EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • PhD 1990, University of Leipzig.
    Habilitation 1995, Humboldt University, Berlin.
    At EMBL since 1991. Head of Unit since 2001.
    Strategic Head of Bioinformatics at EMBL Heidelberg since 2011.
    Group leader in the Molecular Medicine Partnership Unit.
    ERC Advanced Investigator.


Total: 535 publication(s)


Suyama M, Doerks T, Braun IC, Sattler M, Izaurralde E, Bork P. (2000)

Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins

EMBO Rep. 1(1):53-58. doi: 10.1093/embo-reports/kvd009
Europe PMC | doi

Andrade MA, Bork P. (2000)

Automated extraction of information in molecular biology

FEBS Lett. 476(1-2):12-17. doi: 10.1016/s0014-5793(00)01661-6
Europe PMC | doi

Dimopoulos G, Casavant TL, Chang S, Scheetz T, Roberts C, Donohue M, Schultz J, Benes V, Bork P, Ansorge W, Soares MB, Kafatos FC. (2000)

Anopheles gambiae pilot gene discovery project: identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines

Proc. Natl. Acad. Sci. U.S.A. 97(12):6619-6624. doi: 10.1073/pnas.97.12.6619
Europe PMC | doi

Huynen M, Snel B, Lathe W, Bork P. (2000)

Exploitation of gene context

Curr. Opin. Struct. Biol. 10(3):366-370. doi: 10.1016/s0959-440x(00)00098-1
Europe PMC | doi

Schultz J, Doerks T, Ponting CP, Copley RR, Bork P. (2000)

More than 1,000 putative new human signalling proteins revealed by EST data mining

Nat. Genet. 25(2):201-204. doi: 10.1038/76069
Europe PMC | doi

Andrade MA, Ponting CP, Gibson TJ, Bork P. (2000)

Homology-based method for identification of protein repeats using statistical significance estimates

J. Mol. Biol. 298(3):521-537. doi: 10.1006/jmbi.2000.3684
Europe PMC | doi

Brett D, Hanke J, Lehmann G, Haase S, Delbrück S, Krueger S, Reich J, Bork P. (2000)

EST comparison indicates 38% of human mRNAs contain possible alternative splice forms

FEBS Lett. 474(1):83-86. doi: 10.1016/s0014-5793(00)01581-7
Europe PMC | doi

Sunyaev S, Ramensky V, Bork P. (2000)

Towards a structural basis of human non-synonymous single nucleotide polymorphisms

Trends Genet. 16(5):198-200. doi: 10.1016/s0168-9525(00)01988-0
Europe PMC | doi

Bork P. (2000)

Powers and pitfalls in sequence analysis: the 70% hurdle

Genome Res. 10(4):398-400. doi: 10.1101/gr.10.4.398
Europe PMC | doi

Stutz F, Bachi A, Doerks T, Braun IC, Séraphin B, Wilm M, Bork P, Izaurralde E. (2000)

REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export

RNA 6(4):638-650. doi: 10.1017/s1355838200000078
Europe PMC | doi

Otto IM, Raabe T, Rennefahrt UE, Bork P, Rapp UR, Kerkhoff E. (2000)

The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization

Curr. Biol. 10(6):345-348. doi: 10.1016/s0960-9822(00)00388-2
Europe PMC | doi

Isaksson A, Landegren U, Syvänen AC, Bork P, Stein C, Ortigao F, Brookes AJ. (2000)

Discovery, scoring and utilization of human single nucleotide polymorphisms: a multidisciplinary problem

Eur. J. Hum. Genet. 8(2):154-156. doi: 10.1038/sj.ejhg.5200424
Europe PMC | doi

Bork P. (2000)

Analysis of Amino Acid Sequences

Academic Press.
Europe PMC

Bork P (ed). (2000)

Advances in Protein Chemistry

Advances in Protein Chemistry and Structural Biology.
Europe PMC

Bork P, Eisenberg D. (2000)

Genome and proteome informatics - Editorial overview

Curr. Opin. Struct. Biol. 10(3):341-342.
Europe PMC

Bork P, Snel B, Lehmann G, Suyama M, Dandekar T, Lathe W III, Huynen M. (2000)

Comparative genome analysis: exploiting the context of genes to infer evolution and predict function

In: Sankoff D, Nadeau JF (eds), Comparative Genomics. Springer Netherlands. pp 281-294.doi: 10.1007/978-94-011-4309-7_25
Europe PMC | doi

