Location & dates EMBL Heidelberg, Germany 5 - 8 Nov 2017
Deadlines Registration closed Abstract submission closed

Programme

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Day 1 - Sunday 5 November 2017
TimeSpeaker
11.15-13.15 Arrival / Registration with light refreshments
13.15-13.30 Opening remarks
13.30-16.15 Session 1: Structural genomics and cancer
Chairs: Peter Lichter (13.30-15.00) and Peter Campbell (15.30-16.15)
13.30-14.00

Advancing the field of mutational signatures: Insights into mutational mechanisms and clinical applications
Serena Nik-Zainal, Wellcome Trust Sanger Institute

14.00-14.15

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours
Bernardo Rodriguez-Martin, The Biomedical Research Centre (CINBIO), University of Vigo

14.15-14.30

Genomic footprints of activated telomere maintenance mechanisms in cancer
Lina Sieverling, DKFZ

14.30-15.00

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes
Jan Korbel, EMBL Heidelberg

15.00-15.30 Coffee Break
15.30-15.45

Inherited determinants of early recurrent somatic mutations in prostate cancer
Alessandro Romanel, Centre for Integrative Biology, University of Trento 

15.45-16.00

Validating the concept of mutational signatures with isogenic cell models
Xueqing Zou, Wellcome Trust Sanger Institute

16.00-16.15

Canonical fusions in bone and soft tissue cancer are generated by replication-associated genomic catastrophes
Nathaniel Anderson, The Hospital for Sick Children

16.15-17.00

Coffee Break & Meet the Speakers

17.00-18.00

Keynote: Challenges in understanding the biological and clinical behavior of tumors on the basis of structural and functional genomics
Peter Lichter, German Cancer Research Center

18.00-20.30 Welcome reception with light refreshments
Day 2 - Monday 6 November 2017
TimeSpeaker
09.00-12.15

Session 2: Systems biology and drivers of cancer
Chairs: Nuria Lopez-Bigas (9.00-10.30) and Stefan Pfister (11.00-12.15)

09.00-09.30

The Genomic Landscape of Childhood Cancers and its Clinical Implications
Stefan Pfister, German Cancer Research Center

09.30-09.45

Pan-cancer driver discovery in more than 2,500 whole cancer genomes
Jakob Pedersen

09.45-10.00

Identification and characterization of oncogenic SOS1 mutations in lung adenocarcinoma
Diana Cai, Harvard University

10.00-10.30

Núria López-Bigas, ICREA, Institute for Research in Biomedicine

10.30-11.00

Coffee Break

11.00-11.15

Non-coding cancer driver mutations in super-enhancers and long-range chromatin interaction networks
Juri Reimand, Ontario Institute for Cancer Research

11.15-11.30 The evolutionary history of 2,658 cancers
Peter Van Loo, The Francis Crick Institute
11.30-11.45

Pervasive intra-tumour heterogeneity and subclonal selection across cancer types
Kerstin Haase, The Francis Crick Institute

11.45-12.00

Identification of non-neutral tumour evolution across human cancer types
Maxime Tarabichi, The Francis Crick Institute

12.00-12.15

Elucidating the effects of SNPs in genotype-phenotype mappings of carcinogenesis
Jimmie Haellman, University of Sheffield

12.15-13.45

Lunch

13.00-13.45

Workshop hosted by Thermo Fisher Scientific in Flex Lab A+B

13.45-15.45

Poster Session I (odd numbers) in Helix A

15.45-16.45

Session 3: Cancer immunogenomics
Chair: Lynda Chin

15.45-16.00

The pan-cancer landscape of interactions between solid tumors and infiltrating immune cell populations
David Tamborero, Universitat Pompeu Fabra

16.00-16.30

A novel mechanism of cancer immune evasion vis 3'-UTR disruption of PD-L1
Seishi Ogawa, Kyoto University

16:30-16:45

Analysis of allele specific HLA loss in lung cancer evolution
Rachel Rosenthal, UCL Cancer Institute

16.45-17.30

Coffee Break & Meet the Speakers

17.30-18.30

Keynote: Whole-organism clone-tracing using single-cell sequencing
Alexander van Oudenaarden, Hubrecht Institute-KNAW & University Medical Center Utrecht

