Location & dates EMBL Heidelberg, Germany 24 - 27 Oct 2017
Deadlines Registration closed Abstract submission closed

EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.

Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.

More information for participants of events at EMBL Heidelberg can be found here.

Conference Programme

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Day 1 - Tuesday 24 October 2017
08.30-13.00 Registration
09:00-12:15 Workshops
GeneWeaver Workshop
Room: ATC Helix B11
New NIH initiative the "Alliance of Genome Resources”    
Room: ATC B18 VC
Next Generation Sequencing (NGS)
Room: Room V207 (Genome Biology)
13.00-17.30 Trainee Symposium

Martin Hrabě de Angelis - Helmholtz Center Munich and Technical University Munich, Germany
Teresa M. Gunn - McLaughlin Research Institute, USA
Monica J. Justice - The Hospital for Sick Children (SickKids), Canada
13.00-13.15 Protein disulfide isomerase associated 6 gene is important for pancreatic ß-cell homeostasis
Nirav Chhabra - HelmholtzZentrum München, Germany
13.15-13.30 Genetic background-dependent cardiotoxicity from long-term pharmacological inhibition of EGFR
Selene Howe - Texas A&M University, United States of America   
13.30-13.45 Single-cell RNA sequencing reveals developmental heterogeneity and early differentiation events in in vitro fertilized cow embryos
Ilaria Lavagi - Laboratory for Functional Genome Analysis (LAFUGA), Ludwig-Maximilians-Universität, Germany
13.45-14.00 A system level investigation to unravel mechanisms and potential direct targets of the osteogenic small molecule TH
Mochammad Ichsan - Department of Bioengineering, The University of Tokyo, Japan   
14.00-14.15 Neonatal Lethality and Genetic Modifiers in a new Mouse Model of Niemann-Pick Disease, Type C
Jorge Rodriguez-Gil - NHGRI, NIH (US). University of Oxford (UK), University of Wisconsin Madison School of Medicine and Public Health, United States of America
14.15-14.30 Evolution and Function of Evolutionarily New Homeobox Genes in Rodent Preimplantation Development
Amy Royall - University of Oxford, United Kingdom
14.30-14.45 Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross
John Shorter - University of North Carolina Chapel Hill, United States of America
14.45-15.00 Genetic Architecture of Hybrid Male Sterility in the Mouse
Samuel Widmayer - North Carolina State University, United States of America

Coffee Break
Sponsored by The Jackson Laboratory

15.30-15.45 Cancer Gene Somatic Mutagenesis by CRISPR/Cas9
Hsiang-Hsuan Fan - Graduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, Taiwan 
15.45-16.00 In vitro iCLIP uncovers U2AF65 regulation in 3’ splice site definition
FX Reymond Sutandy - IMB, Mainz, Germany
16.00-16.15 Identifying an Elusive Dominant ENU Suppressor of Lethal Venous Thromboembolism in the Mouse
Marisa Brake - Oakland University, United States of America
16.15-16.30 High Protein Diet lowers blood glucose through regeneration of ß-Cell in Diabetic Rat Model
Humaira Muzaffar - University of Agriculture, Faisalabad, Pakistan
16.30-16.45 From GWAS to gene function: analysis of the Glypican 6 and its involvement in cardiac septation and Tetralogy of Fallot
Gennadiy Tenin - University of Manchester, United Kingdom
16.45-17.00 Allelic diversity of immunity loci in wild-derived and classical inbred mouse strains
Jingtao Lilue - Wellcome trust Sanger Institute, United Kingdom
17.00-17.15 Crosstalk of ROCK2 with DNA repair machinery regulates radioresistance in cervical cancer
Annapurna Pranatharthi - National Centre for Biological Sciences/St.Johns medical college hospital, India 
17.15-17.30 The pluripotency regulator Prdm14 hijacks hematopoietic regulatory partners to initiate leukemia in mice
Lauren Tracey - Hospital for Sick Children, Canada
17.30-18.30 Registration
18.30-20.00 Dinner
20.00-20.15 Welcome remarks
20.15-21.15 Verne Chapman Lecture