Brookes AJ, Lehväslaiho H, Siegfried M, Boehm JG, Yuan YP, Sarkar CM, Bork P, Ortigao F. (2000)

HGBASE: a database of SNPs and other variations in and around human genes

Nucleic Acids Res. 28(1):356-360. doi: 10.1093/nar/28.1.356
Europe PMC | doi

Ponting CP, Schultz J, Copley RR, Andrade MA, Bork P. (2000)

Evolution of domain families

Adv. Protein Chem. 54:185-244. doi: 10.1016/s0065-3233(00)54007-8
Europe PMC | doi

Schultz J, Copley RR, Doerks T, Ponting CP, Bork P. (2000)

SMART: a web-based tool for the study of genetically mobile domains

Nucleic Acids Res. 28(1):231-234. doi: 10.1093/nar/28.1.231
Europe PMC | doi

Snel B, Bork P, Huynen M. (2000)

Genome evolution. Gene fusion versus gene fission

Trends Genet. 16(1):9-11. doi: 10.1016/s0168-9525(99)01924-1
Europe PMC | doi

Sunyaev S, Hanke J, Brett D, Aydin A, Zastrow I, Lathe W, Bork P, Reich J. (2000)

Individual variation in protein-coding sequences of human genome

Adv. Protein Chem. 54:409-437. doi: 10.1016/s0065-3233(00)54012-1
Europe PMC | doi


Liu Z, Macias MJ, Bottomley MJ, Stier G, Linge JP, Nilges M, Bork P, Sattler M. (1999)

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins

Structure 7(12):1557-1566. doi: 10.1016/s0969-2126(00)88346-x
Europe PMC | doi

Bork P, Huynen MA. (1999)

A point of entry into genomics

Nat. Genet. 23(3):273. doi: 10.1038/15453
Europe PMC | doi

Sunyaev S, Hanke J, Aydin A, Wirkner U, Zastrow I, Reich J, Bork P. (1999)

Prediction of nonsynonymous single nucleotide polymorphisms in human disease-associated genes

J. Mol. Med. 77(11):754-760. doi: 10.1007/s001099900059
Europe PMC | doi

Barnes MR, Russell RB, Copley RR, Ponting CP, Bork P, Cumberledge S, Reichsman F, Moore HM. (1999)

A lipid-binding domain in Wnt: a case of mistaken identity?

Curr. Biol. 9(19):R717-9. doi: 10.1016/s0960-9822(99)80465-5
Europe PMC | doi

Copley RR, Ponting CP, Bork P. (1999)

Phospholipases A2 and Wnts are unlikely to share a common ancestor

Curr. Biol. 9(19):R718-9. doi: 10.1016/s0960-9822(99)80466-7
Europe PMC | doi

Dandekar T, Schuster S, Snel B, Huynen M, Bork P. (1999)

Pathway alignment: application to the comparative analysis of glycolytic enzymes

Biochem. J. 343 Pt 1:115-124. doi: 10.1042/0264-6021:3430115
Europe PMC | doi

Hanke J, Brett D, Zastrow I, Aydin A, Delbrück S, Lehmann G, Luft F, Reich J, Bork P. (1999)

Alternative splicing of human genes: more the rule than the exception?

Trends Genet. 15(10):389-390. doi: 10.1016/s0168-9525(99)01830-2
Europe PMC | doi

Smalla M, Schmieder P, Kelly M, Ter Laak A, Krause G, Ball L, Wahl M, Bork P, Oschkinat H. (1999)

Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites

Protein Sci. 8(10):1954-1961. doi: 10.1110/ps.8.10.1954
Europe PMC | doi

Eisenhaber B, Bork P, Eisenhaber F. (1999)

Prediction of potential GPI-modification sites in proprotein sequences

J. Mol. Biol. 292(3):741-758. doi: 10.1006/jmbi.1999.3069
Europe PMC | doi

Hanke J, Lehmann G, Bork P, Reich JG. (1999)

Associative database of protein sequences

Bioinformatics 15(9):741-748. doi: 10.1093/bioinformatics/15.9.741
Europe PMC | doi

Müller SA, Sasaki T, Bork P, Wolpensinger B, Schulthess T, Timpl R, Engel A, Engel J. (1999)

Domain organization of Mac-2 binding protein and its oligomerization to linear and ring-like structures

J. Mol. Biol. 291(4):801-813. doi: 10.1006/jmbi.1999.2996
Europe PMC | doi

Ponting CP, Hofmann K, Bork P. (1999)

A latrophilin/CL-1-like GPS domain in polycystin-1

Curr. Biol. 9(16):R585-8. doi: 10.1016/s0960-9822(99)80379-0
Europe PMC | doi

Bork P, Dandekar T, Snel B, Huynen MA. (1999)

Genome comparisons to monitor molecular evolution

In: Göbel UB, Ruf BR (eds), Microbial Evolution and Infection: 50. Congress of DGHM and 25. Annual Meeting of DGI. Einhorn-presse Verlag, Reinbek.

