Location & dates EMBL Heidelberg, Germany 30 Aug - 1 Sep 2017
Deadlines Registration closed Abstract submission closed

EMBL Courses and Conferences during the Coronavirus pandemic

With the onsite programme paused, many of our events are now being offered in virtual formats.

Registration is open as usual for many events, with back-up plans in place to move further courses and conferences online as necessary. Registration fees for any events affected by the COVID-19 disruption are fully refundable.

More information for participants of events at EMBL Heidelberg can be found here.

Conference Programme

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Day 1 - Wednesday 30 August 2017
11.00-13.00 Registration and Lunch
13.00-13.10 Opening remarks

Keynote lecture: The Nucleosome: Guardian and Gateway to Genomes
Tim Richmond - ETH Zurich, Switzerland


Session 1 - The Nucleosome Structure


A little history and some loose ends
Jean Thomas - University of Cambridge, UK


Epichromatin: Structure at the Edge
Ada Olins - University of New England, USA


Coffee Break

15.30-15.45 Cryo EM structures of nucleosome breathing
Silvija Bilokapic - LMU, Germany
15.45-16.00 Multiscale structural dynamics of chromatin fibers revealed by single-molecule FRET
Beat Fierz - EPFL, Switzerland
16.00-16.15 Selective pull down and single-molecule analysis of native chromatin
John van Noort - Leiden University, The Netherlands

Keynote lecture:
The +1 Nucleosome
Roger Kornberg - Stanford Medicine, USA


Flash Talks

Structural and functional characterization of LEDGF/p75 in complex with cellular and pathogenic binding partners
Katerina Cermakova - Institute of Organic Chemistry and Biochemistry, Czech Republic

Nucleosome mobility and the regulation of gene expression: insights from single-molecule studies
Ariel Kaplan - Technion - Israel Institute of Technology, Israel

Capturing structural heterogeneity in chromatin fibers
Ekundayo Babatunde - University of Geneva, Switzerland

Recruitment and allosteric stimulation of a histone deubiquitinating enzyme during heterochromatin assembly
Aaron Johnson - University of Colorado School of Medicine, USA


Poster Session I (Odd numbers)

18.30-20:00 Dinner 
20:00-22:00 Welcome reception - with live music in the roof top lounge
Day 2 - Thursday 31 August 2017
09.00-12.30 Session 2 - Recognition and Enzymatic Activity on the Nucleosome
09.00-09.30 Structural studies of chromatin complexes
Song Tan - Penn State University, USA

The birth and assembly pathways of chromatin remodelling complexes
Laszlo Tora - Institute of Genetics and Molecular and Cellular Biology, France


Structural versatility and dynamics of chromatin units
Hitoshi Kurumizaka - Waseda University, Japan

10.30-11.00 Coffee Break

Protein complexes that modify chromatin for transcription
Jerry Workman - Stowers Institute for Medical Research, USA


Cryo-EM structure of the SAGA and NuA4 subunit Tra1 at 3.7 A° resolution
Alan Cheung - University College London, UK

11.45-12.00 Structural basis of specific H2A K13/K15 ubiquitination by RNF168
Hugo van Ingen - Leiden University, The Netherlands
12.00-12.15 Non-consensus sequence driven binding of RUNX1 to histone acetyltransferase promoters
Alex Woodworth - University of Tasmania, Australia

Mating type switching guided by epigenetic structure
Celia Raimondi -  CNRS, Institut Pasteur, France


Meet the Speakers and Lunch

14.30-18.30 Session 3 - Chromatin Remodeling and Nucleosome Diversity

Genome-wide mapping of chromatin dynamics
Steven Henikoff - Fred Hutchinson Cancer Reseach Center, USA


ATP-dependent mechanisms of nucleosome remodeling
Geeta Narlikar - UCSF School of Medicine, USA


Structure and mechanism of the human INO80 complex
Dale Wigley - Imperial College London, UK


Coffee Break


Building chromatin: assembly and evolution of nucleosomes
Karolin Luger - Howard Hughes Medical Institute, USA