The Role of Essential Genes in Human Disease

Maja Bucan - Perelman School of Medicine at the University of Pennsylvania, USA
Chair: Martin Hrabě de Angelis
21.15-23.00 After Dinner Drinks and Welcome reception with Live Music (Jazz Duo)
Day 2 - Wednesday 25 October 2017
08.45-09.00 Announcement
Session 1: Comparative Genomics, Computational Methods & Evolution I
Chairs: Steve Munger and Thomas Keane
09.00-09.25 A proposal to increase rigor and reproducibility of mouse research through genetic quality control
Fernando Pardo-Manuel de Villena - The University of North Carolina, USA
09.25-09.40 Multiple mouse reference genomes defines subspecies specific haplotypes and novel coding sequences
Anthony Doran - Wellcome Trust Sanger Institute, UK
09.40-09.55 Investigating the evolutionary history and spermatogenic functions of the Mus lineage- specific Slx and Slxl1 ampliconic gene families
Alyssa Kruger - University of Michigan, USA
09.55-10.10 Trainee Talk 1
10.10-10.25 Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in Collaborative Cross mice    
Jing Zhang - Institut Pasteur, France
10.25-10.50 Coffee Break
Sponsored by The Jackson Laboratory

Session 2: Comparative Genomics, Computational Methods & Evolution II
Chairs: Lluis Montoliu and Karen Svenson
10.50-11.05 Characterization of Genes Required For Normal Mammalian Development Identified By Estimating Heterozygous Selective Effects in Human Populations    
David Beier - Seattle Children's Research Institute/Department of Pediatrics, University of Washington, USA
11.05-11.20 Trainee Talk 2
11.20-11.35 Dark DNA and divergence: a mutation hotspot in the genome of a diabetes-prone desert rodent    
Adam Hargreaves - University of Oxford, UK
11.35-11.50 Trainee Talk 3
11.50-12.05 Genetic mapping of species differences via “in vitro crosses” in mouse embryonic stem cells    
Frank Chan - Friedrich Miescher Laboratory, Germany
12.05-12.20 Trainee Talk 4
12.20-12.35 Non-additive genetic effects on complex traits in pigs, rats and mice are associated with trans-acting non-additive gene expression effects    
Richard Mott - University College London, UK 
12.35-14.00 Lunch
12.35-13.35 Mammalian Genome Editorial Board Meeting
Room: ATC Helix B11
14.00-15.45 Poster Session 1 - Odd numbers
ATC Helix A
Session 3: Translational & Systems Genetics
Chairs: Bill Pavan and Marty Ferris
15.45-16.10 Translational gene therapy approaches to treat genetic diseases
Fatima Bosch - Autonomous University of Barcelona, Spain
16.10-16.25 Lessons from combined proteomic and transcriptomic studies in genetically diverse mice
Steven Munger - The Jackson Laboratory, USA
16.25-16.40 QTL mapping and transcriptome analysis revealed candidate genes affecting susceptibility to periodontitis in the collaborative cross mouse population and confirmed in human populations    
Fuad Iraqi - Tel-Aviv University, Israel                 
16.40-16.55 ZGRF1 variants in a sensory epilepsy triggered by touch and temperature stimuli    
Shalini Roy Choudhury - Jawaharlal Nehru Centre for Advanced Scientific Research, India                   
16.55-17.10 Radically truncated MeCP2 rescues Rett syndrome-like neurological defects    
Rebekah Tillotson - University of Edinburgh, UK
17.10-17.30 Coffee Break
Sponsored by The Jackson Laboratory

Session 4: Human Disease Models I
Chairs: Teresa Gunn and Binnaz Yalcin
17.30-17.55 Structural Variations in the Light of the 3D Genome
Stefan Mundlos - Max Planck Institute for Molecular Genetics, Germany
17.55-18.10 Generation of new CRISPR-edited mouse models for investigating non-syndromic types of albinism
Lluis Montoliu - CNB-CSIC and CIBERER-ISCIII, Spain
18.10-18.25 Role of Histone demethylation in neural cell fate: Lessons from mouse model    
Prem Prakash Tripathi - Amity University, India                   