Bork P, Doerks T, Springer TA, Snel B. (1999)

Domains in plexins: links to integrins and transcription factors

Trends Biochem. Sci. 24(7):261-263. doi: 10.1016/s0968-0004(99)01416-4
Europe PMC | doi

Huynen MA, Dandekar T, Bork P. (1999)

Variation and evolution of the citric-acid cycle: a genomic perspective

Trends Microbiol. 7(7):281-291. doi: 10.1016/s0966-842x(99)01539-5
Europe PMC | doi

Copley RR, Schultz J, Ponting CP, Bork P. (1999)

Protein families in multicellular organisms

Curr. Opin. Struct. Biol. 9(3):408-415. doi: 10.1016/s0959-440x(99)80055-4
Europe PMC | doi

Morett E, Bork P. (1999)

A novel transactivation domain in parkin

Trends Biochem. Sci. 24(6):229-231. doi: 10.1016/s0968-0004(99)01381-x
Europe PMC | doi

Ponting CP, Aravind L, Schultz J, Bork P, Koonin EV. (1999)

Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer

J. Mol. Biol. 289(4):729-745. doi: 10.1006/jmbi.1999.2827
Europe PMC | doi

Ponting CP, Bork P, Schultz J, Aravind L. (1999)

No Sec7-homology domain in guanine-nucleotide-exchange factors that act on Ras and Rho

Trends Biochem. Sci. 24(5):177-178. doi: 10.1016/s0968-0004(99)01379-1
Europe PMC | doi

Nagle DL, McGrail SH, Vitale J, Woolf EA, Dussault BJ Jr, DiRocco L, Holmgren L, Montagno J, Bork P, Huszar D, Fairchild-Huntress V, Ge P, Keilty J, Ebeling C, Baldini L, Gilchrist J, Burn P, Carlson GA, Moore KJ. (1999)

The mahogany protein is a receptor involved in suppression of obesity

Nature 398(6723):148-152. doi: 10.1038/18210
Europe PMC | doi

Bansal AK, Bork P. (1999)

Applying logic programming ro derive novel functional information of genomes.

Paper presented at the First International Workshop on Practical Aspects of Declarative Languages, PADL'99, San Antonio, Texas, USA, January 1999.In: Gupta G (ed), Lecture notes in computer science 1551: Practical aspects of declarative languages. Springer Verlag. pp 275-289.

Bork P. (1999)

Bioinformatik... (editorial)

Biospektrum 3:172.

Eisenhaber F, Bork P. (1999)

Evaluation of human-readable annotation in biomolecular sequence databases with biological rule libraries

Paper presented at the 1st International Conference on Bioinformatics of Genome Regulation and Structure (BGRS 98), NOVOSIBIRSK, RUSSIA, AUG 24-31, 1998.Bioinformatics 15(7-8):528-535. doi: 10.1093/bioinformatics/15.7.528
Europe PMC | doi

Gibson T, Bork P. (1999)

Sequence analysis, dotplot, aligning sequences, indels and gap-penalty

In: Creighton T (ed.), Encyclopedia of Molecular Biology. Wiley & Sons Inc., New York. pp 86-90; 765-766; 961-962; 1252; 2220-2324.

