019-0344-3
Europe PMC | doi


Deliu E, Arecco N, Morandell J, Dotter CP, Contreras X, Girardot C, Käsper EL, Kozlova A, Kishi K, Chiaradia I, Noh KM, Novarino G. (2018)

Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition.

Nat Neurosci 21(12) doi: 10.1038/s41593-018-0266-2
Europe PMC | doi

Mathieson T, Franken H, Kosinski J, Kurzawa N, Zinn N, Sweetman G, Poeckel D, Ratnu VS, Schramm M, Becher I, Steidel M, Noh KM, Bergamini G, Beck M, Bantscheff M, Savitski MM. (2018)

Systematic analysis of protein turnover in primary cells.

Nat Commun 9(1):689. doi: 10.1038/s41467-018-03106-1
Europe PMC | doi


Ruiz-Velasco M, Kumar M, Lai MC, Bhat P, Solis-Pinson AB, Reyes A, Kleinsorg S, Noh KM, Gibson TJ, Zaugg JB. (2017)

CTCF-Mediated Chromatin Loops between Promoter and Gene Body Regulate Alternative Splicing across Individuals.

Cell Syst 5(6) doi: 10.1016/j.cels.2017.10.018
Europe PMC | doi

Lee SM, Lee J, Noh KM, Choi WY, Jeon S, Oh GT, Kim-Ha J, Jin Y, Cho SW, Kim YJ. (2017)

Intragenic CpG islands play important roles in bivalent chromatin assembly of developmental genes.

Proc. Natl. Acad. Sci. U.S.A. 114(10):E1885-E1894. doi: 10.1073/pnas.1613300114
Europe PMC | doi


Noh KM, Allis CD, Li H. (2016)

Reading between the Lines: "ADD"-ing Histone and DNA Methylation Marks toward a New Epigenetic "Sum".

ACS Chem. Biol. 11(3):554-563. doi: 10.1021/acschembio.5b00830
Europe PMC | doi


Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Elsässer SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, Rafii S, Birtwistle MR, Akbarian S, Buchholz BA, Blitzer RD, Nestler EJ, Yuan ZF, Garcia BA, Shen L, Molina H, Allis CD. (2015)

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.

Neuron 87(1):77-94. doi: 10.1016/j.neuron.2015.06.014
Europe PMC | doi

Elsässer SJ, Noh KM, Diaz N, Allis CD, Banaszynski LA. (2015)

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.

Nature 522(7555):240-244. doi: 10.1038/nature14345
Europe PMC | doi

Noh KM, Wang H, Kim HR, Wenderski W, Fang F, Li CH, Dewell S, Hughes SH, Melnick AM, Patel DJ, Li H, Allis CD. (2015)

Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs.

Mol. Cell 59(1):89-103. doi: 10.1016/j.molcel.2015.05.017
Europe PMC | doi

Noh KM, Maze I, Zhao D, Xiang B, Wenderski W, Lewis PW, Shen L, Li H, Allis CD. (2015)

ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.

Proc. Natl. Acad. Sci. U.S.A. 112(22):6820-6827. doi: 10.1073/pnas.1411258112
Europe PMC | doi


Wen D, Noh KM, Goldberg AD, Allis CD, Rosenwaks Z, Rafii S, Banaszynski LA. (2014)

Genome editing a mouse locus encoding a variant histone, H3.3B, to report on its expression in live animals.

Genesis 52(12):959-966. doi: 10.1002/dvg.22827
Europe PMC | doi

Hwang JY, Kaneko N, Noh KM, Pontarelli F, Zukin RS. (2014)

The gene silencing transcription factor REST represses miR-132 expression in hippocampal neurons destined to die.

J. Mol. Biol. 426(20):3454-3466. doi: 10.1016/j.jmb.2014.07.032
Europe PMC | doi

Wen D, Banaszynski LA, Liu Y, Geng F, Noh KM, Xiang J, Elemento O, Rosenwaks Z, Allis CD, Rafii S. (2014)

Histone variant H3.3 is an essential maternal factor for oocyte reprogramming.

Proc. Natl. Acad. Sci. U.S.A. 111(20):7325-7330. doi: 10.1073/pnas.1406389111
Europe PMC | doi

Maze I, Noh KM, Soshnev AA, Allis CD. (2014)

Every amino acid matters: essential contributions of histone variants to mammalian development and disease

Nat. Rev. Genet. 15(4):259-271. doi: 10.1038/nrg3673
Europe PMC | doi


Maze I, Noh KM, Allis CD. (2013)

Histone regulation in the CNS: basic principles of epigenetic plasticity.