Fine mapping a major obesity locus (jObes1) also involved in visual impairment in the Berlin Fat Mouse    
Derk Arends - Humboldt-Universität zu Berlin, Germany

18.40-18.55        FAM172A, a gene mutated in CHARGE syndrome, codes for a new regulator of co-transcriptional alternative splicing   
Felix-Antoine B Simard - University of Quebec at Montreal, Canada                  
18.55-19.10 Beyond the D1/D2 receptor dichotomy in basal ganglia circuits    
Ozgun Gokce - Klinikum der Universität München, Germany
19.10-20.30 Dinner

Mentor Dinner
20.30-23.00 After Dinner Drinks with SOULmate Band
Day 3 - Thursday 26 October 2017
08.45-09.00 Announcements
Session 5: Cancer & Immunology
Chairs: Monica Justice and Carol Bult
09.00-09.25 David Masopust - University of Minnesota, USA
09.25-09.40 Tumor Incidence Studies in Congenic Strains of Mice Inform Drug Combinations for Myeloma    
Beverly Mock - National Cancer Institute, USA
09.40-09.55 Progression of colorectal cancer through epidermal growth factor receptor (EGFR)-independent mechanisms    
Carolina Mantilla Rojas - Texas A&M University, USA
09.55-10.10 Obligate haploinsufficiency in cancer: Expression levels of PTPRO determine its role as a tumor promoter or suppressor in chronic lymphocytic leukemia    
Ari Elson - The Weizmann Institute of Science, Israel                  
10.10-10.25 A mouse model of endothelium-initiated leukemia    
Viive M Howell - Kolling Institute, The University of Sydney, Australia               
10.25-10.50 Transcriptional vulnerabilities of the cancer cell
Chris Vakoc - Cold Spring Harbor Laboratory, USA
10.50-11.15 Coffee Break
Sponsored by The Jackson Laboratory
Session 6: Epigenetics and Gene Regulation
Chairs: Phil Avner and Maja Bucan
11.15-11.40 Epigenetic Reprogramming, Female Sex Determination and Meiotic Entry of Mouse Germ Cells In Vitro
Mitinori Saitou - Kyoto University, Japan
11.40-11.55 Genetic control of the epigenetic landscape    
Christopher Baker - The Jackson Laboratory, USA
11.55-12.10 Mammalian phenotypes: Looking beyond the genome    
Siddharth Sethi - MRC Harwell Institute, UK
12.10-12.25 Histone-methyltransferase PRDM9 is not required for rat meiosis    
Zdeněk Trachtulec - Institute of Molecular Genetics of the ASCR, v. v. i.             
12.25-12.50 Epigenetic control of trophoblast stem cells - a tool to understand successful placentation
Myriam Hemberger - Babraham Institute, UK
12.50-13.45 Lunch
12.50-13.50 Nomenclature Committee Meeting
Room: Helix B18
13.45-15.30 Poster Session 2 - Even numbers
ATC Helix A
Session 7: Technological Advances I
Chairs: Fernando Pardo-Manuel de Villena and Lydia Teboul
15.30-15.55 The power of ONE: Immunology in the age of single cell genomics
Ido Amit - Weizmann Institute of Science, Israel
15.55-16.10 Generation genomic structural variants and chromosomal manipulation by CRISPR/Cas9 genome editing in rodents    
Marie-Christine Birling - PHENOMIN-ICS, France
16.10-16.30 Darla Miller Distinguished Service lecture

