Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Baßler J, Roessler S, Breuhahn K, Zender L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S. (2019)

Nucleoporin Nup155 is part of the p53 network in liver cancer.

Nat Commun 10(1) doi: 10.1038/s41467-019-10133-z
Europe PMC | doi

Romanov N, Kuhn M, Aebersold R, Ori A, Beck M, Bork P. (2019)

Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.

Cell doi: 10.1016/j.cell.2019.03.015
Europe PMC | doi

Beck M, Mosalaganti S, Kosinski J. (2018)

From the resolution revolution to evolution: structural insights into the evolutionary relationships between vesicle coats and the nuclear pore.

Curr. Opin. Struct. Biol. 52:32-40. doi: 10.1016/j.sbi.2018.07.012
Europe PMC | doi

Kehrer J, Kuss C, Andres-Pons A, Reustle A, Dahan N, Devos D, Kudryashev M, Beck M, Mair GR, Frischknecht F. (2018)

Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei.

Sci Rep 8(1) doi: 10.1038/s41598-018-29590-5
Europe PMC | doi

Parca L, Beck M, Bork P, Ori A. (2018)

Quantifying compartment-associated variations of protein abundance in proteomics data.

Mol. Syst. Biol. 14(7) doi: 10.15252/msb.20178131
Europe PMC | doi

Mosalaganti S, Kosinski J, Albert S, Schaffer M, Strenkert D, Salomé PA, Merchant SS, Plitzko JM, Baumeister W, Engel BD, Beck M. (2018)

In situ architecture of the algal nuclear pore complex.

Nat Commun 9(1) doi: 10.1038/s41467-018-04739-y
Europe PMC | doi

Becher I, Andrés-Pons A, Romanov N, Stein F, Schramm M, Baudin F, Helm D, Kurzawa N, Mateus A, Mackmull MT, Typas A, Müller CW, Bork P, Beck M, Savitski MM. (2018)

Pervasive Protein Thermal Stability Variation during the Cell Cycle.

Cell 173(6) doi: 10.1016/j.cell.2018.03.053
Europe PMC | doi

Buczak K, Ori A, Kirkpatrick JM, Holzer K, Dauch D, Roessler S, Endris V, Lasitschka F, Parca L, Schmidt A, Zender L, Schirmacher P, Krijgsveld J, Singer S, Beck M. (2018)

Spatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma.

Mol Cell Proteomics 17(4) doi: 10.1074/mcp.RA117.000189
Europe PMC | doi

Mathieson T, Franken H, Kosinski J, Kurzawa N, Zinn N, Sweetman G, Poeckel D, Ratnu VS, Schramm M, Becher I, Steidel M, Noh KM, Bergamini G, Beck M, Bantscheff M, Savitski MM. (2018)

Systematic analysis of protein turnover in primary cells.

Nat Commun 9(1):689. doi: 10.1038/s41467-018-03106-1
Europe PMC | doi

Otsuka S, Steyer AM, Schorb M, Hériché JK, Hossain MJ, Sethi S, Kueblbeck M, Schwab Y, Beck M, Ellenberg J. (2018)

Postmitotic nuclear pore assembly proceeds by radial dilation of small membrane openings

Nat. Struct. Mol. Biol. 25(1):21-28. doi: 10.1038/s41594-017-0001-9
Europe PMC | doi

Albert S, Schaffer M, Beck F, Mosalaganti S, Asano S, Thomas HF, Plitzko JM, Beck M, Baumeister W, Engel BD. (2017)

Proteasomes tether to two distinct sites at the nuclear pore complex.

Proc. Natl. Acad. Sci. U.S.A. 114(52) doi: 10.1073/pnas.1716305114
Europe PMC | doi

Mackmull MT, Klaus B, Heinze I, Chokkalingam M, Beyer A, Russell RB, Ori A, Beck M. (2017)

Landscape of nuclear transport receptor cargo specificity.

Mol. Syst. Biol. 13(12) doi: 10.15252/msb.20177608
Europe PMC | doi

Beck M, Schirmacher P, Singer S. (2017)

Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.

J Hepatol 67(5):1051-1061. doi: 10.1016/j.jhep.2017.06.021
Europe PMC | doi

Teimer R, Kosinski J, von Appen A, Beck M, Hurt E. (2017)

A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex.

