EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • PhD 1984, Cambridge University.
    Postdoctoral research at the Laboratory of Molecular Biology, Cambridge.
    At EMBL since 1986.
    Team leader at EMBL since 1996.


Total: 153 publication(s)


Gibson TJ, Ramu C, Gemünd C, Aasland R. (1998)

The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor

Trends Biochem. Sci. 23(7):242-244. doi: 10.1016/s0968-0004(98)01231-6
Europe PMC | doi

Gibson TJ, Spring J. (1998)

Genetic redundancy in vertebrates: polyploidy and persistence of genes encoding multidomain proteins

Trends Genet. 14(2):46-9; discussion 49-50. doi: 10.1016/s0168-9525(97)01367-x
Europe PMC | doi


Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. (1997)

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

Nucleic Acids Res. 25(24):4876-4882. doi: 10.1093/nar/25.24.4876
Europe PMC | doi

Musco G, Kharrat A, Stier G, Fraternali F, Gibson TJ, Nilges M, Pastore A. (1997)

The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome

NAT STRUCT BIOL 4(9):712-716. doi: 10.1038/nsb0997-712
Europe PMC | doi


Gibson TJ, Koonin EV, Musco G, Pastore A, Bork P. (1996)

Friedreich's ataxia protein: phylogenetic evidence for mitochondrial dysfunction

Trends Neurosci. 19(11):465-468. doi: 10.1016/s0166-2236(96)20054-2
Europe PMC | doi

Birney E, Thompson JD, Gibson TJ. (1996)

PairWise and SearchWise: finding the optimal alignment in a simultaneous comparison of a protein profile against all DNA translation frames

Nucleic Acids Res. 24(14):2730-2739. doi: 10.1093/nar/24.14.2730
Europe PMC | doi

Musco G, Stier G, Joseph C, Castiglione Morelli MA, Nilges M, Gibson TJ, Pastore A. (1996)

Three-dimensional structure and stability of the KH domain: molecular insights into the fragile X syndrome.

Cell 85(2):237-45. doi: 10.1016/S0092-8674(00)81100-9
Europe PMC | doi

Aasland R, Stewart AF, Gibson T. (1996)

The SANT domain: A putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional corepressor N-CoR and TFIIIB

Trends Biochem Sci 21(3):87-88. doi: 10.1016/0968-0004(96)30009-1
Europe PMC | doi

Bork P, Gibson TJ. (1996)

Applying motif and profile searches

Meth. Enzymol. 266:162-184. doi: 10.1016/s0076-6879(96)66013-3
Europe PMC | doi

Higgins DG, Thompson JD, Gibson TJ. (1996)

Using CLUSTAL for multiple sequence alignments

Method Enzymol 266:383-402.
Europe PMC


Winder SJ, Gibson TJ, Kendrick-Jones J. (1995)

Dystrophin and utrophin: the missing links!

FEBS Lett 369(1):27-33. doi: 10.1016/0014-5793(95)00398-S
Europe PMC | doi

Kharrat A, Macias MJ, Gibson TJ, Nilges M, Pastore A. (1995)

Structure of the dsRNA binding domain of E. coli RNase III.

EMBO J 14(14):3572-84. doi: 10.1002/j.1460-2075.1995.tb07363.x
Europe PMC | doi

Aasland R, Gibson TJ, Stewart AF. (1995)

The PHD finger: implications for chromatin-mediated transcriptional regulation.

Trends Biochem Sci 20(2):56-9. doi: 10.1016/S0968-0004(00)88957-4
Europe PMC | doi

Castiglone Morelli MA, Stier G, Gibson T, Joseph C, Musco G, Pastore A, Travè G. (1995)

The KH module has an alpha beta fold.

FEBS Lett 358(2):193-8. doi: 10.1016/0014-5793(94)01422-W
Europe PMC | doi


Thompson JD, Higgins DG, Gibson TJ. (1994)

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Nucleic Acids Res. 22(22):4673-4680. doi: 10.1093/nar/22.22.4673
Europe PMC | doi

Muhle-Goll C, Gibson T, Schuck P, Schubert D, Nalis D, Nilges M, Pastore A. (1994)

The dimerization stability of the HLH-LZ transcription protein family is modulated by the leucine zippers: a CD and NMR study of TFEB and c-Myc.

Biochemistry 33(37):11296-306. doi: 10.1021/bi00203a027
Europe PMC | doi

Gibson TJ, Hyvönen M, Musacchio A, Saraste M, Birney E. (1994)

PH domain: the first anniversary.

Trends Biochem. Sci. 19(9):349-353. doi: 10.1016/0968-0004(94)90108-2
Europe PMC | doi

Gibson TJ, Thompson JD. (1994)

Detection of dsRNA-binding domains in RNA helicase A and Drosophila maleless: implications for monomeric RNA helicases.

