Total: 39 publication(s)


Sankaranarayanan R, Joshi S, Muwonge R, Esmy PO, Basu P, Prabhu P, Bhatla N, Nene BM, Shaw J, Poli URR, Verma Y, Zomawia E, Pimple S, Tommasino M, Pawlita M, Gheit T, Waterboer T, Sehr P, Pillai MR, Pillai MR. (2018)

Can a single dose of human papillomavirus (HPV) vaccine prevent cervical cancer? Early findings from an Indian study.

Vaccine doi: 10.1016/j.vaccine.2018.02.087
Europe PMC | doi

Bhatla N, Nene BM, Joshi S, Esmy PO, Poli URR, Joshi G, Verma Y, Zomawia E, Pimple S, Prabhu PR, Basu P, Muwonge R, Hingmire S, Sauvaget C, Lucas E, Pawlita M, Gheit T, Jayant K, Malvi SG, Siddiqi M, Michel A, Butt J, Subha Sankaran J, Kannan TPRA, Varghese R, Divate U, Willhauck-Fleckenstein M, Waterboer T, Müller M, Sehr P, Kriplani A, Mishra G, Jadhav R, Thorat R, Tommasino M, Radhakrishna Pillai M, Sankaranarayanan R, Sankaranarayanan R. (2018)

Are two doses of human papillomavirus vaccine sufficient for girls aged 15-18 years? Results from a cohort study in India.

Papillomavirus Res 5 doi: 10.1016/j.pvr.2018.03.008
Europe PMC | doi

Fritzsch C, Baumgärtner S, Kuban M, Steinshorn D, Reid G, Legewie S. (2018)

Estrogen-dependent control and cell-to-cell variability of transcriptional bursting.

Mol Syst Biol 14(2) doi: 10.15252/msb.20177678
Europe PMC | doi

Dietrich S, Oleś M, Lu J, Sellner L, Anders S, Velten B, Wu B, Hüllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Oleś AK, Słabicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, Dürig J, Ringshausen I, Zapatka M, Huber W, Zenz T. (2018)

Drug-perturbation-based stratification of blood cancer.

J. Clin. Invest. 128(1) doi: 10.1172/JCI93801
Europe PMC | doi


Bowen TS, Adams V, Werner S, Fischer T, Vinke P, Brogger MN, Mangner N, Linke A, Sehr P, Lewis J, Labeit D, Gasch A, Labeit S. (2017)

Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia.

J Cachexia Sarcopenia Muscle 8(6) doi: 10.1002/jcsm.12233
Europe PMC | doi

Dzida T, Iqbal M, Charapitsa I, Reid G, Stunnenberg H, Matarese F, Grote K, Honkela A, Rattray M. (2017)

Predicting stimulation-dependent enhancer-promoter interactions from ChIP-Seq time course data.

PeerJ 5:e3742. doi: 10.7717/peerj.3742
Europe PMC | doi

Sun H, Horatscheck A, Martos V, Bartetzko M, Uhrig U, Lentz D, Schmieder P, Nazaré M. (2017)

Direct Experimental Evidence for Halogen-Aryl π Interactions in Solution from Molecular Torsion Balances.

Angew Chem Int Ed Engl 56(56):1-6. doi: 10.1002/anie.201700520
Europe PMC | doi


Fontanillo M, Zemskov I, Häfner M, Uhrig U, Salvi F, Simon B, Wittmann V, Köhn M. (2016)

Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1.

Angew. Chem. Int. Ed. Engl. 55(45):13985-13989. doi: 10.1002/anie.201606449
Europe PMC | doi

La Venuta G, Wegehingel S, Sehr P, Müller HM, Dimou E, Steringer JP, Grotwinkel M, Hentze N, Mayer MP, Will DW, Uhrig U, Lewis JD, Nickel W. (2016)

Small molecule inhibitors targeting Tec kinase block unconventional secretion of fibroblast growth factor 2.

J. Biol. Chem. 291(34):17787-17803. doi: 10.1074/jbc.M116.729384
Europe PMC | doi

Faust H, Toft L, Sehr P, Müller M, Bonde J, Forslund O, Østergaard L, Tolstrup M, Dillner J. (2016)

Human Papillomavirus neutralizing and cross-reactive antibodies induced in HIV-positive subjects after vaccination with quadrivalent and bivalent HPV vaccines.

