EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Biography
PhD 1991, Institute of Molecular Pathology, Vienna.
Postdoctoral research at EMBL.
Group and Global HCV project leader at Anadys Pharmaceuticals, Heidelberg.
MBA 2008, Mannheim Business School.
Facility head at EMBL since 2004.
Publications
Total: 23 publication(s)
2020
Mueller WF, Jakob P, Sun H, Clauder-Münster S, Ghidelli-Disse S, Ordonez D, Boesche M, Bantscheff M, Collier P, Haase B, Benes V, Paulsen M, Sehr P, Lewis J, Drewes G, Steinmetz LM. (2020)
Loss of N-glycanase 1 alters transcriptional and translational regulation in K562 cell lines.
G3 (Bethesda) 10(5) doi: 10.1534/g3.119.401031
Europe PMC | doi
Beshnova DA, Carolan C, Grigorenko VG, Rubtsova MY, Gbekor E, Lewis J, Lamzin VS, Egorov AM. (2020)
Scaffold hopping computational approach for searching novel beta-Lactamase inhibitors.
Biochem Mosc Suppl B Biomed Chem 14(2):127-135. doi: 10.1134/S199075082002002X
doi
2019
Beshnova DA, Carolan C, Grigorenko VG, Rubtsova MY, Gbekor E, Lewis J, Lamzin VS, Egorov AM. (2019)
[Scaffold hopping computational approach for searching novel β-lactamase inhibitors].
Biomed Khim 65(6):468-476. doi: 10.18097/PBMC20196506468
Europe PMC | doi
Adams V, Bowen TS, Werner S, Barthel P, Amberger C, Konzer A, Graumann J, Sehr P, Lewis J, Provaznik J, Benes V, Büttner P, Gasch A, Mangner N, Witt CC, Linke A, Labeit D, Labeit S. (2019)
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure.
J Cachexia Sarcopenia Muscle 10(5):1102-1115. doi: 10.1002/jcsm.12448
Europe PMC | doi
Ahmed M, Legrand C, Yagüe Relimpio A, Beretta CA, Muschko A, Wegehingel S, Müller HM, Sehr P, Will DW, Lewis JD, Nickel W. (2019)
A time-resolved live cell imaging assay to identify small molecule inhibitors of FGF2 signaling.
FEBS Lett. 593(16):2162-2176. doi: 10.1002/1873-3468.13462
Europe PMC | doi
2018
Dietrich S, Oleś M, Lu J, Sellner L, Anders S, Velten B, Wu B, Hüllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Oleś AK, Słabicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, Dürig J, Ringshausen I, Zapatka M, Huber W, Zenz T. (2018)
Drug-perturbation-based stratification of blood cancer.
J. Clin. Invest. 128(1) doi: 10.1172/JCI93801
Europe PMC | doi
2017
Bowen TS, Adams V, Werner S, Fischer T, Vinke P, Brogger MN, Mangner N, Linke A, Sehr P, Lewis J, Labeit D, Gasch A, Labeit S. (2017)
Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia.
J Cachexia Sarcopenia Muscle 8(6) doi: 10.1002/jcsm.12233
Europe PMC | doi
2016
La Venuta G, Wegehingel S, Sehr P, Müller HM, Dimou E, Steringer JP, Grotwinkel M, Hentze N, Mayer MP, Will DW, Uhrig U, Lewis JD, Nickel W. (2016)
Small molecule inhibitors targeting Tec kinase block unconventional secretion of fibroblast growth factor 2.
J. Biol. Chem. 291(34):17787-17803. doi: 10.1074/jbc.M116.729384
Europe PMC | doi
Machara A, Lux V, Kozisek M, Saskova KG, Stepanek O, Kotora M, Parkan K, Pavova M, Glass B, Sehr P, Lewis J, Mueller B, Krausslich HG, Konvalinka J. (2016)
Specific Inhibitors of HIV Capsid Assembly Binding to the C-Terminal Domain of the Capsid Protein: Evaluation of 2-Arylquinazolines as Potential Antiviral Compounds
J MED CHEM 59(2):545-558. doi: 10.1021/acs.jmedchem.5b01089
Europe PMC | doi
2015
Daum S, Chekhun VF, Todor IN, Lukianova NY, Shvets YV, Sellner L, Putzker K, Lewis J, Zenz T, de Graaf IAM, Groothuis GMM, Casini A, Zozulia O, Hampel F, Mokhir A. (2015)
Improved Synthesis of N-Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity
J. Med. Chem. 58(4):2015-2024. doi: 10.1021/jm5019548
Europe PMC | doi
Zacherl S, La Venuta G, Müller HM, Wegehingel S, Dimou E, Sehr P, Lewis JD, Erfle H, Pepperkok R, Nickel W. (2015)
A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2.