Huynen M, Snel B, Bork P. (1999)

Lateral Gene Transfer, Genome Surveys, and the Phylogeny of Prokaryotes

Science 286(5444):1443.
Europe PMC

Ponting CP, Schultz J, Milpetz F, Bork P. (1999)

SMART: identification and annotation of domains from signalling and extracellular protein sequences

Nucleic Acids Res. 27(1):229-232. doi: 10.1093/nar/27.1.229
Europe PMC | doi

Snel B, Bork P, Huynen MA. (1999)

Genome phylogeny based on gene content

Nat. Genet. 21(1):108-110. doi: 10.1038/5052
Europe PMC | doi


Cai Y, Bork P. (1998)

Homology-based gene prediction using neural nets

Anal. Biochem. 265(2):269-274. doi: 10.1006/abio.1998.2876
Europe PMC | doi

Eisenhaber B, Bork P, Eisenhaber F. (1998)

Sequence properties of GPI-anchored proteins near the omega-site: constraints for the polypeptide binding site of the putative transamidase

Protein Eng. 11(12):1155-1161. doi: 10.1093/protein/11.12.1155
Europe PMC | doi

Willeke F, Ridder R, Bork P, Klaes R, Mechtersheimer G, Schwarzbach M, Zimmer D, Kloor M, Lehnert T, Herfarth C, von Knebel Doeberitz M. (1998)

Identical variant TSG101 transcripts in soft tissue sarcomas and various non-neoplastic tissues

Mol. Carcinog. 23(4):195-200. doi: 10.1002/(sici)1098-2744(199812)23:4<195::aid-mc1>3.3.co;2-7
Europe PMC | doi

Bork P, Dandekar T, Diaz-Lazcoz Y, Eisenhaber F, Huynen M, Yuan Y. (1998)

Predicting function: from genes to genomes and back

J. Mol. Biol. 283(4):707-725. doi: 10.1006/jmbi.1998.2144
Europe PMC | doi

Dandekar T, Snel B, Huynen M, Bork P. (1998)

Conservation of gene order: a fingerprint of proteins that physically interact

Trends Biochem. Sci. 23(9):324-328. doi: 10.1016/s0968-0004(98)01274-2
Europe PMC | doi

Morett E, Bork P. (1998)

Evolution of new protein function: recombinational enhancer Fis originated by horizontal gene transfer from the transcriptional regulator NtrC

FEBS Lett. 433(1-2):108-112. doi: 10.1016/s0014-5793(98)00888-6
Europe PMC | doi

Huynen M, Doerks T, Eisenhaber F, Orengo C, Sunyaev S, Yuan Y, Bork P. (1998)

Homology-based fold predictions for Mycoplasma genitalium proteins

J. Mol. Biol. 280(3):323-326. doi: 10.1006/jmbi.1998.1884
Europe PMC | doi

Doerks T, Bairoch A, Bork P. (1998)

Protein annotation: detective work for function prediction

Trends Genet. 14(6):248-250. doi: 10.1016/s0168-9525(98)01486-3
Europe PMC | doi

Kharrat A, Millevoi S, Baraldi E, Ponting CP, Bork P, Pastore A. (1998)

Conformational stability studies of the pleckstrin DEP domain: definition of the domain boundaries

Biochim. Biophys. Acta 1385(1):157-164. doi: 10.1016/s0167-4838(98)00041-7
Europe PMC | doi

Bansal A , Bork P, Stuckey P. (1998)


JMMSC 9(1):1-23.

Huynen MA, Bork P. (1998)

Measuring genome evolution

Paper presented at the Colloquium on Computational Biomolecular Science, IRVINE, CALIFORNIA, SEP 11-13, 1997.Proc. Natl. Acad. Sci. U.S.A. 95(11):5849-5856. doi: 10.1073/pnas.95.11.5849
Europe PMC | doi

Schultz J, Milpetz F, Bork P, Ponting CP. (1998)

SMART, a simple modular architecture research tool: identification of signaling domains

Paper presented at the Colloquium on Computational Biomolecular Science, IRVINE, CALIFORNIA, SEP 11-13, 1997.Proc. Natl. Acad. Sci. U.S.A. 95(11):5857-5864. doi: 10.1073/pnas.95.11.5857
Europe PMC | doi

Bork P, Koonin EV. (1998)

Predicting functions from protein sequences--where are the bottlenecks?

Nat. Genet. 18(4):313-318. doi: 10.1038/ng0498-313
Europe PMC | doi

Eisenhaber F, Bork P. (1998)

Wanted: subcellular localization of proteins based on sequence

Trends Cell Biol. 8(4):169-170. doi: 10.1016/s0962-8924(98)01226-4
Europe PMC | doi

Huynen M, Dandekar T, Bork P. (1998)

Differential genome analysis applied to the species-specific features of Helicobacter pylori

FEBS Lett. 426(1):1-5. doi: 10.1016/s0014-5793(98)00276-2
Europe PMC | doi

Beckmann G, Hanke J, Bork P, Reich JG. (1998)

Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins

J. Mol. Biol. 275(5):725-730. doi: 10.1006/jmbi.1997.1510
Europe PMC | doi

Bork P, Dandekar T, Eisenhaber F, Huynen M. (1998)

Characterization of targeting domains by sequence analysis: glycogen-binding domains in protein phosphatases

J. Mol. Med. 76(2):77-79. doi: 10.1007/s001090050194
Europe PMC | doi

Bork P, Eisenberg D. (1998)

Sequences and topology - Deriving biological knowledge from genomic sequences

Curr. Opin. Struct. Biol. 8(3):331-332.
Europe PMC

Brown NP, Sander C, Bork P. (1998)

Frame: detection of genomic sequencing errors

Bioinformatics 14(4):367-371. doi: 10.1093/bioinformatics/14.4.367
Europe PMC | doi

Dandekar T, Beyer K, Bork P, Kenealy MR, Pantopoulos K, Hentze M, Sonntag-Buck V, Flouriot G, Gannon F, Schreiber S. (1998)

Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: combining experimental and computational approaches

Paper presented at the German Conference on Bioinformatics (GCB 97), KLOSTER IRSEE, GERMANY, SEP, 1997.Bioinformatics 14(3):271-278. doi: 10.1093/bioinformatics/14.3.271
Europe PMC | doi

Schuster S, Fell DA, Pfeiffer T, Dandekar T, Bork, P. (1998)

Elementary modes analysis illustrated with human red cell metabolism

In: Larsson, C., Pahlman, I.-L. & Gustafsson, L. (eds.), BioThermoKinectis in the Post Genomic Era. pp 332-339.

Schwirzke M, Gnirke A, Bork P, Tarin D, Weidle UH. (1998)

Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis

Anticancer Res. 18(3A):1409-1421.
Europe PMC

Yuan YP, Eulenstein O, Vingron M, Bork P. (1998)

Towards detection of orthologues in sequence databases

Paper presented at the German Conference on Bioinformatics (GCB 97), KLOSTER IRSEE, GERMANY, SEP, 1997.Bioinformatics 14(3):285-289. doi: 10.1093/bioinformatics/14.3.285
Europe PMC | doi


Hegyi H, Lai JM, Bork P. (1997)

The Sequence Alerting Server--a new WEB server

Comput. Appl. Biosci. 13(6):619-620.
Europe PMC

Morozov V, Mushegian AR, Koonin EV, Bork P. (1997)

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

Trends Biochem. Sci. 22(11):417-418. doi: 10.1016/s0968-0004(97)01128-6
Europe PMC | doi

Green EA, Pietrokovski S, Henikoff S, Bork P, Attwood T, Hood L, Bairoch A. (1997)

Genome maps 8. Building gene families. Wall chart

Science 278(5338):615-630. doi: 10.1126/science.278.5338.615
Europe PMC | doi

Henikoff S, Greene EA, Pietrokovski S, Bork P, Attwood TK, Hood L. (1997)

Gene families: the taxonomy of protein paralogs and chimeras

Science 278(5338):609-614. doi: 10.1126/science.278.5338.609
Europe PMC | doi

Huynen MA, Diaz-Lazcoz Y, Bork P. (1997)

Differential genome display

Trends Genet. 13(10):389-390. doi: 10.1016/s0168-9525(97)01255-9
Europe PMC | doi

Bork P, Schultz J, Ponting CP. (1997)

Cytoplasmic signalling domains: the next generation

Trends Biochem. Sci. 22(8):296-298. doi: 10.1016/s0968-0004(97)01084-0
Europe PMC | doi

Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E. (1997)

A novel class of RanGTP binding proteins

J. Cell Biol. 138(1):65-80. doi: 10.1083/jcb.138.1.65
Europe PMC | doi

Hegyi H, Bork P. (1997)

On the classification and evolution of protein modules

J. Protein Chem. 16(5):545-551. doi: 10.1023/a:1026382032119
Europe PMC | doi

Ponting CP, Cai YD, Bork P. (1997)

The breast cancer gene product TSG101: a regulator of ubiquitination?

