EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • PhD 1997-2001, Stanford University.
    Postdoctoral research at Stanford Genome Technology Center.
    Visiting group leader at Stanford Genome Technology Center since 2003, Co-Director since 2013.
    Group leader at EMBL since 2003. Senior Scientist since 2009. Joint Head of Genome Biology Unit 2009-2013. Associate Head of Unit 2013-2016.
    Professor of Genetics, Stanford University since 2013. Director of Stanford | EMBL Life Science Alliance since 2017.
    ERC Advanced Investigator since 2012.


Total: 138 publication(s)


Mischo HE, Gómez-González B, Grzechnik P, Rondón AG, Wei W, Steinmetz L, Aguilera A, Proudfoot NJ. (2011)

Yeast Sen1 helicase protects the genome from transcription-associated instability

Mol. Cell 41(1):21-32. doi: 10.1016/j.molcel.2010.12.007
Europe PMC | doi


Nishant KT, Wei W, Mancera E, Argueso JL, Schlattl A, Delhomme N, Ma X, Bustamante CD, Korbel JO, Gu Z, Steinmetz LM, Alani E. (2010)

The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis

PLoS Genet. 6(9):e1001109. doi: 10.1371/journal.pgen.1001109
Europe PMC | doi

Nagarajan M, Veyrieras JB, de Dieuleveult M, Bottin H, Fehrmann S, Abraham AL, Croze S, Steinmetz LM, Gidrol X, Yvert G. (2010)

Natural single-nucleosome epi-polymorphisms in yeast

PLoS Genet. 6(4):e1000913. doi: 10.1371/journal.pgen.1000913
Europe PMC | doi

Zheng W, Zhao H, Mancera E, Steinmetz LM, Snyder M. (2010)

Genetic analysis of variation in transcription factor binding in yeast

Nature 464(7292):1187-1191. doi: 10.1038/nature08934
Europe PMC | doi

Granovskaia MV, Jensen LJ, Ritchie ME, Toedling J, Ning Y, Bork P, Huber W, Steinmetz LM. (2010)

High-resolution transcription atlas of the mitotic cell cycle in budding yeast

Genome Biol. 11(3):R24. doi: 10.1186/gb-2010-11-3-r24
Europe PMC | doi

Guan W, Jiang H, Guo X, Mancera E, Xu L, Li Y, Steinmetz L, Li Y, Gu Z. (2010)

Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen

PLoS ONE 5(6):e11309. doi: 10.1371/journal.pone.0011309
Europe PMC | doi


Blandin SA, Wang-Sattler R, Lamacchia M, Gagneur J, Lycett G, Ning Y, Levashina EA, Steinmetz LM. (2009)

Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae

Science 326(5949):147-150. doi: 10.1126/science.1175241
Europe PMC | doi

Camblong J, Beyrouthy N, Guffanti E, Schlaepfer G, Steinmetz LM, Stutz F. (2009)

Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae

Genes Dev. 23(13):1534-1545. doi: 10.1101/gad.522509
Europe PMC | doi

Bourgon R, Mancera E, Brozzi A, Steinmetz LM, Huber W. (2009)

Array-based genotyping in S.cerevisiae using semi-supervised clustering

Bioinformatics 25(8):1056-1062. doi: 10.1093/bioinformatics/btp104
Europe PMC | doi

Neil H, Malabat C, d'Aubenton-Carafa Y, Xu Z, Steinmetz LM, Jacquier A. (2009)

Widespread bidirectional promoters are the major source of cryptic transcripts in yeast

Nature 457(7232):1038-1042. doi: 10.1038/nature07747
Europe PMC | doi

Xu Z, Wei W, Gagneur J, Perocchi F, Clauder-Münster S, Camblong J, Guffanti E, Stutz F, Huber W, Steinmetz LM. (2009)

Bidirectional promoters generate pervasive transcription in yeast

Nature 457(7232):1033-1037. doi: 10.1038/nature07728
Europe PMC | doi

Gagneur J, Sinha H, Perocchi F, Bourgon R, Huber W, Steinmetz LM. (2009)

Genome-wide allele- and strand-specific expression profiling

Mol. Syst. Biol. 5:274. doi: 10.1038/msb.2009.31
Europe PMC | doi


Aiyar RS, Gagneur J, Steinmetz LM. (2008)

Identification of mitochondrial disease genes through integrative analysis of multiple datasets

Methods 46(4):248-255. doi: 10.1016/j.ymeth.2008.10.002
Europe PMC | doi

Sinha H, David L, Pascon RC, Clauder-Münster S, Krishnakumar S, Nguyen M, Shi G, Dean J, Davis RW, Oefner PJ, McCusker JH, Steinmetz LM. (2008)

Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast

Genetics 180(3):1661-1670. doi: 10.1534/genetics.108.092932
Europe PMC | doi

Mancera E, Bourgon R, Brozzi A, Huber W, Steinmetz LM. (2008)

High-resolution mapping of meiotic crossovers and non-crossovers in yeast

Nature 454(7203):479-485. doi: 10.1038/nature07135
Europe PMC | doi

Perocchi F, Mancera E, Steinmetz LM. (2008)

Systematic screens for human disease genes, from yeast to human and back

Mol Biosyst 4(1):18-29. doi: 10.1039/b709494a
Europe PMC | doi


Wei W, McCusker JH, Hyman RW, Jones T, Ning Y, Cao Z, Gu Z, Bruno D, Miranda M, Nguyen M, Wilhelmy J, Komp C, Tamse R, Wang X, Jia P, Luedi P, Oefner PJ, David L, Dietrich FS, Li Y, Davis RW, Steinmetz LM. (2007)