Nat Commun 8(1):107. doi: 10.1038/s41467-017-01160-9
Europe PMC | doi

Sadian Y, Tafur L, Kosinski J, Jakobi AJ, Wetzel R, Buczak K, Hagen WJ, Beck M, Sachse C, Müller CW. (2017)

Structural insights into transcription initiation by yeast RNA polymerase I.

EMBO J 36(18) doi: 10.15252/embj.201796958
Europe PMC | doi

Kastritis PL, O'Reilly FJ, Bock T, Li Y, Rogon MZ, Buczak K, Romanov N, Betts MJ, Bui KH, Hagen WJ, Hennrich ML, Mackmull MT, Rappsilber J, Russell RB, Bork P, Beck M, Gavin AC. (2017)

Capturing protein communities by structural proteomics in a thermophilic eukaryote.

Mol Syst Biol 13(7):936. doi: 10.15252/msb.20167412
Europe PMC | doi

Beck M, Hurt E. (2017)

The nuclear pore complex: understanding its function through structural insight.

Nat. Rev. Mol. Cell Biol. 18(2):73-89. doi: 10.1038/nrm.2016.147
Europe PMC | doi

Dauden MI, Kosinski J, Kolaj-Robin O, Desfosses A, Ori A, Faux C, Hoffmann NA, Onuma OF, Breunig KD, Beck M, Sachse C, Séraphin B, Glatt S, Müller CW. (2016)

Architecture of the yeast Elongator complex

EMBO Rep. 18(2):e201643353. doi: 10.15252/embr.201643353
Europe PMC | doi

Kiosze-Becker K, Ori A, Gerovac M, Heuer A, Nürenberg-Goloub E, Rashid UJ, Becker T, Beckmann R, Beck M, Tampé R. (2016)

Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry.

Nat Commun 7(13248):1-9. doi: 10.1038/ncomms13248
Europe PMC | doi

Scharaw S, Iskar M, Ori A, Boncompain G, Laketa V, Poser I, Lundberg E, Perez F, Beck M, Bork P, Pepperkok R. (2016)

The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.

J. Cell Biol. 215(4):543-558. doi: 10.1083/jcb.201601090
Europe PMC | doi

Beck M, Baumeister W. (2016)

Cryo-Electron Tomography: Can it Reveal the Molecular Sociology of Cells in Atomic Detail?

Trends Cell Biol. 26(11):825-837. doi: 10.1016/j.tcb.2016.08.006
Europe PMC | doi

Otsuka S, Bui KH, Schorb M, Hossain MJ, Politi AZ, Koch B, Eltsov M, Beck M, Ellenberg J. (2016)

Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope

Elife 5 doi: 10.7554/eLife.19071
Europe PMC | doi

Hampoelz B, Mackmull MT, Machado P, Ronchi P, Bui KH, Schieber N, Santarella-Mellwig R, Necakov A, Andrés-Pons A, Philippe JM, Lecuit T, Schwab Y, Beck M. (2016)

Pre-assembled Nuclear Pores Insert into the Nuclear Envelope during Early Development.

Cell 166(3):664-678. doi: 10.1016/j.cell.2016.06.015
Europe PMC | doi

Hoelz A, Glavy JS, Beck M. (2016)

Toward the atomic structure of the nuclear pore complex: when top down meets bottom up.

Nat. Struct. Mol. Biol. 23(7):624-630. doi: 10.1038/nsmb.3244
Europe PMC | doi

Ferber M, Kosinski J, Ori A, Rashid UJ, Moreno-Morcillo M, Simon B, Bouvier G, Batista PR, Müller CW, Beck M, Nilges M. (2016)

Automated structure modeling of large protein assemblies using crosslinks as distance restraints.

Nat. Methods 13(6) doi: 10.1038/nmeth.3838
Europe PMC | doi

Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M. (2016)

Molecular architecture of the inner ring scaffold of the human nuclear pore complex.

Science 352(6283):363-365. doi: 10.1126/science.aaf0643
Europe PMC | doi

Thierry E, Guilligay D, Kosinski J, Bock T, Gaudon S, Round A, Pflug A, Hengrung N, El Omari K, Baudin F, Hart DJ, Beck M, Cusack S. (2016)

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.

Mol. Cell 61(1):125-137. doi: 10.1016/j.molcel.2015.11.016
Europe PMC | doi

Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andrés-Pons A, Singer S, Bork P, Beck M. (2016)

Spatiotemporal variation of mammalian protein complex stoichiometries.

Genome Biol. 17(1) doi: 10.1186/s13059-016-0912-5
Europe PMC | doi

von Appen A, Beck M. (2016)

Structure Determination of the Nuclear Pore Complex with Three-dimensional Cryo Electron Microscopy.

