Location & dates EMBL Heidelberg, Germany 12 - 15 May 2014
Deadlines Registration closed Abstract submission closed

Final Programme

Day 1 - Monday, 12 May 2014
TimeSpeaker
14:00 'Parasite' an audio visual exhibition by Deborah Robinson opens to conference delegates and the public in the  Friedrichsbaukeller at Heidelberg Castle. Admission free  to delegates upon presentation of their conference pass. Viewing 12th 15th May. Please refer to posters for opening times.
09:00 - 11:00 ESAB / Exec Meeting (members only)
10:30 - 11:00 Coffee Break
11:00 - 12:00

General assembly (members only)

11:00 - 13:00 Registration
11:30 - 13:00 Lunch
13:00 - 13:15 Welcome remarks
Andrew Waters, University of Glasgow, United Kingdom

Scientific Session 1: Vaccines and immune avoidance
13:15 – 14:45


Chair: Mariana De Niz, University of Bern, Switzerland    
Co‑chair: Robert Sauerwein, Radboud University Medical Centre, The Netherlands

13:15 - 13:45

Keynote lecture
Pathogenesis of and Protection from Placental Malaria

Patrick E. Duffy, Vaccinology National Institute of Immunology and Infectious Diseases National Institutes of Health Bethesda MD, USA

13:45 - 13:55

Masking of MSPDBL and MSPDBL2 from the host immune system by human IgM
Cecile Crosnier, Wellcome Trust Sanger Institute, United Kingdom

13:55 - 14:15

IL-21 is critical to control Plasmodium chabaudi replication during the chronic phase of an erythrocytic-stage infection
Damian Perez-Mazliah, MRC National Institute for Medical Research, United Kingdom

14:15 - 14:25

Immune-Mediated Competition in Rodent Malaria Is Most Likely Caused by Induced Changes in Innate Immune Clearance of Merozoites
Jayanthi Santhanam, University of Edinburgh, United Kingdom

14:25 - 14:45

Liver stage Plasmodium berghei parasites escape host cell autophagy by shedding of the parasitophorous vacuole membrane
Carolina Agop-Nersesian, University of Bern, Switzerland

14:45 - 15:05 Coffee Break

Scientific Session 2: New technologies
15:05 – 16:30


Chair: Sujaan Das, MRC, National Institute for Medical Research, United Kingdom
Co chair: Oliver Billker, Wellcome Trust Sanger Institute, United Kingdom

15:05 - 15:25

Rapid and inducible protein degradation system reveals Calcineurin phosphatase function at multiple stages during Plasmodium life-cycle
Nisha Philip, Wellcome Centre for Molecular Parasitology, University of Glasgow, United Kingdom

15:25 - 15:45

Quantitation of P. falciparum merozoite-erythrocyte cell-cell interactions using optical tweezers
Alex Crick, University of Cambridge, United Kingdom

15:45 – 15:55

Efficient genome editing of human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
Medhi Ghorbal, Institut Pasteur, France

15:55 – 16:05

Versatile and tunable control of gene expression in Plasmodium falciparum
Jacquin Niles, Massachusetts Institute of Technology, United States of America

16:05 - 16:30 Poster preview talks
Poster number 55, 59, 60, 62, 68, 70, 72, 84, 101, 103
16:30 - 18:30

Poster Session A
Helix A

Cluster 1: Immunobiology and Pathophysiology, Poster number 46 - 60
Cluster 2: Parasite Molecular and Cell Biology, Poster number 61 - 98
Cluster 3: Vector Parasite Interactions, Poster number 99 - 100
Cluster 4: Modelling and Systems Biology, Poster number 101 – 103
Resource Posters
Beginning of Helix A and B, Poster number 104 - 109 and 166

18:00 - 18:30 ESAB / EC Meeting (members only)
18:30 - 20:00 Dinner
20:00 – 20:30 Foundations for Growth: EVIMalaR Career Development and Gender
20:30 – 21:00

Laudatory speech I
EVIMalaR Lifetime Achievement Award 2014
: Professor Marita Troye-Blomberg, Stockholm University, Sweden

Professor Wilfred Mbacham, University of Yaounde, Cameroon will speak in honour of Professor Marita Troye-Blomberg, Department of Immunology, Stockholm University, Sweden.

21:00 – 21:10 Laudatory speech II
EVIMalaR Promising African Scientist Award 2014: Dr Faith Osier

Professor Jean Langhorne, Division of Parasitology, National Institute for Medical Research, London, United Kingdom will speak in honour of Dr Faith Osier, Clinical Research Fellow and Group Leader, Kenya Medical Research Institute – Centre for Geographic Medicine Research, Coast (KEMRI-CGMRC), Kilifi, KENYA
21:10 - 23:00 Get together
Day 2 - Tuesday 13 May 2014
TimeSpeaker
07.30-09.00

Enhancing Career Confidence: EVIMalaR Breakfast Seminar (Ticket Invitation)

Scientific Session 3: Transmission
09:00 - 10:30


Chair: Harshal Patil, University of Heidelberg Medical School, Germany
Co chair: Maria Mota, Instituto de Medicina Molecular, Portugal

