EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

ORCID iD: iD icon0000-0002-5017-379X

Biography

  • PhD in Molecular Biology, 2013, University of Göttingen/International Max Planck Research School, Germany.
    Postdoctoral research at Wyss Institute for Biologically Inspired Engineering, Harvard University, USA.
    EMBO Postdoctoral Fellow 2016–2017.
    Human Frontier Science Program Fellow 2017–2019.
    Group leader at EMBL since January 2021.

Publications

Total: 13 publication(s)

2020

Wang Y, Zeng Y, Saka SK, Xie W, Goldaracena I, Kohman RE, Yin P, Church GM. (2020)

Multiplexed in situ protein imaging using DNA-barcoded antibodies with extended hybridization chain reactions.

bioRxiv doi: 10.1101/274456
doi


2019

Liu N, Dai M, Saka SK, Yin P. (2019)

Super-resolution labelling with Action-PAINT.

Nat Chem 11(11):1001-1008. doi: 10.1038/s41557-019-0325-7
Europe PMC | doi

Saka SK, Wang Y, Kishi JY, Zhu A, Zeng Y, Xie W, Kirli K, Yapp C, Cicconet M, Beliveau BJ, Lapan SW, Yin S, Lin M, Boyden ES, Kaeser PS, Pihan G, Church GM, Yin P. (2019)

Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues.

Nat. Biotechnol. 37(9):1080-1090. doi: 10.1038/s41587-019-0207-y
Europe PMC | doi

HuBMAP Consortium (Snyder MP, Lin S, Posgai A, Atkinson M, Regev A, Rood J, Rozenblatt-Rosen O, Gaffney L, Hupalowska A, Satija R, Gehlenborg N, Shendure J, Laskin J, Harbury P, Nystrom NA, Silverstein JC, Bar-Joseph Z, Zhang K, Borner K, Lin Y, Conroy R, Procaccini D, Roy AL, Pillai A, Brown M, Galis ZS, Cai L, Shendure J, Trapnell C, Lin S, Jackson D, Snyder MP, Nolan G, Greenleaf WJ, Lin Y, Plevritis S, Ahadi S, Nevins SA, Lee H, Schuerch CM, Black S, Venkataraaman VG, Esplin E, Horning A, Bahmani A, Zhang K, Sun X, Jain S, Hagood J, Pryhuber G, Kharchenko P, Atkinson M, Bodenmiller B, Brusko T, Clare-Salzler M, Nick H, Otto K, Posgai A, Wasserfall C, Jorgensen M, Brusko M, Maffioletti S, Caprioli RM, Spraggins JM, Gutierrez D, Patterson NH, Neumann EK, Harris R, deCaestecker M, Fogo AB, van de Plas R, Lau K, Cai L, Yuan GC, Zhu Q, Dries R, Yin P, Saka SK, Kishi JY, Wang Y, Goldaracena I, Laskin J, Ye DY, Burnum-Johnson KE, Piehowski PD, Ansong C, Zhu Y, Harbury P, Desai T, Mulye J, Chou P, Nagendran M, Bar-Joseph Z, Teichmann SA, Paten B, Murphy RF, Ma J, Kiselev VY, Kingsford C, Ricarte A, Keays M, Akoju SA, Ruffalo M, Gehlenborg N, Kharchenko P, Vella M, McCallum C, Borner K, Cross LE, Friedman SH, Heiland R, Herr B, Macklin P, Quardokus EM, Record L, Sluka JP, Weber GM, Nystrom NA, Silverstein JC, Blood PD, Ropelewski AJ, Shirey WE, Scibek RM, Mabee P, Lenhardt WC, Robasky K, Michailidis S, Satija R, Marioni J, Regev A, Butler A, Stuart T, Fisher E, Ghazanfar S, Rood J, Gaffney L, Eraslan G, Biancalani T, Vaishnav ED, Conroy R, Procaccini D, Roy A, Pillai A, Brown M, Galis Z, Srinivas P, Pawlyk A, Sechi S, Wilder E, Anderson J). (2019)

The human body at cellular resolution: the NIH Human Biomolecular Atlas Program.

Nature 574(7777):187-192. doi: 10.1038/s41586-019-1629-x
Europe PMC | doi

Kishi JY, Lapan SW, Beliveau BJ, West ER, Zhu A, Sasaki HM, Saka SK, Wang Y, Cepko CL, Yin P. (2019)

SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues.

Nat. Methods 16(6):533-544. doi: 10.1038/s41592-019-0404-0
Europe PMC | doi


2018

Beliveau BJ, Kishi JY, Nir G, Sasaki HM, Saka SK, Nguyen SC, Wu CT, Yin P. (2018)

OligoMiner provides a rapid, flexible environment for the design of genome-scale oligonucleotide in situ hybridization probes.

Proc. Natl. Acad. Sci. U.S.A. 115(10):E2183-E2192. doi: 10.1073/pnas.1714530115
Europe PMC | doi

Schueder F, Lara-Gutiérrez J, Beliveau BJ, Saka SK, Sasaki HM, Woehrstein JB, Strauss MT, Grabmayr H, Yin P, Jungmann R. (2018)

Multiplexed 3D super-resolution imaging of whole cells using spinning disk confocal microscopy and DNA-PAINT.

Nat Commun 8(1) doi: 10.1038/s41467-017-02028-8
Europe PMC | doi


2015

Kabatas S, Vreja IC, Saka SK, Höschen C, Kröhnert K, Opazo F, Rizzoli SO, Diederichsen U. (2015)

A contamination-insensitive probe for imaging specific biomolecules by secondary ion mass spectrometry.

Chem. Commun. (Camb.) 51(67):13221-4. doi: 10.1039/c5cc03895b
Europe PMC | doi

Ta H, Keller J, Haltmeier M, Saka SK, Schmied J, Opazo F, Tinnefeld P, Munk A, Hell SW. (2015)

Mapping molecules in scanning far-field fluorescence nanoscopy.

Nat Commun 6 doi: 10.1038/ncomms8977
Europe PMC | doi

Vreja IC, Kabatas S, Saka SK, Kröhnert K, Höschen C, Opazo F, Diederichsen U, Rizzoli SO. (2015)

Secondary-ion mass spectrometry of genetically encoded targets.

Angew. Chem. Int. Ed. Engl. 54(19):5784-8. doi: 10.1002/anie.201411692
Europe PMC | doi


2014

Saka SK, Honigmann A, Eggeling C, Hell SW, Lang T, Rizzoli SO. (2014)

Multi-protein assemblies underlie the mesoscale organization of the plasma membrane.

Nat Commun 5 doi: 10.1038/ncomms5509
Europe PMC | doi

Saka SK, Vogts A, Kröhnert K, Hillion F, Rizzoli SO, Wessels JT. (2014)

Correlated optical and isotopic nanoscopy.

Nat Commun 5 doi: 10.1038/ncomms4664
Europe PMC | doi


2012

Saka S, Rizzoli SO. (2012)

Super-resolution imaging prompts re-thinking of cell biology mechanisms: selected cases using stimulated emission depletion microscopy.

Bioessays 34(5):386-95. doi: 10.1002/bies.201100080
Europe PMC | doi