EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany


  • PhD 1991, Institute of Molecular Pathology, Vienna.

  • Postdoctoral research at EMBL.

  • Group and Global HCV project leader at Anadys Pharmaceuticals, Heidelberg.

  • MBA 2008, Mannheim Business School.

  • Facility head at EMBL since 2004.


Total: 23 publication(s)


Mueller WF, Jakob P, Sun H, Clauder-Münster S, Ghidelli-Disse S, Ordonez D, Boesche M, Bantscheff M, Collier P, Haase B, Benes V, Paulsen M, Sehr P, Lewis J, Drewes G, Steinmetz LM. (2020)

Loss of N-glycanase 1 alters transcriptional and translational regulation in K562 cell lines.

G3 (Bethesda) 10(5) doi: 10.1534/g3.119.401031
Europe PMC | doi

Beshnova DA, Carolan C, Grigorenko VG, Rubtsova MY, Gbekor E, Lewis J, Lamzin VS, Egorov AM. (2020)

Scaffold hopping computational approach for searching novel beta-Lactamase inhibitors.

Biochem Mosc Suppl B Biomed Chem 14(2):127-135. doi: 10.1134/S199075082002002X


Beshnova DA, Carolan C, Grigorenko VG, Rubtsova MY, Gbekor E, Lewis J, Lamzin VS, Egorov AM. (2019)

[Scaffold hopping computational approach for searching novel β-lactamase inhibitors].

Biomed Khim 65(6):468-476. doi: 10.18097/PBMC20196506468
Europe PMC | doi

Adams V, Bowen TS, Werner S, Barthel P, Amberger C, Konzer A, Graumann J, Sehr P, Lewis J, Provaznik J, Benes V, Büttner P, Gasch A, Mangner N, Witt CC, Linke A, Labeit D, Labeit S. (2019)

Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure.

J Cachexia Sarcopenia Muscle 10(5):1102-1115. doi: 10.1002/jcsm.12448
Europe PMC | doi

Ahmed M, Legrand C, Yagüe Relimpio A, Beretta CA, Muschko A, Wegehingel S, Müller HM, Sehr P, Will DW, Lewis JD, Nickel W. (2019)

A time-resolved live cell imaging assay to identify small molecule inhibitors of FGF2 signaling.

FEBS Lett. 593(16):2162-2176. doi: 10.1002/1873-3468.13462
Europe PMC | doi


Dietrich S, Oleś M, Lu J, Sellner L, Anders S, Velten B, Wu B, Hüllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Oleś AK, Słabicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, Dürig J, Ringshausen I, Zapatka M, Huber W, Zenz T. (2018)

Drug-perturbation-based stratification of blood cancer.

J. Clin. Invest. 128(1) doi: 10.1172/JCI93801
Europe PMC | doi


Bowen TS, Adams V, Werner S, Fischer T, Vinke P, Brogger MN, Mangner N, Linke A, Sehr P, Lewis J, Labeit D, Gasch A, Labeit S. (2017)

Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia.

J Cachexia Sarcopenia Muscle 8(6) doi: 10.1002/jcsm.12233
Europe PMC | doi


La Venuta G, Wegehingel S, Sehr P, Müller HM, Dimou E, Steringer JP, Grotwinkel M, Hentze N, Mayer MP, Will DW, Uhrig U, Lewis JD, Nickel W. (2016)

Small molecule inhibitors targeting Tec kinase block unconventional secretion of fibroblast growth factor 2.

J. Biol. Chem. 291(34):17787-17803. doi: 10.1074/jbc.M116.729384
Europe PMC | doi

Machara A, Lux V, Kozisek M, Saskova KG, Stepanek O, Kotora M, Parkan K, Pavova M, Glass B, Sehr P, Lewis J, Mueller B, Krausslich HG, Konvalinka J. (2016)

Specific Inhibitors of HIV Capsid Assembly Binding to the C-Terminal Domain of the Capsid Protein: Evaluation of 2-Arylquinazolines as Potential Antiviral Compounds

J MED CHEM 59(2):545-558. doi: 10.1021/acs.jmedchem.5b01089
Europe PMC | doi


Daum S, Chekhun VF, Todor IN, Lukianova NY, Shvets YV, Sellner L, Putzker K, Lewis J, Zenz T, de Graaf IAM, Groothuis GMM, Casini A, Zozulia O, Hampel F, Mokhir A. (2015)

Improved Synthesis of N-Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity

J. Med. Chem. 58(4):2015-2024. doi: 10.1021/jm5019548
Europe PMC | doi

Zacherl S, La Venuta G, Müller HM, Wegehingel S, Dimou E, Sehr P, Lewis JD, Erfle H, Pepperkok R, Nickel W. (2015)

A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2.

