EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Biography
PhD in Chemistry 2010, Weizmann Institute of Science, Rehovot, Israel
Postdoctoral research at the Max Planck Institute of Biochemistry, Munich, Germany
Group leader at EMBL since 2017.
ERC Investigator.
Publications
Total: 38 publication(s)
2021
Tegunov D, Xue L, Dienemann C, Cramer P, Mahamid J. (2021)
Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells.
Nat Methods 18(2):186-193. doi: 10.1038/s41592-020-01054-7
Europe PMC | doi
2020
Jawerth L, Fischer-Friedrich E, Saha S, Wang J, Franzmann T, Zhang X, Sachweh J, Ruer M, Ijavi M, Saha S, Mahamid J, Hyman AA, Jülicher F. (2020)
Protein condensates as aging Maxwell fluids.
Science 370(6522):1317-1323. doi: 10.1126/science.aaw4951
Europe PMC | doi
Vignaud T, Copos C, Leterrier C, Toro-Nahuelpan M, Tseng Q, Mahamid J, Blanchoin L, Mogilner A, Théry M, Kurzawa L. (2020)
Author Correction: stress fibres are embedded in a contractile cortical network.
Nat Mater 20(3) doi: 10.1038/s41563-020-00862-8
Europe PMC | doi
Vignaud T, Copos C, Leterrier C, Toro-Nahuelpan M, Tseng Q, Mahamid J, Blanchoin L, Mogilner A, Théry M, Kurzawa L. (2020)
Author Correction: stress fibres are embedded in a contractile cortical network.
Nat Mater 20(3) doi: 10.1038/s41563-020-00874-4
Europe PMC | doi
Vignaud T, Copos C, Leterrier C, Toro-Nahuelpan M, Tseng Q, Mahamid J, Blanchoin L, Mogilner A, Théry M, Kurzawa L. (2020)
Stress fibres are embedded in a contractile cortical network.
Nat Mater 20(3) doi: 10.1038/s41563-020-00825-z
Europe PMC | doi
Goetz SK, Mahamid J. (2020)
Visualizing molecular architectures of cellular condensates: hints of complex coacervation scenarios.
Dev Cell 55(1):97-107. doi: 10.1016/j.devcel.2020.09.003
Europe PMC | doi
Allegretti M, Zimmerli CE, Rantos V, Wilfling F, Ronchi P, Fung HKH, Lee CW, Hagen W, Turoňová B, Karius K, Börmel M, Zhang X, Müller CW, Schwab Y, Mahamid J, Pfander B, Kosinski J, Beck M. (2020)
In-cell architecture of the nuclear pore and snapshots of its turnover.
Nature 586(7831):796-800. doi: 10.1038/s41586-020-2670-5
Europe PMC | doi
O'Reilly FJ, Xue L, Graziadei A, Sinn L, Lenz S, Tegunov D, Blötz C, Singh N, Hagen WJH, Cramer P, Stülke J, Mahamid J, Rappsilber J. (2020)
In-cell architecture of an actively transcribing-translating expressome.
Science 369(6503):554-557. doi: 10.1126/science.abb3758
Europe PMC | doi
Zhang X, Mahamid J. (2020)
Addressing the challenge of in situ structural studies of RNP granules in light of emerging opportunities.
Curr. Opin. Struct. Biol. 65:149-158. doi: 10.1016/j.sbi.2020.06.012
Europe PMC | doi
Tichelaar W, Hagen WJH, Gorelik TE, Xue L, Mahamid J. (2020)
TEM bright field imaging of thick specimens: nodes in Thon ring patterns.
Ultramicroscopy 216 doi: 10.1016/j.ultramic.2020.113023
Europe PMC | doi
Guillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruß M, Richter D, Zhang X, Guck J, Chang YT, Mahamid J, Honigmann A, Pappu RV, Hyman AA, Franzmann TM, Alberti S. (2020)
RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation.
Cell 181(2):346-361.e17. doi: 10.1016/j.cell.2020.03.049
Europe PMC | doi
Toro-Nahuelpan M, Zagoriy I, Senger F, Blanchoin L, Théry M, Mahamid J. (2020)
Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies.
