EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • PhD in Chemistry 2010, Weizmann Institute of Science, Rehovot, Israel
    Postdoctoral research at the Max Planck Institute of Biochemistry, Munich, Germany
    Group leader at EMBL since 2017.
    ERC Investigator.


Total: 38 publication(s)


Tegunov D, Xue L, Dienemann C, Cramer P, Mahamid J. (2021)

Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells.

Nat Methods 18(2):186-193. doi: 10.1038/s41592-020-01054-7
Europe PMC | doi


Jawerth L, Fischer-Friedrich E, Saha S, Wang J, Franzmann T, Zhang X, Sachweh J, Ruer M, Ijavi M, Saha S, Mahamid J, Hyman AA, Jülicher F. (2020)

Protein condensates as aging Maxwell fluids.

Science 370(6522):1317-1323. doi: 10.1126/science.aaw4951
Europe PMC | doi

Vignaud T, Copos C, Leterrier C, Toro-Nahuelpan M, Tseng Q, Mahamid J, Blanchoin L, Mogilner A, Théry M, Kurzawa L. (2020)

Author Correction: stress fibres are embedded in a contractile cortical network.

Nat Mater 20(3) doi: 10.1038/s41563-020-00862-8
Europe PMC | doi

Vignaud T, Copos C, Leterrier C, Toro-Nahuelpan M, Tseng Q, Mahamid J, Blanchoin L, Mogilner A, Théry M, Kurzawa L. (2020)

Author Correction: stress fibres are embedded in a contractile cortical network.

Nat Mater 20(3) doi: 10.1038/s41563-020-00874-4
Europe PMC | doi

Vignaud T, Copos C, Leterrier C, Toro-Nahuelpan M, Tseng Q, Mahamid J, Blanchoin L, Mogilner A, Théry M, Kurzawa L. (2020)

Stress fibres are embedded in a contractile cortical network.

Nat Mater 20(3) doi: 10.1038/s41563-020-00825-z
Europe PMC | doi

Goetz SK, Mahamid J. (2020)

Visualizing molecular architectures of cellular condensates: hints of complex coacervation scenarios.

Dev Cell 55(1):97-107. doi: 10.1016/j.devcel.2020.09.003
Europe PMC | doi

Allegretti M, Zimmerli CE, Rantos V, Wilfling F, Ronchi P, Fung HKH, Lee CW, Hagen W, Turoňová B, Karius K, Börmel M, Zhang X, Müller CW, Schwab Y, Mahamid J, Pfander B, Kosinski J, Beck M. (2020)

In-cell architecture of the nuclear pore and snapshots of its turnover.

Nature 586(7831):796-800. doi: 10.1038/s41586-020-2670-5
Europe PMC | doi

O'Reilly FJ, Xue L, Graziadei A, Sinn L, Lenz S, Tegunov D, Blötz C, Singh N, Hagen WJH, Cramer P, Stülke J, Mahamid J, Rappsilber J. (2020)

In-cell architecture of an actively transcribing-translating expressome.

Science 369(6503):554-557. doi: 10.1126/science.abb3758
Europe PMC | doi

Zhang X, Mahamid J. (2020)

Addressing the challenge of in situ structural studies of RNP granules in light of emerging opportunities.

Curr. Opin. Struct. Biol. 65:149-158. doi: 10.1016/j.sbi.2020.06.012
Europe PMC | doi

Tichelaar W, Hagen WJH, Gorelik TE, Xue L, Mahamid J. (2020)

TEM bright field imaging of thick specimens: nodes in Thon ring patterns.

Ultramicroscopy 216 doi: 10.1016/j.ultramic.2020.113023
Europe PMC | doi

Guillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruß M, Richter D, Zhang X, Guck J, Chang YT, Mahamid J, Honigmann A, Pappu RV, Hyman AA, Franzmann TM, Alberti S. (2020)

RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation.

Cell 181(2):346-361.e17. doi: 10.1016/j.cell.2020.03.049
Europe PMC | doi

Toro-Nahuelpan M, Zagoriy I, Senger F, Blanchoin L, Théry M, Mahamid J. (2020)

Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies.

