EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

ORCID iD: iD icon0000-0002-8534-2530


Total: 17 publication(s)


Hammarén HM, Virtanen AT, Abraham BG, Peussa H, Hubbard SR, Silvennoinen O. (2018)

Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.

J Allergy Clin Immunol 143(4) doi: 10.1016/j.jaci.2018.07.022
Europe PMC | doi

Hammarén HM, Virtanen AT, Raivola J, Silvennoinen O. (2018)

The regulation of JAKs in cytokine signaling and its breakdown in disease.

Cytokine 118 doi: 10.1016/j.cyto.2018.03.041
Europe PMC | doi


Puleo DE, Kucera K, Hammarén HM, Ungureanu D, Newton AS, Silvennoinen O, Jorgensen WL, Schlessinger J. (2017)

Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.

ACS Med Chem Lett 8(6):618-621. doi: 10.1021/acsmedchemlett.7b00153
Europe PMC | doi


Hammarén HM, Virtanen AT, Silvennoinen O. (2015)

Nucleotide-binding mechanisms in pseudokinases.

Biosci. Rep. 36(1) doi: 10.1042/BSR20150226
Europe PMC | doi

Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z. (2015)

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).

J. Biol. Chem. 290(45):27261-70. doi: 10.1074/jbc.M115.672048
Europe PMC | doi

Hammarén HM, Ungureanu D, Grisouard J, Skoda RC, Hubbard SR, Silvennoinen O. (2015)

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Proc. Natl. Acad. Sci. U.S.A. 112(15):4642-7. doi: 10.1073/pnas.1423201112
Europe PMC | doi

Pärssinen J, Hammarén H, Rahikainen R, Sencadas V, Ribeiro C, Vanhatupa S, Miettinen S, Lanceros-Méndez S, Hytönen VP. (2015)

Enhancement of adhesion and promotion of osteogenic differentiation of human adipose stem cells by poled electroactive poly(vinylidene fluoride).

J Biomed Mater Res A 103(3):919-28. doi: 10.1002/jbm.a.35234
Europe PMC | doi


Takala H, Lehtivuori H, Hammarén H, Hytönen VP, Ihalainen JA. (2014)

Connection between absorption properties and conformational changes in Deinococcus radiodurans phytochrome.

Biochemistry 53(45):7076-85. doi: 10.1021/bi501180s
Europe PMC | doi

Sanz Sanz A, Niranjan Y, Hammarén H, Ungureanu D, Ruijtenbeek R, Touw IP, Silvennoinen O, Hilhorst R. (2014)

The JH2 domain and SH2-JH2 linker regulate JAK2 activity: A detailed kinetic analysis of wild type and V617F mutant kinase domains.

Biochim. Biophys. Acta 1844(10):1835-41. doi: 10.1016/j.bbapap.2014.07.003
Europe PMC | doi

Shan Y, Gnanasambandan K, Ungureanu D, Kim ET, Hammarén H, Yamashita K, Silvennoinen O, Shaw DE, Hubbard SR. (2014)

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.

Nat. Struct. Mol. Biol. 21(7):579-84. doi: 10.1038/nsmb.2849
Europe PMC | doi

Varghese LN, Ungureanu D, Liau NP, Young SN, Laktyushin A, Hammaren H, Lucet IS, Nicola NA, Silvennoinen O, Babon JJ, Murphy JM. (2014)

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

Biochem. J. 458(2):395-405. doi: 10.1042/BJ20131516
Europe PMC | doi

Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Mudgett MB, Nimchuk Z, Gee CL, Elowe S, Daly RJ, Liu L, Babon JJ, Manning G, Lucet IS. (2014)

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

Biochem. J. 457(2):323-34. doi: 10.1042/BJ20131174
Europe PMC | doi


Javanainen M, Hammaren H, Monticelli L, Jeon JH, Miettinen MS, Martinez-Seara H, Metzler R, Vattulainen I. (2013)

Anomalous and normal diffusion of proteins and lipids in crowded lipid membranes.

Faraday Discuss. 161 doi: 10.1039/c2fd20085f
Europe PMC | doi

Niranjan Y, Ungureanu D, Hammarén H, Sanz-Sanz A, Westphal AH, Borst JW, Silvennoinen O, Hilhorst R. (2013)

Analysis of steady-state Förster resonance energy transfer data by avoiding pitfalls: interaction of JAK2 tyrosine kinase with N-methylanthraniloyl nucleotides.

Anal. Biochem. 442(2):213-22. doi: 10.1016/j.ab.2013.07.020
Europe PMC | doi

Silvennoinen O, Ungureanu D, Niranjan Y, Hammaren H, Bandaranayake R, Hubbard SR. (2013)

New insights into the structure and function of the pseudokinase domain in JAK2.

Biochem. Soc. Trans. 41(4):1002-7. doi: 10.1042/BST20130005
Europe PMC | doi


Leppiniemi J, Määttä JA, Hammaren H, Soikkeli M, Laitaoja M, Jänis J, Kulomaa MS, Hytönen VP. (2011)

Bifunctional avidin with covalently modifiable ligand binding site.

PLoS ONE 6(1) doi: 10.1371/journal.pone.0016576
Europe PMC | doi


Niemelä PS, Miettinen MS, Monticelli L, Hammaren H, Bjelkmar P, Murtola T, Lindahl E, Vattulainen I. (2010)

Membrane proteins diffuse as dynamic complexes with lipids.

J. Am. Chem. Soc. 132(22):7574-5. doi: 10.1021/ja101481b
Europe PMC | doi