Location & dates EMBL Heidelberg, Germany 8 - 11 Nov 2014
Deadlines Registration closed Abstract submission closed

Final Programme

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Day 1 - Saturday 8 November
13:00-15:00 Arrival and Registration
15:00-15:05 Welcome Address

Session 1
15:05 - 18:50
Chair: Eileen Furlong


Evolutionary tradeoffs and the geometry of gene expression space
Uri Alon, Weizmann Institute of Science, Israel


Noncanonical mechanisms in the evolution of transcription factors’ DNA binding specificities
Martha Bulyk, Brigham & Women's Hospital and Harvard Medical School, United States of America


Modeling cell cycle variation in Single-Cell RNA-seq data reveals novel substructure between cells
Oliver Stegle, EMBL-EBI, United Kingdom

16:20-16:50 Exaptation and the space of possible metabolisms
Andreas Wagner, University of Zurich, Switzerland
16:50-17:20 Coffee Break
17:20-17:50 From cell populations to single molecule analysis of chromosome folding
Peter Fraser, Babraham Institute, United Kingdom
17:50-18:05 DNA methylation: genomic and epigenomic determinants of pattern generation
Tuncay Baubec, Friedrich Miescher Institute, Switzerland
18:05-18:20 The BLMP-1/LIN-42 regulatory circuit couples oscillatory transcription to temporal cell fate determination
Christopher Hammell, Cold Spring Harbor Laboratory, United States of America
18:20-18:50 Why are individuals different?
Ben Lehner, CRG, Spain
19:00-21:00 Dinner
21:00-23:00 Drinks in the ATC Roof Top Lounge
Day 2 - Sunday 9 November

Session 2 kindly sponsored by Nature Reviews Genetics
Chair: Howard Chang

09:00-09:30 Enhancers/eRNAs in regulation of gene transcriptional programmes
Michael Rosenfeld, University of California, San Diego, United States of America
09:30-10:00 Sensing amino acid deficiencies in cancer
Reuven Agami, Netherlands Cancer Institute, The Netherlands
10:00-10:15 Nucleosome organisation in Drosophila
Fulvia Ferrazzi, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
10:15-10:45 RNA-binding proteins, metabolism and a new function for the genome?
Matthias W. Hentze, EMBL Heidelberg, Germany
10:45-11:15 Coffee Break
11:15-11:45 Cellular mechanisms of genome transcription
Patrick Cramer, MPI for Biophysical Chemistry, Germany
11:45-12:00 Negative feedback buffers effects of regulatory mutations
Julien Gagneur, Gene Center, LMU, Germany
12:00-12:15 The logic of the regulatory mechanism underlying growth-rate control in Escherichia coli
Evert Bosdriesz, Netherlands Cancer Institute, The Netherlands
12:15-12:45 Dissecting the genetic and epigenetic control of X-chromosome inactivation
Edith Heard, Institut Curie, France
12:45-14:00 Lunch
14:00-16:30 Poster Session I: odd numbers

