Location & dates EMBL Heidelberg, Germany 5 - 8 Nov 2017
Deadlines Registration closed Abstract submission closed

EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.


Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.


More information for participants of events at EMBL Heidelberg can be found here.

Programme

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Day 1 - Sunday 5 November 2017
TimeSpeaker
11.15-13.15 Arrival / Registration with light refreshments
13.15-13.30 Opening remarks
13.30-16.15 Session 1: Structural genomics and cancer
Chairs: Peter Lichter (13.30-15.00) and Peter Campbell (15.30-16.15)
13.30-14.00

Advancing the field of mutational signatures: Insights into mutational mechanisms and clinical applications
Serena Nik-Zainal, Wellcome Trust Sanger Institute

14.00-14.15

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours
Bernardo Rodriguez-Martin, The Biomedical Research Centre (CINBIO), University of Vigo

14.15-14.30

Genomic footprints of activated telomere maintenance mechanisms in cancer
Lina Sieverling, DKFZ

14.30-15.00

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes
Jan Korbel, EMBL Heidelberg

15.00-15.30 Coffee Break
15.30-15.45

Inherited determinants of early recurrent somatic mutations in prostate cancer
Alessandro Romanel, Centre for Integrative Biology, University of Trento 

15.45-16.00

Validating the concept of mutational signatures with isogenic cell models
Xueqing Zou, Wellcome Trust Sanger Institute

16.00-16.15

Canonical fusions in bone and soft tissue cancer are generated by replication-associated genomic catastrophes
Nathaniel Anderson, The Hospital for Sick Children

16.15-17.00

Coffee Break & Meet the Speakers

17.00-18.00

Keynote: Challenges in understanding the biological and clinical behavior of tumors on the basis of structural and functional genomics
Peter Lichter, German Cancer Research Center

18.00-20.30 Welcome reception with light refreshments
Day 2 - Monday 6 November 2017
TimeSpeaker
09.00-12.15

Session 2: Systems biology and drivers of cancer
Chairs: Nuria Lopez-Bigas (9.00-10.30) and Stefan Pfister (11.00-12.15)

09.00-09.30

The Genomic Landscape of Childhood Cancers and its Clinical Implications
Stefan Pfister, German Cancer Research Center

09.30-09.45

Pan-cancer driver discovery in more than 2,500 whole cancer genomes
Jakob Pedersen

09.45-10.00

Identification and characterization of oncogenic SOS1 mutations in lung adenocarcinoma
Diana Cai, Harvard University

10.00-10.30

Núria López-Bigas, ICREA, Institute for Research in Biomedicine

10.30-11.00

Coffee Break

11.00-11.15

Non-coding cancer driver mutations in super-enhancers and long-range chromatin interaction networks
Juri Reimand, Ontario Institute for Cancer Research

11.15-11.30 The evolutionary history of 2,658 cancers
Peter Van Loo, The Francis Crick Institute
11.30-11.45

Pervasive intra-tumour heterogeneity and subclonal selection across cancer types
Kerstin Haase, The Francis Crick Institute

11.45-12.00

Identification of non-neutral tumour evolution across human cancer types
Maxime Tarabichi, The Francis Crick Institute

12.00-12.15

Elucidating the effects of SNPs in genotype-phenotype mappings of carcinogenesis
Jimmie Haellman, University of Sheffield

12.15-13.45

Lunch

13.00-13.45

Workshop hosted by Thermo Fisher Scientific in Flex Lab A+B

13.45-15.45

Poster Session I (odd numbers) in Helix A

15.45-16.45

Session 3: Cancer immunogenomics
Chair: Lynda Chin

15.45-16.00

The pan-cancer landscape of interactions between solid tumors and infiltrating immune cell populations
David Tamborero, Universitat Pompeu Fabra

16.00-16.30

A novel mechanism of cancer immune evasion vis 3'-UTR disruption of PD-L1
Seishi Ogawa, Kyoto University

16:30-16:45

Analysis of allele specific HLA loss in lung cancer evolution
Rachel Rosenthal, UCL Cancer Institute