J. Biol. Chem. 290(6):3654-3665. doi: 10.1074/jbc.m114.590067
Europe PMC | doi
2014
Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE. (2014)
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
EMBO Mol Med 6(12):1509-1639. doi: 10.15252/emmm.201404461
Europe PMC | doi
2013
Pautus S, Sehr P, Lewis J, Fortuné A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Décout JL, Cusack S. (2013)
New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain
J. Med. Chem. 56(21):8915-8930. doi: 10.1021/jm401369y
Europe PMC | doi
Kesisova IA, Nakos KC, Tsolou A, Angelis D, Lewis J, Chatzaki A, Agianian B, Giannis A, Koffa MD. (2013)
Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules
PLoS ONE 8(3):e58485. doi: 10.1371/journal.pone.0058485
Europe PMC | doi
2012
Fueller F, Jehle B, Putzker K, Lewis JD, Krauth-Siegel RL. (2012)
High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin
J. Biol. Chem. 287(12):8792-8802. doi: 10.1074/jbc.m111.338285
Europe PMC | doi
2009
Hose D, Rème T, Meissner T, Moreaux J, Seckinger A, Lewis J, Benes V, Benner A, Hundemer M, Hielscher T, Shaughnessy JD Jr, Barlogie B, Neben K, Krämer A, Hillengass J, Bertsch U, Jauch A, De Vos J, Rossi JF, Möhler T, Blake J, Zimmermann J, Klein B, Goldschmidt H. (2009)
Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma
Blood 113(18):4331-4340. doi: 10.1182/blood-2008-09-178350
Europe PMC | doi
2008
Bartonova V, Igonet S, Sticht J, Glass B, Habermann A, Vaney MC, Sehr P, Lewis J, Rey FA, Kraüsslich HG. (2008)
Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid protein
J. Biol. Chem. 283(46):32024-32033. doi: 10.1074/jbc.m804230200
Europe PMC | doi
Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S. (2008)
The structural basis for cap binding by influenza virus polymerase subunit PB2
Nat. Struct. Mol. Biol. 15(5):500-506. doi: 10.1038/nsmb.1421
Europe PMC | doi
2007
Sehr P, Pawlita M, Lewis J. (2007)
Evaluation of different glutathione S-transferase-tagged protein captures for screening E6/E6AP interaction inhibitors using AlphaScreen
J Biomol Screen 12(4):560-567. doi: 10.1177/1087057107301246
Europe PMC | doi
Polycarpou-Schwarz M, Müller K, Denger S, Riddell A, Lewis J, Gannon F, Reid G. (2007)
Thanatop: a novel 5-nitrofuran that is a highly active, cell-permeable inhibitor of topoisomerase II
Cancer Res. 67(9):4451-4458. doi: 10.1158/0008-5472.can-07-0393
Europe PMC | doi
Lewis JD. (2007)
The role of the chemical biology core facility at EMBL: a vision for a European roadmap
ACS Chem. Biol. 2(1):21-23. doi: 10.1021/cb600453y
Europe PMC | doi
2005
Neduva V, Linding R, Su-Angrand I, Stark A, de Masi F, Gibson TJ, Lewis J, Serrano L, Russell RB. (2005)
Systematic discovery of new recognition peptides mediating protein interaction networks
PLoS Biol. 3(12):e405. doi: 10.1371/journal.pbio.0030405
Europe PMC | doi
Boehringer D, Thermann R, Ostareck-Lederer A, Lewis JD, Stark H. (2005)
Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES
Structure 13(11):1695-1706. doi: 10.1016/j.str.2005.08.008
Europe PMC | doi