Nat. Methods 17(1):50-54. doi: 10.1038/s41592-019-0630-5
Europe PMC | doi
2019
Schaffer M, Pfeffer S, Mahamid J, Kleindiek S, Laugks T, Albert S, Engel BD, Rummel A, Smith AJ, Baumeister W, Plitzko JM. (2019)
A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native caenorhabditis elegans tissue.
Nat Methods. 16(8):757-762. doi: 10.1038/s41592-019-0497-5
Europe PMC | doi
Mahamid J, Tegunov D, Maiser A, Arnold J, Leonhardt H, Plitzko JM, Baumeister W. (2019)
Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association.
Proc Natl Acad Sci U S A 116(34):16866-16871. doi: 10.1073/pnas.1903642116
Europe PMC | doi
Zhao DY, Poege M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. (2019)
Cryo-EM structure of the native rhodopsin dimer in nanodiscs.
J. Biol. Chem. 294(39):14215-14230. doi: 10.1074/jbc.RA119.010089
Europe PMC | doi
Toro-Nahuelpan M, Zagoriy I, Senger F, Blanchoin L, Thery M, Mahamid J. (2019)
Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies.
bioRxivorg doi: 10.1101/676189
doi
Zou Z, Habraken WJEM, Matveeva G, Jensen ACS, Bertinetti L, Hood MA, Sun CY, Gilbert PUPA, Polishchuk I, Pokroy B, Mahamid J, Politi Y, Weiner S, Werner P, Bette S, Kolb U, Dinnebier R, Fratzl P, Zolotoyabko E. (2019)
A hydrated crystalline calcium carbonate phase: Calcium carbonate hemihydrate.
Science 363(6425):396-400. doi: 10.1126/science.aav0210
Europe PMC | doi
2018
Pfeffer S, Mahamid J. (2018)
Unravelling molecular complexity in structural cell biology.
Curr Opin Struct Biol 52:111-118. doi: 10.1016/j.sbi.2018.08.009
Europe PMC | doi
Franzmann T, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S. (2018)
Phase separation of a yeast prion protein promotes cellular fitness
Science 359(6371) doi: 10.1126/science.aao5654
Europe PMC | doi
2017
Woodruff JB, Ferreira Gomes B, Widlund PO, Mahamid J, Honigmann A and Hyman AA.. (2017)
The centrosome is a selective phase that nucleates microtubules by concentrating tubulin
Cell 169(6) doi: 10.1016/j.cell.2017.05.028
Europe PMC | doi
Earnest TM, Watanabe R, Stone JE, Mahamid J, Baumeister W, Villa E, Luthey-Schulten Z. (2017)
Challenges of Integrating Stochastic Dynamics and Cryo-Electron Tomograms in Whole-Cell Simulations.
J Phys Chem B 121(15) doi: 10.1021/acs.jpcb.7b00672
Europe PMC | doi
Schaffer M, Mahamid J, Engel BD, Laugks T, Baumeister W, Plitzko JM. (2017)
Optimized cryo-focused ion beam sample preparation aimed at in situ structural studies of membrane proteins
J. Struct. Biol. 197(2):73-82. doi: 10.1016/j.jsb.2016.07.010
Europe PMC | doi
2016
Saha S, Weber CA, Nousch M, Adame-Arana O, Hoege C, Hein MY, Osborne-Nishimura E, Mahamid J, Jahnel M, Jawerth L, Pozniakovski A, Eckmann CR, Jülicher F, Hyman AA. (2016)
Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism
Cell 166(6):1572. doi: 10.1016/j.cell.2016.08.006
Europe PMC | doi
Mahamid J, Pfeffer S, Schaffer M, Villa E, Danev R, Cuellar LK, Förster F, Hyman AA, Plitzko JM, Baumeister W. (2016)
Visualizing the molecular sociology at the HeLa cell nuclear periphery
Science 351(6276):969-972. doi: 10.1126/science.aad8857
Europe PMC | doi
Arnold J, Mahamid J, Lucic V, de Marco A, Fernandez JJ, Laugks T, Mayer T, Hyman AA, Baumeister W, Plitzko JM. (2016)
Site-Specific Cryo-focused Ion Beam Sample Preparation Guided by 3D Correlative Microscopy
Biophys. J. 110(4):860-869. doi: 10.1016/j.bpj.2015.10.053
Europe PMC | doi
2015
Mahamid J, Schampers R, Persoon H, Hyman AA, Baumeister W, Plitzko JM. (2015)
A focused ion beam milling and lift-out approach for site-specific preparation of frozen-hydrated lamellas from multicellular organisms
J. Struct. Biol. 192(2):262-269. doi: 10.1016/j.jsb.2015.07.012
Europe PMC | doi
Schaffer M, Engel BD, Laugks T, Mahamid J, Plitzko JM, Baumeister W. (2015)
Cryo-focused Ion Beam Sample Preparation for Imaging Vitreous Cells by Cryo-electron Tomography.
