EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

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  • PhD 2009, Linköping University, Sweden.
    Postdoctoral research at Helmholtz.
    Zentrum München and Technische Universität München.
    Group Leader – Emmy Noether Programme since 2015.


Total: 26 publication(s)


Li X, Krafczyk R, Macošek J, Li Y-L, Zou Y, Simon B, Pan X, Wu Q-Y, Yan F, Li S, Hennig J, Jung K, Lassak J, Hu H-G. (2016)

Resolving the α-glycosidic linkage of arginine-rhamnosylated translation elongation factor P triggers generation of the first ArgRha specific antibody

Chem. Sci. 7(12):6995-7001. doi: 10.1039/C6SC02889F

Carlon A, Ravera E, Hennig J, Parigi G, Sattler M, Luchinat C. (2016)

Improved accuracy from joint X-ray and NMR refinement of a protein-RNA complex structure.

J. Am. Chem. Soc. doi: 10.1021/jacs.5b11598
Europe PMC | doi


Horn A, Hennig J, Ahmed YL, Stier G, Wild K, Sattler M, Sinning I. (2015)

Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.

Nat Commun 6:8875. doi: 10.1038/ncomms9875
Europe PMC | doi

Loedige I, Jakob L, Treiber T, Ray D, Stotz M, Treiber N, Hennig J, Cook KB, Morris Q, Hughes TR, Engelmann JC, Krahn MP, Meister G. (2015)

The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation.

Cell Rep 13(6):1206-1220. doi: 10.1016/j.celrep.2015.09.068
Europe PMC | doi

Freiburger L, Sonntag M, Hennig J, Li J, Zou P, Sattler M. (2015)

Efficient segmental isotope labeling of multi-domain proteins using Sortase A.

J. Biomol. NMR doi: 10.1007/s10858-015-9981-0
Europe PMC | doi

Hennig J, Sattler M. (2015)

Deciphering the protein-RNA recognition code: Combining large-scale quantitative methods with structural biology.

Bioessays doi: 10.1002/bies.201500033
Europe PMC | doi

Hennig J, Warner LR, Simon B, Geerlof A, Mackereth CD, Sattler M. (2015)

Structural Analysis of Protein-RNA Complexes in Solution Using NMR Paramagnetic Relaxation Enhancements.

Meth. Enzymol. 558:333-362. doi: 10.1016/bs.mie.2015.02.006
Europe PMC | doi

Friberg A, Thumann S, Hennig J, Zou P, Nössner E, Ling PD, Sattler M, Kempkes B. (2015)

The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation.

PLoS Pathog. 11(5) doi: 10.1371/journal.ppat.1004910
Europe PMC | doi

Hennig J, Andrésen C, Museth AK, Lundström P, Tibell LA, Jonsson BH. (2015)

Local destabilization of the metal-binding region in human copper-zinc superoxide dismutase by remote mutations is a possible determinant for progression of ALS.

Biochemistry 54(2):323-333. doi: 10.1021/bi500606j
Europe PMC | doi


Hennig J, Militti C, Popowicz GM, Wang I, Sonntag M, Geerlof A, Gabel F, Gebauer F, Sattler M. (2014)

Structural basis for the assembly of the Sxl-Unr translation regulatory complex.

Nature 515(7526):287-290. doi: 10.1038/nature13693
Europe PMC | doi

Feige MJ, Gräwert MA, Marcinowski M, Hennig J, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J. (2014)

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins.

Proc. Natl. Acad. Sci. U.S.A. 111(22):8155-8160. doi: 10.1073/pnas.1321502111
Europe PMC | doi

Hennig J, Sattler M. (2014)

The dynamic duo: combining NMR and small angle scattering in structural biology.

Protein Sci. 23(6):669-682. doi: 10.1002/pro.2467
Europe PMC | doi

Hennig J, Gebauer F, Sattler M. (2014)

Breaking the protein-RNA recognition code.

Cell Cycle 13(23):3619-3620. doi: 10.4161/15384101.2014.986625
Europe PMC | doi

Wang I, Hennig J, Jagtap PK, Sonntag M, Valcárcel J, Sattler M. (2014)

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.

