Location & dates EMBL Heidelberg, Germany 15 - 20 Oct 2017
Deadlines Application closed
organiser_EMBO_Course_2017

Programme

Got something to say? Share it with #EMBOMice

Day 1 - Sunday 15 October 2017
TimeSpeaker
12.00 Arrival and check-in B&B Hotel
13.45 - 14.00 Bus from B&B Hotel to Heidelberg City Tour
14.00 - 16.00 Heidelberg city excursion for speakers and participants
16.00 - 16:30 Bus from Neckarmunzplatz to EMBL
16.30 - 17.00

Registration

17.00 - 18.00

Welcome and introduction to the meeting
Rules and regulations for the ATC
Jacqueline Dreyer-Lamm- EMBL Heidelberg, Germany
Highlights and perspectives of humanized mice 

Leonard Shultz - The Jackson Laboratory, USA

18.00 - 20.00

Moderating participants and speakers for introductions
Renata Stripecke- Hannover Medical School, Germany

20.00 Dinner
Day 2 - Monday 16 October 2017
TimeSpeaker
08.30 – 09.15

New strains of mice for humanization
Michael Brehm- University of Massachusetts Medical School, USA

09.15 - 10.00

Human HSC engraftment in Kit-mutant recipient mice
Claudia Waskow- Technische Universität Dresden, Germany

10.00- 10.30 Coffee break
10.30 – 11.15

Development of innate and adaptive responses
James di Santo- Institut Pasteur, France

11.15 - 12.00

Adoptive DCs, adaptive immune response and CMV infection
Renata Stripecke- Hannover Medical School, Germany

12.00 - 12.45

Long term immune reconstitution in humanized mice
Roberto Speck- Universtiy Hospital Zürich, Switzerland

12.45 - 13.45 Lunch break
14.00 - 14.45

DC and NK innate immune responses and EBV infection
Christian Muenz - University of Zurich, Switzerland

14.45 - 15.30

Investigating antibody-mediated therapies in HIV-1-infected humanized mice
Florian Klein- University of Cologne, Germany

15.30 - 16.00

Coffee break

16.00 - 16.45

Liver-immune system and innate immune responses HBV and HCV
Marcus Dorner - Imperial College London, UK

16.45 - 17.45

Adenovirus, Ebola and Merkel Cell Polyoma infections
Estefania Rodriguez-Burgos - Heinrich Pette Institute Hamburg, Germany

18.00 - 19.00

Dinner

19.00 - 21.00

Poster Session (even numbers) & Drinks

Day 3 - Tuesday 17 October 2017
TimeSpeaker
09.00 - 12.30

Practical Class 1:
Selection of human hematopoietic stem cells, T cells,
monocytes for humanization and post transplantation analyses of immune reconstitutions
Renata Stripecke -Hannover Medical School, Germany
Michael Brehm -University of Massachusetts Medical School, USA
Claudia Waskow -Technische Universität Dresden, Germany
Roberto Speck -Universtiy Hospital Zürich, Switzerland
James Di Santo -Institut Pasteur, France 
Sebastian Theobald -Hannover Medical School, Germany

12.30 - 13.30

Lunch

13.30 - 18.00

Practical Class 2:
Analyses of human infections in mice 

Christian Muenz - University of Zurich, Switzerland
Chun Yu - The Jackson Laboratory, USA
Florian Klein - Centre for Molecular Medicine Cologne, Germany
Marcus Dorner - Imperial College London, UK
Estefania Rodriguez - Heinrich Pette Institute Hamburg, Germany

18.00 - 19.00 General Discussion of Results and Troubleshooting
19.00 - 20.00

Dinner

20.00 - 22.00

Poster Session (odd numbers) & Drinks

Day 4 - Wednesday 18 October 2017
TimeSpeaker
09.00 - 09.45

Ossicle implants for engraftment of hematopoietic stem cells and leukemia
J.J. Schuringa - University of Groningen, The Netherlands

09.45 - 10.30

Cytokine KI mice and their use in engrafting human myeloid malignancies 
Alexandre Theocharides - Universtiy Hospital Zürich, Switzerland

10.30 - 11.00

Coffee break

11.00 - 11.45 DX models as tools to identify and target therapy resistance mechanism
in human pancreatic cancer
Andreas Trumpp - DKFZ ,Heidelberg, Germany
11.45 - 12.30 PDX: Melanoma
Chun Yu - The Jackson Laboratory, USA
12.30 - 13.45

Lunch

14.00 - 18.00

Practical Class 3: Biopsy collections and analyses of human malignancies in mice 
J.J. Schuringa -University of Groningen, The Netherlands
Alexandre Theocharides - Universtiy Hospital Zürich, Switzerland
Anja Wege - University Medical Center Regensburg, Germany
James Keck - The Jackson Laboratory, USA
Andreas Trumpp - DKFZ – Heidelberg, Germany
Lisa Becker - DKFZ- Heidelberg, Germany
Corinna Klein - HI-STEM, Germany
Beat Bornhauser - University of Zurich, Switzerland

18.00 - 19.00 General Discussion of Results and Troubleshooting
19.00 - 20.00

Dinner

20.00 - 20.45

PDX models combined with human immune system
James Keck - The Jackson Laboratory, USA

20.45 - 21.45

Evaluation of immune related therapeutic strategies for breast cancer in Humanized Tumor Mice (HTM)
Anja Wege -University Medical Center Regensburg, Germany

Day 5 - Thursday 19 October 2017
TimeSpeaker
09.00 - 09.45

Applications of human liver chimeric mice in biomedical science
Karl-Dimiter Bissig - Baylor College of Medicine, USA

09.45 - 10.30

Molecular regulators of liver regeneration
Amar Sharma - Hannover Medical School, Germany

10.30 - 11.00

Coffee break

11.00 - 11.45

In vitro expansion of human cells for generation of xenograft infection models
Dagmar Wirth- Helmholtz Centre for Infection Research, Germany

11.45 - 12.30

Testing monoclonal antibodies against cancer
Johannes Sam- Roche Zurich, Switzerland

12.30 - 13.45 Lunch
13.45 - 18.00

Practical Class 4: Regenerative Medicine
Karl -Dimiter Bissig - Baylor College of Medicine, USA
Amar Sharma - Hannover, Germany
Dagmar Wirth -Helmholtz Centre for Infection Research, Germany
Johannes Sam - Roche Zurich, Switzerland

18.00

Dinner Downtown  

Day 6 - Friday 20 October 2017
TimeSpeaker
09.00 - 09.45

Genetic analyses and profiling of ALL
Jean Pierre Bourquin- University of Zurich, Switzerland

09.45 - 10.30

Muscle development, disease and repair
Nadia Rosenthal- The Jackson Laboratory, USA

10.30 - 11.00 Coffee break
11.00 -11.30

Immune response to vaccines, biotherapeutic medicines
and stem cells with a regulatory perspective

Sandrine Vessillier- Biotherapeutics NIBSC, UK

11.30 - 12.00

Drug Safety and Efficacy Testing in BLT Humanized Mice
Kristina Howard - Food and Drug Administration, USA

12.00 - 13:15

Lunch

13:15 - 15:00

Discussions, closing remarks and departure