Location & dates
EMBL Heidelberg, Germany
24 - 27 Oct 2017
Deadlines
Registration closed
Abstract submission closed
Coronavirus information for participants
The onsite course and conference programme at EMBL has been paused until the end of June 2020.
We aim to continue offering our advanced training for the scientific community however we safely can. While some events have been cancelled, many have been rescheduled for a later date and others will be delivered as virtual events.
Registration is open for onsite courses and conferences starting after 1 July and for the virtual events. All registration fees for any events which don’t take place due to the COVID-19 disruption are fully refundable.
More information for participants of events at EMBL Heidelberg can be found here.
Conference Programme
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| Time | Speaker |
|---|---|
| 08.30-13.00 | Registration |
| 09:00-12:15 | Workshops |
| GeneWeaver Workshop Room: ATC Helix B11 |
|
| New NIH initiative the "Alliance of Genome Resources” Room: ATC B18 VC |
|
| Next Generation Sequencing (NGS) Room: Room V207 (Genome Biology) |
|
| 13.00-17.30 | Trainee Symposium Chairs: Martin Hrabě de Angelis - Helmholtz Center Munich and Technical University Munich, Germany Teresa M. Gunn - McLaughlin Research Institute, USA Monica J. Justice - The Hospital for Sick Children (SickKids), Canada |
| 13.00-13.15 | Protein disulfide isomerase associated 6 gene is important for pancreatic ß-cell homeostasis Nirav Chhabra - HelmholtzZentrum München, Germany |
| 13.15-13.30 | Genetic background-dependent cardiotoxicity from long-term pharmacological inhibition of EGFR Selene Howe - Texas A&M University, United States of America |
| 13.30-13.45 | Single-cell RNA sequencing reveals developmental heterogeneity and early differentiation events in in vitro fertilized cow embryos Ilaria Lavagi - Laboratory for Functional Genome Analysis (LAFUGA), Ludwig-Maximilians-Universität, Germany |
| 13.45-14.00 | A system level investigation to unravel mechanisms and potential direct targets of the osteogenic small molecule TH Mochammad Ichsan - Department of Bioengineering, The University of Tokyo, Japan |
| 14.00-14.15 | Neonatal Lethality and Genetic Modifiers in a new Mouse Model of Niemann-Pick Disease, Type C Jorge Rodriguez-Gil - NHGRI, NIH (US). University of Oxford (UK), University of Wisconsin Madison School of Medicine and Public Health, United States of America |
| 14.15-14.30 | Evolution and Function of Evolutionarily New Homeobox Genes in Rodent Preimplantation Development Amy Royall - University of Oxford, United Kingdom |
| 14.30-14.45 | Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross John Shorter - University of North Carolina Chapel Hill, United States of America |
| 14.45-15.00 | Genetic Architecture of Hybrid Male Sterility in the Mouse Samuel Widmayer - North Carolina State University, United States of America |
| 15.00-15.30 |
Coffee Break |
| 15.30-15.45 | Cancer Gene Somatic Mutagenesis by CRISPR/Cas9 Hsiang-Hsuan Fan - Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, Taiwan |
| 15.45-16.00 | In vitro iCLIP uncovers U2AF65 regulation in 3’ splice site definition FX Reymond Sutandy - IMB, Mainz, Germany |
| 16.00-16.15 | Identifying an Elusive Dominant ENU Suppressor of Lethal Venous Thromboembolism in the Mouse Marisa Brake - Oakland University, United States of America |
| 16.15-16.30 | High Protein Diet lowers blood glucose through regeneration of ß-Cell in Diabetic Rat Model Humaira Muzaffar - University of Agriculture, Faisalabad, Pakistan |
| 16.30-16.45 | From GWAS to gene function: analysis of the Glypican 6 and its involvement in cardiac septation and Tetralogy of Fallot Gennadiy Tenin - University of Manchester, United Kingdom |
