Location & dates EMBL Heidelberg, Germany 30 Aug - 1 Sep 2017
Deadlines Registration closed Abstract submission closed

Conference Programme

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Day 1 - Wednesday 30 August 2017
11.00-13.00 Registration and Lunch
13.00-13.10 Opening remarks

Keynote lecture: The Nucleosome: Guardian and Gateway to Genomes
Tim Richmond - ETH Zurich, Switzerland


Session 1 - The Nucleosome Structure


A little history and some loose ends
Jean Thomas - University of Cambridge, UK


Epichromatin: Structure at the Edge
Ada Olins - University of New England, USA


Coffee Break

15.30-15.45 Cryo EM structures of nucleosome breathing
Silvija Bilokapic - LMU, Germany
15.45-16.00 Multiscale structural dynamics of chromatin fibers revealed by single-molecule FRET
Beat Fierz - EPFL, Switzerland
16.00-16.15 Selective pull down and single-molecule analysis of native chromatin
John van Noort - Leiden University, The Netherlands

Keynote lecture:
The +1 Nucleosome
Roger Kornberg - Stanford Medicine, USA


Flash Talks

Structural and functional characterization of LEDGF/p75 in complex with cellular and pathogenic binding partners
Katerina Cermakova - Institute of Organic Chemistry and Biochemistry, Czech Republic

Nucleosome mobility and the regulation of gene expression: insights from single-molecule studies
Ariel Kaplan - Technion - Israel Institute of Technology, Israel

Capturing structural heterogeneity in chromatin fibers
Ekundayo Babatunde - University of Geneva, Switzerland

Recruitment and allosteric stimulation of a histone deubiquitinating enzyme during heterochromatin assembly
Aaron Johnson - University of Colorado School of Medicine, USA


Poster Session I (Odd numbers)

18.30-20:00 Dinner 
20:00-22:00 Welcome reception - with live music in the roof top lounge
Day 2 - Thursday 31 August 2017
09.00-12.30 Session 2 - Recognition and Enzymatic Activity on the Nucleosome
09.00-09.30 Structural studies of chromatin complexes
Song Tan - Penn State University, USA

The birth and assembly pathways of chromatin remodelling complexes
Laszlo Tora - Institute of Genetics and Molecular and Cellular Biology, France


Structural versatility and dynamics of chromatin units
Hitoshi Kurumizaka - Waseda University, Japan

10.30-11.00 Coffee Break

Protein complexes that modify chromatin for transcription
Jerry Workman - Stowers Institute for Medical Research, USA


Cryo-EM structure of the SAGA and NuA4 subunit Tra1 at 3.7 A° resolution
Alan Cheung - University College London, UK

11.45-12.00 Structural basis of specific H2A K13/K15 ubiquitination by RNF168
Hugo van Ingen - Leiden University, The Netherlands
12.00-12.15 Non-consensus sequence driven binding of RUNX1 to histone acetyltransferase promoters
Alex Woodworth - University of Tasmania, Australia

Mating type switching guided by epigenetic structure
Celia Raimondi -  CNRS, Institut Pasteur, France


Meet the Speakers and Lunch

14.30-18.30 Session 3 - Chromatin Remodeling and Nucleosome Diversity

Genome-wide mapping of chromatin dynamics
Steven Henikoff - Fred Hutchinson Cancer Reseach Center, USA


ATP-dependent mechanisms of nucleosome remodeling
Geeta Narlikar - UCSF School of Medicine, USA


Structure and mechanism of the human INO80 complex
Dale Wigley - Imperial College London, UK


Coffee Break


Building chromatin: assembly and evolution of nucleosomes
Karolin Luger - Howard Hughes Medical Institute, USA


Nucleosome-Chd1 complex structure elucidates chromatin remodelling
Lucas Farnung - Max Planck Institute for Biophysical Chemistry, Germany


Structure and function of the chromatin remodeling enzyme ISWI
Felix Mueller-Planitz - LMU Munich, Germany


The yeast INO80 chromatin remodeling complex is a length-sensitive “switch” that moves nucleosomes quickly and bi-directionally over long distances
Stephanie Johnson - University of California, San Francisco, USA


Open chromatin configuration at primed promoters is formed during embryogenesis and accelerates transcriptional activation during differentiation and nuclear reprogramming
Kei Miyamoto - Kindai University, Japan


Flash talks

Recruitment and allosteric stimulation of a histone deubiquitinating enzyme during heterochromatin assembly
Aaron Johnson - University of Colorado School of Medicine, USA

Unbiased proteomics of transcription start sites supports a role for nucleoskeletal proteins in chromatin structure
Lauren Cole - Florida State University, USA

Dominant-negative Smarca4 (Brg1) mutations induce convergent effects on the enhancer landscape
Courtney Hodges - Baylor College of Medicine, USA

Distinct roles for different modules of the SAGA chromatin-modifying complex in Drosophila gene expression
Jelly Soffers - Stowers Institute for Medical Research, USA

Sequence-directed action of chromatin remodelers and pioneer factors positions promoter nucleosomes to facilitate transcription initiation
Slawomir Kubik - University of Geneva, Switzerland


Poster Session II (Even numbers)

20.00-00.00 Dinner & Party
Day 3 - Friday 1 September 2017
09.00-12.30 Session 4 - Higher Order Chromatin and Genome Organisation
09.00-09.30 Remodeling of the chromatin fiber and the nucleosome by histone chaperone FACT in gene regulation
Guohong Li - Institute of Biophysics, Chinese Academy of Sciences, China
09.30-10.00 Cryo-EM structure of nucleosome core complexes
Daniela Rhodes - Nanyang Technologicall University, Singapore
10.00-10.30 Chromosome folding in yeast: from beads on a string to 3D folding
Oliver Rando - University of Massachusetts Medical School, USA

Coffee Break


3D Genome Dynamics
Peter Fraser - Babraham Institute, UK


Genome dynamics in real-time

Kerstin Bystricky - Laboratoire de Biologie Laboratoire de Biologie Moléculaire Eucaryote, University of Toulouse, France
12.00-12.15 Cohesin loss eliminates all loop domains, leading to links among superenhancers and downregulation of nearby genes
Suhas Rao - Stanford University, Baylor College of Medicine
12.15-12.30 Folding chromatin fibers by mesoscale simulations: hierarchical looping and enhanced kb contacts
Tamar Schlick - New York University, USA

Studying 3D genome structure using single cell Hi-C
David Lando - University of Cambridge, UK


Meet the Speakers and Lunch

14.30-17:15 Session 5 - Translational Applications Inspired by Structure

Targeting epigenetic reader domains
Stefan Knapp - Goethe University of Frankfurt, Germany


“Lighting the chaos, ordering the dark” – fluorescence microscopy in living cells to link chromatin organization and gene expression
Karsten Rippe - DKFZ, Germany


Higher Order Chromatin Arrays Form Heterogeneous Disrupted Structures
Hannah Sutcliffe - University of Edinburgh, Scotland


TRIC/CCT serves as a checkpoint in the assembly of basal transcription factor TFIID
Simona Antonova - UMC Utrecht, The Netherlands


Coffee Break


Decoding Chromatin Modification States Using Chemical Biology and Proteomic Approaches
Till Bartke - Helmholtz Zentrum Muenchen, Germany

16:45-17:00 Binding of Transcription Factors to Nucleosomal DNA
Fangjie Zhu - Karolinska Institute, Sweden

Epigenetic modifications of chromatin and RNA: their function and role in cancer
Tony Kouzarides -The Gurdon Institute, UK


Closing Remarks