EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Publications

Total: 19 publication(s)

2021

Kalxdorf M, Günthner I, Becher I, Kurzawa N, Knecht S, Savitski MM, Eberl HC, Bantscheff M. (2021)

Cell surface thermal proteome profiling tracks perturbations and drug targets on the plasma membrane.

Nat Methods 18(1):84-91. doi: 10.1038/s41592-020-01022-1
Europe PMC | doi


2020

Quintero A, Hübschmann D, Kurzawa N, Steinhauser S, Rentzsch P, Krämer S, Andresen C, Park J, Eils R, Schlesner M, Herrmann C. (2020)

ShinyButchR: interactive NMF-based decomposition workflow of genome-scale datasets.

Biol Methods Protoc 5(1) doi: 10.1093/biomethods/bpaa022
Europe PMC | doi

Kurzawa N, Becher I, Sridharan S, Franken H, Mateus A, Anders S, Bantscheff M, Huber W, Savitski MM. (2020)

A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles.

Nat Commun 11(1) doi: 10.1038/s41467-020-19529-8
Europe PMC | doi

Mateus A, Hevler J, Bobonis J, Kurzawa N, Shah M, Mitosch K, Goemans CV, Helm D, Stein F, Typas A, Savitski MM. (2020)

The functional proteome landscape of Escherichia coli.

Nature 588(7838):473-478. doi: 10.1038/s41586-020-3002-5
Europe PMC | doi

Määttä TA, Rettel M, Sridharan S, Helm D, Kurzawa N, Stein F, Savitski MM. (2020)

Aggregation and disaggregation features of the human proteome.

Mol Syst Biol 16(10) doi: 10.15252/msb.20209500
Europe PMC | doi

Selkrig J, Stanifer M, Mateus A, Mitosch K, Barrio-Hernandez I, Rettel M, Kim H, Voogdt C, Walch P, Kee C, Kurzawa N, Stein F, Potel C, Jarzab A, Kuster B, Bartenschlager R, Boulant S, Beltrao P, Typas A, Savitski MM. (2020)

SARS-CoV-2 infection remodels the host protein thermal stability landscape.

Research Square doi: 10.21203/rs.3.rs-105193/v1
doi

Kurzawa N, Mateus A, Savitski MM. (2020)

Rtpca: an R package for differential thermal proximity coaggregation analysis.

Bioinformatics doi: 10.1093/bioinformatics/btaa682
Europe PMC | doi

Hoermann B, Kokot T, Helm D, Heinzlmeir S, Chojnacki JE, Schubert T, Ludwig C, Berteotti A, Kurzawa N, Kuster B, Savitski MM, Köhn M. (2020)

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A.

Nat Commun 11(1) doi: 10.1038/s41467-020-17334-x
Europe PMC | doi

Jarzab A, Kurzawa N, Hopf T, Moerch M, Zecha J, Leijten N, Bian Y, Musiol E, Maschberger M, Stoehr G, Becher I, Daly C, Samaras P, Mergner J, Spanier B, Werner T, Angelov A, Wilhelm M, Bantscheff M, Lemeer S, Klingenspor M, Hahne H, Liebl W, Kuster B, Savitski MM. (2020)

Meltome atlas-thermal proteome stability across the tree of life.

Nat. Methods 17(5):495-503. doi: 10.1038/s41592-020-0801-4
Europe PMC | doi

Mateus A, Kurzawa N, Becher I, Sridharan S, Helm D, Stein F, Typas A, Savitski MM. (2020)

Thermal proteome profiling for interrogating protein interactions.

Mol. Syst. Biol. 16(3) doi: 10.15252/msb.20199232
Europe PMC | doi

Perrin J, Werner T, Kurzawa N, Rutkowska A, Childs DD, Kalxdorf M, Poeckel D, Stonehouse E, Strohmer K, Heller B, Thomson DW, Krause J, Becher I, Eberl HC, Vappiani J, Rau CE, Sevin DC, Huber W, Franken H, Savitski MM, Faelth-Savitski M, Bergamini G, Bantscheff M. (2020)

Identifying drug targets in tissues and whole blood with thermal-shift profiling.

Nat Biotechnol 38(3):303-308. doi: 10.1038/s41587-019-0388-4
Europe PMC | doi


2019

Childs D, Bach K, Franken H, Anders S, Kurzawa N, Bantscheff M, Savitski M, Huber W. (2019)

Non-parametric analysis of thermal proteome profiles reveals novel drug-binding proteins.

Mol. Cell Proteomics 18(12) doi: 10.1074/mcp.TIR119.001481
Europe PMC | doi

Sridharan S, Kurzawa N, Werner T, Günthner I, Helm D, Huber W, Bantscheff M, Savitski MM. (2019)

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP.

Nat Commun 10(1) doi: 10.1038/s41467-019-09107-y
Europe PMC | doi


2018

Mateus A, Bobonis J, Kurzawa N, Stein F, Helm D, Hevler J, Typas A, Savitski MM. (2018)

Thermal proteome profiling in bacteria: probing protein state in vivo.

Mol. Syst. Biol. 14(7) doi: 10.15252/msb.20188242
Europe PMC | doi

Becher I, Andrés-Pons A, Romanov N, Stein F, Schramm M, Baudin F, Helm D, Kurzawa N, Mateus A, Mackmull MT, Typas A, Müller CW, Bork P, Beck M, Savitski MM. (2018)

Pervasive protein thermal stability variation during the cell cycle.

Cell 173(6) doi: 10.1016/j.cell.2018.03.053
Europe PMC | doi

Mathieson T, Franken H, Kosinski J, Kurzawa N, Zinn N, Sweetman G, Poeckel D, Ratnu VS, Schramm M, Becher I, Steidel M, Noh KM, Bergamini G, Beck M, Bantscheff M, Savitski MM. (2018)

Systematic analysis of protein turnover in primary cells.

Nat Commun 9(1):689. doi: 10.1038/s41467-018-03106-1
Europe PMC | doi


2017

Kurzawa N, Summerfield C, Bogacz R. (2017)

Neural Circuits Trained with Standard Reinforcement Learning Can Accumulate Probabilistic Information during Decision Making.

Neural Comput 29(2):368-393. doi: 10.1162/NECO_a_00917
Europe PMC | doi


2016

Steinhauser S, Kurzawa N, Eils R, Herrmann C. (2016)

A comprehensive comparison of tools for differential ChIP-seq analysis.

Brief Bioinform 17(6):953-966. doi: 10.1093/bib/bbv110
Europe PMC | doi


2014

Beer R, Herbst K, Ignatiadis N, Kats I, Adlung L, Meyer H, Niopek D, Christiansen T, Georgi F, Kurzawa N, Meichsner J, Rabe S, Riedel A, Sachs J, Schessner J, Schmidt F, Walch P, Niopek K, Heinemann T, Eils R, Di Ventura B. (2014)

Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange.

Mol Biosyst 10(7):1709-1718. doi: 10.1039/c3mb70594c
Europe PMC | doi