EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

ORCID iD: iD icon0000-0001-9321-2069

Publications

Total: 11 publication(s)

2019

Girstmair H, Tippel F, Lopez A, Tych K, Stein F, Haberkant P, Schmid PWN, Helm D, Rief M, Sattler M, Buchner J. (2019)

The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range.

Nat Commun 10(1) doi: 10.1038/s41467-019-11518-w
Europe PMC | doi

Sridharan S, Kurzawa N, Werner T, Günthner I, Helm D, Huber W, Bantscheff M, Savitski MM. (2019)

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP.

Nat Commun 10(1) doi: 10.1038/s41467-019-09107-y
Europe PMC | doi


2018

Mateus A, Bobonis J, Kurzawa N, Stein F, Helm D, Hevler J, Typas A, Savitski MM. (2018)

Thermal proteome profiling in bacteria: probing protein state in vivo.

Mol. Syst. Biol. 14(7) doi: 10.15252/msb.20188242
Europe PMC | doi

Becher I, Andrés-Pons A, Romanov N, Stein F, Schramm M, Baudin F, Helm D, Kurzawa N, Mateus A, Mackmull MT, Typas A, Müller CW, Bork P, Beck M, Savitski MM. (2018)

Pervasive Protein Thermal Stability Variation during the Cell Cycle.

Cell 173(6) doi: 10.1016/j.cell.2018.03.053
Europe PMC | doi


2016

da Silva BF, Meng C, Helm D, Pachl F, Schiller J, Ibrahim E, Lynne CM, Brackett NL, Bertolla R, Kuster B. (2016)

Towards understanding male infertility after spinal cord injury using quantitative proteomics.

Mol. Cell Proteomics 15(4) doi: 10.1074/mcp.M115.052175
Europe PMC | doi


2015

Meng C, Helm D, Frejno M, Kuster B. (2015)

moCluster: Identifying joint patterns across multiple omics datasets.

J. Proteome Res. 15(3) doi: 10.1021/acs.jproteome.5b00824
Europe PMC | doi

Médard G, Pachl F, Ruprecht B, Klaeger S, Heinzlmeir S, Helm D, Qiao H, Ku X, Wilhelm M, Kuehne T, Wu Z, Dittmann A, Hopf C, Kramer K, Kuster B. (2015)

Optimized chemical proteomics assay for kinase inhibitor profiling.

J. Proteome Res. 14(3):1574-1586. doi: 10.1021/pr5012608
Europe PMC | doi


2014

Helm D, Vissers JPC, Hughes CJ, Hahne H, Ruprecht B, Pachl F, Grzyb A, Richardson K, Wildgoose J, Maier SK, Marx H, Wilhelm M, Becher I, Lemeer S, Bantscheff M, Langridge JI, Kuster B. (2014)

Ion Mobility Tandem Mass Spectrometry Enhances Performance of Bottom-up Proteomics

MOL CELL PROTEOMICS 13(12):3709-3715. doi: 10.1074/mcp.M114.041038
Europe PMC | doi

Ku X, Heinzlmeir S, Helm D, Médard G, Kuster B. (2014)

New affinity probe targeting VEGF receptors for kinase inhibitor selectivity profiling by chemical proteomics.

J. Proteome Res. 13(5):2445-2452. doi: 10.1021/pr401247t
Europe PMC | doi


2013

Hahne H, Pachl F, Ruprecht B, Maier SK, Klaeger S, Helm D, Médard G, Wilm M, Lemeer S, Kuster B. (2013)

DMSO enhances electrospray response, boosting sensitivity of proteomic experiments.

Nat. Methods 10(10):989-991. doi: 10.1038/nmeth.2610
Europe PMC | doi

Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B. (2013)

Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.

J. Proteome Res. 12(2):927-936. doi: 10.1021/pr300967y
Europe PMC | doi