J Mol Biol 428(10 Pt A)):2001-2010.. doi: 10.1016/j.jmb.2016.01.004
Europe PMC | doi

Silva-Martin N, Daudén MI, Glatt S, Hoffmann NA, Kastritis P, Bork P, Beck M, Müller CW. (2016)

The Combination of X-Ray Crystallography and Cryo-Electron Microscopy Provides Insight into the Overall Architecture of the Dodecameric Rvb1/Rvb2 Complex.

PLoS ONE 11(1) doi: 10.1371/journal.pone.0146457
Europe PMC | doi

Poli M, Ori A, Child T, Jaroudi S, Spath K, Beck M, Wells D. (2015)

Characterization and quantification of proteins secreted by single human embryos prior to implantation.

EMBO Mol Med 7(11):1465-1479. doi: 10.15252/emmm.201505344
Europe PMC | doi

Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M. (2015)

Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.

Cell Sys 1(3):224-237. doi: 10.1016/j.cels.2015.08.012
Europe PMC | doi

von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio AL, Vollmer B, Mackmull MT, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, Beck M. (2015)

In situ structural analysis of the human nuclear pore complex.

Nature 526(7571):140-143. doi: 10.1038/nature15381
Europe PMC | doi

Dodonova SO, Diestelkoetter-Bachert P, von Appen A, Hagen WJ, Beck R, Beck M, Wieland F, Briggs JA. (2015)

VESICULAR TRANSPORT. A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly.

Science 349(6244):195-198. doi: 10.1126/science.aab1121
Europe PMC | doi

Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C. (2015)

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation

Nucleic Acids Res 43(15):7600-7611. doi: 10.1093/nar/gkv668
Europe PMC | doi

Male G, von Appen A, Glatt S, Taylor NM, Cristovao M, Groetsch H, Beck M, Müller CW. (2015)

Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly.

Nat Commun 6 doi: 10.1038/ncomms8387
Europe PMC | doi

Hurt E, Beck M. (2015)

Towards understanding nuclear pore complex architecture and dynamics in the age of integrative structural analysis.

Curr. Opin. Cell Biol. 34:31-38. doi: 10.1016/j.ceb.2015.04.009
Europe PMC | doi

Mackmull MT, Iskar M, Parca L, Singer S, Bork P, Ori A, Beck M. (2015)

Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs).

Mol. Cell Proteomics 14(5) doi: 10.1074/mcp.m114.042499
Europe PMC | doi

Calviño FR, Kharde S, Ori A, Hendricks A, Wild K, Kressler D, Bange G, Hurt E, Beck M, Sinning I. (2015)

Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.

Nat Commun 6:6510. doi: 10.1038/ncomms7510
Europe PMC | doi

Kosinski J, von Appen A, Ori A, Karius K, Müller CW, Beck M. (2015)

Xlink Analyzer: Software for analysis and visualization of cross-linking data in the context of three-dimensional structures.

J. Struct. Biol. 189(3):177-183. doi: 10.1016/j.jsb.2015.01.014
Europe PMC | doi

Gaik M, Flemming D, von Appen A, Kastritis P, Mücke N, Fischer J, Stelter P, Ori A, Bui KH, Baßler J, Barbar E, Beck M, Hurt E. (2015)

Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold.

J. Cell Biol. 208(3):283-297. doi: 10.1083/jcb.201411003
Europe PMC | doi

Bock T, Chen WH, Ori A, Malik N, Silva-Martin N, Huerta-Cepas J, Powell ST, Kastritis PL, Smyshlyaev G, Vonkova I, Kirkpatrick J, Doerks T, Nesme L, Baßler J, Kos M, Hurt E, Carlomagno T, Gavin AC, Barabas O, Müller CW, van Noort V, Beck M, Bork P. (2014)

An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum.

Nucleic Acids Res. 42(22):13525-13533. doi: 10.1093/nar/gku1147
Europe PMC | doi

Ostenfeld MS, Jeppesen DK, Laurberg JR, Boysen AT, Bramsen JB, Primdal-Bengtson B, Hendrix A, Lamy P, Dagnaes-Hansen F, Rasmussen MH, Bui KH, Fristrup N, Christensen EI, Nordentoft I, Morth JP, Jensen JB, Pedersen JS, Beck M, Theodorescu D, Borre M, Howard KA, Dyrskjøt L, Orntoft TF. (2014)

Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties

Cancer Res. 74(20):5758-5771. doi: 10.1158/0008-5472.can-13-3512
Europe PMC | doi

Winkler J, Ori A, Holzer K, Sticht C, Dauch D, Eiteneuer EM, Pinna F, Geffers R, Ehemann V, Andres-Pons A, Breuhahn K, Longerich T, Lorenzo Bermejo J, Gretz N, Zender L, Schirmacher P, Beck M, Singer S. (2014)

Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.