Nat. Methods 17(1):50-54. doi: 10.1038/s41592-019-0630-5
Europe PMC | doi


Schaffer M, Pfeffer S, Mahamid J, Kleindiek S, Laugks T, Albert S, Engel BD, Rummel A, Smith AJ, Baumeister W, Plitzko JM. (2019)

A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native caenorhabditis elegans tissue.

Nat Methods. 16(8):757-762. doi: 10.1038/s41592-019-0497-5
Europe PMC | doi

Mahamid J, Tegunov D, Maiser A, Arnold J, Leonhardt H, Plitzko JM, Baumeister W. (2019)

Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association.

Proc Natl Acad Sci U S A 116(34):16866-16871. doi: 10.1073/pnas.1903642116
Europe PMC | doi

Zhao DY, Poege M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. (2019)

Cryo-EM structure of the native rhodopsin dimer in nanodiscs.

J. Biol. Chem. 294(39):14215-14230. doi: 10.1074/jbc.RA119.010089
Europe PMC | doi

Toro-Nahuelpan M, Zagoriy I, Senger F, Blanchoin L, Thery M, Mahamid J. (2019)

Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies.

bioRxivorg doi: 10.1101/676189

Zou Z, Habraken WJEM, Matveeva G, Jensen ACS, Bertinetti L, Hood MA, Sun CY, Gilbert PUPA, Polishchuk I, Pokroy B, Mahamid J, Politi Y, Weiner S, Werner P, Bette S, Kolb U, Dinnebier R, Fratzl P, Zolotoyabko E. (2019)

A hydrated crystalline calcium carbonate phase: Calcium carbonate hemihydrate.

Science 363(6425):396-400. doi: 10.1126/science.aav0210
Europe PMC | doi


Pfeffer S, Mahamid J. (2018)

Unravelling molecular complexity in structural cell biology.

Curr Opin Struct Biol 52:111-118. doi: 10.1016/j.sbi.2018.08.009
Europe PMC | doi

Franzmann T, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S. (2018)

Phase separation of a yeast prion protein promotes cellular fitness

Science 359(6371) doi: 10.1126/science.aao5654
Europe PMC | doi


Woodruff JB, Ferreira Gomes B, Widlund PO, Mahamid J, Honigmann A and Hyman AA.. (2017)

The centrosome is a selective phase that nucleates microtubules by concentrating tubulin

Cell 169(6) doi: 10.1016/j.cell.2017.05.028
Europe PMC | doi

Earnest TM, Watanabe R, Stone JE, Mahamid J, Baumeister W, Villa E, Luthey-Schulten Z. (2017)

Challenges of Integrating Stochastic Dynamics and Cryo-Electron Tomograms in Whole-Cell Simulations.

J Phys Chem B 121(15) doi: 10.1021/acs.jpcb.7b00672
Europe PMC | doi

Schaffer M, Mahamid J, Engel BD, Laugks T, Baumeister W, Plitzko JM. (2017)

Optimized cryo-focused ion beam sample preparation aimed at in situ structural studies of membrane proteins

J. Struct. Biol. 197(2):73-82. doi: 10.1016/j.jsb.2016.07.010
Europe PMC | doi


Saha S, Weber CA, Nousch M, Adame-Arana O, Hoege C, Hein MY, Osborne-Nishimura E, Mahamid J, Jahnel M, Jawerth L, Pozniakovski A, Eckmann CR, Jülicher F, Hyman AA. (2016)

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

Cell 166(6):1572. doi: 10.1016/j.cell.2016.08.006
Europe PMC | doi

Mahamid J, Pfeffer S, Schaffer M, Villa E, Danev R, Cuellar LK, Förster F, Hyman AA, Plitzko JM, Baumeister W. (2016)

Visualizing the molecular sociology at the HeLa cell nuclear periphery

Science 351(6276):969-972. doi: 10.1126/science.aad8857
Europe PMC | doi

Arnold J, Mahamid J, Lucic V, de Marco A, Fernandez JJ, Laugks T, Mayer T, Hyman AA, Baumeister W, Plitzko JM. (2016)