Session 3
16:30 - 19:30
Chair: Ben Lehner

16:30-17:00 Individual variation in gene expression during embryonic development: new mechanisms of compensation
Eileen Furlong, EMBL Heidelberg, Germany
17:00-17:15 Relocalisation of the proteome defines a new class of functional genomic interactions
Peter Thorpe, MRC National Institute for Medical Research, United Kingdom
17:15-17:45 Recursive splicing regulates use of poison exons within long neuronal genes
Jernej Ule, UCL Institute of Neurology, United Kingdom
17:45-18:15 Coffee Break
18:15-18:45 Regulatory RNAs
Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
18:45-19:00 Pathway crosstalk quantification reveals synergistic drug combinations against breast cancer
Samira Jaeger, IRB Barcelona, Spain
19:00-19:30 Whole cell model of a small bacteria, what have we learned
Luis Serrano, CRG, Spain
19:30-21:00 Dinner
21:00-23:00 Drinks in the ATC Roof Top Lounge
Day 3 - Monday 10 November
Session 4
09:00 - 12:45
Chair: Joanna Wysocka
09:00-09:30 Deciphering regulatory circuitry by genome-wide analyses
Frank Holstege, University Medical Center Utrecht, The Netherlands
09:30-10:00 Epigenomic signals identify novel genes and pathways associated with cardiac traits
Laurie Boyer, Massachusetts Institute of Technology, United States of America
10:00-10:15 Transcript abundance in human cells approaches perfect controllability
Nico Battich, University of Zurich, Switzerland
10:15-10:45 Genetics and Genomics of piRNA biogenesis
Julius Brennecke, IMBA, Austria
10:45-11:15 Coffee Break
11:15-11:45 Genetic basis of chromatin states and gene expression in humans involves local and distal chromosomal interactions
Judith Zaugg, EMBL Heidelberg, Germany
11:45-12:00 Inferring Directional Genetic Interactions from multi-parametric combinatorial screens
Bernd Fischer, DKFZ, Germany
12:00-12:15 Genome-wide activity maps of signal-dependent enhancers
Daria Shlyueva, Research Institute of Molecular Pathology (IMP), Austria
12:15-12:45 Imaging RNA and RNA biology using RNA mimics of green fluorescent protein
Samie Jaffrey, Weill Cornell Medical College, United States of America
12:45-14:00 Lunch
14:00-16:30 Poster Session II: even numbers
Session 5
Chair: Eran Segal
16:30-17:00 Genome-wide analysis of protein-DNA interactions
Jussi Taipale, Karolinska Institutet, Sweden
17:00-17:15 Arabidopsis ensemble reverse-engineered gene regulatory network discloses interconnected transcription factors in oxidative stress
Vanessa Vermeirssen, VIB - Ghent University, Belgium
17:15-17:45 Intrinsic retroviral reactivation during human development
Joanna Wysocka, Stanford University, United States of America
17:45-18:15 Coffee Break
18:15-18:45 Genome Regulation by Long Noncoding RNAs
Howard Chang, Stanford University, United States of America
18:45-19:00 Genomics of drug sensitivity in primary lymphoid malignancies
Wolfgang Huber, EMBL Heidelberg, Germany
19:00-19:30 Linking epigenetics and signalling in the early mammalian embryo
Amanda Fisher, MRC Clinical Sciences Centre, United Kingdom
19:30-01:00 Conference dinner and Party
Day 4 - Tuesday 11 November
Session 6
Chair: Frank Holstege
09:00-09:30 Direct determination of DNA-protein interactions by proteomics
Matthias Mann, MPI of Biochemistry, Germany
09:30-09:45 The genomic landscape of compensatory evolution
Gabor Boross, Biological Research Centre, Hungary
09:45-10:00 Widespread intron retention in mammals functionally tunes transcriptome
Ulrich Braunschweig, University of Toronto, Canada
10:00-10:15 Specificity, propagation and memory of chromatin states
Karsten Rippe, German Cancer Research Center (DKFZ), Germany
10:15-10:45 Genetic and epigenetic determinants of hematopoiesis in humans
Nicole Soranzo, Wellcome Trust Sanger Institute, United Kingdom
10:45-11:15 Coffee Break
11:15-11:45 Unraveling principles of gene regulation using thousands of designed regulatory sequences
Eran Segal, Weizmann Institute, Israel
11:45-12:00 Mapping chromatin dynamics after DNA replication
Marta Radman-Livaja, CNRS, France
12:00-12:15 Prioritising the investigation of human metabolic functions from their metabolic context
Ottar Rolfsson, Center for Systems Biology, University of Iceland, Iceland
12:15-12:45 Single-cell dynamics of genome - nuclear lamina interactions
Bas van Steensel, Netherlands Cancer Institute, The Netherlands
12:45-12:50 Closing remarks
12:50 Packed Lunch
13:15 Bus Downtown and Frankfurt Airport