J. Mol. Med. 75(7):467-469.
Europe PMC

Ponting C, Schultz J, Bork P. (1997)

SPRY domains in ryanodine receptors (Ca(2+)-release channels)

Trends Biochem. Sci. 22(6):193-194. doi: 10.1016/s0968-0004(97)01049-9
Europe PMC | doi

Mushegian AR, Bassett DE Jr, Boguski MS, Bork P, Koonin EV. (1997)

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

Proc. Natl. Acad. Sci. U.S.A. 94(11):5831-5836. doi: 10.1073/pnas.94.11.5831
Europe PMC | doi

Bork P. (1997)

Bioinformatics and molecular medicine--introduction and call for papers

J. Mol. Med. 75(1):3-4.
Europe PMC

Bork P, Hofmann K, Bucher P, Neuwald AF, Altschul SF, Koonin EV. (1997)

A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins

FASEB J. 11(1):68-76.
Europe PMC

Schultz J, Ponting CP, Hofmann K, Bork P. (1997)

SAM as a protein interaction domain involved in developmental regulation

Protein Sci. 6(1):249-253. doi: 10.1002/pro.5560060128
Europe PMC | doi

Yuan YP, Schultz J, Mlodzik M, Bork P. (1997)

Secreted fringe-like signaling molecules may be glycosyltransferases

Cell 88(1):9-11. doi: 10.1016/s0092-8674(00)81852-8
Europe PMC | doi


Gibson TJ, Koonin EV, Musco G, Pastore A, Bork P. (1996)

Friedreich's ataxia protein: phylogenetic evidence for mitochondrial dysfunction

Trends Neurosci. 19(11):465-468. doi: 10.1016/s0166-2236(96)20054-2
Europe PMC | doi

Nagle DL, Karim MA, Woolf EA, Holmgren L, Bork P, Misumi DJ, McGrail SH, Dussault BJ Jr, Perou CM, Boissy RE, Duyk GM, Spritz RA, Moore KJ. (1996)

Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome

Nat. Genet. 14(3):307-311. doi: 10.1038/ng1196-307
Europe PMC | doi

Bork P, Bairoch A. (1996)

Go hunting in sequence databases but watch out for the traps

Trends Genet. 12(10):425-427. doi: 10.1016/0168-9525(96)60040-7
Europe PMC | doi

Henrissat B, Bork P. (1996)

On the classification of modular proteins

Protein Eng. 9(9):725-726. doi: 10.1093/protein/9.9.725
Europe PMC | doi

Koonin EV, Mushegian AR, Bork P. (1996)

Non-orthologous gene displacement

Trends Genet. 12(9):334-336. doi: 10.1016/0168-9525(96)20010-1
Europe PMC | doi

Okumura M, Matthews RJ, Robb B, Litman GW, Bork P, Thomas ML. (1996)

Comparison of CD45 extracellular domain sequences from divergent vertebrate species suggests the conservation of three fibronectin type III domains

J. Immunol. 157(4):1569-1575.
Europe PMC

Bork P, Brown NP, Hegyi H, Schultz J. (1996)

The protein phosphatase 2C (PP2C) superfamily: detection of bacterial homologues

Protein Sci. 5(7):1421-1425. doi: 10.1002/pro.5560050720
Europe PMC | doi

Koonin EV, Altschul SF, Bork P. (1996)

BRCA1 protein products ... Functional motifs..

Nat. Genet. 13(3):266-268. doi: 10.1038/ng0796-266
Europe PMC | doi

Ponting CP, Bork P. (1996)

Pleckstrin's repeat performance: a novel domain in G-protein signaling?

Trends Biochem. Sci. 21(7):245-246. doi: 10.1016/0968-0004(96)30027-3
Europe PMC | doi

Bork P, Koonin EV. (1996)

Protein sequence motifs

Curr. Opin. Struct. Biol. 6(3):366-376. doi: 10.1016/s0959-440x(96)80057-1
Europe PMC | doi

Bork P, Blomberg N, Nilges M. (1996)

Internal repeats in the BRCA2 protein sequence

Nat. Genet. 13(1):22-23. doi: 10.1038/ng0596-22
Europe PMC | doi

Bork P, Downing AK, Kieffer B, Campbell ID. (1996)

Structure and distribution of modules in extracellular proteins

Q. Rev. Biophys. 29(2):119-167. doi: 10.1017/s0033583500005783
Europe PMC | doi

Koonin EV, Bork P. (1996)

Ancient duplication of DNA polymerase inferred from analysis of complete bacterial genomes

Trends Biochem. Sci. 21(4):128-129. doi: 10.1016/0968-0004(96)30007-8
Europe PMC | doi

Bork P. (1996)

Sperm-egg binding protein or proto-oncogene?

Science 271(5254):1431-2; author reply 1434-5. doi: 10.1126/science.271.5254.1431
Europe PMC | doi