Nucleic Acids Res 22(13):2552-6. doi: 10.1093/nar/22.13.2552
Europe PMC | doi

Higgins DG, Labeit S, Gautel M, Gibson TJ. (1994)

The evolution of titin and related giant muscle proteins.

J Mol Evol 38(4):395-404. doi: 10.1007/BF00163156
Europe PMC | doi

Gibson TJ, Thompson JD, Blocker A, Kouzarides T. (1994)

Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107.

Nucleic Acids Res 22(6):946-52. doi: 10.1093/nar/22.6.946
Europe PMC | doi

Thompson JD, Higgins DG, Gibson TJ. (1994)

Improved sensitivity of profile searches through the use of sequence weights and gap excision.

Comput Appl Biosci 10(1):19-29.
Europe PMC


Gibson TJ, Higgins DG. (1993)

Non-muscle and smooth muscle myosin light chain kinases: no end in sight.

DNA Seq 3(5):333-5.
Europe PMC

Gibson TJ, Rice PM, Thompson JD, Heringa J. (1993)

KH domains within the FMR1 sequence suggest that fragile X syndrome stems from a defect in RNA metabolism.

Trends Biochem Sci 18(9):331-3. doi: 10.1016/0968-0004(93)90068-X
Europe PMC | doi

Musacchio A, Gibson T, Rice P, Thompson J, Saraste M. (1993)

The PH domain: a common piece in the structural patchwork of signalling proteins.

Trends Biochem Sci 18(9):343-8. doi: 10.1016/0968-0004(93)90071-T
Europe PMC | doi

Gibson TJ, Thompson JD, Heringa J. (1993)

The KH domain occurs in a diverse set of RNA-binding proteins that include the antiterminator NusA and is probably involved in binding to nucleic acid.

FEBS Lett 324(3):361-6. doi: 10.1016/0014-5793(93)80152-K
Europe PMC | doi

Gibson TJ, Thompson JD, Abagyan RA. (1993)

Proposed structure for the DNA-binding domain of the helix-loop-helix family of eukaryotic gene regulatory proteins.

Protein Eng 6(1):41-50. doi: 10.1093/protein/6.1.41
Europe PMC | doi


Frampton J, Gibson T, Lim F, McNagny K, Metz T, Ness S, Graf T. (1992)

Mechanisms for the transformation of myeloid and erythroid cells by the nuclear oncogene V-myb.

Leukemia 6 Suppl 3:126S-129S.
Europe PMC

Nardelli J, Gibson T, Charnay P. (1992)

Zinc finger-DNA recognition: analysis of base specificity by site-directed mutagenesis

Nucleic Acids Res. 20(16):4137-4144. doi: 10.1093/nar/20.16.4137
Europe PMC | doi

Musacchio A, Gibson T, Lehto VP, Saraste M. (1992)

SH3--an abundant protein domain in search of a function.

FEBS Lett 307(1):55-61. doi: 10.1016/0014-5793(92)80901-R
Europe PMC | doi

Gibson TJ. (1992)

Assignment of α-Helices in Multiply Aligned Protein Sequences — Applications to DNA Binding Motifs

In: Taylor W, Patterns in Protein Sequence and Structure. Springer Verlag.


Frampton J, Gibson TJ, Ness SA, Döderlein G, Graf T. (1991)

Proposed structure for the DNA-binding domain of the Myb oncoprotein based on model building and mutational analysis.

Protein Eng 4(8):891-901. doi: 10.1093/protein/4.8.891
Europe PMC | doi

Gibson TJ, Sibbald PR, Rice P. (1991)

Rop/helix-loop-helix similarity.

DNA Seq 1(3):213-5.
Europe PMC

Saudek V, Pastore A, Morelli MA, Frank R, Gausepohl H, Gibson T. (1991)

The solution structure of a leucine-zipper motif peptide

Protein Eng. 4(5):519-529. doi: 10.1093/protein/4.5.519
Europe PMC | doi

Labeit S, Gibson T, Lakey A, Leonard K, Zeviani M, Knight P, Wardale J, Trinick J. (1991)

Evidence that nebulin is a protein-ruler in muscle thin filaments.

FEBS Lett 282(2):313-6. doi: 10.1016/0014-5793(91)80503-U
Europe PMC | doi

Saudek V, Pasley HS, Gibson T, Gausepohl H, Frank R, Pastore A. (1991)

Solution structure of the basic region from the transcriptional activator GCN4

Biochemistry 30(5):1310-1317. doi: 10.1021/bi00219a022
Europe PMC | doi

Nardelli J, Gibson TJ, Vesque C, Charnay P. (1991)

Base sequence discrimination by zinc-finger DNA-binding domains

Nature 349(6305):175-178. doi: 10.1038/349175a0
Europe PMC | doi


Saudek V, Pastore A, Castiglione Morelli MA, Frank R, Gausepohl H, Gibson T, Weih F, Roesch P. (1990)

Solution structure of the DNA-binding domain of the yeast transcriptional activator protein GCN4

Protein Eng. 4(1):3-10. doi: 10.1093/protein/4.1.3
Europe PMC | doi

Lamond AI, Gibson TJ. (1990)

Catalytic RNA and the origin of genetic systems.