Neuropsychopharmacology 38(1):3-22. doi: 10.1038/npp.2012.124
Europe PMC | doi


Noh KM, Hwang JY, Follenzi A, Athanasiadou R, Miyawaki T, Greally JM, Bennett MV, Zukin RS. (2012)

Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death

Proc. Natl. Acad. Sci. U.S.A. 109(16):E962-71. doi: 10.1073/pnas.1121568109
Europe PMC | doi


Lewis PW, Elsaesser SJ, Noh KM, Stadler SC, Allis CD. (2010)

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.

Proc. Natl. Acad. Sci. U.S.A. 107(32):14075-14080. doi: 10.1073/pnas.1008850107
Europe PMC | doi

Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, Boydston EA, Holmes MC, Gregory PD, Greally JM, Rafii S, Yang C, Scambler PJ, Garrick D, Gibbons RJ, Higgs DR, Cristea IM, Urnov FD, Zheng D, Allis CD. (2010)

Distinct factors control histone variant H3.3 localization at specific genomic regions

Cell 140(5):678-691. doi: 10.1016/j.cell.2010.01.003
Europe PMC | doi


Miyawaki T, Ofengeim D, Noh KM, Latuszek-Barrantes A, Hemmings BA, Follenzi A, Zukin RS. (2009)

The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death.

Nat. Neurosci. 12(5):618-626. doi: 10.1038/nn.2299
Europe PMC | doi


Miyawaki T, Mashiko T, Ofengeim D, Flannery RJ, Noh KM, Fujisawa S, Bonanni L, Bennett MV, Zukin RS, Jonas EA. (2008)

Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons.

Proc. Natl. Acad. Sci. U.S.A. 105(12):4892-4897. doi: 10.1073/pnas.0800628105
Europe PMC | doi


Formisano L, Noh KM, Miyawaki T, Mashiko T, Bennett MV, Zukin RS. (2007)

Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons.

Proc. Natl. Acad. Sci. U.S.A. 104(10):4170-4175. doi: 10.1073/pnas.0611704104
Europe PMC | doi


Grooms SY, Noh KM, Regis R, Bassell GJ, Bryan MK, Carroll RC, Zukin RS. (2006)

Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons

J. Neurosci. 26(32):8339-8351. doi: 10.1523/jneurosci.0472-06.2006
Europe PMC | doi


Noh KM, Yokota H, Mashiko T, Castillo PE, Zukin RS, Bennett MV. (2005)

Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death

Proc. Natl. Acad. Sci. U.S.A. 102(34):12230-12235. doi: 10.1073/pnas.0505408102
Europe PMC | doi


Calderone A, Jover T, Mashiko T, Noh KM, Tanaka H, Bennett MV, Zukin RS. (2004)

Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death.

J. Neurosci. 24(44):9903-9913. doi: 10.1523/jneurosci.1713-04.2004
Europe PMC | doi


Calderone A, Jover T, Noh KM, Tanaka H, Yokota H, Lin Y, Grooms SY, Regis R, Bennett MV, Zukin RS. (2003)

Ischemic insults derepress the gene silencer REST in neurons destined to die.

J. Neurosci. 23(6):2112-2121.
Europe PMC

Hong JH, Noh KM, Yoo YE, Choi SY, Park SY, Kim YH, Chung JM. (2003)

Iron promotes the survival and neurite extension of serum-starved PC12 cells in the presence of NGF by enhancing cell attachment.

Mol. Cells 15(1):10-19.
Europe PMC


Noh KM, Koh JY. (2000)

Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes.

J. Neurosci. 20(23)
Europe PMC

Noh KM, Hwang JY, Shin HC, Koh JY. (2000)

A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C.

Neurobiol. Dis. 7(4):375-383. doi: 10.1006/nbdi.2000.0297
Europe PMC | doi


Noh KM, Lee JC, Ahn YH, Hong SH, Koh JY. (1999)

Insulin-induced oxidative neuronal injury in cortical culture: mediation by induced N-methyl-D-aspartate receptors.

IUBMB Life 48(3):263-269. doi: 10.1080/713803514
Europe PMC | doi

Noh KM, Kim YH, Koh JY. (1999)

Mediation by membrane protein kinase C of zinc-induced oxidative neuronal injury in mouse cortical cultures.

J. Neurochem. 72(4):1609-1616. doi: 10.1046/j.1471-4159.1999.721609.x
Europe PMC | doi