EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
Publications
Total: 42 publication(s)
2021
Selkrig J, Stanifer M, Mateus A, Mitosch K, Barrio-Hernandez I, Rettel M, Kim H, Voogdt CGP, Walch P, Kee C, Kurzawa N, Stein F, Potel C, Jarzab A, Kuster B, Bartenschlager R, Boulant S, Beltrao P, Typas A, Savitski MM. (2021)
SARS-CoV-2 infection remodels the host protein thermal stability landscape.
Mol Syst Biol 17(2) doi: 10.15252/msb.202010188
Europe PMC | doi
2020
Khan MM, Poeckel D, Halavatyi A, Zukowska-Kasprzyk J, Stein F, Vappiani J, Sevin DC, Tischer C, Zinn N, Eley JD, Gudmann NS, Muley T, Winter H, Fisher AJ, Nanthakumar CB, Bergamini G, Pepperkok R. (2020)
An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices.
Eur Respir J doi: 10.1183/13993003.00221-2020
Europe PMC | doi
Karkampouna S, De Filippo MR, Ng CKY, Klima I, Zoni E, Spahn M, Stein F, Haberkant P, Thalmann GN, Kruithof de Julio M. (2020)
Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals prognostic value of stroma signatures.
Cancers (Basel) 12(12) doi: 10.3390/cancers12123786
Europe PMC | doi
Mateus A, Hevler J, Bobonis J, Kurzawa N, Shah M, Mitosch K, Goemans CV, Helm D, Stein F, Typas A, Savitski MM. (2020)
The functional proteome landscape of Escherichia coli.
Nature 588(7838):473-478. doi: 10.1038/s41586-020-3002-5
Europe PMC | doi
Määttä TA, Rettel M, Sridharan S, Helm D, Kurzawa N, Stein F, Savitski MM. (2020)
Aggregation and disaggregation features of the human proteome.
Mol Syst Biol 16(10) doi: 10.15252/msb.20209500
Europe PMC | doi
Hollmann NM, Jagtap PKA, Masiewicz P, Guitart T, Simon B, Provaznik J, Stein F, Haberkant P, Sweetapple LJ, Villacorta L, Moojiman D, Benes V, Savitski MM, Gebauer F, Hennig J. (2020)
Pseudo-RNA-binding domains mediate RNA structure specificity in Upstream of N-Ras.
Cell Rep 32(3) doi: 10.1016/j.celrep.2020.107930
Europe PMC | doi
Bobonis J, Mateus A, Pfalz B, Garcia-Santamarina S, Galardini M, Kobayashi C, Stein F, Savitski MM, Elfenbein JR, Andrews-Poymenis H, Typas A. (2020)
Bacterial retrons encode tripartite toxin/antitoxin systems.
bioRxivorg doi: 10.1101/2020.06.22.160168
doi
Basappa J, Citir M, Zhang Q, Wang HY, Liu X, Melnikov O, Yahya H, Stein F, Muller R, Traynor-Kaplan A, Schultz C, Wasik MA, Ptasznik A. (2020)
ACLY is the novel signaling target of PIP 2/PIP 3 and Lyn in acute myeloid leukemia.
Heliyon 6(5) doi: 10.1016/j.heliyon.2020.e03910
Europe PMC | doi
Walch P, Selkrig J, Knodler LA, Rettel M, Stein F, Fernandez K, Viéitez C, Potel CM, Scholzen K, Geyer M, Rottner K, Steele-Mortimer O, Savitski MM, Holden DW, Typas A. (2020)
Global mapping of Salmonella enterica-host protein-protein interactions during infection.
bioRxivorg doi: 10.1101/2020.05.04.075937
doi
Backlund M, Stein F, Rettel M, Schwarzl T, Perez-Perri JI, Brosig A, Zhou Y, Neu-Yilik G, Hentze MW, Kulozik AE. (2020)
Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins.
Nucleic Acids Res. 48(9) doi: 10.1093/nar/gkaa256
Europe PMC | doi
Mateus A, Kurzawa N, Becher I, Sridharan S, Helm D, Stein F, Typas A, Savitski MM. (2020)
Thermal proteome profiling for interrogating protein interactions.
Mol. Syst. Biol. 16(3) doi: 10.15252/msb.20199232
Europe PMC | doi
Sueki A, Stein F, Savitski MM, Selkrig J, Typas A. (2020)
Systematic localization of Escherichia coli membrane proteins.
mSystems 5(2) doi: 10.1128/mSystems.00808-19
Europe PMC | doi
Banzhaf M, Yau HC, Verheul J, Lodge A, Kritikos G, Mateus A, Cordier B, Hov AK, Stein F, Wartel M, Pazos M, Solovyova AS, Breukink E, van Teeffelen S, Savitski MM, den Blaauwen T, Typas A, Vollmer W. (2020)
Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli.