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789

Proc. Natl. Acad. Sci. U.S.A. 104(31):12825-12830. doi: 10.1073/pnas.0701291104
Europe PMC | doi

Perocchi F, Xu Z, Clauder-Münster S, Steinmetz LM. (2007)

Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D

Nucleic Acids Res. 35(19):e128. doi: 10.1093/nar/gkm683
Europe PMC | doi

Wang-Sattler R, Blandin S, Ning Y, Blass C, Dolo G, Touré YT, delle Torre A, Lanzaro GC, Steinmetz LM, Kafatos FC, Zheng L. (2007)

Mosaic genome architecture of the Anopheles gambiae species complex

PLoS ONE 2(11):e1249. doi: 10.1371/journal.pone.0001249
Europe PMC | doi


Perocchi F, Jensen LJ, Gagneur J, Ahting U, von Mering C, Bork P, Prokisch H, Steinmetz LM. (2006)

Assessing systems properties of yeast mitochondria through an interaction map of the organelle

PLoS Genet. 2(10):e170. doi: 10.1371/journal.pgen.0020170
Europe PMC | doi

Gagneur J, David L, Steinmetz LM. (2006)

Capturing cellular machines by systematic screens of protein complexes

Trends Microbiol. 14(8):336-339. doi: 10.1016/j.tim.2006.06.002
Europe PMC | doi

Huber W, Toedling J, Steinmetz LM. (2006)

Transcript mapping with high-density oligonucleotide tiling arrays

Bioinformatics 22(16):1963-1970. doi: 10.1093/bioinformatics/btl289
Europe PMC | doi

David L, Huber W, Granovskaia M, Toedling J, Palm CJ, Bofkin L, Jones T, Davis RW, Steinmetz LM. (2006)

A high-resolution map of transcription in the yeast genome

Proc. Natl. Acad. Sci. U.S.A. 103(14):5320-5325. doi: 10.1073/pnas.0601091103
Europe PMC | doi

Sinha H, Nicholson BP, Steinmetz LM, McCusker JH. (2006)

Complex genetic interactions in a quantitative trait locus

PLoS Genet. 2(2):e13. doi: 10.1371/journal.pgen.0020013
Europe PMC | doi


Jensen LJ, Steinmetz LM. (2005)

Re-analysis of data and its integration

FEBS Lett. 579(8):1802-1807. doi: 10.1016/j.febslet.2005.02.006
Europe PMC | doi

Gu Z, David L, Petrov D, Jones T, Davis RW, Steinmetz LM. (2005)

Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae

Proc. Natl. Acad. Sci. U.S.A. 102(4):1092-1097. doi: 10.1073/pnas.0409159102
Europe PMC | doi


Prokisch H, Scharfe C, Camp DG 2nd, Xiao W, David L, Andreoli C, Monroe ME, Moore RJ, Gritsenko MA, Kozany C, Hixson KK, Mottaz HM, Zischka H, Ueffing M, Herman ZS, Davis RW, Meitinger T, Oefner PJ, Smith RD, Steinmetz LM. (2004)

Integrative analysis of the mitochondrial proteome in yeast

PLoS Biol. 2(6):e160. doi: 10.1371/journal.pbio.0020160
Europe PMC | doi

Steinmetz LM, Davis RW. (2004)

Maximizing the potential of functional genomics

Nat. Rev. Genet. 5(3):190-201. doi: 10.1038/nrg1293
Europe PMC | doi


Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, Li WH. (2003)

Role of duplicate genes in genetic robustness against null mutations

Nature 421(6918):63-66. doi: 10.1038/nature01198
Europe PMC | doi


Steinmetz LM, Deutschbauer AM. (2002)

Gene function on a genomic scale

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 782(1-2):151-163. doi: 10.1016/s1570-0232(02)00549-4
Europe PMC | doi

Steinmetz LM, Scharfe C, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW. (2002)

Systematic screen for human disease genes in yeast

Nat. Genet. 31(4):400-404. doi: 10.1038/ng929
Europe PMC | doi

Fraser HB, Hirsh AE, Steinmetz LM, Scharfe C, Feldman MW. (2002)

Evolutionary rate in the protein interaction network

Science 296(5568):750-752. doi: 10.1126/science.1068696
Europe PMC | doi

Steinmetz LM, Sinha H, Richards DR, Spiegelman JI, Oefner PJ, McCusker JH, Davis RW. (2002)

Dissecting the architecture of a quantitative trait locus in yeast

Nature 416(6878):326-330. doi: 10.1038/416326a
Europe PMC | doi


Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ. (2001)

Transcriptional regulation and function during the human cell cycle

Nat. Genet. 27(1):48-54. doi: 10.1038/83751
Europe PMC | doi


Steinmetz LM, Mindrinos M, Oefner PJ. (2000)

Combining genome sequences and new technologies for dissecting the genetics of complex phenotypes

Trends Plant Sci. 5(9):397-401. doi: 10.1016/s1360-1385(00)01724-6
Europe PMC | doi

Davis RW. (2000)

High-Density Arrays and Insights into Genome function

In: Unknown, Biotechnology and Genetic Engineering Reviews, vol 17. pp 109-146.doi: http://www.tandfonline.com/doi/ref/10.1080/02648725.2000.10647990#tabModule

Steinmetz LM, Davis RW. (2000)

High-density arrays and insights into genome function

Biotechnol. Genet. Eng. Rev. 17:109-146. doi: 10.1080/02648725.2000.10647990
Europe PMC | doi


Cho RJ, Campbell MJ, Winzeler EA, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ, Davis RW. (1998)

A genome-wide transcriptional analysis of the mitotic cell cycle

Mol. Cell 2(1):65-73. doi: 10.1016/s1097-2765(00)80114-8
Europe PMC | doi