Hepatology 60(3):884-895. doi: 10.1002/hep.27207
Europe PMC | doi

Piazza I, Rutkowska A, Ori A, Walczak M, Metz J, Pelechano V, Beck M, Haering CH. (2014)

Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits

Nat. Struct. Mol. Biol. 21(6):560-568. doi: 10.1038/nsmb.2831
Europe PMC | doi

Ori A, Andrés-Pons A, Beck M. (2014)

The use of targeted proteomics to determine the stoichiometry of large macromolecular assemblies.

Methods Cell Biol. 122:117-146. doi: 10.1016/b978-0-12-417160-2.00006-0
Europe PMC | doi

Beck M, Glavy JS. (2014)

Toward understanding the structure of the vertebrate nuclear pore complex

Nucleus 5(2):119-123. doi: 10.4161/nucl.28739
Europe PMC | doi

Bui KH, von Appen A, DiGuilio AL, Ori A, Sparks L, Mackmull MT, Bock T, Hagen W, Andrés-Pons A, Glavy JS, Beck M. (2013)

Integrated structural analysis of the human nuclear pore complex scaffold.

Cell 155(6):1233-1243. doi: 10.1016/j.cell.2013.10.055
Europe PMC | doi

Banterle N, Bui KH, Lemke EA, Beck M. (2013)

Fourier ring correlation as a resolution criterion for super-resolution microscopy

J. Struct. Biol. 183(3):363-367. doi: 10.1016/j.jsb.2013.05.004
Europe PMC | doi

Thierbach K, von Appen A, Thoms M, Beck M, Flemming D, Hurt E. (2013)

Protein interfaces of the conserved Nup84 complex from Chaetomium thermophilum shown by crosslinking mass spectrometry and electron microscopy

Structure 21(9):1672-1682. doi: 10.1016/j.str.2013.07.004
Europe PMC | doi

Milles S, Huy Bui K, Koehler C, Eltsov M, Beck M, Lemke EA. (2013)

Facilitated aggregation of FG nucleoporins under molecular crowding conditions

EMBO Rep. 14(2):178-183. doi: 10.1038/embor.2012.204
Europe PMC | doi

Ori A, Banterle N, Iskar M, Andrés-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M. (2013)

Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines

Mol. Syst. Biol. 9:648. doi: 10.1038/msb.2013.4
Europe PMC | doi

Herzog F, Kahraman A, Boehringer D, Mak R, Bracher A, Walzthoeni T, Leitner A, Beck M, Hartl FU, Ban N, Malmström L, Aebersold R. (2012)

Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry

Science 337(6100):1348-1352. doi: 10.1126/science.1221483
Europe PMC | doi

Walzthoeni T, Claassen M, Leitner A, Herzog F, Bohn S, Förster F, Beck M, Aebersold R. (2012)

False discovery rate estimation for cross-linked peptides identified by mass spectrometry

Nat. Methods 9(9):901-903. doi: 10.1038/nmeth.2103
Europe PMC | doi

Xu M, Beck M, Alber F. (2012)

High-throughput subtomogram alignment and classification by Fourier space constrained fast volumetric matching

J. Struct. Biol. 178(2):152-164. doi: 10.1016/j.jsb.2012.02.014
Europe PMC | doi

Xu M, Beck M, Alber F. (2011)

Template-free detection of macromolecular complexes in cryo electron tomograms

Paper presented at the 19th Annual International Conference on Intelligent Systems for Molecular Biology/10th European Conference on Computational Biology, Vienna, AUSTRIA, JUL 17-19, 2011.Bioinformatics 27(13):i69-76. doi: 10.1093/bioinformatics/btr207
Europe PMC | doi

Reiter L, Rinner O, Picotti P, Hüttenhain R, Beck M, Brusniak MY, Hengartner MO, Aebersold R. (2011)

mProphet: automated data processing and statistical validation for large-scale SRM experiments

Nat. Methods 8(5):430-435. doi: 10.1038/nmeth.1584
Europe PMC | doi

Beck M, Topf M, Frazier Z, Tjong H, Xu M, Zhang S, Alber F. (2011)