EMBO J. 39(5) doi: 10.15252/embj.2019102246
Europe PMC | doi
2019
Viéitez C, Busby BP, Ochoa D, Mateus A, Galardini M, Jawed A, Memon D, Potel CM, Vonesch SC, Tu CS, Shahraz M, Stein F, Steinmetz LM, Savitski MM, Typas A, Beltrao P. (2019)
Towards a systematic map of the functional role of protein phosphorylation.
bioRxivorg doi: 10.1101/872770
doi
Ochoa D, Jarnuczak AF, Viéitez C, Gehre M, Soucheray M, Mateus A, Kleefeldt AA, Hill A, Garcia-Alonso L, Stein F, Krogan NJ, Savitski MM, Swaney DL, Vizcaíno JA, Noh KM, Beltrao P. (2019)
The functional landscape of the human phosphoproteome.
Nat. Biotechnol. 38(3):365-373. doi: 10.1038/s41587-019-0344-3
Europe PMC | doi
Girstmair H, Tippel F, Lopez A, Tych K, Stein F, Haberkant P, Schmid PWN, Helm D, Rief M, Sattler M, Buchner J. (2019)
The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range.
Nat Commun 10(1) doi: 10.1038/s41467-019-11518-w
Europe PMC | doi
Doroudgar S, Hofmann C, Boileau E, Malone B, Riechert E, Gorska AA, Jakobi T, Sandmann C, Jürgensen L, Kmietczyk V, Malovrh E, Burghaus J, Rettel M, Stein F, Younesi F, Mauz V, Friedrich UA, Kramer G, Backs J, Dieterich C, Katus HA, Völkers M. (2019)
Monitoring cell-type-specific gene expression using ribosome profiling in vivo during cardiac hemodynamic stress.
Circ. Res. 125(4):431-448. doi: 10.1161/CIRCRESAHA.119.314817
Europe PMC | doi
Boos F, Krämer L, Groh C, Jung F, Haberkant P, Stein F, Wollweber F, Gackstatter A, Zöller E, van der Laan M, Savitski MM, Benes V, Herrmann JM. (2019)
Publisher Correction: Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme.
Nat. Cell Biol. 21(6) doi: 10.1038/s41556-019-0326-1
Europe PMC | doi
Boos F, Krämer L, Groh C, Jung F, Haberkant P, Stein F, Wollweber F, Gackstatter A, Zöller E, van der Laan M, Savitski MM, Benes V, Herrmann JM. (2019)
Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme.
Nat. Cell Biol. 21(4) doi: 10.1038/s41556-019-0294-5
Europe PMC | doi
Pereira F, Rettel M, Stein F, Savitski MM, Collinson I, Römisch K. (2019)
Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation.
PLoS ONE 14(1) doi: 10.1371/journal.pone.0211180
Europe PMC | doi
2018
Perez-Perri JI, Rogell B, Schwarzl T, Stein F, Zhou Y, Rettel M, Brosig A, Hentze MW. (2018)
Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture.
Nat Commun 9(1) doi: 10.1038/s41467-018-06557-8
Europe PMC | doi
Hoffmann JE, Dziuba D, Stein F, Schultz C. (2018)
A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation.
Biochemistry 57(31) doi: 10.1021/acs.biochem.8b00397
Europe PMC | doi
Mateus A, Bobonis J, Kurzawa N, Stein F, Helm D, Hevler J, Typas A, Savitski MM. (2018)
Thermal proteome profiling in bacteria: probing protein state in vivo.
Mol. Syst. Biol. 14(7) doi: 10.15252/msb.20188242
Europe PMC | doi
Jethwa A, Słabicki M, Hüllein J, Jentzsch M, Dalal V, Rabe S, Wagner L, Walther T, Klapper W, Bohnenberger H, Rettel M, Lu J, Smits AH, Stein F, Savitski MM, Huber W, Aylon Y, Oren M, Zenz T. (2018)
TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.
Blood 131(25) doi: 10.1182/blood-2017-09-806679
Europe PMC | doi
Becher I, Andrés-Pons A, Romanov N, Stein F, Schramm M, Baudin F, Helm D, Kurzawa N, Mateus A, Mackmull MT, Typas A, Müller CW, Bork P, Beck M, Savitski MM. (2018)
Pervasive protein thermal stability variation during the cell cycle.
Cell 173(6) doi: 10.1016/j.cell.2018.03.053
Europe PMC | doi
Schulze WM, Stein F, Rettel M, Nanao M, Cusack S. (2018)
Author Correction: Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
Nat Commun 9(1) doi: 10.1038/s41467-018-04643-5
Europe PMC | doi
Strucko T, Zirngibl K, Pereira F, Kafkia E, Mohamed ET, Rettel M, Stein F, Feist AM, Jouhten P, Patil KR, Forster J. (2018)
Laboratory evolution reveals regulatory and metabolic trade-offs of glycerol utilization in Saccharomyces cerevisiae.