09:00 - 09:30

Keynote Lecture
Mosquito Immunity and the in invisible parasite: Implication for global malaria transmission
Carolina Barillas-Mury, Laboratory of Malaria and Vector Research National Institutes of Health Bethesda MD, United States of America

09:30 - 09:40

Role of mosquito nutrient transporters in reproduction and Plasmodium transmission
Giulia Costa, Max Planck Institute for Infection Biology, Germany

09:40 - 10:00

Ecological and genetic factors influencing the vectorial competence of Anopheles gambiae
Perrine Marcenac, Harvard School of Public Health, United States of America

10:00 - 10:10

Visualizing the function of two Plasmodium sporozoite surface proteins by in vivo imaging of the dermal inoculation site
Christine Hopp, Johns Hopkins Bloomberg School of Public Health, United States of America

10:10 - 10:30

Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum
Marije Behet, Radboud University Medical Center, The Netherlands

10:30 - 10:50 Coffee Break

Scientific Session 4: Cellular mechanisms
10:50 – 12:30


Chair: Thuvaraka Thavayogarajah, Philipps University Marburg, Germany
Co chair: Volker Heussler, Institute of Cell Biology, Switzerland

10:50 - 11:20 Keynote Lecture
Gametocytogenesis: I'm a parasite get me out of here
Andrew Waters, University of Glasgow, United Kingdom
11:20 - 11:30

Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes
Gabriele Pradel, RWTH Aachen University, Germany

11:30 – 11:45

Targeted disruption of exported chaperone Hsp70-x reveals a role in virulence of P. falciparum
Sarah Charnaud, Burnet Institute,Australia               

11:45 – 12:00

Identification of a P. knowlesi gene essential for invasion of human erythrocytes
Robert Moon, MRC, National Institute for Medical Research,United Kingdom

12:00 – 12:10

Inhibition of dual targeted tRNA synthetases in P. falciparum; Two birds with one stone
Katherine Jackson, The University of Melbourne, Australia

12:10 - 12:30 Poster preview talks
Poster number 108, 118, 120, 122, 123, 124, 125, 129, 139, 153
12:30 - 14:30 Poster session B and lunch
Helix A

Cluster 1: Immunobiology and Pathophysiology, Poster number 110 - 124
Cluster 2: Parasite Molecular and Cell Biology, Poster number 125 - 162
Cluster 3: Vector Parasite Interactions, Poster number 163 - 164
Cluster 4: Modelling and Systems Biology, Poster number 165 – 167
Resource Posters
Beginning of Helix A and B, Poster number 104 - 109 and 166


Scientific Session 5: Immunology
14:30 - 16:00


Chair: Kartik Bane, University of Heidelberg, Germany  
Co chair: Jean Langhorne, NIMR, United Kingdom

14:30 - 15:00 Keynote Lecture
Targets and mechanisms of human immunity to malaria

James Beeson, Burnet Institute, Australia
15:00 - 15:10

Autoimmunity loci play a role in the susceptibility to Plasmodium falciparum infection and uncomplicated disease
Valentina Mangano, Sapienza University of Rome, Italy

15:10 - 15:30

Kinetics of B cell responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) in Ghanaian women naturally exposed to malaria parasites
Lars Hviid,University of Copenhagen, Denmark

15:30 - 15:40

B-cell activating factor (BAFF) and BAFF-R levels correlate with B-cell subset activation and redistribution in controlled human malaria infection
Anja Scholzen, Radboud University Medical Center, the Netherlands

15:40 – 16:00

Host cell sensors for Plasmodium activate innate immunity against liver stage infection
Peter Liehl, Instituto de Medicina Moelcular, Portugal      

16:00 – 16:20 Coffee break

Scientific Session 6: var gene diversity and regulation
16:20 – 17:30


Chair:Liz Stevenson, University of Copenhagen, Denmark
Co chair: Till Voss, Swiss TPH, Switzerland

16:20 – 16:40

Update on the analysis of the global var gene repertoire
Thomas Otto,Wellcome Trust Sanger Institute, United Kingdom

16:40 – 16:50

Analysis of var genes from the Laverania clade
Daniel Larremore, Harvard School of Public Health, United States of America

16:50 – 17:10

Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of var genes
Antoine Claessens, Wellcome Trust Sanger Institute, United Kingdom

17:10 – 17:20

Antisense non-coding RNAs regulate var genes activation in Plasmodim falciparum
Ron Dzikowski, Hebrew University, Israel       

17:20 - 17:40 Poster preview talks
Poster number 175, 176, 177, 187, 200, 202, 207, 208, 209, 226
17:30 - 19:30 Poster session 3
Helix B

Cluster 1: Immunobiology and Pathophysiology, Poster number 168 - 180
Cluster 2: Parasite Molecular and Cell Biology, Poster number 181 - 223
Cluster 3: Vector Parasite Interactions, Poster number 224
Cluster 4: Modelling and Systems Biology, Poster number 225 – 228
Resource Posters
Beginning of Helix A and B, Poster number 104 - 109 and 166
19:30 - 00:00 BBQ & Party
Day 3 - Wednesday 14 May 2014
TimeSpeaker