Exploring the spatial and temporal organization of a cell's proteome

J. Struct. Biol. 173(3):483-496. doi: 10.1016/j.jsb.2010.11.011
Europe PMC | doi

Beck M, Claassen M, Aebersold R. (2011)

Comprehensive proteomics

Curr. Opin. Biotechnol. 22(1):3-8. doi: 10.1016/j.copbio.2010.09.002
Europe PMC | doi

Beck M, Schmidt A, Malmstroem J, Claassen M, Ori A, Szymborska A, Herzog F, Rinner O, Ellenberg J, Aebersold R. (2011)

The quantitative proteome of a human cell line

Mol. Syst. Biol. 7:549. doi: 10.1038/msb.2011.82
Europe PMC | doi

Schmidt A, Beck M, Malmström J, Lam H, Claassen M, Campbell D, Aebersold R. (2011)

Absolute quantification of microbial proteomes at different states by directed mass spectrometry

Mol. Syst. Biol. 7:510. doi: 10.1038/msb.2011.37
Europe PMC | doi

Bohn S, Beck F, Sakata E, Walzthoeni T, Beck M, Aebersold R, Förster F, Baumeister W, Nickell S. (2010)

Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution

Proc. Natl. Acad. Sci. U.S.A. 107(49):20992-20997. doi: 10.1073/pnas.1015530107
Europe PMC | doi

Leitner A, Walzthoeni T, Kahraman A, Herzog F, Rinner O, Beck M, Aebersold R. (2010)

Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics

Mol. Cell Proteomics 9(8):1634-1649. doi: 10.1074/mcp.r000001-mcp201
Europe PMC | doi

Förster F, Han BG, Beck M. (2010)

Visual proteomics

Meth. Enzymol. 483:215-243. doi: 10.1016/s0076-6879(10)83011-3
Europe PMC | doi

Beck M, Malmström JA, Lange V, Schmidt A, Deutsch EW, Aebersold R. (2009)

Visual proteomics of the human pathogen Leptospira interrogans

Nat. Methods 6(11):817-823. doi: 10.1038/nmeth.1390
Europe PMC | doi

Malmström J, Beck M, Schmidt A, Lange V, Deutsch EW, Aebersold R. (2009)

Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans

Nature 460(7256):762-765. doi: 10.1038/nature08184
Europe PMC | doi

Medalia N, Beer A, Zwickl P, Mihalache O, Beck M, Medalia O, Navon A. (2009)

Architecture and molecular mechanism of PAN, the archaeal proteasome regulatory ATPase

J. Biol. Chem. 284(34):22952-22960. doi: 10.1074/jbc.m809643200
Europe PMC | doi

Beck M, Medalia O. (2008)

Structural and functional insights into nucleocytoplasmic transport

Histol. Histopathol. 23(8):1025-1033.
Europe PMC

Rinner O, Seebacher J, Walzthoeni T, Mueller LN, Beck M, Schmidt A, Mueller M, Aebersold R. (2008)

Identification of cross-linked peptides from large sequence databases

Nat. Methods 5(4):315-318. doi: 10.1038/nmeth.1192
Europe PMC | doi

Beck M, Lucić V, Förster F, Baumeister W, Medalia O. (2007)

Snapshots of nuclear pore complexes in action captured by cryo-electron tomography

Nature 449(7162):611-615. doi: 10.1038/nature06170
Europe PMC | doi

Medalia O, Beck M, Ecke M, Weber I, Neujahr R, Baumeister W, Gerisch G. (2007)

Organization of actin networks in intact filopodia

Curr. Biol. 17(1):79-84. doi: 10.1016/j.cub.2006.11.022
Europe PMC | doi

Garvalov BK, Zuber B, Bouchet-Marquis C, Kudryashev M, Gruska M, Beck M, Leis A, Frischknecht F, Bradke F, Baumeister W, Dubochet J, Cyrklaff M. (2006)

Luminal particles within cellular microtubules

J. Cell Biol. 174(6):759-765. doi: 10.1083/jcb.200606074
Europe PMC | doi

Beck M, Förster F, Ecke M, Plitzko JM, Melchior F, Gerisch G, Baumeister W, Medalia O. (2004)

Nuclear pore complex structure and dynamics revealed by cryoelectron tomography

Science 306(5700):1387-1390. doi: 10.1126/science.1104808
Europe PMC | doi