Metab Eng 47:73-82. doi: 10.1016/j.ymben.2018.03.006
Europe PMC | doi
Schulze WM, Stein F, Rettel M, Nanao M, Cusack S. (2018)
Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
Nat Commun 9(1) doi: 10.1038/s41467-018-04142-7
Europe PMC | doi
2017
Schifferer M, Yushchenko DA, Stein F, Bolbat A, Schultz C. (2017)
A Ratiometric Sensor for Imaging Insulin Secretion in Single β Cells.
Cell Chem Biol 24(4):525-531. doi: 10.1016/j.chembiol.2017.03.001
Europe PMC | doi
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A. (2017)
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development
Dev. Cell 40(4):331-341. doi: 10.1016/j.devcel.2017.01.015
Europe PMC | doi
Höglinger D, Nadler A, Haberkant P, Kirkpatrick J, Schifferer M, Stein F, Hauke S, Porter FD, Schultz C. (2017)
Trifunctional lipid probes for comprehensive studies of single lipid species in living cells.
Proc. Natl. Acad. Sci. U.S.A. 114(7):1566-1571. doi: 10.1073/pnas.1611096114
Europe PMC | doi
Schifferer M, Feng S, Stein F, Schultz C. (2017)
Reversible Chemical Dimerization by rCD1.
Meth. Enzymol. 583:173-195. doi: 10.1016/bs.mie.2016.10.035
Europe PMC | doi
2016
Kuchenov D, Laketa V, Stein F, Salopiata F, Klingmüller U, Schultz C. (2016)
High-Content Imaging Platform for Profiling Intracellular Signaling Network Activity in Living Cells.
Cell Chem Biol 23(12):1550-1559. doi: 10.1016/j.chembiol.2016.11.008
Europe PMC | doi
Haberkant P, Stein F, Höglinger D, Gerl MJ, Brügger B, Van Veldhoven PP, Krijgsveld J, Gavin AC, Schultz C. (2016)
Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions.
ACS Chem Biol 11(1):222-230. doi: 10.1021/acschembio.5b00810
Europe PMC | doi
2015
Nadler A, Yushchenko DA, Müller R, Stein F, Feng S, Mulle C, Carta M, Schultz C. (2015)
Exclusive photorelease of signalling lipids at the plasma membrane.
Nat Commun 6 doi: 10.1038/ncomms10056
Europe PMC | doi
MacNamara A, Stein F, Feng S, Schultz C, Saez-Rodriguez J. (2015)
A single-cell model of PIP3 dynamics using chemical dimerization.
Bioorg. Med. Chem. 23(12) doi: 10.1016/j.bmc.2015.04.074
Europe PMC | doi
Schifferer M, Feng S, Stein F, Tischer C, Schultz C. (2015)
Reversible chemical dimerizer-induced recovery of PIP2 levels moves clathrin to the plasma membrane.
Bioorg. Med. Chem. 23(12):2862-2867. doi: 10.1016/j.bmc.2015.03.048
Europe PMC | doi
2014
Feng S, Laketa V, Stein F, Rutkowska A, MacNamara A, Depner S, Klingmüller U, Saez-Rodriguez J, Schultz C. (2014)
A rapidly reversible chemical dimerizer system to study lipid signaling in living cells
Angew. Chem. Int. Ed. Engl. 53(26):6720-6723. doi: 10.1002/anie.201402294
Europe PMC | doi
2013
Stein F, Kress M, Reither S, Piljić A, Schultz C. (2013)
FluoQ: a tool for rapid analysis of multiparameter fluorescence imaging data applied to oscillatory events
ACS Chem. Biol. 8(9):1862-1868. doi: 10.1021/cb4003442
Europe PMC | doi
Nadler A, Reither G, Feng S, Stein F, Reither S, Müller R, Schultz C. (2013)
The fatty acid composition of diacylglycerols determines local signaling patterns
Angew. Chem. Int. Ed. Engl. 52(24):6330-6334. doi: 10.1002/anie.201301716
Europe PMC | doi
2012
Cobos-Correa A, Stein F, Schultz C. (2012)
Target-Activated Prodrugs (TAPs) for the autoregulated inhibition of MMP12
ACS Med Chem Lett 3(8):653-657. doi: 10.1021/ml3001193
Europe PMC | doi
2011
Stein F, Mehmood T, Plass T, Zaidi JH, Diederichsen U. (2011)
Synthesis of trifunctional cyclo-β-tripeptide templates.
Beilstein J Org Chem 8:1576-1583. doi: 10.3762/bjoc.8.180
Europe PMC | doi