Nucleic Acids Res. 42(9):5949-5966. doi: 10.1093/nar/gku193
Europe PMC | doi

Loedige I, Stotz M, Qamar S, Kramer K, Hennig J, Schubert T, Löffler P, Längst G, Merkl R, Urlaub H, Meister G. (2014)

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.

Genes Dev. 28(7):749-764. doi: 10.1101/gad.236513.113
Europe PMC | doi


Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, Meister G. (2013)

Structural features of Argonaute-GW182 protein interactions.

Proc. Natl. Acad. Sci. U.S.A. 110(40):E3770-9. doi: 10.1073/pnas.1308510110
Europe PMC | doi

Weininger U, Blissing AT, Hennig J, Ahlner A, Liu Z, Vogel HJ, Akke M, Lundström P. (2013)

Protein conformational exchange measured by 1H R1ρ relaxation dispersion of methyl groups.

J. Biomol. NMR 57(1):47-55. doi: 10.1007/s10858-013-9764-4
Europe PMC | doi

Hennig J, Wang I, Sonntag M, Gabel F, Sattler M. (2013)

Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex.

J. Biomol. NMR 56(1):17-30. doi: 10.1007/s10858-013-9719-9
Europe PMC | doi


Wennerstrand P, Dametto P, Hennig J, Klingstedt T, Skoglund K, Appell ML, Mårtensson LG. (2012)

Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5.

Biochemistry 51(30):5912-5920. doi: 10.1021/bi300377d
Europe PMC | doi

Hennig J, de Vries SJ, Hennig KD, Randles L, Walters KJ, Sunnerhagen M, Bonvin AM. (2012)

MTMDAT-HADDOCK: high-throughput, protein complex structure modeling based on limited proteolysis and mass spectrometry.

BMC Struct. Biol. 12 doi: 10.1186/1472-6807-12-29
Europe PMC | doi


Espinosa A, Hennig J, Ambrosi A, Anandapadmanaban M, Abelius MS, Sheng Y, Nyberg F, Arrowsmith CH, Sunnerhagen M, Wahren-Herlenius M. (2011)

Anti-Ro52 autoantibodies from patients with Sjogren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface.

J. Biol. Chem. 286(42):36478-36491. doi: 10.1074/jbc.m111.241786
Europe PMC | doi


Hennig J, Hennig KD, Sunnerhagen M. (2008)

MTMDAT: Automated analysis and visualization of mass spectrometry data for tertiary and quaternary structure probing of proteins.

Bioinformatics 24(10):1310-1312. doi: 10.1093/bioinformatics/btn116
Europe PMC | doi

Hennig J, Bresell A, Sandberg M, Hennig KD, Wahren-Herlenius M, Persson B, Sunnerhagen M. (2008)

The fellowship of the RING: the RING-B-box linker region interacts with the RING in TRIM21/Ro52, contains a native autoantigenic epitope in Sjogren syndrome, and is an integral and conserved region in TRIM proteins.

J. Mol. Biol. 377(2):431-449. doi: 10.1016/j.jmb.2008.01.005
Europe PMC | doi


Ottosson L, Hennig J, Espinosa A, Brauner S, Wahren-Herlenius M, Sunnerhagen M. (2006)

Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjogren's syndrome.

Mol. Immunol. 43(6):588-598. doi: 10.1016/j.molimm.2005.04.013
Europe PMC | doi


Hennig J, Ottosson L, Andrésen C, Horvath L, Kuchroo VK, Broo K, Wahren-Herlenius M, Sunnerhagen M. (2005)

Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52.

J. Biol. Chem. 280(39):33250-33261. doi: 10.1074/jbc.m503066200
Europe PMC | doi

Ottosson L, Salomonsson S, Hennig J, Sonesson SE, Dörner T, Raats J, Kuchroo VK, Sunnerhagen M, Wahren-Herlenius M. (2005)

Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein.

Scand. J. Immunol. 61(2):109-118. doi: 10.1111/j.0300-9475.2005.01542.x
Europe PMC | doi