30 Years of Transgenesis

Thom Saunders - Model Core, University of Michigan, USA
16.30-17.30 IMGS Business Meeting
17.30-18.00 Coffee Break
Sponsored by The Jackson Laboratory
18.00-19.00 Rosa Beddington Memorial Lecture
Alexandra L. Joyner - Sloan-Kettering Institute, USA
Chair: Monica Justice
19.15   Free evening Walking Tour Old Town Heidelberg
Day 4 - Friday 27 October 2017
08.45-09:00 Announcement
Session 8: Development and Stem Cells
Chairs: David Beier and Viive Howell
09.00-09.25 The Gene Regulatory Logic of Spinal Cord Development
James Briscoe - The Francis Crick Institute, UK
09.25-09.40 Catalytic-independent functions of DNA oxygenase TET1 in cranial neural tube closure    
Kian Koh - KU Leuven, Belgium                  
09.40-09.55 Aberrant NC Development and Altered Bladder Function in a Mouse Model of Spina bifida    
Michelle Southard-Smith - Vanderbilt University Medical Center, USA
09.55-10.20 From GWAS to gene function: analysis of the Glypican 6 and its involvement in cardiac septation and Tetralogy of Fallot
Gennadiy Tenin - University of Manchester, United Kingdom
10.20-10.35 An evolutionarily conserved ribosome-rescue pathway maintains mammalian epidermal stem cell function    
Kif Liakath-Ali - King's College London, UK
10.35-10.50 A potential role for the kinetochore protein, Kinetochore associated 1 (KNTC1) in ciliary signaling
Laura Reinholdt - The Jackson Laboratory, USA
10.50-11.15 Coffee Break
Session 9: International Resources and INFRAFRONTIER
Chairs: Martin Hrabě de Angelis and Michelle Southard-Smith
11.15-11.30 INFRAFRONTIER – resources and services to advance the understanding of human health and disease using mammalian models    
Sabine Fessele - INFRAFRONTIER GmbH, Germany
11.30-11.45 The IMPC: A global research infrastructure for understanding the role of genes in human development and disease    
Kent Lloyd - University of California, USA 
Martin Ringwald - The Jackson Laboratory, USA
12.00-12.15 Alliance of Genome Resources (AGR): An experiment in community genome resource sustainability    
Carol J. Bult - The Jackson Laboratory, USA



Secretariat Meeting
Room: ATC Helix B11

Session 10: Technological Advances II
Chairs: François Spitz and Peter Horvath

In-vivo imaging of cellular processes in deep mammalian tissues
Robert Prevedel - EMBL Heidelberg, Germany


Dual ifgMosaic : a versatile method for multispectral and combinatorial mosaic gene function analysis    
Rui Benedito - CNIC (National Center for Cardiovascular Research), Spain                   


Diacylglycerol biosensor mice    
Teresa Gunn - McLaughlin Research Institute, USA

Session 11:  Human Disease Models II
Chairs: Linda Siracusa and Laura Reinholdt


Modeling the genetic landscape of congenital heart disease with mouse forward genetics
Cecilia Lo - University of Pittsburgh, USA


Misregulation of an activity-dependent splicing network as a common mechanism underlying autism spectrum disorders    
Sabine Cordes - Lunenfeld-Tanenbaum Research Institute/University of Toronto, Canada


Coffee Break


Defining the TTC21B Interactome to Understand Ciliopathic Disease    
Rolf Stottmann - Cincinnati Childrens Hospital Medical Center, United States of America


Altered Metabolism by Global Deletion of Pla2G6 Leads to Ageing-dependent Gastrointestinal Disorders  
Walee Chamulitrat - University Heidelberg Hospital, Germany


Mutation of MFSD12 in the classic coat color mutant grizzled    
Bill Pavan - NIH, USA


Novel Gain-of-Function Mutation in a Member of the Src Family Tyrosine Kinases Causes Autoinflammatory Bone Disease in the Mouse    
Koichiro Abe - Tokai University School of Medicine, Japan  


Exploring genetic diseases with intellectual disability due to copy number variation in rodents    
Yann Herault - IGBMC, UMR7104, CNRS, INSERM U964, Université de Strasbourg, Institut Clinique de la Souris, CELPHEDIA-PHENOMIN-ICS, France


Closing remarks


Free time


Conference farewell dinner and Awards Ceremony


Conference Party
DJane Heidi Van De Alm, University of Popular Music and Music Business, Mannheim. Photobooth will be organized.