Site-Specific Cryo-focused Ion Beam Sample Preparation Guided by 3D Correlative Microscopy

Biophys. J. 110(4):860-869. doi: 10.1016/j.bpj.2015.10.053
Europe PMC | doi


Mahamid J, Schampers R, Persoon H, Hyman AA, Baumeister W, Plitzko JM. (2015)

A focused ion beam milling and lift-out approach for site-specific preparation of frozen-hydrated lamellas from multicellular organisms

J. Struct. Biol. 192(2):262-269. doi: 10.1016/j.jsb.2015.07.012
Europe PMC | doi

Schaffer M, Engel BD, Laugks T, Mahamid J, Plitzko JM, Baumeister W. (2015)

Cryo-focused Ion Beam Sample Preparation for Imaging Vitreous Cells by Cryo-electron Tomography.

Bio Protoc 5(17) doi: 10.21769/BioProtoc.1575
Europe PMC | doi

Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S. (2015)

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

Cell 162(5):1066-1077. doi: 10.1016/j.cell.2015.07.047
Europe PMC | doi

Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S, Zinke A, Hong SH, Decker M, Baumeister W, Andersen JS, Oegema K, Hyman AA. (2015)

Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro.

Science 348(6236):808-812. doi: 10.1126/science.aaa3923
Europe PMC | doi


Vidavsky N, Addadi S, Mahamid J, Shimoni E, Ben-Ezra D, Shpigel M, Weiner S, Addadi L. (2014)

Initial stages of calcium uptake and mineral deposition in sea urchin embryos

Proc. Natl. Acad. Sci. U.S.A. 111(1):39-44. doi: 10.1073/pnas.1312833110
Europe PMC | doi


Mahamid J, Baumeister W. (2012)

Cryo-Electron Tomography: The realization of a vision.

Microsc Anal (Am Ed) 26(6):45-48.


Mahamid J, Sharir A, Gur D, Zelzer E, Addadi L, Weiner S. (2011)

Bone mineralization proceeds through intracellular calcium phosphate loaded vesicles: a cryo-electron microscopy study.

J. Struct. Biol. 174(3):527-535. doi: 10.1016/j.jsb.2011.03.014
Europe PMC | doi

Killian CE, Metzler RA, Gong YT, Churchill TH, Olson IC, Trubetskoy V, Christensen MB, Fournelle JH, De Carlo F, Cohen S, Mahamid J, Scholl A, Young A, Doran A, Wilt FH, Coppersmith SN, Gilbert PUPA. (2011)

Self-Sharpening Mechanism of the Sea Urchin Tooth

Adv Funct Mater 21(4):682-690. doi: 10.1002/adfm.201001546

Mahamid J, Addadi L, Weiner S. (2011)

Crystallization pathways in bone.

Cells Tissues Organs (Print) 194(2-4):92-97. doi: 10.1159/000324229
Europe PMC | doi


Mahamid J, Aichmayer B, Shimoni E, Ziblat R, Li C, Siegel S, Paris O, Fratzl P, Weiner S, Addadi L. (2010)

Mapping amorphous calcium phosphate transformation into crystalline mineral from the cell to the bone in zebrafish fin rays

Proc. Natl. Acad. Sci. U.S.A. 107(14):6316-6321. doi: 10.1073/pnas.0914218107
Europe PMC | doi


Weiner S, Mahamid J, Politi Y, Ma Y, Addadi L. (2009)

Overview of the amorphous precursor phase strategy in biomineralization

Front Mater Sci China 3(2):104-108. doi: 10.1007/s11706-009-0036-x


Mahamid J, Sharir A, Addadi L, Weiner S. (2008)

Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase

Proc. Natl. Acad. Sci. U.S.A. 105(35):12748-12753. doi: 10.1073/pnas.0803354105
Europe PMC | doi


Politi Y, Mahamid J, Goldberg H, Weiner S, Addadi L. (2007)

Asprich mollusk shell protein: in vitro experiments aimed at elucidating function in CaCO3 crystallization

CRYSTENGCOMM 9(12):1171-1177. doi: 10.1039/b709749b