J. Biol. Chem. 290(6):3654-3665. doi: 10.1074/jbc.m114.590067
Europe PMC | doi


Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE. (2014)

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.

EMBO Mol Med 6(12):1509-1639. doi: 10.15252/emmm.201404461
Europe PMC | doi


Pautus S, Sehr P, Lewis J, Fortuné A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Décout JL, Cusack S. (2013)

New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain

J. Med. Chem. 56(21):8915-8930. doi: 10.1021/jm401369y
Europe PMC | doi

Kesisova IA, Nakos KC, Tsolou A, Angelis D, Lewis J, Chatzaki A, Agianian B, Giannis A, Koffa MD. (2013)

Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules

PLoS ONE 8(3):e58485. doi: 10.1371/journal.pone.0058485
Europe PMC | doi


Fueller F, Jehle B, Putzker K, Lewis JD, Krauth-Siegel RL. (2012)

High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin

J. Biol. Chem. 287(12):8792-8802. doi: 10.1074/jbc.m111.338285
Europe PMC | doi


Hose D, Rème T, Meissner T, Moreaux J, Seckinger A, Lewis J, Benes V, Benner A, Hundemer M, Hielscher T, Shaughnessy JD Jr, Barlogie B, Neben K, Krämer A, Hillengass J, Bertsch U, Jauch A, De Vos J, Rossi JF, Möhler T, Blake J, Zimmermann J, Klein B, Goldschmidt H. (2009)

Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma

Blood 113(18):4331-4340. doi: 10.1182/blood-2008-09-178350
Europe PMC | doi


Bartonova V, Igonet S, Sticht J, Glass B, Habermann A, Vaney MC, Sehr P, Lewis J, Rey FA, Kraüsslich HG. (2008)

Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid protein

J. Biol. Chem. 283(46):32024-32033. doi: 10.1074/jbc.m804230200
Europe PMC | doi

Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S. (2008)

The structural basis for cap binding by influenza virus polymerase subunit PB2

Nat. Struct. Mol. Biol. 15(5):500-506. doi: 10.1038/nsmb.1421
Europe PMC | doi


Sehr P, Pawlita M, Lewis J. (2007)

Evaluation of different glutathione S-transferase-tagged protein captures for screening E6/E6AP interaction inhibitors using AlphaScreen

J Biomol Screen 12(4):560-567. doi: 10.1177/1087057107301246
Europe PMC | doi

Polycarpou-Schwarz M, Müller K, Denger S, Riddell A, Lewis J, Gannon F, Reid G. (2007)

Thanatop: a novel 5-nitrofuran that is a highly active, cell-permeable inhibitor of topoisomerase II

Cancer Res. 67(9):4451-4458. doi: 10.1158/0008-5472.can-07-0393
Europe PMC | doi

Lewis JD. (2007)

The role of the chemical biology core facility at EMBL: a vision for a European roadmap

ACS Chem. Biol. 2(1):21-23. doi: 10.1021/cb600453y
Europe PMC | doi


Neduva V, Linding R, Su-Angrand I, Stark A, de Masi F, Gibson TJ, Lewis J, Serrano L, Russell RB. (2005)

Systematic discovery of new recognition peptides mediating protein interaction networks

PLoS Biol. 3(12):e405. doi: 10.1371/journal.pbio.0030405
Europe PMC | doi

Boehringer D, Thermann R, Ostareck-Lederer A, Lewis JD, Stark H. (2005)

Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES

Structure 13(11):1695-1706. doi: 10.1016/j.str.2005.08.008
Europe PMC | doi