18.30-20.00

Dinner in the EMBL Canteen

20.00-21.30 After-dinner drinks in ATC Rooftop Lounge
Day 3 - Tuesday 7 November 2017
TimeSpeaker
09.00-12.00 Session 4: Cancer genome and epigenome
Chairs: Matthew Meyerson (9.00-10.30) and Elizabeth Murchison (11.00-12.00)
09.00-09.30 Clarifying the impact of genetic defects in prostate cancer through epigenetics
Mathieu Lupien, Princess Margaret Cancer Centre
09.30-09.45

A pan-cancer analysis of promoter activity highlights the regulatory role of alternative transcription start sites and their association with noncoding mutations
Jonathan Goeke, Genome Institute of Singapore

09.45-10.00

Mutation accumulation during human foetal development
Francis Blokzijl, UMC Utrecht

10.00-10.30

Genomic instability triggered by chromosome gains
Zuzana Storchova,
Technical University Kaiserslautern

10.30-11.00

Coffee Break

11.00-11.30

Mutations and their interactions in individuals
Ben Lehner, Centre for Genomic Regulation (CRG)

11.30-11.45 Identification and characterization of recurrent deletions in the human genome promoted by expression of transposase-derived gene across different tumor types
Elias Rodriguez-Fos, Barcelona Supercomputing Center (BSC)
11.45-12.00 Pan-cancer analysis of DNA replication strand asymmetry in mutational signatures
Marketa Tomkova, University of Oxford
12.00-13.30

Lunch

13.30-15.30

Poster Session II (even numbers) in Helix A

15.30-18.30

Session 5: Cancer genome medicine
Chair: Mathieu Lupien

15.30-16.00

Genomic Medicine: A Case for Phenomics in the world of genomics
Lynda Chin, Institute for Health Transformation, University of Texas System

16.00-16.15

The TARGET pilot study of a comprehensive precision medicine platform for children with high-risk cancer
Emily Mould, Children's Cancer Institute

16.15-16.45

Integrative Literature Mining and Knowledge Networks for Kinase Cancer Drug Analytics
Cathy H. Wu, University of Delaware

16.45-17.30

Coffee Break & Meet the Speakers

17.30-17.45

Establishment and characterization of an ovarian cancer organoid biobank
Jose Espejo Valle-Inclan, UMC Utrecht

17.45-18.00

Mapping the evolution of carboplatin resistance in ovarian cancer with single cell sequencing
Oliver Harismendy, UC San Diego

18.00-18.30

Genomics of liver tumors: identification of new risk factors
Jessica Zucman-Rossi, INSERM

18.30-20.30 Banquet Dinner in the EMBL Canteen
20.30-00.00 Conference Party in the ATC Foyer
Day 4 - Wednesday 8 November 2017
TimeSpeaker
09.00-12.00 Session 6: The future of cancer genomics
Chairs: Zuzana Storchová (9.00-10:30) and Jan Korbel (11.00-12.00)
09.00-09.30

Interrogating the architecture of cancer genomes
Peter Campbell, Wellcome Trust Sanger Institute

09.30-09.45

Copy number signatures across primary tumours
Tauanne Amarante, Wellcome Trust Sanger Institute

09.45-10.15

Two transmissible cancers in Tasmanian devils
Elizabeth Murchison, University of Cambridge

10.15-10.30

Somatic variation and mutagenesis in a canine transmissible cancer
Adrian Baez-Ortega, University of Cambridge

10.30-11.00

Coffee Break & Meet the Speakers

11.00-11.15

Tumor heterogeneity over time in zebrafish using single-cell RNA-Seq
Itai Yanai, New York University Langone Health

11.15-11.30 High density of cancer mutations in normal oesophagus
Inigo Martincorena, Wellcome Trust Sanger Institute
11.30-12.00

Genomic analysis of human cancers
Matthew L. Meyerson, Dana-Farber Cancer Institute

12.00-12.10 Closing remarks & Poster prize giving
12.10-12.30 Packed lunch