EMBL Conference - Revolutions in Structural Biology: Celebrating the 100th Anniversary of Sir John Kendrew

Location & dates EMBL Heidelberg, Germany 16 - 17 Nov 2017

Deadlines Registration closed Abstract submission closed

Conference Programme

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Day 1 - Thursday 16 November 2017
Time	Speaker
08:00-09:00	Registration and light breakfast
09.00-12.15	Session 1: The X-ray crystallography revolution (historical perspective) Chair: Stephen Cusack
09.00-09.15	John Kendrew and EMBL Iain Mattaj - EMBL Heidelberg, Germany
09.15-09.45	John Kendrew and the early days of protein crystallography Soraya de Chadarevian - UCLA Institute for Society and Genetics, USA
09.45-10.15	Virus structures: from a small plant virus to human pathogens Stephen Harrison - Harvard Medical School / Howard Hughes Medical Institute, USA
10.15-10.45	Structural Basis for RyR1 Calcium Release Activity Wayne Hendrickson - Columbia University Medical Center, USA
10.45-11.15	Coffee Break
11.15-11.45	Structural biology of the amyloid state of proteins David Eisenberg - UCLA, USA
11.45-12.00	"If your experiment needs statistics, you ought to have done a better experiment": the dialectics of diffraction data collection, processing and exploitation in crystal structure determination, with special attention to structure-based drug discovery Gerard Bricogne, Global Phasing Limited, United Kingdom
12.00-12.15	Structural Basis for a Safety-Belt Mechanism that Anchors Condensin Complexes to Chromosomes Marc Kschonsak - EMBL Heidelberg, Germany
12.15-13.30	Lunch
13.30-16.00	Session 2: The EM revolution Chair: Christoph Müller
13.30-14.00	CryoEM and the resolution revolution - membrane protein complexes Werner Kühlbrandt - Max Planck Institute of Biophysics, Germany
14.00-14.30	Using cryo-electron tomography to determine protein structures in situ John Briggs - MRC Laboratory of Molecular Biology, UK
14.30-15.00	Structural Biology in situ: The Promise and Challenges of Cryo-Electron Tomography Wolfgang Baumeister - Max Planck Institute of Biochemistry, Germany
15.00-15.30	Navigating the cellular landscape with new imaging technologies Jennifer Lippincott-Schwartz - NICHD NIH, USA
15.30-15.45	Single-particle 3D reconstruction with molecular specificity Christian Sieben, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
15.45-16.00	Genomic RNA folding mediates assembly of human parechovirus Sarah Butcher, University of Helsinki, Finland
16.00-16.30	Coffee Break
16.30-19.00	Session 3: The Computational Revolution (modelling, bridging scales to systems biology) Chair: Janet Thornton
16.30-17.00	Evolution and assembly of protein complexes Sarah Teichmann - Wellcome Trust Sanger Institute, UK
17.00-17.30	The coming of age of de novo protein design David Baker - University of Washington, USA
17.30-18.00	Integrative modeling of biomolecular assembly structures and pathways Andrei Sali - University of California, San Francisco, USA
18.00-18.30	Architecture of the human nuclear pore – solving a 3D jigsaw with 1000 pieces Martin Beck - EMBL Heidelberg, Germany
18.30-18.45	Targeting FPPS of Trypanosoma cruzi by fragment-based drug discovery Joy Petrick - Novartis, Switzerland
18.45-19.00	Proteins evolve on the edge of supramolecular self-assembly Emmanuel Levy - Weizmann Institute of Science, Israel
19.00-20.30	Poster Session
20.30-21.30	Dinner

Day 2 - Friday 17 November 2017
Time	Speaker
09.00-12.30	Session 4: Highlights in Structural Biology Chair: Orsolya Barabas
09.00-09.30	Snapshots of DNA mismatch repair: trapping transient states Titia Sixma - Netherlands Cancer Institute, The Netherlands
09.30-10.00	Structural biology and the molecular mechanics of cell guidance signalling Yvonne Jones - University of Oxford, UK
10.00-10.30	Integrated structural biology of gene transcription Patrick Cramer - Max Planck Institute for Biophysical Chemistry, Germany
10.30-11.00	Coffee Break
11.00-11.30	The exosome – ribosome connection: coupling the RNA degradation and translation machineries Elena Conti - Max Planck Institute of Biochemistry, Germany
11.30-11.45	Molecular basis of APC/C regulation by the spindle assembly checkpoint Claudio Alfieri, MRC Laboratory of Molecular Biology, United Kingdom
11.45-12.00	Mechanistic insights into cell adhesion receptors in brain development Elena Seiradake, University of Oxford, United Kingdom
12.00-12.15	Quantitative cross-linking MS of native complexes for integrative differential structural biology Marco Faini - ETH Zurich, Switzerland
12.15-14.00	Lunch and meet the speakers
13.00-14.00	Thermo Fischer Workshop Enabling in situ structural biology by cryo-focused-ion-beam sample preparation
14.00-17.30	Session 5: The radiation revolution: Photons, Neutrons and Electrons Chair: Matthias Wilmanns
14.00-14.30	(R)Evolution(s) in macromolecular crystallography Thomas Schneider - EMBL Hamburg, Germany
14.30-15.00	Macromolecular imaging using X-ray lasers Henry Chapman - DESY / University of Hamburg, Germany
15.00-15.30	Myoglobin revisited, picosecond dynamics from XFEL crystallography Ilme Schlichting - Max Planck Institute for Medical Research, Germany
15.30-16.00	Combining NMR and integrative structural biology to reveal mechanisms of regulatory protein-RNA interactions and dynamics in gene regulation Michael Sattler - Technical University of Munich & Helmholtz Center Munich, Germany
16.00-16.15	Phase-contrast X-ray microscopy and tomography on EMBL beamline P14 at PETRA III Maxim Polikarpov, EMBL, Germany
16.15-16.30	In meso in situ serial crystallography (IMISX) of soluble and membrane protein Chia-Ying Huang, Swiss Light Source/PSI, Switzerland
16.30-17.00	Coffee Break
17.00-19:30	Session 6: Nobel Prize in Chemistry for Cryo-EM in 2017 Chair: Stephen Cusack
17.00-17.40	Early cryo-EM at EMBL Jacques Dubochet – University of Lausanne, Switzerland
17.40-18:20	What are the barriers to progress with electrons, X-rays and neutrons for biological imaging Richard Henderson - MRC Laboratory of Molecular Biology, UK
18.20-18.30	Coffee Break
18.30-19.30	“Round Table on Future Perspectives” with Jacques Dubochet, Richard Henderson, Elena Conti, Wayne Hendrickson, Gerard Kleywegt, Stephen Cusack (Moderator)
19.30-20.30	Reception
20.30-21.30	Dinner in the EMBL Canteen
21.30-23.00	Blue Note Jazz Band