| 16.45-17.00 | Allelic diversity of immunity loci in wild-derived and classical inbred mouse strains Jingtao Lilue - Wellcome trust Sanger Institute, United Kingdom |
| 17.00-17.15 | Crosstalk of ROCK2 with DNA repair machinery regulates radioresistance in cervical cancer Annapurna Pranatharthi - National Centre for Biological Sciences/St.Johns medical college hospital, India |
| 17.15-17.30 | The pluripotency regulator Prdm14 hijacks hematopoietic regulatory partners to initiate leukemia in mice Lauren Tracey - Hospital for Sick Children, Canada |
| 17.30-18.30 | Registration |
| 18.30-20.00 | Dinner |
| 20.00-20.15 | Welcome remarks |
| 20.15-21.15 | Verne Chapman Lecture The Role of Essential Genes in Human Disease Maja Bucan - Perelman School of Medicine at the University of Pennsylvania, USA Chair: Martin Hrabě de Angelis |
| 21.15-23.00 | After Dinner Drinks and Welcome reception with Live Music (Jazz Duo) |
| Time | Speaker | |
|---|---|---|
| 08.45-09.00 | Announcement | |
| 09.00-10.25 Session 1: Comparative Genomics, Computational Methods & Evolution I Chairs: Steve Munger and Thomas Keane |
||
| 09.00-09.25 | A proposal to increase rigor and reproducibility of mouse research through genetic quality control Fernando Pardo-Manuel de Villena - The University of North Carolina, USA |
|
| 09.25-09.40 | Multiple mouse reference genomes defines subspecies specific haplotypes and novel coding sequences Anthony Doran - Wellcome Trust Sanger Institute, UK |
|
| 09.40-09.55 | Investigating the evolutionary history and spermatogenic functions of the Mus lineage- specific Slx and Slxl1 ampliconic gene families Alyssa Kruger - University of Michigan, USA |
|
| 09.55-10.10 | Trainee Talk 1 | |
| 10.10-10.25 | Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in Collaborative Cross mice Jing Zhang - Institut Pasteur, France |
|
| 10.25-10.50 | Coffee Break Sponsored by The Jackson Laboratory |
|
| 10.50-12.35 Session 2: Comparative Genomics, Computational Methods & Evolution II Chairs: Lluis Montoliu and Karen Svenson |
||
| 10.50-11.05 | Characterization of Genes Required For Normal Mammalian Development Identified By Estimating Heterozygous Selective Effects in Human Populations David Beier - Seattle Children's Research Institute/Department of Pediatrics, University of Washington, USA |
|
| 11.05-11.20 | Trainee Talk 2 | |
| 11.20-11.35 | Dark DNA and divergence: a mutation hotspot in the genome of a diabetes-prone desert rodent Adam Hargreaves - University of Oxford, UK |
|
| 11.35-11.50 | Trainee Talk 3 | |
| 11.50-12.05 | Genetic mapping of species differences via “in vitro crosses” in mouse embryonic stem cells Frank Chan - Friedrich Miescher Laboratory, Germany |
|
| 12.05-12.20 | Trainee Talk 4 | |
| 12.20-12.35 | Non-additive genetic effects on complex traits in pigs, rats and mice are associated with trans-acting non-additive gene expression effects Richard Mott - University College London, UK |
|
| 12.35-14.00 | Lunch |
|
| 12.35-13.35 | Mammalian Genome Editorial Board Meeting Room: ATC Helix B11 |
|
| 14.00-15.45 | Poster Session 1 - Odd numbers ATC Helix A |
|
| 15.45-17.10 Session 3: Translational & Systems Genetics Chairs: Bill Pavan and Marty Ferris |
||
| 15.45-16.10 | Translational gene therapy approaches to treat genetic diseases Fatima Bosch - Autonomous University of Barcelona, Spain |
|
| 16.10-16.25 | Lessons from combined proteomic and transcriptomic studies in genetically diverse mice Steven Munger - The Jackson Laboratory, USA |
|
| 16.25-16.40 | QTL mapping and transcriptome analysis revealed candidate genes affecting susceptibility to periodontitis in the collaborative cross mouse population and confirmed in human populations Fuad Iraqi - Tel-Aviv University, Israel |
|
| 16.40-16.55 | ZGRF1 variants in a sensory epilepsy triggered by touch and temperature stimuli Shalini Roy Choudhury - Jawaharlal Nehru Centre for Advanced Scientific Research, India |