Nucleosome-Chd1 complex structure elucidates chromatin remodelling
Lucas Farnung - Max Planck Institute for Biophysical Chemistry, Germany


Structure and function of the chromatin remodeling enzyme ISWI
Felix Mueller-Planitz - LMU Munich, Germany


The yeast INO80 chromatin remodeling complex is a length-sensitive “switch” that moves nucleosomes quickly and bi-directionally over long distances
Stephanie Johnson - University of California, San Francisco, USA


Open chromatin configuration at primed promoters is formed during embryogenesis and accelerates transcriptional activation during differentiation and nuclear reprogramming
Kei Miyamoto - Kindai University, Japan


Flash talks

Recruitment and allosteric stimulation of a histone deubiquitinating enzyme during heterochromatin assembly
Aaron Johnson - University of Colorado School of Medicine, USA

Unbiased proteomics of transcription start sites supports a role for nucleoskeletal proteins in chromatin structure
Lauren Cole - Florida State University, USA

Dominant-negative Smarca4 (Brg1) mutations induce convergent effects on the enhancer landscape
Courtney Hodges - Baylor College of Medicine, USA

Distinct roles for different modules of the SAGA chromatin-modifying complex in Drosophila gene expression
Jelly Soffers - Stowers Institute for Medical Research, USA

Sequence-directed action of chromatin remodelers and pioneer factors positions promoter nucleosomes to facilitate transcription initiation
Slawomir Kubik - University of Geneva, Switzerland


Poster Session II (Even numbers)

20.00-00.00 Dinner & Party
Day 3 - Friday 1 September 2017
09.00-12.30 Session 4 - Higher Order Chromatin and Genome Organisation
09.00-09.30 Remodeling of the chromatin fiber and the nucleosome by histone chaperone FACT in gene regulation
Guohong Li - Institute of Biophysics, Chinese Academy of Sciences, China
09.30-10.00 Cryo-EM structure of nucleosome core complexes
Daniela Rhodes - Nanyang Technologicall University, Singapore
10.00-10.30 Chromosome folding in yeast: from beads on a string to 3D folding
Oliver Rando - University of Massachusetts Medical School, USA

Coffee Break


3D Genome Dynamics
Peter Fraser - Babraham Institute, UK


Genome dynamics in real-time

Kerstin Bystricky - Laboratoire de Biologie Laboratoire de Biologie Moléculaire Eucaryote, University of Toulouse, France
12.00-12.15 Cohesin loss eliminates all loop domains, leading to links among superenhancers and downregulation of nearby genes
Suhas Rao - Stanford University, Baylor College of Medicine
12.15-12.30 Folding chromatin fibers by mesoscale simulations: hierarchical looping and enhanced kb contacts
Tamar Schlick - New York University, USA

Studying 3D genome structure using single cell Hi-C
David Lando - University of Cambridge, UK


Meet the Speakers and Lunch

14.30-17:15 Session 5 - Translational Applications Inspired by Structure

Targeting epigenetic reader domains
Stefan Knapp - Goethe University of Frankfurt, Germany


“Lighting the chaos, ordering the dark” – fluorescence microscopy in living cells to link chromatin organization and gene expression
Karsten Rippe - DKFZ, Germany


Higher Order Chromatin Arrays Form Heterogeneous Disrupted Structures
Hannah Sutcliffe - University of Edinburgh, Scotland


TRIC/CCT serves as a checkpoint in the assembly of basal transcription factor TFIID
Simona Antonova - UMC Utrecht, The Netherlands


Coffee Break


Decoding Chromatin Modification States Using Chemical Biology and Proteomic Approaches
Till Bartke - Helmholtz Zentrum Muenchen, Germany

16:45-17:00 Binding of Transcription Factors to Nucleosomal DNA
Fangjie Zhu - Karolinska Institute, Sweden

Epigenetic modifications of chromatin and RNA: their function and role in cancer
Tony Kouzarides -The Gurdon Institute, UK


Closing Remarks