Vaccine 34(13):1559-1565. doi: 10.1016/j.vaccine.2016.02.019
Europe PMC | doi

Machara A, Lux V, Kozisek M, Saskova KG, Stepanek O, Kotora M, Parkan K, Pavova M, Glass B, Sehr P, Lewis J, Mueller B, Krausslich HG, Konvalinka J. (2016)

Specific Inhibitors of HIV Capsid Assembly Binding to the C-Terminal Domain of the Capsid Protein: Evaluation of 2-Arylquinazolines as Potential Antiviral Compounds

J MED CHEM 59(2):545-558. doi: 10.1021/acs.jmedchem.5b01089
Europe PMC | doi

Sankaranarayanan R, Prabhu PR, Pawlita M, Gheit T, Bhatla N, Muwonge R, Nene BM, Esmy PO, Joshi S, Poli URR, Jivarajani P, Verma Y, Zomawia E, Siddiqi M, Shastri SS, Jayant K, Malvi SG, Lucas E, Michel A, Butt J, Vijayamma JMB, Sankaran S, Kannan TPRA, Varghese R, Divate U, Thomas S, Joshi G, Willhauck-Fleckenstein M, Waterboer T, Muller M, Sehr P, Hingmire S, Kriplani A, Mishra G, Pimple S, Jadhav R, Sauvaget C, Tommasino M, Pillai MR. (2016)

Immunogenicity and HPV infection after one, two, and three doses of quadrivalent HPV vaccine in girls in India: a multicentre prospective cohort study

LANCET ONCOL 17(1):67-77. doi: 10.1016/S1470-2045(15)00414-3
Europe PMC | doi


Daum S, Chekhun VF, Todor IN, Lukianova NY, Shvets YV, Sellner L, Putzker K, Lewis J, Zenz T, de Graaf IAM, Groothuis GMM, Casini A, Zozulia O, Hampel F, Mokhir A. (2015)

Improved Synthesis of N-Benzylaminoferrocene-Based Prodrugs and Evaluation of Their Toxicity and Antileukemic Activity

J. Med. Chem. 58(4):2015-2024. doi: 10.1021/jm5019548
Europe PMC | doi

Zacherl S, La Venuta G, Müller HM, Wegehingel S, Dimou E, Sehr P, Lewis JD, Erfle H, Pepperkok R, Nickel W. (2015)

A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2.

J. Biol. Chem. 290(6):3654-3665. doi: 10.1074/jbc.m114.590067
Europe PMC | doi


Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE. (2014)

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.

EMBO Mol Med 6(12):1509-1639. doi: 10.15252/emmm.201404461
Europe PMC | doi

Zanier K, Stutz C, Kintscher S, Reinz E, Sehr P, Bulkescher J, Hoppe-Seyler K, Travé G, Hoppe-Seyler F. (2014)

The E6AP Binding Pocket of the HPV16 E6 Oncoprotein Provides a Docking Site for a Small Inhibitory Peptide Unrelated to E6AP, Indicating Druggability of E6.

PLoS ONE 9(11) doi: 10.1371/journal.pone.0112514
Europe PMC | doi

Brown D, Müller M, Sehr P, Pawlita M, Seitz H, Rubio I, Antonello J, Radley D, Roberts C, Saah A. (2014)

Concordance assessment between a multiplexed competitive Luminex immunoassay, a multiplexed IgG Luminex immunoassay, and a pseudovirion-based neutralization assay for detection of human papillomaviruses types 16 and 18

Vaccine 32(44) doi: 10.1016/j.vaccine.2014.08.004
Europe PMC | doi

Toft L, Storgaard M, Müller M, Sehr P, Bonde J, Tolstrup M, Østergaard L, Søgaard OS. (2014)

Comparison of the immunogenicity and reactogenicity of Cervarix and Gardasil human papillomavirus vaccines in HIV-infected adults: a randomized, double-blind clinical trial.

J. Infect. Dis. 209(8):1165-1173. doi: 10.1093/infdis/jit657
Europe PMC | doi

Toft L, Tolstrup M, Müller M, Sehr P, Bonde J, Storgaard M, Ostergaard L, Søgaard OS. (2014)

Comparison of the immunogenicity of Cervarix(®) and Gardasil(®) human papillomavirus vaccines for oncogenic non-vaccine serotypes HPV-31, HPV-33 and HPV-45 in HIV-infected adults.

Hum Vaccin Immunother 10(5):1147-1154. doi: 10.4161/hv.27925
Europe PMC | doi


Alfieri C, Gambetta MC, Matos R, Glatt S, Sehr P, Fraterman S, Wilm M, Müller J, Müller CW. (2013)

Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements.

Genes Dev. 27(21):2367-2379. doi: 10.1101/gad.226621.113
Europe PMC | doi

Pautus S, Sehr P, Lewis J, Fortuné A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Décout JL, Cusack S. (2013)

New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain

J. Med. Chem. 56(21):8915-8930. doi: 10.1021/jm401369y
Europe PMC | doi

Kesisova IA, Nakos KC, Tsolou A, Angelis D, Lewis J, Chatzaki A, Agianian B, Giannis A, Koffa MD. (2013)

Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules

PLoS ONE 8(3):e58485. doi: 10.1371/journal.pone.0058485
Europe PMC | doi

Sehr P, Rubio I, Seitz H, Putzker K, Ribeiro-Müller L, Pawlita M, Müller M. (2013)

High-throughput pseudovirion-based neutralization assay for analysis of natural and vaccine-induced antibodies against human papillomaviruses

PLoS ONE 8(10):e75677. doi: 10.1371/journal.pone.0075677
Europe PMC | doi


Casanova CM, Sehr P, Putzker K, Hentze MW, Neumann B, Duncan KE, Thoma C. (2012)