|
| 16.55-17.10 | Radically truncated MeCP2 rescues Rett syndrome-like neurological defects Rebekah Tillotson - University of Edinburgh, UK |
|
| 17.10-17.30 | Coffee Break Sponsored by The Jackson Laboratory |
|
| 17.30-19.10 Session 4: Human Disease Models I Chairs: Teresa Gunn and Binnaz Yalcin |
||
| 17.30-17.55 | Structural Variations in the Light of the 3D Genome Stefan Mundlos - Max Planck Institute for Molecular Genetics, Germany |
|
| 17.55-18.10 | Generation of new CRISPR-edited mouse models for investigating non-syndromic types of albinism Lluis Montoliu - CNB-CSIC and CIBERER-ISCIII, Spain |
|
| 18.10-18.25 | Role of Histone demethylation in neural cell fate: Lessons from mouse model Prem Prakash Tripathi - Amity University, India |
|
| 18.25-18.40 |
Fine mapping a major obesity locus (jObes1) also involved in visual impairment in the Berlin Fat Mouse |
|
| 18.40-18.55 | FAM172A, a gene mutated in CHARGE syndrome, codes for a new regulator of co-transcriptional alternative splicing Felix-Antoine B Simard - University of Quebec at Montreal, Canada |
|
| 18.55-19.10 | Beyond the D1/D2 receptor dichotomy in basal ganglia circuits Ozgun Gokce - Klinikum der Universität München, Germany |
|
| 19.10-20.30 | Dinner Mentor Dinner |
|
| 20.30-23.00 | After Dinner Drinks with SOULmate Band |
|
| Time | Speaker | |
|---|---|---|
| 08.45-09.00 | Announcements | |
| 09.00-10.50 Session 5: Cancer & Immunology Chairs: Monica Justice and Carol Bult |
||
| 09.00-09.25 | David Masopust - University of Minnesota, USA | |
| 09.25-09.40 | Tumor Incidence Studies in Congenic Strains of Mice Inform Drug Combinations for Myeloma Beverly Mock - National Cancer Institute, USA |
|
| 09.40-09.55 | Progression of colorectal cancer through epidermal growth factor receptor (EGFR)-independent mechanisms Carolina Mantilla Rojas - Texas A&M University, USA |
|
| 09.55-10.10 | Obligate haploinsufficiency in cancer: Expression levels of PTPRO determine its role as a tumor promoter or suppressor in chronic lymphocytic leukemia Ari Elson - The Weizmann Institute of Science, Israel |
|
| 10.10-10.25 | A mouse model of endothelium-initiated leukemia Viive M Howell - Kolling Institute, The University of Sydney, Australia |
|
| 10.25-10.50 | Transcriptional vulnerabilities of the cancer cell Chris Vakoc - Cold Spring Harbor Laboratory, USA |
|
| 10.50-11.15 | Coffee Break Sponsored by The Jackson Laboratory |
|
| 11.15-12.25 Session 6: Epigenetics and Gene Regulation Chairs: Phil Avner and Maja Bucan |
||
| 11.15-11.40 | Epigenetic Reprogramming, Female Sex Determination and Meiotic Entry of Mouse Germ Cells In Vitro Mitinori Saitou - Kyoto University, Japan |
|
| 11.40-11.55 | Genetic control of the epigenetic landscape Christopher Baker - The Jackson Laboratory, USA |
|
| 11.55-12.10 | Mammalian phenotypes: Looking beyond the genome Siddharth Sethi - MRC Harwell Institute, UK |
|
| 12.10-12.25 | Histone-methyltransferase PRDM9 is not required for rat meiosis Zdeněk Trachtulec - Institute of Molecular Genetics of the ASCR, v. v. i. |
|
| 12.25-12.50 | Epigenetic control of trophoblast stem cells - a tool to understand successful placentation Myriam Hemberger - Babraham Institute, UK |
|
| 12.50-13.45 | Lunch |
|
| 12.50-13.50 | Nomenclature Committee Meeting Room: Helix B18 |
|
| 13.45-15.30 | Poster Session 2 - Even numbers ATC Helix A |
|
| 15.30-16.30 Session 7: Technological Advances I Chairs: Fernando Pardo-Manuel de Villena and Lydia Teboul |
||
| 15.30-15.55 | The power of ONE: Immunology in the age of single cell genomics Ido Amit - Weizmann Institute of Science, Israel |
|
| 15.55-16.10 | Generation genomic structural variants and chromosomal manipulation by CRISPR/Cas9 genome editing in rodents Marie-Christine Birling - PHENOMIN-ICS, France |