Scientific Session 7: Large-scale approaches
09:00 - 10:30


Chair: Sonal Sethia, University of Glasgow, United Kingdom
Co chair: Artur Scherf, Institut Pasteur, France

09:00 - 09:30

Keynote lecture
Transcriptional regulation of Plasmodium falciparum,  a driving force of natural phenotypic variation and adaptation to its host environment

Zbynek Bozdech, Nanyang Technologial University, Singapore

09:30 - 09:50

Comparative metabolomics of erythroid lineage: implications for malaria control
Anubhav Srivastava, University of Glasgow, United Kingdom

09:50 - 10:00

The chromatin protein Plasmodium falciparum bromodomain protein 1 (PfBDP1) is required for red blood cell invasion
Michaela Petter, University of Melbourne, Australia

10:00 - 10:20

Protein S-nitrosylation in Plasmodium falciparum
Lihui Wang, Giessen University, Germany

10:20 - 10:30

Dynamics of Plasmodium falciparum protein interaction network: the membrane microdomain interactome
Gabriella Sferra, Istituto Superiore di Sanità, Italy

10:30 – 10:50 Coffee break

Scientific Session 8: Pathogenesis
10:50 – 12:20

Chair: Ana Rita Gomes, Wellcome Trust Sanger Institute, United Kingdom
Co chair: Clemens Kocken, BPRC, The Netherlands

10:50 - 11:05

Severity of Malarial Retinopathy is Associated with Intensity of Parasite Sequestration in Retinal and Cerebral Microvasculature in Malawian Children with Cerebral Malaria
Valentina Barrera, University of Liverpool, United Kingdom

11:05 - 11:15

Relationships between infected erythrocyte surface recognition, parasite PfEMP1 expression and severe malaria
Peter Bull, KEMRI/Wellcome Trust, Kenya

11:15 – 11:25

The role of Histidine Rich Protein II in Cerebral Malaria
Priya Pal, Washington University in St Louis, School of Medicine, United States of America

11:25 – 11:40

Mosquito passage of Plasmodium falciparum NF54 parasites changes the var gene transcriptional hierarchy from favored transcription of central to telomeric var genes
Sandra Dimonte, University of Tuebingen, Germany

11:40 – 12:00

Functional dissection of the myosin motors implicated in the circular, helical, and twirling gliding trajectories of coccidian parasites
Dominique Soldati-Favre, University of Geneva, Switzerland

12:00 - 12:20 Poster Prize-giving and closing remarks
12:20 - 14:00 Packed lunch
14:00 - 16:00 TAC meetings and networking
Day 4 - Thursday 15 May 2014
Time

EVIMalaR Symposium:

From BioMalPar to EVIMalaR : The Highs and the Highs, 2004-2014
09:00 - 09:30 Arrival (Tea/coffee will be served)
09:30 - 09:45

Welcome and Chair for morning session
Professor Andy Waters
Scientific Director, EVIMalaR; University of Glasgow, Scotland, United Kingdom

09:45 - 10:20 Speakers Cluster 1:
Immune responses and virulence in Plasmodium chabaudi infection
Professor Jean Langhorne, MRC National Institute for Medical Research, United KIngdom
10:20 - 10:55 Speakers Cluster 2:
Cellular and molecular approaches to Plasmodium parasites - the importance of networks
Dr Julian Rayner, Wellcome Trust Sanger Institute, United Kingdom
Professor Dominique Soldati-Favre
10:55 - 11:40

PhD Programme
Professor Michael Lanzer, Uniklinikum Heidelberg, Germany

Experiences of the PhD Programme
Dr António Mendes, Instituto de Medicina Molecular, Portugal
Dr Valentina Mangano, Sapienza University of Rome, Italy

11:40 - 11:55 Coffee break
11:55 - 12:30 Speaker Cluster 3:
Insights on Malaria Epidemiology from the perspective of the three Life Cycle Variomes
Professor Muntaser Ibrahim, University of Khartoum, Sudan
12:30 - 13:05 Speaker Cluster 4:
Plasmodium Molecular Genetic Toolkit: getting high
Dr Robert Menard, Institut Pasteur, France
13:05 - 14:00 Lunch
14:00 - 15:30 Chair for afternoon session
Professor Michael Lanzer, Uniklinikum Heidelberg, Germany
14:00 - 14:30 Artemisinin resistance
Dr Odile Puijalon, Institut Pasteur, France
14:30 - 15:00 Understanding immunity to malaria: future directions and aspirations
Dr Faith Osier, KEMRI-Wellcome Trust Programme, Kenya
(EVIMalaR Promising African Scientist Award)
15:00 - 15:30 Malaria immunology -  the learning journey of a lifetime
Professor Marita Troye-Blomberg, Stockholm University, Sweden
(EVIMalaR Lifetime Achievement Award)
15:30 - 16:00 Summary and Close
Professor Andy Waters
Scientific Director, EVIMalaR; University of Glasgow, Scotland, United Kingdom