Trends Genet 6(5):145-9. doi: 10.1016/0168-9525(90)90148-Y
Europe PMC | doi

Labeit S, Barlow DP, Gautel M, Gibson T, Holt J, Hsieh CL, Francke U, Leonard K, Wardale J, Whiting A. (1990)

A regular pattern of two types of 100-residue motif in the sequence of titin

Nature 345(6272):273-276. doi: 10.1038/345273a0
Europe PMC | doi

Gibson TJ, Argos P. (1990)

Protruding domain of tomato bushy stunt virus coat protein is a hitherto unrecognized class of jellyroll conformation.

J Mol Biol 212(1):7-9. doi: 10.1016/0022-2836(90)90298-Z
Europe PMC | doi

Gibson TJ, Lamond AI. (1990)

Metabolic complexity in the RNA world and implications for the origin of protein synthesis

J. Mol. Evol. 30(1):7-15. doi: 10.1007/bf02102448
Europe PMC | doi


Frampton J, Leutz A, Gibson TJ, Graf T. (1989)

DNA-binding domain ancestry

NATURE 342(6246):134. doi: 10.1038/342134a0
Europe PMC | doi

Campbell JI, Scahill S, Gibson T, Ambler RP. (1989)

The phototrophic bacterium Rhodopseudomonas capsulata sp108 encodes an indigenous class A beta-lactamase.

Biochem J 260(3):803-12. doi: 10.1042/bj2600803
Europe PMC | doi


Gibson TJ, Postma JP, Brown RS, Argos P. (1988)

A model for the tertiary structure of the 28 residue DNA-binding motif ('zinc finger') common to many eukaryotic transcriptional regulatory proteins.

Protein Eng 2(3):209-18. doi: 10.1093/protein/2.3.209
Europe PMC | doi


Gibson TJ, Coulson AR, Sulston JE, Little PF. (1987)

Lorist2, a cosmid with transcriptional terminators insulating vector genes from interference by promoters within the insert: effect on DNA yield and cloned insert frequency.

Gene 53(2-3):275-81. doi: 10.1016/0378-1119(87)90016-3
Europe PMC | doi

Gibson TJ, Rosenthal A, Waterston RH. (1987)

Lorist6, a cosmid vector with BamHI, NotI, ScaI and HindIII cloning sites and altered neomycin phosphotransferase gene expression.

Gene 53(2-3):283-6. doi: 10.1016/0378-1119(87)90017-5
Europe PMC | doi


Gibson TJ, Barrell BG, Farrell PJ. (1986)

Coding content and expression of the EBV B95-8 genome in the region from base 62,248 to base 82,920.

Virology 152(1):136-48. doi: 10.1016/0042-6822(86)90379-X
Europe PMC | doi


Hudson GS, Gibson TJ, Barrell BG. (1985)

The BamHI F region of the B95-8 Epstein-Barr virus genome.

Virology 147(1):99-109. doi: 10.1016/0042-6822(85)90230-2
Europe PMC | doi


Wetsel RA, Lundwall A, Davidson F, Gibson T, Tack BF, Fey GH. (1984)

Structure of murine complement component C3. II. Nucleotide sequence of cloned complementary DNA coding for the alpha chain.

J Biol Chem 259(22):13857-62.
Europe PMC

Gibson T, Stockwell P, Ginsburg M, Barrell B. (1984)

Homology between two EBV early genes and HSV ribonucleotide reductase and 38K genes.

Nucleic Acids Res 12(12):5087-99. doi: 10.1093/nar/12.12.5087
Europe PMC | doi


Biggin MD, Gibson TJ, Hong GF. (1983)

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

Proc Natl Acad Sci U S A 80(13):3963-5. doi: 10.1073/pnas.80.13.3963
Europe PMC | doi


Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Séguin C. (1900)

DNA sequence and expression of the B95-8 Epstein-Barr virus genome.

Nature 310(5974):207-11. doi: 10.1038/310207a0
Europe PMC | doi

Gibson TJ, Sulston JE. (1900)

Preparation of large numbers of plasmid DNA samples in microtiter plates by the alkaline lysis method.

Gene Anal Tech 4(3):41-4. doi: 10.1016/0735-0651(87)90016-1
Europe PMC | doi