|
| 16.10-16.30 | Darla Miller Distinguished Service lecture 30 Years of Transgenesis Thom Saunders - Model Core, University of Michigan, USA |
|
| 16.30-17.30 | IMGS Business Meeting | |
| 17.30-18.00 | Coffee Break Sponsored by The Jackson Laboratory |
|
| 18.00-19.00 | Rosa Beddington Memorial Lecture Alexandra L. Joyner - Sloan-Kettering Institute, USA Chair: Monica Justice |
|
| 19.15 | Free evening Walking Tour Old Town Heidelberg | |
| Time | Speaker | |
|---|---|---|
| 08.45-09:00 | Announcement | |
| 09.00-10.50 Session 8: Development and Stem Cells Chairs: David Beier and Viive Howell |
||
| 09.00-09.25 | The Gene Regulatory Logic of Spinal Cord Development James Briscoe - The Francis Crick Institute, UK |
|
| 09.25-09.40 | Catalytic-independent functions of DNA oxygenase TET1 in cranial neural tube closure Kian Koh - KU Leuven, Belgium |
|
| 09.40-09.55 | Aberrant NC Development and Altered Bladder Function in a Mouse Model of Spina bifida Michelle Southard-Smith - Vanderbilt University Medical Center, USA |
|
| 09.55-10.20 | From GWAS to gene function: analysis of the Glypican 6 and its involvement in cardiac septation and Tetralogy of Fallot Gennadiy Tenin - University of Manchester, United Kingdom |
|
| 10.20-10.35 | An evolutionarily conserved ribosome-rescue pathway maintains mammalian epidermal stem cell function Kif Liakath-Ali - King's College London, UK |
|
| 10.35-10.50 | A potential role for the kinetochore protein, Kinetochore associated 1 (KNTC1) in ciliary signaling Laura Reinholdt - The Jackson Laboratory, USA |
|
| 10.50-11.15 | Coffee Break Sponsored by INFRAFRONTIER |
|
| 11.15-12.15 Session 9: International Resources and INFRAFRONTIER Chairs: Martin Hrabě de Angelis and Michelle Southard-Smith |
||
| 11.15-11.30 | INFRAFRONTIER – resources and services to advance the understanding of human health and disease using mammalian models Sabine Fessele - INFRAFRONTIER GmbH, Germany |
|
| 11.30-11.45 | The IMPC: A global research infrastructure for understanding the role of genes in human development and disease Kent Lloyd - University of California, USA |
|
| 11.45-12.00 | THE MOUSE GENE EXPRESSION DATABASE (GXD) Martin Ringwald - The Jackson Laboratory, USA |
|
| 12.00-12.15 | Alliance of Genome Resources (AGR): An experiment in community genome resource sustainability Carol J. Bult - The Jackson Laboratory, USA |
|
| 12.15-13.45 |
Lunch |
|
| 12.15-13.15 |
Secretariat Meeting |
|
| 13.45-14.40 Session 10: Technological Advances II Chairs: François Spitz and Peter Horvath |
||
| 13.45-14.10 |
In-vivo imaging of cellular processes in deep mammalian tissues |
|
| 14.10-14.25 |
Dual ifgMosaic : a versatile method for multispectral and combinatorial mosaic gene function analysis |
|
| 14.25-14.40 |
Diacylglycerol biosensor mice |
|
|
14.40-17.05 |
||
| 14.40-15.05 |
Modeling the genetic landscape of congenital heart disease with mouse forward genetics |
|
| 15.05-15.20 |
Misregulation of an activity-dependent splicing network as a common mechanism underlying autism spectrum disorders |
|
| 15.20-15.50 |
Coffee Break |
|
| 15.50-16.05 |
Defining the TTC21B Interactome to Understand Ciliopathic Disease |
|
| 16.05-16.20 |
Altered Metabolism by Global Deletion of Pla2G6 Leads to Ageing-dependent Gastrointestinal Disorders |
|
| 16.20-16.35 |
Mutation of MFSD12 in the classic coat color mutant grizzled |
|
| 16.35-16.50 |
Novel Gain-of-Function Mutation in a Member of the Src Family Tyrosine Kinases Causes Autoinflammatory Bone Disease in the Mouse |
|
| 16.50-17.05 |
Exploring genetic diseases with intellectual disability due to copy number variation in rodents |
|
| 17.05-17.15 |
Closing remarks |
|
| 17.15-18.00 |
Free time |
|
| 18.00-21.00 |
Conference farewell dinner and Awards Ceremony |
|
| 21.00-24.00 |
Conference Party |
|