16.45-17.30

Coffee Break & Meet the Speakers

17.30-18.30

Keynote: Whole-organism clone-tracing using single-cell sequencing
Alexander van Oudenaarden, Hubrecht Institute-KNAW & University Medical Center Utrecht

18.30-20.00

Dinner in the EMBL Canteen

20.00-21.30 After-dinner drinks in ATC Rooftop Lounge
Day 3 - Tuesday 7 November 2017
TimeSpeaker
09.00-12.00 Session 4: Cancer genome and epigenome
Chairs: Matthew Meyerson (9.00-10.30) and Elizabeth Murchison (11.00-12.00)
09.00-09.30 Clarifying the impact of genetic defects in prostate cancer through epigenetics
Mathieu Lupien, Princess Margaret Cancer Centre
09.30-09.45

A pan-cancer analysis of promoter activity highlights the regulatory role of alternative transcription start sites and their association with noncoding mutations
Jonathan Goeke, Genome Institute of Singapore

09.45-10.00

Mutation accumulation during human foetal development
Francis Blokzijl, UMC Utrecht

10.00-10.30

Genomic instability triggered by chromosome gains
Zuzana Storchova,
Technical University Kaiserslautern

10.30-11.00

Coffee Break

11.00-11.30

Mutations and their interactions in individuals
Ben Lehner, Centre for Genomic Regulation (CRG)

11.30-11.45 Identification and characterization of recurrent deletions in the human genome promoted by expression of transposase-derived gene across different tumor types
Elias Rodriguez-Fos, Barcelona Supercomputing Center (BSC)
11.45-12.00 Pan-cancer analysis of DNA replication strand asymmetry in mutational signatures
Marketa Tomkova, University of Oxford
12.00-13.30

Lunch

13.30-15.30

Poster Session II (even numbers) in Helix A

15.30-18.30

Session 5: Cancer genome medicine
Chair: Mathieu Lupien

15.30-16.00

Genomic Medicine: A Case for Phenomics in the world of genomics
Lynda Chin, Institute for Health Transformation, University of Texas System

16.00-16.15

The TARGET pilot study of a comprehensive precision medicine platform for children with high-risk cancer
Emily Mould, Children's Cancer Institute

16.15-16.45

Integrative Literature Mining and Knowledge Networks for Kinase Cancer Drug Analytics
Cathy H. Wu, University of Delaware

16.45-17.30

Coffee Break & Meet the Speakers

17.30-17.45

Establishment and characterization of an ovarian cancer organoid biobank
Jose Espejo Valle-Inclan, UMC Utrecht

17.45-18.00

Mapping the evolution of carboplatin resistance in ovarian cancer with single cell sequencing
Oliver Harismendy, UC San Diego

18.00-18.30

Genomics of liver tumors: identification of new risk factors
Jessica Zucman-Rossi, INSERM

18.30-20.30 Banquet Dinner in the EMBL Canteen
20.30-00.00 Conference Party in the ATC Foyer
Day 4 - Wednesday 8 November 2017
TimeSpeaker
09.00-12.00 Session 6: The future of cancer genomics
Chairs: Zuzana Storchová (9.00-10:30) and Jan Korbel (11.00-12.00)
09.00-09.30

Interrogating the architecture of cancer genomes
Peter Campbell, Wellcome Trust Sanger Institute

09.30-09.45

Copy number signatures across primary tumours
Tauanne Amarante, Wellcome Trust Sanger Institute

09.45-10.15

Two transmissible cancers in Tasmanian devils
Elizabeth Murchison, University of Cambridge

10.15-10.30

Somatic variation and mutagenesis in a canine transmissible cancer
Adrian Baez-Ortega, University of Cambridge

10.30-11.00

Coffee Break & Meet the Speakers

11.00-11.15

Tumor heterogeneity over time in zebrafish using single-cell RNA-Seq
Itai Yanai, New York University Langone Health

11.15-11.30 High density of cancer mutations in normal oesophagus
Inigo Martincorena, Wellcome Trust Sanger Institute
11.30-12.00

Genomic analysis of human cancers
Matthew L. Meyerson, Dana-Farber Cancer Institute

12.00-12.10 Closing remarks & Poster prize giving
12.10-12.30 Packed lunch