Automated high-throughput RNAi screening in human cells combined with reporter mRNA transfection to identify novel regulators of translation

PLoS ONE 7(9):e45943. doi: 10.1371/journal.pone.0045943
Europe PMC | doi

Fueller F, Jehle B, Putzker K, Lewis JD, Krauth-Siegel RL. (2012)

High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin

J. Biol. Chem. 287(12):8792-8802. doi: 10.1074/jbc.m111.338285
Europe PMC | doi

Nieto K, Weghofer M, Sehr P, Ritter M, Sedlmeier S, Karanam B, Seitz H, Müller M, Kellner M, Hörer M, Michaelis U, Roden RB, Gissmann L, Kleinschmidt JA. (2012)

Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate

PLoS ONE 7(6):e39741. doi: 10.1371/journal.pone.0039741
Europe PMC | doi


Wendt B, Uhrig U, Bös F. (2011)

Capturing structure-activity relationships from chemogenomic spaces

J Chem Inf Model 51(4):843-851. doi: 10.1021/ci100270x
Europe PMC | doi

Simon B, Kirkpatrick JP, Eckhardt S, Reuter M, Rocha EA, Andrade-Navarro MA, Sehr P, Pillai RS, Carlomagno T. (2011)

Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein

Structure 19(2):172-180. doi: 10.1016/j.str.2010.11.015
Europe PMC | doi

Rubio I, Seitz H, Canali E, Sehr P, Bolchi A, Tommasino M, Ottonello S, Müller M. (2011)

The N-terminal region of the human papillomavirus L2 protein contains overlapping binding sites for neutralizing, cross-neutralizing and non-neutralizing antibodies

Virology 409(2):348-359. doi: 10.1016/j.virol.2010.10.017
Europe PMC | doi


Churruca F, Fousteris M, Ishikawa Y, Rekowski Mv, Hounsou C, Surrey T, Giannis A. (2010)

A novel approach to indoloditerpenes by Nazarov photocyclization: synthesis and biological investigations of terpendole E analogues

Org. Lett. 12(9):2096-2099. doi: 10.1021/ol100579w
Europe PMC | doi


Hose D, Rème T, Meissner T, Moreaux J, Seckinger A, Lewis J, Benes V, Benner A, Hundemer M, Hielscher T, Shaughnessy JD Jr, Barlogie B, Neben K, Krämer A, Hillengass J, Bertsch U, Jauch A, De Vos J, Rossi JF, Möhler T, Blake J, Zimmermann J, Klein B, Goldschmidt H. (2009)

Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma

Blood 113(18):4331-4340. doi: 10.1182/blood-2008-09-178350
Europe PMC | doi

Dymalla S, Scheffner M, Weber E, Sehr P, Lohrey C, Hoppe-Seyler F, Hoppe-Seyler K. (2009)

A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein

J. Mol. Med. 87(3):321-331. doi: 10.1007/s00109-008-0432-1
Europe PMC | doi


Bartonova V, Igonet S, Sticht J, Glass B, Habermann A, Vaney MC, Sehr P, Lewis J, Rey FA, Kraüsslich HG. (2008)

Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid protein

J. Biol. Chem. 283(46):32024-32033. doi: 10.1074/jbc.m804230200
Europe PMC | doi

Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S. (2008)

The structural basis for cap binding by influenza virus polymerase subunit PB2

Nat. Struct. Mol. Biol. 15(5):500-506. doi: 10.1038/nsmb.1421
Europe PMC | doi


Sehr P, Pawlita M, Lewis J. (2007)

Evaluation of different glutathione S-transferase-tagged protein captures for screening E6/E6AP interaction inhibitors using AlphaScreen

J Biomol Screen 12(4):560-567. doi: 10.1177/1087057107301246
Europe PMC | doi

Polycarpou-Schwarz M, Müller K, Denger S, Riddell A, Lewis J, Gannon F, Reid G. (2007)

Thanatop: a novel 5-nitrofuran that is a highly active, cell-permeable inhibitor of topoisomerase II

Cancer Res. 67(9):4451-4458. doi: 10.1158/0008-5472.can-07-0393
Europe PMC | doi

Lewis JD. (2007)

The role of the chemical biology core facility at EMBL: a vision for a European roadmap

ACS Chem. Biol. 2(1):21-23. doi: 10.1021/cb600453y
Europe PMC | doi


Neduva V, Linding R, Su-Angrand I, Stark A, de Masi F, Gibson TJ, Lewis J, Serrano L, Russell RB. (2005)

Systematic discovery of new recognition peptides mediating protein interaction networks

PLoS Biol. 3(12):e405. doi: 10.1371/journal.pbio.0030405
Europe PMC | doi


Wagner W, Ansorge A, Wirkner U, Eckstein V, Schwager C, Blake J, Miesala K, Selig J, Saffrich R, Ansorge W, Ho AD. (2004)

Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis

Blood 104(3):675-686. doi: 10.1182/blood-2003-10-3423
Europe PMC | doi