Bio Protoc 5(17) doi: 10.21769/BioProtoc.1575
Europe PMC | doi
Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S. (2015)
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
Cell 162(5):1066-1077. doi: 10.1016/j.cell.2015.07.047
Europe PMC | doi
Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S, Zinke A, Hong SH, Decker M, Baumeister W, Andersen JS, Oegema K, Hyman AA. (2015)
Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro.
Science 348(6236):808-812. doi: 10.1126/science.aaa3923
Europe PMC | doi
2014
Vidavsky N, Addadi S, Mahamid J, Shimoni E, Ben-Ezra D, Shpigel M, Weiner S, Addadi L. (2014)
Initial stages of calcium uptake and mineral deposition in sea urchin embryos
Proc. Natl. Acad. Sci. U.S.A. 111(1):39-44. doi: 10.1073/pnas.1312833110
Europe PMC | doi
2012
Mahamid J, Baumeister W. (2012)
Cryo-Electron Tomography: The realization of a vision.
Microsc Anal (Am Ed) 26(6):45-48.
2011
Mahamid J, Sharir A, Gur D, Zelzer E, Addadi L, Weiner S. (2011)
Bone mineralization proceeds through intracellular calcium phosphate loaded vesicles: a cryo-electron microscopy study.
J. Struct. Biol. 174(3):527-535. doi: 10.1016/j.jsb.2011.03.014
Europe PMC | doi
Killian CE, Metzler RA, Gong YT, Churchill TH, Olson IC, Trubetskoy V, Christensen MB, Fournelle JH, De Carlo F, Cohen S, Mahamid J, Scholl A, Young A, Doran A, Wilt FH, Coppersmith SN, Gilbert PUPA. (2011)
Self-Sharpening Mechanism of the Sea Urchin Tooth
Adv Funct Mater 21(4):682-690. doi: 10.1002/adfm.201001546
doi
Mahamid J, Addadi L, Weiner S. (2011)
Crystallization pathways in bone.
Cells Tissues Organs (Print) 194(2-4):92-97. doi: 10.1159/000324229
Europe PMC | doi
2010
Mahamid J, Aichmayer B, Shimoni E, Ziblat R, Li C, Siegel S, Paris O, Fratzl P, Weiner S, Addadi L. (2010)
Mapping amorphous calcium phosphate transformation into crystalline mineral from the cell to the bone in zebrafish fin rays
Proc. Natl. Acad. Sci. U.S.A. 107(14):6316-6321. doi: 10.1073/pnas.0914218107
Europe PMC | doi
2009
Weiner S, Mahamid J, Politi Y, Ma Y, Addadi L. (2009)
Overview of the amorphous precursor phase strategy in biomineralization
Front Mater Sci China 3(2):104-108. doi: 10.1007/s11706-009-0036-x
doi
2008
Mahamid J, Sharir A, Addadi L, Weiner S. (2008)
Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase
Proc. Natl. Acad. Sci. U.S.A. 105(35):12748-12753. doi: 10.1073/pnas.0803354105
Europe PMC | doi
2007
Politi Y, Mahamid J, Goldberg H, Weiner S, Addadi L. (2007)
Asprich mollusk shell protein: in vitro experiments aimed at elucidating function in CaCO3 crystallization
CRYSTENGCOMM 9(12):1171-1177. doi: 10.1039/b709749b
doi